• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of monocyte and macrophage in chronic GVHD

Research Project

Project/Area Number 18K08328
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54010:Hematology and medical oncology-related
Research InstitutionOkayama University

Principal Investigator

Maeda Yoshinobu  岡山大学, 医歯薬学総合研究科, 教授 (60403474)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords慢性GVHD / 免疫学 / 慢性移植片対宿主病
Outline of Final Research Achievements

Chronic graft-versus-host disease (GVHD) is the main cause of late death and morbidity after allogeneic stem cell transplantation (SCT). Fibrosis constitutes the end stage of the inflammatory process in chronic GVHD leading to major morbidity. Recently, segregated-nucleus-containing atypical monocytes (SatM) that involved in lung fibrosis has been identified. Ly6clow monocyte, Ly6c+ monocyte and SatM increased in BALF of allogeneic recipient. In the sclerodermatous chronic GVHD model, SatM increased in ear of allogeneic group. From these results, we hypothesized that SatM may cause the fibrosis of chronic GVHD. To demonstrate that SatM causes the fibrosis of chronic GVHD, we established GVHD model with SatM deficiency mouse (Cebpb-/- mouse). Recipient of SatM deficiency mouse showed exacerbated GVHD, suggesting that Cebpb-/- donor cells have decreased regulatory function.

Academic Significance and Societal Importance of the Research Achievements

慢性GVHDの予防・治療薬としてこれまでT細胞を抑制する薬剤が使用されてきたが、十分な効果を発揮できていない。本研究により慢性GVHD、特に肺病変における単球・マクロファージの関与が明らかとなった。SatM (Segregatd-nucleus-containing atypical monocytes)と名付けられたLy6C- 単球のなかでもCeacam1+, MSR1+の集団が肺合併症に関与することが示唆された。また、C/EBPbが移植後の免疫抑制に関与することも明らかとなった。これにより治療のターゲットが明らかとなり新規治療薬の開発に繋がる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi