Roles of ribosome biogenesis disorder in the development of hematopoietic malignancies

• Project/Area Number: 18K08334
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Kumamoto University
• Principal Investigator: MATSUI HIROTAKA 熊本大学, 大学院生命科学研究部(医), 教授 (60379849)
• Co-Investigator(Kenkyū-buntansha): 神力 悟 熊本大学, 大学院生命科学研究部(医), 准教授 (00583048)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: RNAヘリケース / 骨髄異形成症候群 / 急性骨髄性白血病 / R-loop / DNA損傷応答 / RNA翻訳制御 / DDX41 / リボソームプロファイリング / リボソーム

Outline of Final Research Achievements

In this study, we analyzed the molecular function of DDX41, a DEAD-box type RNA helicase, to elucidate molecular pathogenesis of myeloid malignancies. We performed a comprehensive translation analysis by taking advantage of ribosome-profiling method and found that transcription and translation are only marginally correlate with each other. We also found that ribosome-associated proteins were selectively induced at translation level when the expression of DDX41 was decreased. This is possibly due to the presence of a feedback regulation against the disorder of ribosome biogenesis by DDX41 inhibition/dysfunction, and we assume this newly identified regulation system would be involved in the hematopoiesis and/or leukemogenesis. The results have been compiled into a manuscript and is currently being submitted to a scientific journal.

Academic Significance and Societal Importance of the Research Achievements

造血器腫瘍の一定の割合で、DDX41遺伝子の変異を有する例が見出される。DDX41はRNAヘリケースと呼ばれる酵素をコードする遺伝子のひとつであるが、DDX41の造血細胞における役割は不明であり、本遺伝子の変異が造血器腫瘍を起こす機序も未解明であった。
我々はこれまでにDDX41がリボソームRNAのプロセシングを介してリボソーム生合成に関与することを示してきたが、今回さらに本研究を発展させ、網羅的な翻訳解析を行うことで、本分子の翻訳制御機構への関わりを検討した。DDX41の発現を抑制した細胞ではリボソーム生合成関連分子の発現が翻訳レベルで増加することを明らかにし、腫瘍発症への関与を示した。

Research Products

• [Int'l Joint Research] University of Saskatchewan(カナダ)
• [Int'l Joint Research] University Health Network(カナダ)
• [Int'l Joint Research] University of Saskatchewan(カナダ)
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• [Journal Article] Glycosylated ferritin as an improved marker for post-transfusion iron overload (2021)
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  • Journal Title: International Journal of Hematology Volume: 113 Issue: 4 Pages: 537-546
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• [Journal Article] Multi-organ failure with abnormal receptor metabolism in mice mimicking Samd9/9L syndromes (2021)
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• [Journal Article] Elevated C-reactive protein is significantly associated with left ventricular dysfunction in patients with aortic regurgitation and concomitant collagen disease (2021)
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• [Journal Article] Current Awareness and Status of Transthoracic Echocardiography in Kumamoto Prefecture ― A Report of the Kumamoto Cardiovascular Echocardiography Standardization Project ― (2020)
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  • Journal Title: Circulation Reports Volume: 2 Issue: 6 Pages: 297-305
  • DOI: 10.1253/circrep.CR-20-0028
  • NAID: 130007853642
  • ISSN: 2434-0790
  • Year and Date: 2020-06-10
  • Peer Reviewed
• [Journal Article] Estimation of the hemoglobin glycation rate constant. (2020)
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• [Journal Article] Usefulness of relative apical longitudinal strain index to predict positive 99m Tc‐labeled pyrophosphate scintigraphy findings in advanced‐age patients with suspected transthyretin amyloid cardiomyopathy (2020)
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  • Journal Title: Echocardiography Volume: 37 Issue: 11 Pages: 1774-1783
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• [Journal Article] Plasma growth differentiation factor 15: a novel tool to detect early changes of hereditary transthyretin amyloidosis (2020)
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• [Journal Article] Activation of CpG-Rich Promoters Mediated by MLL Drives MOZ-Rearranged Leukemia (2020)
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  • Journal Title: Cell Reports Volume: 32 Issue: 13 Pages: 108200-108200
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• [Journal Article] Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status. (2020)
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  • Journal Title: Blood Adv. Volume: 4(5) Issue: 5 Pages: 845-854
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• [Journal Article] Evaluation of an amplicon-based custom gene panel for the diagnosis of hereditary tumors. (2020)
  • Author(s): Shinriki S, Maeshiro M, Shimamura K, Kawashima J, Araki E, Ibusuki M, Yamamoto Y, Iwase H, Miyamoto Y, Baba H, Yamaguchi M, Matsui H.
  • Journal Title: Neoplasma Volume: － Issue: 04 Pages: 898-908
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• [Journal Article] Novel dot-blot assay for detection of vascular Notch3 aggregates in patients with CADASIL (2020)
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• [Journal Article] Identification of novel methylation markers in HPV-associated oropharyngeal cancer: genome-wide discovery, tissue verification and validation testing in ctDNA. (2020)
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• [Journal Article] Clinical, pathological, and proteomic characteristics of newly diagnosed amyloidosis patients: Experience from a single referral center in Japan (2020)
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  • Journal Title: Neurology and Clinical Neuroscience Volume: 9 Issue: 1 Pages: 37-44
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• [Journal Article] De novo p.G696S mutation in COL4A1 causes intracranial calcification and late-onset cerebral hemorrhage: A case report and review of the literature. (2020)
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  • Journal Title: Eur J Med Genet Volume: 63 Issue: 4 Pages: 103825-103825
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  • Peer Reviewed
• [Journal Article] 血液細胞画像判定におけるAIの構築 (2020)
  • Author(s): 松井啓隆
  • Journal Title: JOHNS Volume: 36 Pages: 1606-1611
• [Journal Article] 大学病院でのNGSを利用した遺伝子検査 (2020)
  • Author(s): 2.神力悟、松井啓隆
  • Journal Title: 臨床病理レビュー 特集 Volume: 164 Pages: 111-118
• [Journal Article] Clinical, pathological, and proteomic characteristics of newly diagnosed amyloidosis patients: Experience from a single referral center in Japan. (2020)
  • Author(s): Ando Y, Yamashita T, Misumi Y, Nomura T, Sasada K, Okada M, Inoue Y, Masuda T, Takamatsu K, Obayashi K, Matsui H, Naiki H, Ueda M.
  • Journal Title: Neurology and Clinical Neuroscience Volume: -
  • Peer Reviewed
• [Journal Article] Current awareness and status of transthoracic echocardiography in Kumamoto Prefecture - a report of the Kumamoto Cardiovascular Echocardiography Standardization Project (2020)
  • Author(s): Usuku H, Yamamoto E, Oike F, Yoshinouchi T, Imamura K, Yoshida K, Kanesaki D, Toma Y, Tomita A, Ogata Y, Matsumoto S, Iwayama Y, Sassa T, Tanaka S, Fukuyoshi Y, Matsumoto T, Tanaka E, Shono H, Nishigami K, Tsujita K, Matsui H
  • Journal Title: Circulation Reports Volume: -
  • NAID: 130007853642
  • Peer Reviewed
• [Journal Article] Evaluation of an amplicon-based custom gene panel for the diagnosis of hereditary tumors. (2020)
  • Author(s): Shinriki S, Maeshiro M, Shimamura K, Kawashima J, Araki E, Ibusuki M, Yamamoto Y, Iwase H, Miyamoto Y, Bana H, Yamaguchi M, Matsui H
  • Journal Title: Neoplasma Volume: -
  • Peer Reviewed
• [Journal Article] PROSPECTS AND CHALLENGES OF CANCER GENOMIC PROFILING TEST (2019)
  • Author(s): 松井啓隆
  • Journal Title: Japanese Journal of Transfusion and Cell Therapy Volume: 65 Issue: 5 Pages: 777-781
  • DOI: 10.3925/jjtc.65.777
  • NAID: 130007746166
  • ISSN: 1881-3011, 1883-0625
  • Year and Date: 2019-10-25
• [Journal Article] Hereditary ATTR Amyloidosis with Cardiomyopathy Caused by the Novel Variant Transthyretin Y114S (p.Y134S) (2019)
  • Author(s): Nakase Taku、Yamashita Taro、Matsuo Yoshimasa、Nomura Toshiya、Sasada Keiko、Masuda Teruaki、Misumi Yohei、Takamatsu Kotaro、Oda Seitaro、Furukawa Yutaro、Obayashi Konen、Matsui Hirotaka、Ando Yukio、Ueda Mitsuharu
  • Journal Title: Internal Medicine Volume: 58 Issue: 18 Pages: 2695-2698
  • DOI: 10.2169/internalmedicine.2456-18
  • NAID: 130007706923
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-09-15
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• [Journal Article] Development of caseous calcification of mitral annulus after initiation of hemodialysis therapy (2019)
  • Author(s): Usuku H, Yamamoto E, Oike F, Tsunoda R, Nishigami K, Sakaguchi T, Suzuki R, Uekihara S, Matsui H, Tsujita K
  • Journal Title: J Cardiol Cases Volume: 19(6) Issue: 6 Pages: 190-193
  • DOI: 10.1016/j.jccase.2019.02.002
  • Peer Reviewed
• [Journal Article] New simple and quick method to analyze serum variant transthyretins: direct MALDI method for the screening of hereditary transthyretin amyloidosis (2019)
  • Author(s): Nomura Toshiya、Ueda Mitsuharu、Tasaki Masayoshi、Misumi Yohei、Masuda Teruaki、Inoue Yasuteru、Tsuda Yukimoto、Okada Masamitsu、Okazaki Takahiro、Kanenawa Kyosuke、Isoguchi Aito、Nakamura Makoto、Obayashi Konen、Shinriki Satoru、Matsui Hirotaka、Yamashita Taro、Ando Yukio
  • Journal Title: Orphanet Journal of Rare Diseases Volume: 14 Issue: 1 Pages: 116-116
  • DOI: 10.1186/s13023-019-1100-y
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• [Journal Article] HbA1c adjusted by erythrocyte creatine is a useful glycemic control indicator in patients with hemolysis. (2019)
  • Author(s): Koga M, Inada S, Shibata M, Ijima H, Jinnouchi H, Ono Y, Iwasaka T, Tokuhiro S, Matsumura Y, Matsui H, Okumiya T.
  • Journal Title: Clin Biochem. Volume: 73 Pages: 77-81
  • DOI: 10.1016/j.clinbiochem.2019.08.004
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• [Journal Article] A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH (2019)
  • Author(s): Ueda Mitsuharu、Okada Masamitsu、Mizuguchi Mineyuki、et al.
  • Journal Title: Journal of Biological Chemistry Volume: 294 Issue: 29 Pages: 11259-11275
  • DOI: 10.1074/jbc.ra119.007851
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• [Journal Article] Accumulation of coronary risk factors is associated with progression of mitral annular calcification in patients undergoing dialysis therapy: A long-term follow-up study (2019)
  • Author(s): Usuku H, Yamamoto E, Arima Y, Takashio S, Araki S, Sueta D, Kanazawa H, Suzuki S, Yoshimura H, Tsunoda R, Nishigami K, Uekihara S, Sakamoto K, Kawano H, Kaikita K, Matsui H, Tsujita K
  • Journal Title: Int J Cardiol Volume: 293 Pages: 248-253
  • DOI: 10.1016/j.ijcard.2019.05.001
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• [Journal Article] Hemolysis causes a decrease in HbA1c level but not in glycated albumin or 1,5-anhydroglucitol level (2019)
  • Author(s): Kiniwa N, Okumiya T, Tokuhiro S, Matsumura Y, Matsui H, Koga M
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• [Journal Article] A novel assay for triglycerides using glycerol dehydrogenase and a water-soluble formazan dye, WST-8 (2019)
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• [Journal Article] NUP98-HBO1-fusion generates phenotypically and genetically relevant chronic myelomonocytic leukemia pathogenesis (2019)
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• [Journal Article] A novel age-related venous amyloidosis derived from EGF-containing fibulin-like extracellular matrix protein 1 (2019)
  • Author(s): Tasaki M, Ueda M, Hoshii Y, Mizukami M, Matsumoto S, Nakamura M, Yamashita T, Ueda A, Misumi Y, Masuda T, Inoue Y, Torikai T, Nomura T, Tsuda Y, Kanenawa K, Isoguchi A, Okada M, Matsui H, Obayashi K, Ando Y.
  • Journal Title: The Journal of Pathology Volume: 247 Issue: 4 Pages: 444-455
  • DOI: 10.1002/path.5203
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• [Journal Article] モノソミー7の獲得が造血器腫瘍を発症させるメカニズム (2019)
  • Author(s): 松井啓隆
  • Journal Title: 臨床病理 Volume: 67(9) Pages: 933-940
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  • Author(s): 前川 真人, 安部 正義, 加藤 智行, 繁田 勝美, 滝野 寿, 田澤 裕光, 堤 正好, 登 勉, 東 俊一, 松井 啓隆, 松下 一之, 横田 浩充, 近藤 直人, 北川 昌伸, 矢冨 裕, 西田 美和, 渡辺 玲子, 臨床検査振興協議会, 臨床検査振興協議会医療政策委員会, ゲノム検査に関する小委員会
  • Journal Title: 臨床病理レビュー Volume: 162 Pages: 1-31
• [Journal Article] 【血液学検査を使いこなす】血液学検査を取り巻く話題 人工知能を活用した血液検査の未来 (2019)
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  • Author(s): 松井啓隆
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• [Journal Article] A novel age-related venous amyloidosis derived from EGF-containing fibulin-like extracellular matrix protein 1 (2018)
  • Author(s): Tasaki M, Ueda M, Hoshii Y, Mizukami M, Matsumoto S, Nakamura M, Yamashita T, Ueda A, Misumi Y, Masuda T, Inoue Y, Torikai T, Nomura T, Tsuda Y, Kanenawa K, Isoguchi A, Okada M, Matsui H, Obayashi K, Ando Y
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• [Journal Article] CSF TACI and BAFF levels in patients with primary CNS lymphoma as novel diagnostic biomarkers. (2018)
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  • Journal Title: Microrna Volume: 7(3) Pages: 195-203
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• [Journal Article] A novel ASXL1-OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies (2018)
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  • Journal Title: Leukemia Volume: 32(6) Pages: 1327-1337
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• [Journal Article] The enigma of monosomy 7. (2018)
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  • Journal Title: Blood Volume: 131(26) Pages: 2891-2898
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  • Journal Title: Leuk Res Volume: 69 Pages: 54-59
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• [Journal Article] 被災地での臨床検査支援体制の構築 (2018)
  • Author(s): 松井啓隆、池田勝義
  • Journal Title: 臨床検査 Volume: 63巻2号 Pages: 186-190
• [Journal Article] 自動血球分析装置による末梢血幹細胞動員不良予測の試み (2018)
  • Author(s): 舛田 博貴, 笹田 景子, 福吉 葉子, 大隈 雅紀, 内場 光浩, 井上 明威, 野坂 生郷, 奥野 豊, 松岡 雅雄, 松井 啓隆, 米村 雄士
  • Journal Title: 日本輸血細胞治療学会誌 Volume: 64巻3号 Pages: 510-515
  • NAID: 130007404550
• [Presentation] 血液細胞形態の自動判定に向けたシステム開発 (2020)
  • Author(s): 松井啓隆
  • Organizer: 日本医療検査科学会 第52回大会
  • Invited
• [Presentation] 検査血液領域におけるAIの導入 (2020)
  • Author(s): 松井啓隆
  • Organizer: 第21回日本検査血液学会学術集会
  • Invited
• [Presentation] 高度メカノセンシティブ癌細胞の血中ホモティピッククラスター形成を介した遠隔臓器への生着 (2020)
  • Author(s): 神力悟、松井啓隆
  • Organizer: 第67回日本臨床検査医学会学術集会
• [Presentation] Translational regulation of a subset of genes by DDX41 (2020)
  • Author(s): トンガラグ・サロール、神力悟、金井昭教、長町安希子、稲葉俊哉、松井啓隆
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] DDX41の機能抑制は翻訳変化とDNAダメージを誘導する (2020)
  • Author(s): 神力悟、松井啓隆
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] CYLDの発現低下はEGFRエンドサイトーシスの阻害を介してセツキシマブ耐性を誘導する (2020)
  • Author(s): 劉隣、神力悟、前城学、城野博史、中山秀樹、松井啓隆
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] モノソミー7を伴うMDSを多発するMIRAGE症候群モデルマウスに見られた受容体取込み異常 (2020)
  • Author(s): 長町安希子、松井啓隆、金井昭教、神力悟、稲葉俊哉
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 高度メカノセンシティブ腫瘍細胞は安定な循環ホモクラスター形成を介して遠隔臓器に定着する (2020)
  • Author(s): 前城学、神力悟、劉隣、仲地ゆたか、菰原義弘、藤原章雄、大坪和明、吉田遼司、中山秀樹、松井啓隆
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 遺伝子とがん：がん細胞の遺伝子検査でなにがわかるか・なにができるか (2020)
  • Author(s): 松井啓隆
  • Organizer: 第72回肥後医育塾 公開セミナー「知っておきたい次世代がん治療」2
• [Presentation] Need for accurate diagnosis of hematological malignancies (2019)
  • Author(s): Matsui H
  • Organizer: Meeting of Mongolia External Quality Assurance Surveillance (MEQAS)
  • Invited
• [Presentation] 遺伝子パネル検査の精度確保 (2019)
  • Author(s): 松井啓隆
  • Organizer: 第5回クリニカルバイオバンク学会シンポジウム
  • Invited
• [Presentation] がんゲノム医療の推進における検査部としての対応 (臨床検査専門医Catch upセミナー) (2019)
  • Author(s): 松井啓隆
  • Organizer: 第29回臨床検査専門医会春季大会
  • Invited
• [Presentation] 次世代シーケンサーの臨床応用 ―現状・課題・展望― (教育講演) (2019)
  • Author(s): 松井啓隆
  • Organizer: 第67回日本輸血・細胞治療学会学術総会
  • Invited
• [Presentation] 造血器腫瘍：ゲノム解析と分子メカニズム解析の連携により見えてきた病態 (シンポジウム) (2019)
  • Author(s): 松井啓隆
  • Organizer: 第11回日本臨床検査医学会 特別例会
  • Invited
• [Presentation] Roles of Monosomy 7 and SAMD9/SAMD9L mutations in myeloid leukemogenesis (2018)
  • Author(s): Matsui H
  • Organizer: 2019 International Conference & 60th Annual Meeting of Korean Society of Hematology
  • Int'l Joint Research / Invited
• [Presentation] Dysregulated translation control via inappropriate ribosome biogenesis is involved in myeloid leukemogenesis. (2018)
  • Author(s): Matsui H., Shinriki S., Kanai A.
  • Organizer: 47th Annual Scientific Meeting of International Society of Experimental Hematology
  • Int'l Joint Research
• [Presentation] Perspective of integrated diagnosis of Myelodysplastic syndrome. (2018)
  • Author(s): Matsui H
  • Organizer: 10th meeting of Mongolia External Quality Assurance Surveillance (MEQAS)
  • Int'l Joint Research / Invited
• [Presentation] リボソーム生合成障害の白血病発症への関与 (2018)
  • Author(s): 神力 悟, 松井 啓隆
  • Organizer: 第65回臨床検査医学会学術集会
• [Presentation] 発信される臨床検査情報の活用 診療最前線と中央検査室の自動化機器の連携 (2018)
  • Author(s): 池田 勝義, 長島 美紀, 山内 露子, 山下 昭一郎, 福吉 葉子, 松井 啓隆
  • Organizer: 第65回臨床検査医学会学術集会
• [Presentation] DNA脱メチル化剤によるMDS貧血改善遺伝子の探索 (2018)
  • Author(s): 金井 昭教, 長町 安希子, 松井 啓隆, 稲葉 俊哉
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Tet2/3遺伝子の欠失数がマウス造血器腫瘍の発症を決定する (2018)
  • Author(s): 真家 紘一郎, Shrestha Raksha, 坂田 麻実子[柳元], 大島 基彦, 中島 やえ子, 松井 啓隆, 加藤 貴康, 武藤 秀治, Mouly Enguerran, Bernard Olivier A., 古関 明彦, 岩間 厚志, 千葉 滋
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] リボソーム生合成異常の白血病発症への関与 (2018)
  • Author(s): 神力 悟, 金井 昭教, 長町 安希子, 一戸 辰夫, 稲葉 俊哉, 松井 啓隆
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Samd9/Samd9L変異体による造血障害メカニズムの解明 (2018)
  • Author(s): 長町 安希子, 松井 啓隆, 金井 昭教, 神力 悟, 稲葉 俊哉
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] NUP98-HBO1によるヒストンアセチル化制御異常は慢性骨髄単球性白血病を引き起こす (2018)
  • Author(s): 林 嘉宏, 原田 結花, 鍵山 侑希, 丁 曄, 今川 潤, 新谷 直樹, 加藤 菜穂子, 北浦 次郎, 小松 則夫, 松井 啓隆, 北林 一生, 岩間 厚志, 北村 俊雄, 原田 浩徳
  • Organizer: 第80回日本血液学会学術集会.
• [Presentation] 放射線を用いたがん研究とがん治療: モノソミー7を伴う放射線誘発MDSにおけるエンドソームタンパク質Samd9/Lの役割 (2018)
  • Author(s): 稲葉 俊哉, 長町 安希子, 金井 昭教, 松井 啓隆
  • Organizer: 第77回日本癌学会学術総会.
• [Presentation] 自律的細胞特性が骨髄播種癌細胞の休眠に寄与する (2018)
  • Author(s): 前城 学, 神力 悟, 中村 拓哉, 城野 博史, 中山 秀樹, 安東 由喜雄, 松井 啓隆
  • Organizer: 第77回日本癌学会学術総会.
• [Presentation] ヒストンアセチル化制御破綻による慢性骨髄単球性白血病の新規発症機序 (2018)
  • Author(s): 林 嘉宏, 原田 結花, 鍵山 侑希, 新谷 直樹, 小松 則夫, 松井 啓隆, 北林 一生, 岩間 厚志, 北村 俊雄, 原田 浩徳
  • Organizer: 第77回日本癌学会学術総会.
• [Presentation] Loss of TET2 and TET3 alleles accentuate development of hematological malignancies (2018)
  • Author(s): Shrestha Raksha, 真家 紘一郎, Sakata-Yanagimoto Mamiko, Oshima Motohiko, Nakajima-Takagi Yaeko, 松井 啓隆, Kato Takayasu, 武藤 秀治, Mouly Enguerran, Bernard Olivier A, 古関 明彦, 岩間 厚志, 千葉 滋
  • Organizer: 第77回日本癌学会学術総会.
• [Presentation] リボソーム生合成障害は白血病発症に関与する (2018)
  • Author(s): 神力 悟, 金井 昭教, 長町 安希子, 一戸 辰夫, 稲葉 俊哉, 松井 啓隆
  • Organizer: 第77回日本癌学会学術総会.
• [Presentation] 休眠に寄与する骨髄播種癌細胞の自律的分子特性の解析 (2018)
  • Author(s): 前城 学, 神力 悟, 中村 拓哉, 城野 博史, 中山 秀樹, 安東 由喜雄, 松井 啓隆
  • Organizer: 第60回 歯科基礎医学会学術大会.
• [Presentation] ヘモグロビンA1cに対する赤血球の平均加齢変化の影響 グリコアルブミンとの比較. (2018)
  • Author(s): 徳弘 慎治, 奥宮 敏可, 古賀 正史, 西村 仁志, 松井 啓隆, 久原 太助, 小西 小百合, 亀山 智代, 朝霧 正, 山中 茂雄, 上岡 樹生, 松村 敬久
  • Organizer: 日本臨床化学会第58回年次学術集会.
• [Presentation] リボソーム生合成異常が招く白血病発症メカニズムの検証 (2018)
  • Author(s): 神力 悟, 前城 学, 松井 啓隆
  • Organizer: 日本臨床化学会第58回年次学術集会.
• [Presentation] 骨髄に潜伏する播種性癌細胞の特性の解析 (2018)
  • Author(s): 前城 学, 神力 悟, 城野 博史, 安東 由喜雄, 松井 啓隆
  • Organizer: 日本臨床化学会第58回年次学術集会.
• [Presentation] 全自動フローサイトメーターAQUIOSの性能評価と業務のワークフロー改善について (2018)
  • Author(s): 福吉 葉子, 米村 雄士, 吉田 朝子, 石原 綾子, 崎田 紫織, 下山 治香, 内場 光浩, 松井 啓隆
  • Organizer: 日本臨床検査自動化学会第50回大会.
• [Presentation] 検体自動廃棄システムの構築 (2018)
  • Author(s): 田中 侑紀, 古賀 尚子, 福村 由佳里, 山内 露子, 山下 昭一郎, 福吉 葉子, 松井 啓隆
  • Organizer: 日本臨床検査自動化学会第50回大会.
• [Presentation] 災害時に機能する臨床検査体制 熊本地震災害からの提案 (2018)
  • Author(s): 池田 勝義, 福吉 葉子, 松井 啓隆
  • Organizer: 日本臨床検査自動化学会第50回大会.
• [Presentation] 骨髄異形成症候群の形態学的分類におけるばらつきと標準化の必要性 (2018)
  • Author(s): 山本 紀子, 笹田 景子, 舛田 博貴, 石原 綾子, 田中 洋子, 高松 泰, 矢冨 裕, 勝田 和一郎, 佐藤 一誠, 松井 啓隆
  • Organizer: 第19回日本検査血液学会学術集会.
• [Presentation] 自動血球分析装置による末梢血幹細胞動員不良予測の試み (2018)
  • Author(s): 舛田 博貴, 笹田 景子, 福吉 葉子, 大隈 雅紀, 内場 光浩, 井上 明威, 野坂 生郷, 奥野 豊, 松岡 雅雄, 松井 啓隆, 米村 雄士
  • Organizer: 第66回日本輸血細胞治療学会総会.