| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We attempted to predict the chromosomal structural abnormalities involved in its formation, based on the fusion gene product information extracted from the transcriptome sequencing data of 100 hematologic tumor cell lines. Of particular interest was the fact that one gene forms a fusion gene with multiple genes in a single cell line, and the combination of such fusion genes was defined as "promiscuous fusion". There were 74 types of promiscuous fusion in 38 cell lines. The formation mode of promiscuous fusion can be divided into those that can be explained by a simple one structural change, such as 3-way translocation or deletion insertion, and those that cannot be formed by one structural change. It was considered to be useful as a new method of genomic structure analysis.
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