| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we aimed to clarify the significance of the interaction between semaphorin 3A (SEMA3A) and neuropilin 1 (NRP1) in adhesion-mediated drug resistance between multiple myeloma (MM) cells and bone marrow stromal cells (BMSCs). We found that SEMA3A is secreted from bone marrow stromal cells, and synergistically cooperates with cytokines such as IGF-1 to promote proliferation of BMSCs at least partly via the SEMA3A-NRP1 pathway in the bone marrow microenvironment. We also found that SEMA3A can overcome the drug resistance mechanism induced by adhesion between MM cells and BMSCs by inducing and promoting the differentiation of bone marrow stromal cells into osteoblasts partly via the AKT pathway.
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