Analysis of the role of anti-citrullinated peptide antibody in RA pathogenesis to aim developing optimal treatment.

• Project/Area Number: 18K08411
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54020:Connective tissue disease and allergy-related
• Research Institution: Nagasaki University
• Principal Investigator: IWAMOTO Naoki 長崎大学, 医歯薬学総合研究科(医学系), 助教 (80437897)
• Co-Investigator(Kenkyū-buntansha): 増山 律子 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (60297596) ; 玉井 慎美 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (60380862) ; 一瀬 邦弘 長崎大学, 医歯薬学総合研究科(医学系), 講師 (60437895) ; 川上 純 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90325639)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 関節リウマチ / 抗CCP抗体 / 破骨細胞 / アバタセプト / ケモカイン / 単球 / M1単球 / 滑膜線維芽細胞 / 骨芽細胞 / 滑膜細胞 / M1・M2単球

Outline of Final Research Achievements

There was no relation anti-citrullinated protein antibody (ACPA) induced osteoclastogensis with treatment of biologics DMARDs, positivity of ACPA and disease activity. However, the number of osteoclast using monocyte from the patients who showed higher level of C-reactive protein (CRP) in the blood was higher as compared with normal level of CRP. Abatacept (Orencia) showed inhibitory effect of not only normal osteoclastogenesis but also ACPA-induced osteoclastogenesis.
Moreover, ACPA increased secretion of chemokine from fibroblast-like synovial cells of rheumatoid arthritis.

Academic Significance and Societal Importance of the Research Achievements

抗CCP抗体（ACPA)誘発性破骨細胞形成がCRP陽性患者において増強していることが明らかになった。一方、疾患活動性や治療薬は破骨細胞形成数と相関しなかった。すなわち、治療薬や疾患活動性に関わらず、ACPA陽性関節リウマチ（RA)患者はCRP陽性であると骨破壊が進行することが示唆され、RA治療でのCRP制御の重要性が改めて明らかとなった。また、ACPA陽性患者におけるオレンシアの有用性が破骨細胞形成の側面からも明らかとなった。
さらに、本研究で明らかとなったACPAによる滑膜細胞からのケモカイン産生増強能を鑑みると、ACPA陽性RA患者においては抗ケモカイン療法がより有効である可能性がある。

Research Products

• [Journal Article] Comparison of the quantitative measurement of 18F-FDG PET/CT and histopathological findings in IgG4-related disease. (2021)
  • Author(s): Tsuji S, Iwamoto N, Horai Y, Fujikawa K, Fujita Y, Fukui S, Ideguchi R, Michitsuji T, Nishihata S, Okamoto M, Tsuji Y, Endo Y, Shimizu T, Sumiyoshi R, Koga T, Kawashiri SY, Igawa T, Ichinose K, Tamai M, Nakamura H, Origuchi T, Kudo T, Kawakami A.
  • Journal Title: Clin Exp Rheumatol. Volume: epub
  • Peer Reviewed
• [Journal Article] Utility of a simplified ultrasonography scoring system among patients with rheumatoid arthritis (2021)
  • Author(s): Endo Yushiro、Kawashiri Shin-ya、Morimoto Shimpei、Nishino Ayako、Okamoto Momoko、Tsuji Sosuke、Takatani Ayuko、Shimizu Toshimasa、Sumiyoshi Remi、Igawa Takashi、Koga Tomohiro、Iwamoto Naoki、
  • Journal Title: Medicine Volume: 100 Issue: 1 Pages: e23254-e23254
  • DOI: 10.1097/md.0000000000023254
  • Peer Reviewed / Open Access
• [Journal Article] Anti-EJ Antibody-positive Anti-synthetase Syndrome Associated with Retroperitoneal Sarcoma (2020)
  • Author(s): Fukui Saeko、Kobayashi Kazuma、Fujita Yuya、Fukui Shoichi、Iwamoto Naoki、Adachi Tomohiko、Hidaka Masaaki、Takatsuki Mitsuhisa、Abe Kuniko、Kuwana Masataka、Kawakami Atsushi、Eguchi Susumu
  • Journal Title: Internal Medicine Volume: 59 Issue: 16 Pages: 2071-2076
  • DOI: 10.2169/internalmedicine.3923-19
  • NAID: 130007887767
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2020-08-15
  • Peer Reviewed
• [Journal Article] Drop Head Syndrome as a Rare Complication in Mixed Connective Tissue Disease (2020)
  • Author(s): Akagi Midori、Umeda Masataka、Hashisako Mikiko、Hara Kazusato、Tsuji Sousuke、Endo Yushiro、Takatani Ayuko、Shimizu Toshimasa、Fukui Shoichi、Koga Tomohiro、Kawashiri Shin-ya、Iwamoto Naoki、Igawa Takashi、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Niino Daisuke、Kawakami Atsushi
  • Journal Title: Internal Medicine Volume: 59 Issue: 5 Pages: 729-732
  • DOI: 10.2169/internalmedicine.3626-19
  • NAID: 130007804508
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2020-03-01
  • Peer Reviewed
• [Journal Article] Life prognosis and renal relapse after induction therapy in Japanese patients with proliferative and pure membranous lupus nephritis. (2020)
  • Author(s): Okamoto M, Kitamura M, Sato S, Fujikawa K, Horai Y, Matsuoka N, Tsuboi M, Nonaka F, Shimizu T, Koga T, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Origuchi T, Nishino T, Kawakami A, Ichinose K.
  • Journal Title: Rheumatology (Oxford). Volume: epub
  • Peer Reviewed
• [Journal Article] Effectiveness and safety of non-tumor necrosis factor inhibitor therapy for anti-human T-cell leukemia virus type 1 antibody-positive rheumatoid arthritis (2020)
  • Author(s): Endo Yushiro、Fukui Shoichi、Umekita Kunihiko、Suzuki Takahisa、Miyamoto Junya、Morimoto Shimpei、Shimizu Toshimasa、Koga Tomohiro、Kawashiri Shin-ya、Iwamoto Naoki、
  • Journal Title: Modern Rheumatology Volume: epub Pages: 1-12
  • Peer Reviewed
• [Journal Article] Next-generation sequencing of the whole MEFV gene in Japanese patients with familial Mediterranean fever: a case-control association study. (2020)
  • Author(s): Koga T, Sato S, Mishima H, Migita K, Endo Y, Umeda M, Sumiyoshi R, Nonaka F, Fukui S, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Ueki Y, Masumoto J, Agematsu K, Yachie A, Yoshiura KI, Eguchi K, Kawakami A.
  • Journal Title: Clin Exp Rheumatol. Volume: 127 Pages: 35-41
  • Peer Reviewed
• [Journal Article] Rheumatoid arthritis patients with low baseline Health Assessment Questionnaire scores have a risk of functional disability progression: a post hoc analysis of a nationwide longitudinal cohort in Japan. (2020)
  • Author(s): Sumiyoshi R, Hidaka T, Koga T, Okada A, Fukuda T, Ishii T, Ueki Y, Kodera T, Nakashima M, Takahashi Y, Honda S, Horai Y, Watanabe R, Okuno H, Aramaki T, Izumiyama T, Takai O, Miyashita T, Kawashiri SY, Iwamoto N,
  • Journal Title: Clin Exp Rheumatol. Volume: 38 Pages: 1096-1101
  • Peer Reviewed
• [Journal Article] Reduction in the percentage of circulating variable delta 2T cells in systemic lupus erythematosus (2020)
  • Author(s): Koga Tomohiro、Endo Yushiro、Umeda Masataka、Sato Tomohito、Mizunoo Yuko、Furukawa Kaori、Shimizu Toshimasa、Sumiyoshi Remi、Kawashiri Shin-ya、Iwamoto Naoki、Igawa Takashi、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Kawakami Atsushi
  • Journal Title: Clinical Immunology Volume: 220 Pages: 108577-108577
  • DOI: 10.1016/j.clim.2020.108577
  • Peer Reviewed
• [Journal Article] Comparison of complete renal response and mortality in early- and late-onset lupus nephritis: a multicenter retrospective study of a Japanese cohort (2020)
  • Author(s): Ichinose Kunihiro、Kitamura Mineaki、Sato Shuntaro、Fujikawa Keita、Horai Yoshiro、Matsuoka Naoki、Tsuboi Masahiko、Nonaka Fumiaki、Shimizu Toshimasa、Sumiyoshi Remi、Koga Tomohiro、Kawashiri Shin-ya、Iwamoto Naoki、Igawa Takashi、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Nishino Tomoya、Kawakami Atsushi
  • Journal Title: Arthritis Research & Therapy Volume: 22 Issue: 1 Pages: 175-175
  • DOI: 10.1186/s13075-020-02271-3
  • NAID: 120006988113
  • Peer Reviewed / Open Access
• [Journal Article] Contributing factors of clinical outcomes at 1 year post-diagnosis in early rheumatoid arthritis patients with tightly controlled disease activity in clinical practice: a retrospective study (2020)
  • Author(s): Kawashiri S-Y、Endo Y、Okamoto M、Tsuji S、Shimizu T、Sumiyoshi R、Koga T、Iwamoto N、Ichinose K、Tamai M、Nakamura H、Origuchi T、Kawakami A
  • Journal Title: Modern Rheumatology Volume: 31 Issue: 2 Pages: 343-349
  • DOI: 10.1080/14397595.2020.1795392
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of lung microbiota between antineutrophil cytoplasmic antibody-associated vasculitis and sarcoidosis. (2020)
  • Author(s): Shoichi Fukui, Shimpei Morimoto, Kunihiro Ichinose, Shota Nakashima, Hiroshi Ishimoto, Atsuko Hara, Tomoyuki Kakugawa, et al.
  • Journal Title: Sci Rep Volume: 10(1) Issue: 1 Pages: 9466-9466
  • DOI: 10.1038/s41598-020-66178-4
  • NAID: 120006988158
  • Peer Reviewed / Open Access
• [Journal Article] Non-TNF inhibitor switchers versus TNF inhibitor cyclers from multicentre rheumatoid arthritis ultrasonography prospective cohort in Japan (2020)
  • Author(s): Endo Y、Koga T、Kawashiri S-Y、Morimoto S、Nishino A、Okamoto M、Tsuji S、Takatani A、Shimizu T、Sumiyoshi R、Igawa T、Iwamoto N、Ichinose K、Tamai M、Nakamura H、Origuchi T、Ueki Y、Yoshitama T、Eiraku N、Matsuoka N、Okada A、Fujikawa K、Hamada H、Tsuru T、Nagano S、Arinobu Y、Hidaka T、Tada Y、Kawakami A
  • Journal Title: Immunological Medicine Volume: 43 Issue: 3 Pages: 115-120
  • DOI: 10.1080/25785826.2020.1757920
  • Peer Reviewed / Open Access
• [Journal Article] Interleukin-18 and fibroblast growth factor 2 in combination is a useful diagnostic biomarker to distinguish adult-onset Still’s disease from sepsis (2020)
  • Author(s): Koga Tomohiro、Sumiyoshi Remi、Furukawa Kaori、Sato Shuntaro、Migita Kiyoshi、Shimizu Toshimasa、Umeda Masataka、Endo Yushiro、Fukui Shoichi、Kawashiri Shin-ya、Iwamoto Naoki、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Nonaka Fumiaki、Yachie Akihiro、Kondo Hideaki、Maeda Takahiro、Kawakami Atsushi
  • Journal Title: Arthritis Research & Therapy Volume: 22 Issue: 1 Pages: 108-108
  • DOI: 10.1186/s13075-020-02200-4
  • NAID: 120006988188
  • Peer Reviewed
• [Journal Article] Thymus and Activation-regulated Chemokine as a Biomarker for IgG4-related Disease (2020)
  • Author(s): Umeda Masataka、Origuchi Tomoki、Kawashiri Shin-ya、Koga Tomohiro、Ichinose Kunihiro、Furukawa Kaori、Sato Tomohito、Tsuji Sousuke、Endo Yushiro、Takatani Ayuko、Shimizu Toshimasa、Fukui Shoichi、Iwamoto Naoki、Igawa Takashi、Tamai Mami、Nakamura Hideki、Kawakami Atsushi
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 6010-6010
  • DOI: 10.1038/s41598-020-62941-9
  • NAID: 120006988235
  • Peer Reviewed
• [Journal Article] Differences in musculoskeletal ultrasound findings between RS3PE syndrome and elderly-onset rheumatoid arthritis. (2020)
  • Author(s): Kawashiri SY, Suzuki T, Okada A, Tsuji S, Takatani A, Shimizu T, Koga T, Iwamoto N, Ichinose K, Nakamura H, Origuchi T, Kawakami A.
  • Journal Title: Clin Rheumatol. Volume: - Issue: 6 Pages: 1981-1988
  • DOI: 10.1007/s10067-020-04931-w
  • Peer Reviewed
• [Journal Article] Phase 1 clinical study of cell therapy with effective-mononuclear cells (E-MNC) for radiogenic xerostomia (first-in-human study) (FIH study on E-MNC therapy for radiogenic xerostomia) (2020)
  • Author(s): Sumita Y, Iwamoto N, Seki M, Yoshida T, Honma R, Iwatake M, Ohba S, Takashi I, Hotokezaka Y, Harada H, Kuroshima S, Nagai K, Asahara T, Atsushi Kawakam I, Asahina I
  • Journal Title: Medicine (Baltimore) Volume: 99 Issue: 26 Pages: e20788-e20788
  • DOI: 10.1097/md.0000000000020788
  • NAID: 120006988135
  • Peer Reviewed / Open Access
• [Journal Article] Gastric Perforation due to Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder during the Treatment of Rheumatoid Arthritis (2019)
  • Author(s): Toyama Shiho、Takatani Ayuko、Iwamoo Naoki、Kawakami Atsushi et al.
  • Journal Title: Internal Medicine Volume: 58 Issue: 22 Pages: 3331-3336
  • DOI: 10.2169/internalmedicine.2782-19
  • NAID: 130007746047
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-11-15
  • Peer Reviewed
• [Journal Article] Atypical Familial Mediterranean Fever Complicated with Gastrointestinal Amyloidosis Diagnosed due to Paroxysmal Arthralgia and Intractable Diarrhea, Successfully Treated with Tocilizumab (2019)
  • Author(s): Aikawa Erika、Shimizu Toshimasa、Koga Tomohiro、Endo Yushiro、Umeda Masataka、Hori Tomoko、Irie Junji、Kuroda Kishio、Eguchi Mizuna、Okamoto Momoko、Tsuji Sosuke、Takatani Ayuko、Igawa Takashi、Sumiyoshi Remi、Kawashiri Shin-ya、Iwamoto Naoki et al.
  • Journal Title: Internal Medicine Volume: 58 Issue: 12 Pages: 1781-1785
  • DOI: 10.2169/internalmedicine.2277-18
  • NAID: 130007663623
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-06-15
• [Journal Article] Paraneoplastic Syndrome Presenting with Polymyalgia Rheumatica-like Accumulations on ¹⁸F-fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography (2019)
  • Author(s): Umetsu Ayaka、Shimizu Toshimasa、Iwamoto Naoki、Hashiguchi Keiichi、Eguchi Mizuna、Okamoto Momoko、Endo Yushiro、Tsuji Sosuke、Takatani Ayuko、Igawa Takashi、Sumiyoshi Remi、Koga Tomohiro、Kawashiri Shin-ya、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Kawakami Atsushi
  • Journal Title: Internal Medicine Volume: 58 Issue: 6 Pages: 861-864
  • DOI: 10.2169/internalmedicine.1847-18
  • NAID: 130007612737
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-03-15
• [Journal Article] Scleroderma Renal Crisis Complicated with Thrombotic Microangiopathy Triggered by Influenza B Virus Infection (2019)
  • Author(s): Shimizu Toshimasa、Iwamoto Naoki、Okamoto Momoko、Endo Yushiro、Tsuji Sosuke、Takatani Ayuko、Igawa Takashi、Umeda Masataka、Fukui Shoichi、Sumiyoshi Remi、Kitamura Mineaki、Koga Tomohiro、Kawashiri Shin-ya、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Nishino Tomoya、Kawakami Atsushi
  • Journal Title: Internal Medicine Volume: 58 Issue: 3 Pages: 441-445
  • DOI: 10.2169/internalmedicine.1441-18
  • NAID: 130007586158
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-02-01
• [Journal Article] Comparative study of the inhibitory effect on bone erosion progression with denosumab treatment and conventional treatment in rheumatoid arthritis patients: study protocol for an open-label randomized controlled trial by HR-pQCT (2019)
  • Author(s): Iwamoto Naoki、Sato Shuntaro、Sumiyoshi Remi、Chiba Ko、Miyamoto Nanami、Arinaga Kumiko、Kobayashi Makiko、Yamamoto Hiroshi、Osaki Makoto、Kawakami Atsushi
  • Journal Title: Trials Volume: 20 Issue: 1 Pages: 494-494
  • DOI: 10.1186/s13063-019-3589-8
  • NAID: 120006988422
  • Peer Reviewed / Open Access
• [Journal Article] Reactive arthritis induced by active extra-articular tuberculosis (2019)
  • Author(s): Endo Yushiro、Kawashiri Shin-ya、Koga Tomohiro、Okamoto Momoko、Tsuji Sosuke、Takatani Ayuko、Shimizu Toshimasa、Sumiyoshi Remi、Igawa Takashi、Iwamoto Naoki、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Kawakami Atsushi
  • Journal Title: Medicine Volume: 98 Issue: 49 Pages: e18008-e18008
  • DOI: 10.1097/md.0000000000018008
  • NAID: 120006988344
  • Peer Reviewed / Open Access
• [Journal Article] Recent findings regarding the effects of microRNAs on fibroblast-like synovial cells in rheumatoid arthritis (2019)
  • Author(s): Iwamoto Naoki、Kawakami Atsushi
  • Journal Title: Immunological Medicine Volume: 42 Issue: 4 Pages: 156-161
  • DOI: 10.1080/25785826.2019.1695490
  • Peer Reviewed / Open Access
• [Journal Article] Chlamydia-induced reactive arthritis diagnosed during gout flares (2019)
  • Author(s): Sumiyoshi Remi、Koga Tomohiro、Tsuji Sosuke、Endo Yushiro、Takatani Ayuko、Shimizu Toshimasa、Igawa Takashi、Umeda Masataka、Fukui Shoichi、Nishino Ayako、Kawashiri Shin-ya、Iwamoto Naoki、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Kawakami Atsushi
  • Journal Title: Medicine Volume: 98 Issue: 40 Pages: e17233-e17233
  • DOI: 10.1097/md.0000000000017233
  • NAID: 120006988395
  • Peer Reviewed / Open Access
• [Journal Article] Ultrasound-Proven Severe Synovitis Induced by PD-1 Inhibitor Therapy in a Patient Predisposed to Seronegative Inflammatory Arthritis (2019)
  • Author(s): Kawashiri Shin-ya、Iwamoto Naoki、Ohba Kojiro、Kawakami Atsushi
  • Journal Title: Case Reports in Rheumatology Volume: 2019 Pages: 1-3
  • DOI: 10.1155/2019/7340692
  • Peer Reviewed
• [Journal Article] Novel multiple heterozygous NUDT15 variants cause an azathioprine-induced severe leukopenia in a patient with systemic lupus erythematosus. (2019)
  • Author(s): Otsuka M, Koga T, Sumiyoshi R, Furukawa K, Okamoto M, Endo Y, Tsuji S, Takatani A, Shimizu T, Igawa T, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Nakamura H, Origuchi T, Kawakami A.
  • Journal Title: Clin Immunol. Volume: 200 Pages: 64-65
  • DOI: 10.1016/j.clim.2019.02.004
  • Peer Reviewed
• [Journal Article] Serum levels of fibroblast growth factor-2 distinguish Takayasu arteritis from giant cell arteritis independent of age at diagnosis (2019)
  • Author(s): Fukui Shoichi、Kuwahara-Takaki Ayako、Ono Nobuyuki、Sato Shuntaro、Koga Tomohiro、Kawashiri Shin-ya、Iwanaga Nozomi、Iwamoto Naoki、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Migita Kiyoshi、Arinobu Yojiro、Niiro Hiroaki、Tada Yoshifumi、Akashi Koichi、Maeda Takahiro、Kawakami Atsushi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 1-8
  • DOI: 10.1038/s41598-018-36825-y
  • NAID: 120006987842
  • Peer Reviewed / Open Access
• [Journal Article] Promotion of Calcium/Calmodulin-Dependent Protein Kinase 4 by GLUT1-Dependent Glycolysis in Systemic Lupus Erythematosus. (2019)
  • Author(s): Koga T, Sato T, Furukawa K, Morimoto S, Endo Y, Umeda M, Sumiyoshi R, Fukui S, Kawashiri SY, Iwamoto N, Ichinose K, Tamai M, Origuchi T, Nakamura H, Kawakami A.
  • Journal Title: Arthritis Rheumatol. Volume: 71 Issue: 5 Pages: 766-772
  • DOI: 10.1002/art.40785
  • Peer Reviewed
• [Journal Article] Anti-MDA5 Antibody-positive Dermatomyositis Complicated by Autoimmune-associated Hemophagocytic Syndrome That Was Successfully Treated with Immunosuppressive Therapy and Plasmapheresis (2018)
  • Author(s): Fujita Yuya、Fukui Shoichi、Suzuki Takahisa、Ishida Midori、Endo Yushiro、Tsuji Sousuke、Takatani Ayuko、Igawa Takashi、Shimizu Toshimasa、Umeda Masataka、Sumiyoshi Remi、Nishino Ayako、Koga Tomohiro、Kawashiri Shin-ya、Iwamoto Naok et al.
  • Journal Title: Internal Medicine Volume: 57 Issue: 23 Pages: 3473-3478
  • DOI: 10.2169/internalmedicine.1121-18
  • NAID: 130007539684
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-12-01
• [Journal Article] Reversible Cognitive Dysfunction in Elderly-onset Systemic Lupus Erythematosus, Successfully Treated with Aggressive Immunosuppressive Therapy (2018)
  • Author(s): Fujita Yuya、Fukui Shoichi、Ishida Midori、Endo Yushiro、Tsuji Sosuke、Takatani Ayuko、Igawa Takashi、Shimizu Toshimasa、Umeda Masataka、Sumiyoshi Remi、Nishino Ayako、Koga Tomohiro、Kawashiri Shin-ya、Iwamoto Naoki、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Kawakami Atsushi
  • Journal Title: Internal Medicine Volume: 57 Issue: 20 Pages: 3025-3028
  • DOI: 10.2169/internalmedicine.0934-18
  • NAID: 120006987912
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-10-15
• [Journal Article] Efficacy of infliximab as a switched biologic in rheumatoid arthritis patients in daily clinical practice (2018)
  • Author(s): Umeda Masataka、Koga Tomohiro、Ichinose Kunihiro、Takatani Ayuko、Igawa Takashi、Shimizu Toshimasa、Fukui Shoichi、Nishino Ayako、Horai Yoshiro、Hirai Yasuko、Kawashiri Shin-Ya、Iwamoto Naoki、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Aramaki Toshiyuki et al.
  • Journal Title: Immunological Medicine Volume: 41 Issue: 4 Pages: 181-186
  • DOI: 10.1080/25785826.2018.1542942
  • Peer Reviewed / Open Access
• [Journal Article] Utility of power Doppler ultrasonography for detecting forefoot bursae in early rheumatoid arthritis (2018)
  • Author(s): Endo Yushiro、Koga Tomohiro、Eguchi Mizuna、Okamoto Momoko、Tsuji Sosuke、Takatani Ayuko、Shimizu Toshimasa、Sumiyoshi Remi、Igawa Takashi、Kawashiri Shin-ya、Iwamoto Naoki、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Kawakami Atsushi
  • Journal Title: Medicine Volume: 97 Issue: 51 Pages: e13295-e13295
  • DOI: 10.1097/md.0000000000013295
• [Journal Article] Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease (2018)
  • Author(s): Kawashiri Shin-ya、Origuchi Tomoki、Umeda Masataka、Nishino Ayako、Shimizu Toshimasa、Fukui Shoichi、Koga Tomohiro、Iwamoto Naoki、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Maeda Takahiro、Kawano Mitsuhiro、Yamamoto Motohisa、Izumi Yasumori、Kawakami Atsushi
  • Journal Title: Arthritis Research & Therapy Volume: 20 Issue: 1
  • DOI: 10.1186/s13075-018-1777-7
  • NAID: 120006987867
• [Journal Article] Clinical predictors of inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) including methotrexate (MTX) in untreated rheumatoid arthritis patients: A single-center observational study. (2018)
  • Author(s): Aramaki Toshiyuki、Ueki Yukitaka、Kojima Kanako、Kurushima Shota、Tsuji Yoshika、Kawachi Natsumi、Iwamoto Naoki、Ichinose Kunihiro、Terada Kaoru、Eguchi Katsumi、Kawakami Atsushi
  • Journal Title: Modern Rheumatology Volume: - Issue: 1 Pages: 1-8
  • DOI: 10.1080/14397595.2018.1553265
• [Journal Article] Antineutrophilic cytoplasmic antibody-associated vasculitis with and without renal involvement: C3 contributes to prognosis, but renal involvement does not (2018)
  • Author(s): Fukui Shoichi、Iwamoto Naoki、Takatani Ayuko、Igawa Takashi、Shimizu Toshimasa、Umeda Masataka、Nishino Ayako、Koga Tomohiro、Kawashiri Shin-ya、Tamai Mami、Ichinose Kunihiro、Nakamura Hideki、Origuchi Tomoki、Sato Shuntaro、Kawakami Atsushi
  • Journal Title: International Journal of Rheumatic Diseases Volume: - Issue: 5 Pages: 789-796
  • DOI: 10.1111/1756-185x.13422
• [Journal Article] Early canakinumab therapy for the sensorineural deafness in a family with Muckle-Wells syndrome due to a novel mutation of NLRP3 gene (2018)
  • Author(s): Iida Yasunori、Wakiguchi Hiroyuki、Okazaki Fumiko、Nakamura Tamaki、Yasudo Hiroki、Kubo Makoto、Sugahara Kazuma、Yamashita Hiroshi、Suehiro Yutaka、Okayama Naoko、Hashimoto Kunio、Iwamoto Naoki、Kawakami Atsushi、Aoki Yoshiharu、Takada Hidetoshi、Ohga Shouichi、Hasegawa Shunji
  • Journal Title: Clinical Rheumatology Volume: 38 Issue: 3 Pages: 943-948
  • DOI: 10.1007/s10067-018-4331-8
  • Peer Reviewed
• [Journal Article] Podocyte foot process width is a prediction marker for complete renal response at 6 and 12 months after induction therapy in lupus nephritis. (2018)
  • Author(s): Ichinose K, Kitamura M, Sato S, Fujikawa K, Horai Y, Matsuoka N, Tsuboi M, Nonaka F, Shimizu T, Fukui S, Umeda M, Koga T, Kawashiri SY, Iwamoto N, Igawa T, Tamai M, Nakamura H, Origuchi T, Nishino T, Kawakami A.
  • Journal Title: Clin Immunol. Volume: 197 Pages: 161-168
  • DOI: 10.1016/j.clim.2018.10.002
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of circulating invariant T cells before and after IL-17 inhibitor treatment in a patient with psoriatic arthritis (2018)
  • Author(s): Koga Tomohiro、Matoba Megumi、Sato Tomohito、Koike Yuta、Endo Yushiro、Sumiyoshi Remi、Kawashiri Shin-ya、Iwamoto Naoki、Ichinose Kunihiro、Tamai Mami、Nakamura Hideki、Origuchi Tomoki、Kawakami Atsushi
  • Journal Title: Clinical Immunology Volume: 197 Pages: 107-109
  • DOI: 10.1016/j.clim.2018.09.011
  • Peer Reviewed
• [Journal Article] Subclinical inflammation in a case of menstruation-induced familial Mediterranean fever (2018)
  • Author(s): Hara Kazusato、Endo Yushiro、Ishida Midori、Fujita Yuya、Tsuji Sosuke、Takatani Ayuko、Shimizu Toshimasa、Sumiyoshi Remi、Igawa Takashi、Umeda Masataka、Fukui Shoichi、Nishino Ayako、Kawashiri Shin-ya、Iwamoto Naoki et al.
  • Journal Title: Medicine Volume: 97 Issue: 38 Pages: e12305-e12305
  • DOI: 10.1097/md.0000000000012305
• [Journal Article] Denosumab is effective toward glucocorticoid-induced osteoporosis patients complicated with rheumatic diseases regardless of prior anti-osteoporotic drugs (2018)
  • Author(s): Iwamoto Naoki、Okamoto Momoko、Tsuji Sosuke et al.
  • Journal Title: Journal of Bone and Mineral Metabolism Volume: 37 Issue: 3 Pages: 554-562
  • DOI: 10.1007/s00774-018-0955-7
• [Journal Article] Frequency of Hospitalized Infections Is Reduced in Rheumatoid Arthritis Patients Who Received Biological and Targeted Synthetic Disease-Modifying Antirheumatic Drugs after 2010. (2018)
  • Author(s): Ichinose K, Shimizu T, Umeda M, Fukui S, Nishino A, Koga T, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Sato S, Origuchi T, Kawakami A.
  • Journal Title: J Immunol Res. Volume: - Pages: 6259010-6259010
  • DOI: 10.1155/2018/6259010
  • NAID: 120006987897
  • Peer Reviewed / Open Access
• [Journal Article] Osteogenic differentiation of fibroblast-like synovial cells in rheumatoid arthritis is induced by microRNA-218 through a ROBO/Slit pathway (2018)
  • Author(s): Iwamoto Naoki、Fukui Shoichi、Takatani Ayuko、Shimizu Toshimasa、Umeda Masataka、Nishino Ayako、Igawa Takashi、Koga Tomohiro、Kawashiri Shin-ya、Ichinose Kunihiro、Tmai Mami、Nakamura Hideki、Origuchi Tomoki、Chiba Ko、Osaki Makoto、J?ngel Astrid、Gay Steffen、Kawakami Atsushi
  • Journal Title: Arthritis Research & Therapy Volume: 20 Issue: 1 Pages: 189-189
  • DOI: 10.1186/s13075-018-1703-z
  • NAID: 120006987960
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Successful treatment of plasma exchange for rapidly progressive interstitial lung disease with anti-MDA5 antibody-positive dermatomyositis (2018)
  • Author(s): Endo Yushiro、Koga Tomohiro、Suzuki Takahisa、Hara Kazusato、Ishida Midori、Fujita Yuya、Tsuji Sosuke、Takatani Ayuko、Shimizu Toshimasa、Sumiyoshi Remi、Igawa Takashi、Umeda Masataka、Fukui Shoichi、Nishino Ayako、Kawashiri Shin-ya、Iwamoto Naoki et al.
  • Journal Title: Medicine Volume: 97 Issue: 15 Pages: e0436-e0436
  • DOI: 10.1097/md.0000000000010436
  • NAID: 120006987328
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 関節リウマチ患者におけるバリシチニブの有効性および安全性の検討 ～トファシチニブからの切り替え療法含めて～ (2020)
  • Author(s): 岩本直樹
  • Organizer: 日本リウマチ学会
• [Presentation] HR-pQCTを用いた関節リウマチ治療経過における関節構造変化の解析. (2020)
  • Author(s): 岩本直樹
  • Organizer: 日本リウマチ学会
• [Presentation] 関節リウマチにおけるHR-pQCTを用いた中手骨頭骨微細構造と滑膜炎、腰椎大腿骨骨密度、骨破壊進行度の関連解析 (2019)
  • Author(s): 岩本直樹
  • Organizer: 日本リウマチ学会
• [Presentation] 新規単球サブセットであるM1・M2単球と全身性強皮症の関連解析 (2019)
  • Author(s): 岩本直樹
  • Organizer: 日本リウマチ学会
• [Presentation] 関節リウマチ患者におけるバリシチニブの有効性および安全性の検討 (2019)
  • Author(s): 岩本直樹
  • Organizer: 九州リウマチ学会
• [Presentation] HR-pQCTによる関節リウマチ治療経過における骨微細構造変化の解析 (2019)
  • Author(s): 岩本直樹
  • Organizer: 臨床リウマチ学会
• [Presentation] 新規単球サブセットであるM1・M2単球と全身性強皮症の関連解析 (2019)
  • Author(s): 岩本直樹
  • Organizer: 臨床免疫学会
• [Presentation] The efficacy of denosumab in glucocorticoid-induced osteoporosis did not depend on prior treatment but was affected by the dosage of glucocorticoid (2018)
  • Author(s): 岩本直樹
  • Organizer: 2018 欧州リウマチ学会
  • Int'l Joint Research
• [Presentation] MicroRNA-887-3p have possibility of downstream effector of MTX in its antiproliferative activity toward fibroblast-like synovial cells in rheumatoid arthritis (2018)
  • Author(s): 岩本直樹
  • Organizer: 2018 アジア太平洋リウマチ学会
  • Int'l Joint Research
• [Presentation] MICRORNA PROFILING OF MTX-TREATED FIBROBLAST-LIKE SYNOVIAL CELLS IN RHEUMATOID ARTHRITIS REVEALED A POSSIBILITY OF MICRORNA-887-3P AS NOVEL THERAPEUTIC TARGET OF RA (2018)
  • Author(s): 岩本直樹
  • Organizer: 第62回 日本リウマチ学会