| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Using a model protease antigen, we reported that the antigen protease activity on inhalation is essential to airway inflammation in epicutaneously presensitized mice; that cyclooxygenase inhibition promotes epicutaneous sensitization and subsequent airway inflammation; that epicutaneous tratment with antigen with inactivated protease activity prophylactically blocks subsequent induction of airway inflammation, and a new mechanism for subcutaneous sensitization. We found other mechanisms and a further new epicutaneous sensitization model with other symptoms, for which investigations are on-going.
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