| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Capsid protein (CA), which is an essential structural protein for HIV-1 and forms a shell that encloses a viral RNA, maintains the shell structure with a certain strength in order to protect the viral RNA in the virion. On the other hand, in order to collapse CA shell smoothly and transport viral RNA to the nuclease (so-called “uncoating”) while new infection, it is also necessary for CA to have a certain degree of "instability". In this project, we newly discovered that 9 amino acids sequence (9AA) of CA C-terminal domain (CTD) is important factor for CA degradation, and that infectivity and replicative capacity are significantly impaired in HIV-1 variants containing CTD-9AA deleted CA.
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