Development of an antiviral drug screening system targeting a novel antiviral innate immune mechanism

• Project/Area Number: 18K08444
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54030:Infectious disease medicine-related
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Shinya Masaharu 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10405277)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 抗ウイルス / 抗ウイルス自然免疫 / 抗ウイルス自然免疫機構

Outline of Final Research Achievements

We constructed a high-throughput screening system that can detect the expression of Fbw7β with high specificity and sensitivity, and selected compounds that can induce the expression of Fbw7β. The screened drugs possessed antiviral activity against several viruses.
Our screened drugs may become a tool to combat emerging viral pandemics that may occur in the future.

Academic Significance and Societal Importance of the Research Achievements

我々がスクリーニングした薬剤は、今後発生するであろう新興ウイルス感染症のパンデミックに対抗できるツールになる可能性がある。

Research Products

• [Journal Article] Instantaneous “catch‐and‐kill” inactivation of SARS‐CoV‐2 by nitride ceramics (2020)
  • Author(s): Giuseppe Pezzotti, Eriko Ohgitani, Masaharu Shin‐Ya, Tetsuya Adachi, Elia Marin, Francesco Boschetto, Wenliang Zhu and Osam Mazda
  • Journal Title: Clin Transl Med. Volume: 10(6) Issue: 6
  • DOI: 10.1002/ctm2.212
  • Peer Reviewed / Open Access
• [Journal Article] Rapid inactivation in vitro of SARS-CoV-2 in saliva by black tea and green tea (2020)
  • Author(s): Ohgitani E, Shin-Ya M, Ichitani M, Kobayashi M, Takihara T, Kawamoto M, Kinugasa H, Mazda O.
  • Journal Title: bioRxiv Volume: 12.28. Pages: 424533-424533
  • DOI: 10.1101/2020.12.28.424533
  • Open Access
• [Journal Article] Significant inactivation of SARS-CoV-2 by a green tea catechin, a catechin-derivative and galloylated theaflavins in vitro (2020)
  • Author(s): Ohgitani E, Shin-Ya M, Ichitani M, Kobayashi M, Takihara T, Kawamoto M, Kinugasa H, Mazda O.
  • Journal Title: bioRxiv Volume: 12.04.
  • DOI: 10.1101/2020.12.04.412098
  • Open Access