Development for effective induction of memory CD8 T cell against influenza virus.
Project/Area Number |
18K08456
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 54030:Infectious disease medicine-related
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Research Institution | International University of Health and Welfare (2019-2021) Institute of Physical and Chemical Research (2018) |
Principal Investigator |
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Project Period (FY) |
2018-04-01 – 2022-03-31
|
Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Keywords | インフルエンザ / CD8 T細胞 / 免疫記憶 / T細胞 / メモリー / 抑制性分子 / CD8T細胞 |
Outline of Final Research Achievements |
During the cellular adaptive immune response, CD8 T lymphocytes play a central role in mediating protection against myriad infectious pathogens. To investigate the role of TCR-pMHC interaction in regulating lung CD8 tissue-resident T cell (TR) differentiation, polyclonal responses were compared against NP366-374/Db and PA224-233/Db, two immunodominant epitopes that arise during influenza A infection in mice. We investigate 1) the memory niche where influenza-antigen specific memory CD8 T cells are generated, 2) the micro-enviroment which gives the interaction with other type of cells and 3) the adhesion molecules on the CD8 T cell which foster the persistance within the airway epithelium.
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Academic Significance and Societal Importance of the Research Achievements |
我々はメモリーCD8 T細胞が形成される“場”のモデルを提唱した。血管と細気管支に近接した粘膜固有層(従来のiBALTとは異なる部位)において、血流を介してCD8 T細胞が集簇する。そこでは、肺マクロファージがTGF-βやIL-15を発現し、一方CD11c陽性樹状細胞がIL-15受容体αを介して、CD8 T細胞にメモリー形質を与える。そして、いくつかは、気道上皮間に移動し、接着分子を介して局在し、次の感染に備えて残留する。こういった、免疫記憶を成立させる微小環境の解明の一端は、今後のウイルスパンデミックに大いに役立つものと考えられる。
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Report
(5 results)
Research Products
(2 results)