Comprehensive study on HIV-specific ADCC responses using library clinical isolates
| Project/Area Number |
18K08458
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54030:Infectious disease medicine-related
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
Shigeyoshi Harada 国立感染症研究所, エイズ研究センター, 主任研究官 (30508643)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | HIV / AIDS / 抗体 |
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| Outline of Final Research Achievements |
The main objective of this study was to comprehensively analyze ADCC activity in HIV-infected specimens as a basic research for a novel therapeutic strategy aimed at cure of HIV latently infected cells.
As a result, we succeeded in constructing a system for measuring ADCC activity and obtained basic data on the relationship between clinical course and ADCC activity, as well as the relationship between ADCC activity and reservoir size.
In addition, we developed the "expansion of the anti-HIV antibody enhancer library" for the purpose of enhancing ADCC activity, and succeeded in finding several categories of "anti-HIV antibody enhancers" and pharmacophores that differ not only in their chemical structural framework but also in their binding regions to target Envs. These are expected to contribute to the development of new therapeutic methods.
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| Academic Significance and Societal Importance of the Research Achievements |
現行の抗HIV薬は治癒できないため、生涯服薬継続という最大課題を残す。他方、理論上では、有効なADCC抗体を誘導できる感染症例では、感染細胞排除が進み、レザボアサイズが縮小され、それに伴いウイルス抑制効果および抗ウイルス治療効果が向上する可能性が推察される。本研究により「ADCC活性測定系の最適化」、「抗HIV抗体増強剤ライブラリーの拡充」、および「臨床検体に対する各種解析」を進展することができ、臨床検体におけるADCC活性知見およびADCC活性を惹起させる新規治療法開発の基盤データを得ることができた。これらは新規治療法開発の一助となると考えられる。
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Report
(4 results)
Research Products
(14 results)
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[Presentation] 網羅的Env標的阻害剤ライブラリーの構築-32018
Author(s)
原田恵嘉, 野村渉, 鳴海哲夫, 横山勝, 前田賢次, 竹内怜音, 紺野奇重, 引地優太, 佐藤裕徳, 玉村啓和, 俣野哲朗, 吉村和久
Organizer
第32回 日本エイズ学会学術集会・総会
Related Report
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