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The role of Protein Tyrosine Phosphatase 1B in the reward system under a high fat diet condition

Research Project

Project/Area Number 18K08473
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionNagoya University

Principal Investigator

Banno Ryoichi  名古屋大学, 総合保健体育科学センター, 准教授 (80597865)

Co-Investigator(Kenkyū-buntansha) 有馬 寛  名古屋大学, 医学系研究科, 教授 (50422770)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肥満 / 食嗜好 / 高脂肪食 / 報酬系 / インスリン / レプチン / 視床下部炎症 / PTP1B / アストロサイト / ミクログリア / エネルギー代謝 / 食行動異常 / 中脳腹側被蓋野 / 側坐核 / 炎症 / プロテインフォスファターゼ1B
Outline of Final Research Achievements

The brain reward system plays an important role in hedonic values of food.The neurons in reward system are regulated by leptin, insulin and inflammation.
We investigated the effect of protein tyrosine phosphatase-1B (PTP1B), which regulates these three factors, on palatability for a high-fat diet.
Our data suggested that PTP1B in the dopaminergic neurons in the ventral tegmental area of the midbrain in the reward system contributes to the formation of preference for a high-fat diet.

Academic Significance and Societal Importance of the Research Achievements

ファーストフードの過食は肥満となる。ファーストフードに代表される高脂肪食への食嗜好について脳内報酬系ニューロンに着目し解析したところ、少なくともドーパミンニューロンにおけるprotein tyrosine phosphatase-1B (PTP1B)というタンパク質が高脂肪食への嗜好形成に寄与することが示唆された。ファーストフードへの食嗜好性の解明は将来における抗肥満薬開発への一助となる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2020 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] Hypothalamic glial cells isolated by MACS reveal that microglia and astrocytes induce hypothalamic inflammation via different processes under high-fat diet conditions2020

    • Author(s)
      Mariko Sugiyama, Ryoichi Banno, Hiroshi Yaginuma, Keigo Taki, Akira Mizoguchi, Taku Tsunekawa, Takeshi Onoue, Hiroshi Takagi, Yoshihiro Ito, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Okiru Komine, Koji Yamanaka, Hiroshi Arima
    • Journal Title

      Neurochemistry International

      Volume: 136 Pages: 1-9

    • DOI

      10.1016/j.neuint.2020.104733

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] タモキシフェン誘導性Creマウスを用いたアストロサイト特異的PTP1B欠損マウスの表現型解析2020

    • Author(s)
      杉山 摩利子、坂野 僚一、孫 汝楠、柳沼 裕史、滝 啓吾、恒川 卓、髙木 博史、伊藤 禎浩、有馬 寛
    • Organizer
      第93回日本内分泌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The regulation of glucose metabolism by astrocytes in diet induced obesity mice2020

    • Author(s)
      Sugiyama M, Banno R, Sun R, Yaginuma H, Taki T, Takagi H, Ito Y, Yamanaka K, Arima H
    • Organizer
      EASD 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 中脳腹側被蓋野ドーパミンニューロンにおけるグルココルチコイド受容体シグナルは ストレス下において高脂肪食への嗜好形成を増強する2019

    • Author(s)
      溝口 暁 坂野 僚一 柳沼 裕史 滝 啓吾 杉山 摩利子 高木 博史 伊藤 禎浩 有馬 寛
    • Organizer
      第92回 日本内分泌学会
    • Related Report
      2019 Research-status Report
  • [Presentation] High-fat feeding causes inflammation and insulin resistance in ventral tegmental area in mice.2019

    • Author(s)
      Mizoguchi A, Banno R, Sun R, Yaginuma H, Taki K, Sugiyama M, Tsunekawa T, Takagi H, Ito Y, Arima H
    • Organizer
      2019 Obesityweek
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高脂肪食の摂取により中脳腹側被蓋野に炎症が生じる2018

    • Author(s)
      溝口 暁、坂野 僚一、滝 啓吾、杉山 摩利子、恒川 卓、高木 博史、伊藤 禎浩、有馬 寛
    • Organizer
      第91回日本内分泌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] High-fat feeding causes microglial activation and inflammation in ventral tegmental area in mice.2018

    • Author(s)
      Mizoguchi A, Banno R, Yaginuma H, Taki K, Sugiyama M, Tsunekawa T, Takagi H, Ito Y, Arima H
    • Organizer
      Neuroscience 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Book] 糖尿病・内分泌代謝科2020

    • Author(s)
      坂野 僚一 杉山 摩利子 恒川 卓 伊藤 禎浩 有馬 寛
    • Total Pages
      6
    • Publisher
      科学評論社
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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