Elucidation of a pathogenic process of diabetes using a noninvasive pancreatic beta cell imaging method
| Project/Area Number |
18K08475
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 膵β細胞イメージング / 膵β細胞量 / SPECT / 糖尿病 / PET |
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| Outline of Final Research Achievements |
In this study, I performed to develop a method for evaluating a beta cell mass (BCM) invasively by using an exendin probe labeled radioisotope. There was correlation between the radiation derived from probe accumulation in pancreas and the pancreatic BCM using a pre-existing pathological method, indicating quantifiability between probe accumulation and pancreatic BCM. The BCMs before and after the onset of diabetes in type 1 diabetes model mouse were evaluated by this imaging technique, the BCM was reduced in the diabetes-onset group compared to the non-diabetes-onset group. In order to evaluate the process of diabetes development in terms of BCM, BCM with SPECT imaging and various factors were examined in mice that develop diabetes moderately on a moderate fat diet.
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| Academic Significance and Societal Importance of the Research Achievements |
非侵襲的にかつ経時的な膵β細胞量の変化を捉えることができれば、糖尿病の病態解明の一助となるだけでなく、より早期に介入することで、糖尿病そのものの発症を抑制するための治療を行うことが可能になると考えられる。そのため、本手法は今後の糖尿病診断や治療方針への寄与、また、糖尿病治療薬の開発にも有用であると考えられることより本研究の学術的かつ社会的意義は大きい。
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] Distinctive detection of insulinoma using [18F]FB(ePEG12)12-exendin-4 PET/CT2021
Author(s)
Murakami Takaaki, Fujimoto Hiroyuki, Hamamatsu Keita, Yamauchi Yuki, Kodama Yuzo, Fujita Naotaka, Fujikura Junji, Shimizu Yoichi, Nakamoto Yuji, Kimura Hiroyuki, Saji Hideo, Inagaki Nobuya
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Journal Title
Scientific Reports
Volume: 11
Issue: 1
Pages: 15014-15014
DOI
Related Report
Peer Reviewed / Open Access
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