| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In this study, I performed to develop a method for evaluating a beta cell mass (BCM) invasively by using an exendin probe labeled radioisotope. There was correlation between the radiation derived from probe accumulation in pancreas and the pancreatic BCM using a pre-existing pathological method, indicating quantifiability between probe accumulation and pancreatic BCM. The BCMs before and after the onset of diabetes in type 1 diabetes model mouse were evaluated by this imaging technique, the BCM was reduced in the diabetes-onset group compared to the non-diabetes-onset group. In order to evaluate the process of diabetes development in terms of BCM, BCM with SPECT imaging and various factors were examined in mice that develop diabetes moderately on a moderate fat diet.
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