| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Female infertility is an urgent problem to be solved; however, the detailed mechanism of the reproductive axis composed of hypothalamus-pituitary-ovary (HPO) has yet to be fully understood. In the present study, we investigated the physiological and endocrinological significance of bone morphogenetic proteins (BMPs) n the ovarian follicles as well as in the HPO axis. It was revealed that the BMP system plays critical roles as a intracellular communicator in the ovarian follicle and that it also works as a fine modulator with various circadian regulators in the HPO axis. These findings would be informative for the clinical application of BMPs for the diagnosis and future treatment for female infertility.
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