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Identification of receptor for novel intestinal secretory protein, Betagenin, and application to diabetes treatment.

Research Project

Project/Area Number 18K08487
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionSaitama Medical University

Principal Investigator

Toyoshima Hideo  埼玉医科大学, 医学部, 客員准教授 (20197966)

Co-Investigator(Kenkyū-buntansha) 横尾 友隆  埼玉医科大学, 医学部, 准教授 (80400688)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords糖尿病
Outline of Final Research Achievements

We identified a gene of betagenin as an intestinal peptide that promotes pancreatic β-cell increase and insulin secretion. In this study, we identified a novel betagenin receptor on pancreatic β-cells and performed a functional analysis of the receptor. Our findings suggest betagenin receptor may be useful for the therapeutic target for diabetes and regeneration of pancreatic β cells.

Academic Significance and Societal Importance of the Research Achievements

糖尿病はインスリンの絶対的、相対的な作用不足により発症する。これまでにインスリンの分泌を増やす治療薬は臨床応用されている。一方で、膵β細胞を増やす試みは行われているが未解決である。我々のBetageninは膵β細胞にインスリンを分泌促進させつつ増殖させるという新しい機序を持つことから、その受容体の同定、その解析は糖尿病発症への理解、新しい糖尿病治療の開発に繋がる可能性が考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (3 results)

  • [Journal Article] Risk Factors of Hypoglycemic Encephalopathy and Prolonged Hypoglycemia in Patients With Severe Hypoglycemia2019

    • Author(s)
      Saikawa Rika、Yamada Hodaka、Suzuki Daisuke、Amamoto Misato、Matsumoto Yuko、Funazaki Shunsuke、Yoshida Masashi、Toyoshima Hideo、Hara Kazuo
    • Journal Title

      Journal of Clinical Medicine Research

      Volume: 11 Issue: 3 Pages: 213-218

    • DOI

      10.14740/jocmr3728

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment2019

    • Author(s)
      Ochiai Nagahiro、Nakachi Yutaka、Yokoo Tomotaka、Ichihara Takahiro、Eriksson Tore、Yonemoto Yuki、Kato Takehiko、Ogata Hitoshi、Fujimoto Natsuko、Kobayashi Yasuhiro、Udagawa Nobuyuki、Kaku Shinsuke、Ueki Tomokazu、Okazaki Yasushi、Takahashi Naoyuki、Suda Tatsuo
    • Journal Title

      Communications Biology

      Volume: 2 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s42003-019-0334-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 消化管由来分泌タンパクBetageninによる糖尿病治療効果の解析2019

    • Author(s)
      横尾友隆、島野仁、岡崎康司、豊島秀男
    • Organizer
      第17回RCGMフロンティアシンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 消化管ペプチドBetageninはヒトβ細胞のアポトーシスを抑制し、増殖とインスリン分泌を促進する2018

    • Author(s)
      豊島秀男、横尾友隆、島野仁、岡崎康司
    • Organizer
      第91回 日本内分泌学会学術総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 消化管ペプチドBetageninはヒト膵島のアポトーシスを抑制し,増殖とインスリン分泌を促進する2018

    • Author(s)
      横尾友隆、島野仁、岡崎康司、豊島秀男
    • Organizer
      第61回 日本糖尿病学会年次学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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