Pathophysiology and clinical utilization of 18oxocortisol secretion in aldosterone-producing adenomas.

• Project/Area Number: 18K08500
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Tohoku University
• Principal Investigator: Satoh Fumitoshi 東北大学, 医学系研究科, 特任教授 (70343051)
• Co-Investigator(Kenkyū-buntansha): 森本 玲 東北大学, 大学病院, 准教授 (30547394) ; 尾股 慧 東北大学, 大学病院, 助教 (40818374)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 原発性アルドステロン症 / 18-オキソコルチゾール / アルドステロン産生腺腫 / アルドステロン / KCNJ5体細胞性変異 / 体細胞性変異 / １８－オキソコルチゾール / 18オキソコルチゾール / 18ハイドロキシコルチゾール

Outline of Final Research Achievements

Our project demonstrated that the synthesis of 18-oxocortisol depends on the number of CYP11B1 and CYP11B2 co-expressing cells in aldosterone-producing adenomas (APAs). Somatic mutation status in APAs was significantly associated with the number of the co-expressing cells, and KCNJ5-mutated APAs had the most abundant intra-tumoral environment with the CYP11B1/CYP11B2 co-expressing cells. Collaborating with University of Michigan, we confirmed that KCNJ5 mutation is the most frequent somatic mutation (73%) in our Japanese APA cohort. Consequently, peripheral steroid profiling including 18-oxocortiol showed great diagnostic ability for APA detection in primary aldosteronism. Based on our findings, steroid profiling is expected as a promising less-invasive tool for subtype differentiation in primary aldosteronism, and may accelerate our screening and diagnostic process.

Academic Significance and Societal Importance of the Research Achievements

原発性アルドステロン症（PA）は、本態性高血圧症と比較して心血管疾患の発症リスクが極めて高く、早期診断・治療が予後に与える影響が大きい。現行の診断手法は患者負担、検査難易度から実施可能施設が限定され、必要な診療が受けられないアンメットニーズが存在した。本研究では、基礎的検討を基づき18オキソコルチゾールを含む血中ステロイドプロファイル解析が新たな病型診断法として有用であることが明らかとなった。血液検査のみで実施可能なステロイドプロファイル解析の臨床応用によって、PA診療が多くの施設に拡大し、アンメットニーズの解消が期待される。

Research Products

• [Int'l Joint Research] ミシガン大学(米国)
• [Int'l Joint Research] ミシガン大学(米国)
• [Journal Article] Aldosterone-induced cardiac damage in primary aldosteronism depends on its subtypes (2021)
  • Author(s): Higuchi Satoshi、Ota Hideki、Tezuka Yuta、Seiji Kazumasa、Takagi Hidenobu、Lee Jongmin、Lee Yi-Wei、Omata Kei、Ono Yoshikiyo、Morimoto Ryo、Kudo Masataka、Satoh Fumitoshi、Takase Kei
  • Journal Title: Endocrine Connections Volume: 10 Issue: 1 Pages: 29-36
  • DOI: 10.1530/ec-20-0504
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gender differences in human adrenal cortex and its disorders (2021)
  • Author(s): Gao Xin、Yamazaki Yuto、Tezuka Yuta、Omata Kei、Ono Yoshikiyo、Morimoto Ryo、Nakamura Yasuhiro、Satoh Fumitoshi、Sasano Hironobu
  • Journal Title: Molecular and Cellular Endocrinology Volume: 526 Pages: 111177-111177
  • DOI: 10.1016/j.mce.2021.111177
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Genotype-Based Morphology of Aldosterone-Producing Adrenocortical Disorders and Their Association with Aging (2021)
  • Author(s): Gao Xin、Yamazaki Yuto、Tezuka Yuta、Omata Kei、Ono Yoshikiyo、Morimoto Ryo、Nakamura Yasuhiro、Satoh Fumitoshi、Sasano Hironobu
  • Journal Title: Endocrinology and Metabolism Volume: 36 Issue: 1 Pages: 12-21
  • DOI: 10.3803/enm.2021.101
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Drug-resistant hypertension in primary aldosteronism patients undergoing adrenal vein sampling: the AVIS-2-RH study (2021)
  • Author(s): Rossi GP, et al
  • Journal Title: European Journal of Preventive Cardiology Volume: - Issue: 2 Pages: e85-e93
  • DOI: 10.1093/eurjpc/zwaa108
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review (2021)
  • Author(s): Tezuka Yuta、Yamazaki Yuto、Nakamura Yasuhiro、Sasano Hironobu、Satoh Fumitoshi
  • Journal Title: Biomedicines Volume: 9 Issue: 3 Pages: 310-310
  • DOI: 10.3390/biomedicines9030310
  • Peer Reviewed / Open Access
• [Journal Article] The Effect of Extracellular Calcium Metabolism on Aldosterone Biosynthesis in Physiological and Pathological Status (2020)
  • Author(s): Gao Xin、Yamazaki Yuto、Tezuka Yuta、Omata Kei、Ono Yoshikiyo、Morimoto Ryo、Nakamura Yasuhiro、Satoh Fumitoshi、Sasano Hironobu
  • Journal Title: Hormone and Metabolic Research Volume: 52 Issue: 06 Pages: 448-453
  • DOI: 10.1055/a-1157-0511
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Subtype diagnosis, treatment, complications and outcomes of primary aldosteronism and future direction of research: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension ? (2020)
  • Author(s): Mulatero Paolo、Sechi Leonardo A.、Williams Tracy Ann、Lenders Jacques W.M.、Reincke Martin、Satoh Fumitoshi、Januszewicz Andrzej、Naruse Mitsuhide、Doumas Michael、Veglio Franco、Wu Vin Cent、Widimsky Jiri
  • Journal Title: Journal of Hypertension Volume: 38 Issue: 10 Pages: 1929-1936
  • DOI: 10.1097/hjh.0000000000002520
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prevalence of Somatic Mutations in Aldosterone-Producing Adenomas in Japanese Patients (2020)
  • Author(s): Nanba Kazutaka、Yamazaki Yuto、Bick Nolan、Onodera Kei、Tezuka Yuta、Omata Kei、Ono Yoshikiyo、Blinder Amy R、Tomlins Scott A、Rainey William E、Satoh Fumitoshi、Sasano Hironobu
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 105 Issue: 11 Pages: e4066-e4073
  • DOI: 10.1210/clinem/dgaa595
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Recent Advances in Histopathological and Molecular Diagnosis in Pheochromocytoma and Paraganglioma: Challenges for Predicting Metastasis in Individual Patients (2020)
  • Author(s): Yamazaki Yuto、Gao Xin、Pecori Alessio、Nakamura Yasuhiro、Tezuka Yuta、Omata Kei、Ono Yoshikiyo、Morimoto Ryo、Satoh Fumitoshi、Sasano Hironobu
  • Journal Title: Frontiers in Endocrinology Volume: 11
  • DOI: 10.3389/fendo.2020.587769
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and safety of esaxerenone (CS-3150), a newly available nonsteroidal mineralocorticoid receptor blocker, in hypertensive patients with primary aldosteronism (2020)
  • Author(s): Satoh Fumitoshi、Ito Sadayoshi、Itoh Hiroshi、Rakugi Hiromi、Shibata Hirotaka、Ichihara Atsuhiro、Omura Masao、Takahashi Katsutoshi、Okuda Yasuyuki、Iijima Setsuko
  • Journal Title: Hypertension Research Volume: 44 Issue: 4 Pages: 464-472
  • DOI: 10.1038/s41440-020-00570-5
  • Peer Reviewed / Open Access
• [Journal Article] International Histopathology Consensus for Unilateral Primary Aldosteronism (2020)
  • Author(s): Williams Tracy Ann、Gomez-Sanchez Celso E、Rainey William E、Giordano Thomas J、Lam Alfred K、Marker Alison、Mete Ozgur、Yamazaki Yuto et al.
  • Journal Title: The Journal of Clinical Endocrinology & Metabolism Volume: 106 Issue: 1 Pages: 42-54
  • DOI: 10.1210/clinem/dgaa484
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Histological characterization of aldosterone-producing adrenocortical adenomas with different somatic mutations. (2020)
  • Author(s): Ono Y, Yamazaki Y, Omata K, Else T, Tomlins SA, Rhayem Y, Williams TA, Reincke M, Carling T, Monticone S, Mulatero P, Beuschlein F, Ito S, Satoh F, Rainey WE, Sasano H
  • Journal Title: J Clin Endocrinol Metab Volume: 105 Issue: 3 Pages: e282-e289
  • DOI: 10.1210/clinem/dgz235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Unique Sex Steroid Profiles in Estrogen-Producing Adrenocortical Adenoma Associated with Bilateral Hyperaldosteronism. (2020)
  • Author(s): Tezuka Y, Yamazaki Y, Ono Y, Morimoto R, Omata K, Seiji K, Takase K, Kawasaki Y, Ito A, Nakamura Y, Harigae H, Sasano H, Satoh F
  • Journal Title: Journal of the Endocrine Society Volume: 4 Issue: 2 Pages: 1-8
  • DOI: 10.1210/jendso/bvaa004
  • Peer Reviewed / Open Access
• [Journal Article] Renal damage in primary aldosteronism (2020)
  • Author(s): Monticone Silvia、Sconfienza Elisa、D’Ascenzo Fabrizio、Buffolo Fabrizio、Satoh Fumitoshi、Sechi Leonardo A.、Veglio Franco、Mulatero Paolo
  • Journal Title: Journal of Hypertension Volume: 38 Issue: 1 Pages: 3-12
  • DOI: 10.1097/hjh.0000000000002216
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 18-Oxocortisol Synthesis in Aldosterone-Producing (2019)
  • Author(s): Yuta Tezuka, Yuto Yamazaki, Masaaki Kitada, Ryo Morimoto, Masataka Kudo, Kazumasa Seiji,
  • Journal Title: Hypertension Volume: 印刷中 Issue: 6 Pages: 1283-1290
  • DOI: 10.1161/hypertensionaha.118.12064
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The crosstalk between aldosterone and calcium metabolism in primary aldosteronism: A possible calcium metabolism-associated aberrant "neoplastic" steroidogenesis in adrenals. (2019)
  • Author(s): Gao X, Yamazaki Y, Tezuka Y, Onodera Y, Ogata H, Omata K, Morimoto R, Nakamura Y, Satoh F, Sasano H
  • Journal Title: J Steroid Biochem Mol Biol Volume: 193 Pages: 105434-105442
  • DOI: 10.1016/j.jsbmb.2019.105434
  • Peer Reviewed / Open Access
• [Journal Article] Non-neoplastic/hyperplastic primary aldosteronism-Its Histopathology and Genotype- (2019)
  • Author(s): Yamazaki Y, Omata K, Tezuka Y, Gao X, Ogata H, Pieroni J, Ono Y, Morimoto R, Nakamura Y, Gomez-Sanchez CE, Satoh F, Sasano H
  • Journal Title: Current Opinion in Endocrine and Metabolic Research Volume: 8 Pages: 122-131
  • DOI: 10.1016/j.coemr.2019.08.006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical Outcomes of 1625 Patients with Primary Aldosteronism Subtyped with Adrenal Vein Sampling. (2019)
  • Author(s): Rossi GP, Rossitto G, Amar L, Azizi M, Riester A, Reincke M, Degenhart C, Widimsky J Jr, Naruse M, Deinum J, Schultze Kool L, Kocjan T, Negro A, Rossi E, Kline G, Tanabe A, Satoh F, et al.
  • Journal Title: Hypertension Volume: 74 Issue: 4 Pages: 800-808
  • DOI: 10.1161/hypertensionaha.119.13463
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Subtyping of Primary Aldosteronism in the AVIS-2 Study: Assessment of Selectivity and Lateralization. (2019)
  • Author(s): Rossitto G, Amar L, Azizi M, Riester A, Reincke M, Degenhart C, Widimsky J, Mitsuhide N, Deinum J, Schultzekool L, Kocjan T, Negro A, Rossi E, Kline G, Tanabe A, Satoh F, et al.
  • Journal Title: J Clin Endocrinol Metab Volume: - Issue: 6 Pages: 2042-2052
  • DOI: 10.1210/clinem/dgz017
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 原発性アルドステロン症診断法のパラダイムシフト (2021)
  • Author(s): 佐藤文俊
  • Organizer: 第28回日本ステロイドホルモン学会学術集会
• [Presentation] The Impact of ACTH on Peripheral Steroids Differs between Unilateral and Bilateral Primary Aldosteronism (2020)
  • Author(s): Yuta Tezuka, Kae Ishii, Lili Zhao, Yuto Yamazaki, Ryo Morimoto, Hironobu Sasano, Aaron Udager, Fumitoshi Satoh, Adina Turcu
  • Organizer: The Endocrine Society`s 103th Annual Meeting and Expo
  • Int'l Joint Research
• [Presentation] Intracellular Cholesterol Metabolism in Aldosterone-Producing Adenoma. ~A Possible Association with Cellular Morphometry and Genotype~ (2020)
  • Author(s): Shogo Harashima, Yuto Yamazaki, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hiroyoshi Suzuki, Hironobu Sasano
  • Organizer: The Endocrine Society`s 103th Annual Meeting and Expo
  • Int'l Joint Research
• [Presentation] Visualization of Ca Channel Blocker on Human Adrenal Tissue by Mass Spectrometry Imaging ~Its Predominant Distribution at Aldosterone-Producing Cells ~ (2020)
  • Author(s): Naoki Motomura, Yuto Yamazaki, Gao Xin, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Fumitoshi Satoh, Yasuhiro Nakamura, Hironobu Sasano
  • Organizer: The Endocrine Society`s 103th Annual Meeting and Expo
  • Int'l Joint Research
• [Presentation] 原発性アルドステロン症(PA)におけるアルドステロンの可視化と免疫組織化学との比較検討 (2020)
  • Author(s): 元村直樹、山崎有人、Gao Xin、手塚雄太、尾股慧、小野美澄、森本玲、佐藤文俊、中村保宏、笹野公伸
  • Organizer: 第109回日本病理学会総会
• [Presentation] 原発性アルドステロン症診療の問題点～新規 CLEIA アルドステロン測定法と従来法である SPAC を LCMS で検証～ (2020)
  • Author(s): 佐藤文俊、小野美澄、尾股慧、手塚雄太、森本玲、伊藤貞嘉
  • Organizer: 第93回日本内分泌学会学術総会
• [Presentation] 新規 CLEIA 法によるアルドステロン/レニン測定の意義は何か？～旧 RIA 法の SPAC-S アルドステロン測定法による診断とどう変わるのか？～ (2020)
  • Author(s): 佐藤文俊
  • Organizer: 第93回日本内分泌学会学術総会
  • Invited
• [Presentation] KCNJ5 および ATP1A1・ATP2B3・CACNA1D 体細胞遺伝子変異陽性アルドステロン産生腺腫の病理学的特徴 (2020)
  • Author(s): 小野美澄、山崎有人、尾股慧、Rainey William E、Beuschlein Felix、Mulatero Paulo、Carling Tobias、伊藤貞義、笹野公伸、佐藤文俊
  • Organizer: 第93回日本内分泌学会学術総会
• [Presentation] 新規ミネラルコルチコイド受容体(MR)ブロッカー、エサキセレノンの高血圧実臨床での降圧効果と安全性の検討～他MRブロッカーからの切り換え投与群 205症例と追加投与群 34症例での検討～ (2020)
  • Author(s): 佐藤文俊、森本玲、手塚雄太、尾股慧、小野美澄、伊藤貞義
  • Organizer: 第93回日本内分泌学会学術総会
• [Presentation] 原発性アルドステロン症(PA)におけるアムロジピンの局在の検討 (2020)
  • Author(s): 元村直樹、山崎有人、Xin Gao、手塚雄太、尾股慧、小野美澄、森本玲、佐藤文俊、中村保宏、笹野公伸
  • Organizer: 第93回日本内分泌学会学術総会
• [Presentation] 新規ミネラルコルチコイド受容体ブロッカー、エサキセレノンの実臨床での降圧力と安全性 (Blood pressure lowering effects and safety of esaxerenone, a newly available mineralocorticoid receptor blocker, in 234 hypertensive patients) (2020)
  • Author(s): 佐藤文俊、森本玲、尾股慧、小野美澄、手塚雄太、伊藤貞嘉
  • Organizer: 第63回日本腎臓学会学術総会
• [Presentation] アルドステロン産生腺腫におけるコレステロール受容体の発現と形態学的特徴及び genotype との関連性：腫瘍細胞における細胞内コレステロール代謝はアルドステロン合成にどのような影響を及ぼすのか (2020)
  • Author(s): 原嶋祥吾、山﨑有人、小野美澄、尾股慧、手塚雄太、森本玲、中村保宏、佐藤文俊、鈴木博義、笹野公伸
  • Organizer: 第24回日本臨床内分泌病理学会学術総会
• [Presentation] アルドステロン産生腺腫にもかかわらず正常血圧を認めた一例 (2020)
  • Author(s): 古田銀次、尾股慧、大黒顕佑、小野美澄、森本玲、張替秀郎、宮崎真理子、佐藤文俊
  • Organizer: 第30回日本内分泌学会臨床内分泌代謝 Update
• [Presentation] Blood Pressure Lowering Effects and Safety of Esaxerenone, A Newly Available Mineralocorticoid Receptor Blocker -The clinical practice in 243 patients at an outpatient unit- (2020)
  • Author(s): Fumitoshi Satoh, Ryo Morimoto, Yuta Tezuka, Kei Omata, Hiroaki Yamanami, Yoshikiyo Ono, Sadayoshi Ito
  • Organizer: Gordon Research Conference The RAAS: Integrating Novel Technologies, Clinical Studies and Personalized Therapeutics to Preserve Health
  • Int'l Joint Research
• [Presentation] 新規ミネラルコルチコイド受容体ブロッカー、エサキセレノンの降圧効果と安全性 ～外来実臨床243症例での検証～ (2020)
  • Author(s): 佐藤文俊、森本玲、手塚雄太、尾股慧、小野美澄、伊藤貞嘉
  • Organizer: 第49回日本心脈管作動物質学会
• [Presentation] エサキセレノンの術前投与が有効であったアルドステロン産生腫瘍の1例 (2020)
  • Author(s): 山並寛明、小野美澄、尾股慧、村上治、森本玲、佐藤文俊
  • Organizer: 第219回日本内科学会東北地方会
• [Presentation] 18-oxocortisol synthesis in aldosterone-producing adrenocortical adenoma and significance of KCNJ5 mutation status. (2019)
  • Author(s): Yuta Tezuka, Yuto Yamazaki, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Sadayoshi Ito, Hironobu Sasano, Fumitoshi Satoh
  • Organizer: 21st European Congress of Endocrinology
  • Int'l Joint Research
• [Presentation] Renal damage in primary aldosteronism: A Systematic review and meta-analysis. (2019)
  • Author(s): Silvia Monticone, Elisa Sconfienza, Fabrizio D'ascenzo, Fabrizio Buffolo, Fumitoshi Satoh, Cristiana Catena, Franco Veglio, Paolo Mulatero
  • Organizer: 29th European Meeting on Hypertension and Cardiovascular Protection
  • Int'l Joint Research
• [Presentation] Renal protective effects of topiroxostat and febuxistat, newly available xanthine oxidase inhibitors, in the hypertensive patients. (2019)
  • Author(s): F Satoh, Y Tezuka, K Omata Y Ono, B Shiratori, M Kudo, R Morimoto, S Ito
  • Organizer: 29th European Meeting on Hypertension and Cardiovascular Protection
  • Int'l Joint Research
• [Presentation] Developing new clinical devices for diagnosing primary aldosteronism. (2019)
  • Author(s): Fumitoshi Satoh
  • Organizer: Progress in Primary Aldosteronism 6
  • Int'l Joint Research / Invited
• [Presentation] Clinical experience of using esaxerenone to aldosterone producing adenoma : a case report. (2019)
  • Author(s): Hiroaki Ymanami, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yuto Yamazaki, Hironobu Sasano, Fumitoshi Satoh
  • Organizer: Progress in Primary Aldosteronism 6
  • Int'l Joint Research
• [Presentation] What’s New in Primary Aldosteronism ~Diagnosis and management~ (2019)
  • Author(s): Fumitoshi Satoh
  • Organizer: 15th Asian-Pacific Congress of Hypertension 2019, Aldosterone and Hypertension Satellite Meeting
  • Int'l Joint Research / Invited
• [Presentation] Somatic mutation in hyperaldosteronism. (2019)
  • Author(s): Kei Omata, Sadayoshi Ito, Fumitoshi Satoh, Scott Tomlins, William E. Rainey
  • Organizer: 第92回日本内分泌学会学術総会
  • Invited
• [Presentation] Primary Aldosteronism; Histopathology and Genotype. (2019)
  • Author(s): Yuto Yamazaki, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yasuhiro Nakamura, Sadayoshi Ito, Fumitoshi Satoh, Hironobu Sasano
  • Organizer: 第92回日本内分泌学会学術総会
  • Invited
• [Presentation] 原発性アルドステロン症の病理診断Update: 片側性・両側性病変の新分類 (2019)
  • Author(s): 中村保宏、山崎有人、佐藤文俊、笹野公伸
  • Organizer: 第92回日本内分泌学会学術総会
  • Invited
• [Presentation] Segmental AVS から考えるアルドステロン分泌動態の多様性；PA Sendai Study レジストリーの解析より (2019)
  • Author(s): 森本玲、手塚雄太、尾股慧、小野美澄、清治和将、川崎芳英、山崎有人、伊藤明宏、高瀬圭、笹野公伸、佐藤文俊
  • Organizer: 第92回日本内分泌学会学術総会
  • Invited
• [Presentation] 原発性アルドステロン症患者の手術治療と薬物治療では何が重要か？ (2019)
  • Author(s): 佐藤文俊、手塚雄太、尾股慧、小野美澄、白鳥ベアタ、森本玲、工藤正孝、伊藤貞嘉
  • Organizer: 第92回日本内分泌学会学術総会
  • Invited
• [Presentation] 原発性アルドステロン症診断・高血圧治療における高感度レニンアッセイ法の臨床的意義 (2019)
  • Author(s): 佐藤文俊
  • Organizer: 第92回日本内分泌学会学術総会
  • Invited
• [Presentation] 高血圧患者における副腎アルドステロン産生の検討 (2019)
  • Author(s): 尾股慧、日下亮、山崎有人、伊藤貞嘉、William E. Rainey、Scott Tomlins、笹野公伸、佐藤文俊
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] ヤヌス粒子を用いたアルドステロン症等の診断システムの開発 (2019)
  • Author(s): 藪浩、前田郁麻、岩本恭典、佐藤さつき、井上久美、珠玖仁、末永智一、根本靖久、佐藤文俊
  • Organizer: 第92回日本内分泌学会学術総会
  • Invited
• [Presentation] Histopathological analysis for aldosterone producing adenoma with somatic mutations (KCNJ5, ATP1A1, ATP2B3, and CACNA1D), using digital image analysis software. (2019)
  • Author(s): Yoshikiyo Ono, Yuto Yamazaki, Kei Omata, William E. Rainey, Felix Beuschlein, Paolo Mulatero, Tobias Carling, Sadayoshi Ito, Hironobu Sasano, Fumitoshi Satoh
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] Endocrinological Crosstalk between Calcium metabolism and Steroidogenesis in Primary Aldosteronism ～A possible PTH-induced aberrant "neoplastic" steroidogenesis in PA patients～ (2019)
  • Author(s): Xin Gao, Yuto Yamazaki, Yuta Tezuka, Hiroko Ogata, Kei Omata, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hironobu Sasano
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] Renal damage in primary aldosteronism: a systematic review and meta-anaylsis. (2019)
  • Author(s): Silvia Monticone, Elisa Sconfienza, Fabrizio D'Ascenzo, Fabrizio Buffolo, Fumitoshi Satoh, Cristiana Catena, Paolo Mulatero
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] Safety/tolerability and efficacy of osilodrostat in Japanese patients with endogenous Cushing syndorome except Cushing disease: results from a phase 2 study. (2019)
  • Author(s): 佐藤文俊、田中知明、宇治原誠、緑川早苗、金子朋美、武田珠美、鈴木明菜、島津章
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] アルドステロン産生腺腫におけるKCNJ5・ATP1A1・ATP2B3・CACNA1D体細胞変異陽性各群の病理組織学的定量解析 (2019)
  • Author(s): 小野美澄、山崎有人、尾股慧、William E. Rainey、Felix Beuschlein、Paolo Mulatero、Tobias Carling、伊藤貞嘉、笹野公伸、佐藤文俊
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] 原発性アルドステロン症における腎障害の病理組織学的検討 (2019)
  • Author(s): 尾形博子、手塚雄太、山崎有人、尾股慧、小野美澄、森本玲、佐藤博、宮崎真理子、城謙輔、中村保弘、荒井陽一、伊藤貞嘉、佐藤文俊、笹野公伸
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] 2012年から2017年の日本人原発性アルドステロン症手術例125例の体細胞遺伝子変異の頻度と病理組織学的所見との相関関係 (2019)
  • Author(s): 小野寺啓、山崎有人、蛯名広貴、Xin Gao、手塚雄太、北脇優子、尾股慧、小野美澄、森本玲、佐藤文俊、笹野公伸
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] ヒト副腎皮質でのアルドステロンの可視化：iMScopeを用いた検討 (2019)
  • Author(s): 元村直樹、山崎有人、Xin Gao、手塚雄太、尾股慧、小野美澄、森本玲、三枝大輔、佐藤文俊、笹野公伸
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] アルドステロン産生腺腫におけるKCNJ5免疫組織学的評価方法の均霑化 (2019)
  • Author(s): 蛯名広貴、山崎有人、木村双葉、小野寺啓、Xin Gao、手塚雄太、尾股慧、小野美澄、森本玲、Celso E. Gomez-Sanchez、佐藤文俊、笹野公伸
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] アルドステロン産生腺腫のgenotypesは腫瘍の形態学的所見を反映するか？ (2019)
  • Author(s): 木村双葉、山崎有人、手塚雄太、尾股慧、Xin Gao、小野美澄、森本玲、Celso E. Gomez-Sanchez、佐藤文俊、笹野公伸
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] Aldosteronism ～history and clinical devices update in Tohoku University～ (2019)
  • Author(s): Fumitoshi Satoh
  • Organizer: International Symposium of Aldosterone and Related Substances in Hypertension 2019
  • Int'l Joint Research / Invited
• [Presentation] The significance of KCNJ5 mutation in aldosterone-producing adenoma on 18-oxocortisol synthesis. (2019)
  • Author(s): Yuta Tezuka, Yuto Yamazaki, Masaaki Kitada, Ryo Morimoto, Masataka Kudo, Kazumasa Seiji, Kei Takase, Yoshihide Kawasaki, Koji Mitsuzuka, Akihiro Ito, Yasuhiro Nakamura, Celso E Gomez-Sanchez, Sadayoshi Ito, Mari Dezawa, Hironobu Sasano, Fumitoshi Satoh
  • Organizer: International Symposium of Aldosterone and Related Substances in Hypertension 2019
  • Int'l Joint Research
• [Presentation] Development of a novel Janus particle-based immunoassay for screening of primary aldosteronism. (2019)
  • Author(s): Satsuki M. Sato, Ryota Kinouchi, Kentaro Ito, Kumi Y. Inoue, Ikuma Maeda, Hiroshi Yabu, Fumitoshi Satoh, Hitoshi Shiku, Tomokazu Matsue
  • Organizer: International Symposium of Aldosterone and Related Substances in Hypertension 2019
  • Int'l Joint Research
• [Presentation] 偶発的に発見された両側副腎腫大で腫瘍との鑑別を要した先天性副腎過形成の1例 (2019)
  • Author(s): 山並寛明、小野美澄、尾股慧、白鳥ベアタ、村上治、森本玲、佐藤文俊
  • Organizer: 第218回日本内科学会東北地方会
• [Presentation] 原発性アルドステロン症(PA)におけるアルドステロン可視化の試み (2019)
  • Author(s): 元村直樹、山﨑有人、Gao Xin、手塚雄太、尾股慧、小野美澄、森本玲、佐藤文俊、笹野公伸
  • Organizer: 第23回日本臨床内分泌病理学会学術総会
• [Presentation] 原発性アルドステロン症における腎病変の病理組織学的検討 (2019)
  • Author(s): 尾形博子、手塚雄太、山﨑有人、尾股慧、小野美澄、森本玲、佐藤博、宮崎真理子、城謙輔、中村保宏、伊藤明宏、荒井陽一、伊藤貞嘉、佐藤文俊、笹野公伸
  • Organizer: 第23回日本臨床内分泌病理学会学術総会
• [Presentation] Cell senescence markers in human adrenal glands and their disorders (2019)
  • Author(s): Gao Xin, Yuto Yamazaki, Jacopo Pieroni, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hironobu Sasano
  • Organizer: 第27回特定非営利活動法人東北内分泌研究会／第39回日本内分泌学会東北地方会
• [Presentation] 原発性アルドステロン症と本能性高血圧症の腎障害の違い～病理組織学的アプローチから～ (2019)
  • Author(s): 尾形博子、手塚雄太、山﨑有人、尾股慧、小野美澄、森本玲、佐藤博、宮崎真理子、城謙輔、中村保宏、伊藤明宏、荒井陽一、伊藤貞義、佐藤文俊、笹野公伸
  • Organizer: 第27回特定非営利活動法人東北内分泌研究会／第39回日本内分泌学会東北地方会
• [Presentation] アルドステロン産生腺腫における KCNJ5 genotype 予測への試み～病理組織像から～ (2019)
  • Author(s): 山﨑有人、Gao Xin、木村双葉、小野美澄、尾股慧、手塚雄太、森本玲、Celso Gomez-Sanchez、中村保宏、佐藤文俊、笹野公伸
  • Organizer: 第27回特定非営利活動法人東北内分泌研究会／第39回日本内分泌学会東北地方会
• [Presentation] 迅速診断法を活用した原発性アルドステロン症のスクリーニングと診断 (2019)
  • Author(s): 森本玲、小野美澄、尾股慧、手塚雄太、宮崎真理子、佐藤文俊
  • Organizer: 第42回日本高血圧学会総会
• [Presentation] 原発性アルドステロン症診断におけるアルドステロン迅速測定キット導入後の迅速ACTH 負荷試験経時解析 (2019)
  • Author(s): 小野美澄、工藤正孝、尾股慧、森本玲、伊藤貞嘉、佐藤文俊
  • Organizer: 第42回日本高血圧学会総会
• [Presentation] 二酸化炭素造影を用いた副腎静脈サンプリングの検討 (2019)
  • Author(s): 尾股慧、山並寛明、小野美澄、森本玲、工藤正孝、村上治、伊藤貞嘉、佐藤文俊
  • Organizer: 第42回日本高血圧学会総会
• [Presentation] 新規ミネラルコルチコイド受容体(MR)ブロッカー エキサセレノンの高血圧症例243例の使用経験 ～降圧力とMRブロッキングの臨床的意義～ (2019)
  • Author(s): 佐藤文俊、森本玲、手塚雄太、尾股慧、小野美澄、伊藤貞嘉
  • Organizer: 第23回日本心血管内分泌代謝学会学術総会
• [Presentation] A Precise Prevalence of Genotypes And Histological Subtypes Of Consecutive JapanesePA CasesUndergoing Surgery From 2012 To 2017 (2019)
  • Author(s): Yuto Yamazaki, Kei Onodera, Hiroki Ebina, Xin Gao, Yuta Tezuka, Yuko Kitawaki, Hiroko Ogata, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Yasuhiro Nakamura, Sadayoshi Ito, Fumitoshi Satoh, Hironobu Sasano
  • Organizer: ENDO2019
  • Int'l Joint Research
• [Presentation] Aldosterone-producing adenoma; Genotype and Histopathology. (2018)
  • Author(s): Fumitoshi Satoh, Yuto Yamazaki, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Yasuhiro Igarashi, Ryo Morimoto, Masataka Kudo, Yasuhiro Nakamura, Kei Takase, Hironobu Sasano and Sadayoshi Ito
  • Organizer: The 18th Adrenal Cortex Conference
  • Int'l Joint Research
• [Presentation] A pathophysiology update of hyperaldosteronism. (2018)
  • Author(s): Fumitoshi Satoh
  • Organizer: RAAS2018 (ISH2018 Satellite Symposium)
  • Int'l Joint Research / Invited
• [Presentation] Segmental adrenal venous sampling may give a key to solution about the debate of cosyntropin stimulation or not. (2018)
  • Author(s): Fumitoshi Satoh, Yuta Tezuka, Ryo Morimoto, Yoshikiyo Ono, Kei Omata, Masataka Kudo, Kei Takase, Hironobu Sasano, Sadayoshi Ito
  • Organizer: Angiotensin/ Gordon Research Conference
  • Int'l Joint Research
• [Presentation] Anatomic variations and AVS. (2018)
  • Author(s): Fumitoshi Satoh
  • Organizer: I-Padua Study Kick off meeting
  • Int'l Joint Research / Invited
• [Presentation] Intratumor Heterogeneity in Adosterone-Producing Adenomas with KCNJ5 Mutations. (2018)
  • Author(s): Kei Omata, Yuka Shishido, Ibuki Higashi, Yuto Yamazaki, Yoshikiyo Ono, Yasuhiro Nakamura, Fumitoshi Satoh, Tobias John Eric Carling, William E. Rainey, Scott Tomlins, Hironobu Sasano
  • Organizer: ENDO2018
  • Int'l Joint Research
• [Presentation] Hormonal Significance of Morphological Cell Subtypes in KCNJ5 Mutated Aldosterone-producing Adenoma. (2018)
  • Author(s): Yuto Yamazaki, Ibuki Higashi, Yuka Shishido, Yuzu Adachi, Kasue Ise, Yuta Tezuka, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Takumi Kitamoto, Tetsuo Nishikawa, Yasuhiro Nakamura, Sadayoshi Ito, Fumitoshi Satoh, Hironobu Sasano
  • Organizer: ENDO2018
  • Int'l Joint Research
• [Presentation] A Comprehensive Screening Assay of Serum Adrenal Corticoids and Hybrid Steroids using Polarity Switching LC-MS. (2018)
  • Author(s): Chaelin Lee, Fumitoshi Satoh, Hironobu Sasano, Jung Hee Kim, Man-Ho Choi
  • Organizer: ENDO2018
  • Int'l Joint Research