| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We found that PP cell hyperplasia and PP+ GCG+ double positive cells were induced in mice lacking the proglucagon gene. We investigated which hormone the proglucagon gene encodes, and found that glucagon action deficiency induced PP cell hyperplasia and PP+ GCG+ double positive cells. Next, we examined which tissues are involved in this phenotype and found that glucagon action deficiency in the liver is involved. These results suggest that glucagon action in the liver may be involved in the regulation of PP cell proliferation and maintenance of PP cell or α cell fate.
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