Molecular mechanism of cell-cell interaction in aging-induced adipose tissue inflammation
Project/Area Number |
18K08508
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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Research Institution | Nagoya University |
Principal Investigator |
Tanaka Miyako 名古屋大学, 環境医学研究所, 講師 (60622793)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | マクロファージ / 炎症 / 加齢 / inflammaging / 慢性炎症 / 脂肪細胞 / 線維化 |
Outline of Final Research Achievements |
In this study, we focused on the adipose tissue remodeling to investigate the molecular mechanism of aging-induced adipose tissue inflammation. We found several genes that changes in the subcutaneous adipose tissue-specific manner with aging. We will generate the mice that these genes genetically knocked out or overexpressed to investigate the effects of them on aging. We also examined the adipose tissue inflammation and ectopic fat accumulation in artificially "rebounded" mice. Generally, it is said that rebound worsens metabolism compared to before weight loss, but in the results of this study, in rebound mice, the metabolism wasn't worsened but rather improved. In the future, I would like to study in more detail and give the accurate information.
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Academic Significance and Societal Importance of the Research Achievements |
高齢化社会を迎え,高齢者の健康や健康寿命に対し関心が集まっている。一方,加齢に伴い,皮下脂肪組織は減少し,逆に内臓脂肪組織が増加することが知られており,「皮膚粗鬆症」という概念も生まれている。本研究において見出した新たな遺伝子の役割を詳細に検討することで,加齢に伴う疾患の予防や治療に貢献できると考えている。また,これまで,リバウンドは減量する前よりも代謝が悪くなると考えられていたが,必ずしもそうではない可能性を見出した。今後,より詳細に検討し,リバウンドを起こす可能性があっても減量した方が健康に良い,というような研究成果に基づいた正しい情報を提供することで,ヒトの健康に寄与したい。
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome2020
Author(s)
Oka Y, Hamada M, Nakazawa Y, ..., Tanaka M, Suganami T, Nakada S, Mitsutake N, Hara Y, Kato K, ..., Kaneko H, Matsumoto N, Matsuda F, Matsuo K, Takahashi Y, Mashimo T, Kojima S, Ogi T
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Journal Title
Science Advances
Volume: 6
Issue: 51
Pages: 7197-7197
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] C-type lectin Mincle mediates cell death-triggered inflammation in acute kidney injury.2020
Author(s)
Tanaka M, Saka-Tanaka M, Ochi K, Fujieda K, Sugiura Y, Miyamoto T, Kohda H, Ito A, Miyazawa T, Matsumoto A, Aoe S, Miyamoto Y, Tsuboi N, Maruyama S, Suematsu M, Yamasaki S, Ogawa Y, Suganami T.
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Journal Title
J Exp Med.
Volume: 217
Issue: 11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system.2020
Author(s)
Matsumoto A, Kuwata H, Kimura S, Matsumoto H, Ochi K, Moro-oka Y, Watanabe A, Yamada H, Ishii H, Miyazawa T, Chen S, Baba T, Yoshida H, Nakamura T, Inoue H, Ogawa Y, Tanaka M, Miyahara Y, Suganami T.
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Journal Title
Commun. Biol.
Volume: 3
Issue: 1
Pages: 313-313
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair2020
Author(s)
Nakazawa Y, Hara Y, Oka Y, Komine O, van den Heuvel D, Guo C, Daigaku Y, Isono M, He Y, Shimada M, Kato K, Jia N, Hashimoto S, Kotani Y, Miyoshi Y, Tanaka M, Sobue A, Mitsutake N, Suganami T, Masuda A, Ohno K, Nakada S, Mashimo T, Yamanaka K, Luijsterburg MS, Ogi T
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Journal Title
Cell
Volume: 19
Issue: 6
Pages: 1228-1244
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis?associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects2020
Author(s)
Kawakubo M, Tanaka M, Ochi K, Watanabe A, Saka-Tanaka M, Kanamori Y, Yoshioka N, Yamashita S, Goto M, Itoh M, Shirakawa I, Kanai S, Suzuki H, Sawada M, Ito A, Ishigami M, Fujishiro M, Arima H, Ogawa Y, Suganami T
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 983-983
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] C-type lectin Mincle accelerates renal ischemia-reperfusion injury2018
Author(s)
Miyako Tanaka, Marie Saka-Tanaka, Kozue Ochi, Kumiko Fujieda, Hiro Kohda, Naotake Tsuboi, Shoichi Maruyama, Tomofumi Miyamoto, Sho Yamasaki, Yoshihiro Ogawa, Takayoshi Suganami
Organizer
Australia-Japan Meeting on Cell Death
Related Report
Int'l Joint Research
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