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Analysis of Srebf1 transcriptional coregulator in adipose oxidative stress and healthy adipose expansion

Research Project

Project/Area Number 18K08513
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionOsaka University

Principal Investigator

Okuno Yosuke  大阪大学, 医学系研究科, 助教 (10534513)

Co-Investigator(Kenkyū-buntansha) 大月 道夫  大阪大学, 医学系研究科, 准教授 (00403056)
福原 淳範  大阪大学, 医学系研究科, 寄附講座准教授 (00437328)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsARMC5 / Srebp1 / Armc5 / 肥満 / 脂肪細胞 / 糖尿病 / 酸化ストレス / SREBP1
Outline of Final Research Achievements

In this study, we found the molecular interaction between full-length SREBF1 and ARMC5, the causal gene of bilateral macronodular adrenal hyperplasia (BMAH). ARMC5 recruited ubiquitin ligase complex containing CUL3 and ubiquitinated full-length SREBF1. In adrenocortical cells, ARMC5 regulated cholesterol synthesis and cell proliferation, which resulted in progression of BMAH.

Academic Significance and Societal Importance of the Research Achievements

クッシング症候群の一部である両側性大結節性副腎皮質過形成の発症機構を明らかにし、その治療に貢献する可能性がある。また、SREBFは脂質合成やコレステロール合成を介して、肥満、脂肪肝、血中コレステロール濃度にも寄与しており、ARMC5を介したhealthy adipose expansion、脂肪肝、高コレステロール血症の制御にもつながる可能性があると考えられる。

Report

(2 results)
  • 2020 Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2019

All Presentation (1 results)

  • [Presentation] 脂肪細胞における核内SREBP1結合因子の探索2019

    • Author(s)
      奥野陽亮
    • Organizer
      第92回日本内分泌学会学術総会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-12-28  

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