The mechanisms underlying visceral fat dysregulation in the subjects with morbid obesity
| Project/Area Number |
18K08523
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
佐々木 章 岩手医科大学, 医学部, 教授 (40275540)
長谷川 豊 岩手医科大学, 医学部, 特任講師 (90451559)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 肥満 / 生活習慣 / インスリン抵抗性 / 脂肪肝 / 小胞体ストレス / 炎症 / 褐色脂肪 / 白色脂肪 / 褐色細胞 / 2型糖尿病 / 糖尿病合併症 / 褐色脂肪細胞 |
|---|
| Outline of Final Research Achievements |
We examined the relationship between serum concentration of adipocytokine CXCL-14, secreted from adipose tissue, and clinical parameters of the subjects with type 2 diabetes (n=176). Serum CXCL-14 level associated with the grade of insulin resistance, obesity and fatty liver.
From baseline data of a general population-based cohort study, we compared between the subjects with weight gain over 10kg (n=3601) and <10kg (n=3601) after age 20,matched by a propensity score model which included current BMI, age and gender. Major weight gain after 20 years of age was associated with unfavorable lifestyle factors and greater waist circumference, possibly leading to elevated risk for metabolic syndrome and other non-communicable diseases.
|
| Academic Significance and Societal Importance of the Research Achievements |
CXCL-14は脂肪肝やインスリン抵抗性を評価できる新しいバイオマーカーとして、臨床応用が期待できる。
成人以降の体重増加は朝食抜きや活動量が低いといった好ましくない生活習慣と関係することが示唆された。また、成人以降体重増加群ではメタボリックシンドロームや高血圧、脂質異常といった代謝疾患と強く関わっていたことから、生活習慣を是正して中年期の肥満を予防することが生活習慣病予防に重要であるというメッセージの発信につながり、地元の新聞などで紹介された。
|
Report
(4 results)
Research Products
(41 results)
-
[Journal Article] Study Profile of the Tohoku Medical Megabank Community-Based Cohort Study2021
Author(s)
Hozawa A, Tanno K, Nakaya N, Nakamura T, Tsuchiya N, Hirata T, Narita A, Kogure M, Nochioka K, Sasaki R, Takanashi N, Otsuka K, Sakata K, Kuriyama S, Kikuya M, 13名略, Kobayashi T, 53名略, Yamamoto M.
-
Journal Title
Journal of Epidemiology
Volume: 31
Issue: 1
Pages: 65-76
DOI
NAID
ISSN
0917-5040, 1349-9092
Year and Date
2021-01-05
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
[Journal Article] Serum C-X-C motif chemokine ligand 14 levels are associated with serum C-peptide and fatty liver index in type 2 diabetes mellitus patients.2020
Author(s)
Matsushita Y, Hasegawa Y, Takebe N, Onodera K, Shozushima M, Oda T, Nagasawa K, Honma H, Nata K, Sasaki A, Ishigaki Y.
-
Journal Title
J Diabetes Investig.
Volume: -
Issue: 6
Pages: 1042-1049
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Identification and Analysis of a Novel NR0B1 Mutation in Late-Onset Adrenal Hypoplasia Congenita and Hypogonadism.2020
Author(s)
Hasegawa Y, Takahashi Y, Kezuka Y, Obara W, Kato Y, Tamura S, Onodera K, Segawa T, Oda T, Sato M, Nata K, Nonaka T, Ishigaki Y.
-
Journal Title
J Endocr Soc.
Volume: 5
Issue: 2
DOI
NAID
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Background characteristics and postoperative outcomes of insufficient weight loss after laparoscopic sleeve gastrectomy in Japanese patients.2019
Author(s)
Saiki A, Yamaguchi T, Tanaka S, Sasaki A, Naitoh T, Seto Y, Matsubara H, Yokote K, Okazumi S, Ugi S, Yamamoto H, Ohta M, Ishigaki Y, et al
-
Journal Title
Ann Gastroenterol Surg.
Volume: 3
Issue: 6
Pages: 638-647
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.2019
Author(s)
Suzuki K, Akiyama M, Ishigaki K, Kanai M, Hosoe J, Shojima N, Hozawa A, Kadota A, Kuriki K, Naito M, Tanno K, Ishigaki Y, et al.
-
Journal Title
Nat Genet.
Volume: 51
Issue: 3
Pages: 379-386
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
[Journal Article] Guidelines for Diagnosis and Treatment of Familial Hypercholesterolemia 20172018
Author(s)
Harada-Shiba Mariko、Arai Hidenori、Ishigaki Yasushi、Ishibashi Shun、Okamura Tomonori、Ogura Masatsune、Dobashi Kazushige、Nohara Atsushi、Bujo Hideaki、Miyauchi Katsumi、Yamashita Shizuya、Yokote Koutaro、Working Group by Japan Atherosclerosis Society for Making Guidance of Familial Hypercholesterolemia
-
Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 25
Issue: 8
Pages: 751-770
DOI
NAID
ISSN
1340-3478, 1880-3873
Year and Date
2018-08-01
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Serum cystatin C level is associated with carotid arterial wall elasticity in subjects with type 2 diabetes mellitus: A potential marker of early-stage atherosclerosis.2018
Author(s)
Kaneko R, Sawada S, Tokita A, Honkura R, Tamura N, Kodama S, Izumi T, Takahashi K, Uno K, Imai J, Yamada T, Miyachi Y, Hasegawa H, Kanai H, Ishigaki Y, Katagiri H
-
Journal Title
Diabetes Research and Clinical Practice
Volume: 139
Pages: 43-51
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation.2018
Author(s)
Izumi T, Imai J, Yamamoto J, Kawana Y, Endo A, Sugawara H, Kohata M, Asai Y, Takahashi K, Kodama S, Kaneko K, Gao J, Uno K, Sawada S, Kalinichenko VV, Ishigaki Y, Yamada T, Katagiri H.
-
Journal Title
Nat Commun.
Volume: 9
Issue: 1
Pages: 5300-5300
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
