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Analysis of the mechanisms of beta cell destruction in fulminant type 1 diabetes with special reference to CD300e and viral infection related factors

Research Project

Project/Area Number 18K08529
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionOsaka Medical College

Principal Investigator

Imagawa Akihisa  大阪医科大学, 医学部, 教授 (80373108)

Co-Investigator(Kenkyū-buntansha) 細川 吉弥  大阪大学, 医学部附属病院, 特任助教(常勤) (10814569)
佐野 寛行  大阪医科大学, 医学部, 助教 (20556435)
寺前 純吾  大阪医科大学, 医学部, 講師 (90351395)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords劇症1型糖尿病 / CD300e / 1型糖尿病
Outline of Final Research Achievements

We have established a method for measuring the expression rate of CD300e and mean fluorointensity (MFI) in peripheral blood monocytes in patients with fulminant type 1 diabetes and healthy subjects as controls. In addition, healthy human-derived iPS cells and fulminant type 1 diabetic iPS cells were induced to differentiate into insulin-positive cells, poly (I;C) -transfected, and only insulin-positive cells were isolated by flow cytometry and gene expression was examined.

Academic Significance and Societal Importance of the Research Achievements

劇症1型糖尿病の発症メカニズムとして想定されている免疫制御機構の異常とウイルス感染の関与について、その研究をCD300eやiPS細胞の観点からさらに前進させたことが本研究の学術的意義である。劇症1型糖尿病は、非常に急激に膵β細胞が破壊され、それによる急激な血糖上昇と代謝異常が生命予後にも影響することから、成因解明を進めることは社会的意義も大きいと考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Fulminant type 1 diabetes: recent research progress and future prospects.2020

    • Author(s)
      Imagawa A, Tachibana M.
    • Journal Title

      Diabetol Int.

      Volume: 11 Issue: 4 Pages: 336-341

    • DOI

      10.1007/s13340-020-00466-2

    • NAID

      40022387424

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two types of fulminant type 1 diabetes mellitus: Immune checkpoint inhibitor-related and conventional2020

    • Author(s)
      Imagawa A
    • Journal Title

      J Diabetes Investig

      Volume: - Issue: 6 Pages: 917-919

    • DOI

      10.1111/jdi.13450

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenesis of fulminant type 1 diabetes: Genes, viruses and the immune mechanism, and usefulness of patient-derived induced pluripotent stem cells for future research.2019

    • Author(s)
      Hosokawa Y, Hanafusa T, Imagawa A.
    • Journal Title

      J Diabetes Investig.

      Volume: 10 Issue: 5 Pages: 1158-1164

    • DOI

      10.1111/jdi.13091

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Usefulness of patient-derived iPS cells in fulminant type 1 diabetes2020

    • Author(s)
      Imagawa A.
    • Organizer
      17th International Congress of Immunology of Diabetes Society 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 劇症1型糖尿病の最新知見と将来展望2020

    • Author(s)
      今川彰久
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 劇症1型糖尿病-抗PD-1抗体薬投与後発症例の委員会調査結果も含めて-2018

    • Author(s)
      今川彰久
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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