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Role of Autophagy in the Cellular Immunity of Biliary Atresia

Research Project

Project/Area Number 18K08535
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55010:General surgery and pediatric surgery-related
Research InstitutionChiba Cancer Center (Research Institute) (2020-2022)
Chiba University (2018-2019)

Principal Investigator

Saito Takeshi  千葉県がんセンター(研究所), がん治療開発グループ がん遺伝創薬研究室, 主任医長 (20406044)

Co-Investigator(Kenkyū-buntansha) 幡野 雅彦  千葉大学, 大学院医学研究院, 教授 (20208523)
吉田 英生  千葉大学, 大学院医学研究院, 教授 (60210712)
坂本 明美  千葉大学, バイオメディカル研究センター, 准教授 (90359597)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords制御性T細胞 / オートファジー / 胆道閉鎖症 / 先天性胆道拡張症 / 獲得免疫 / 自然免疫 / 免疫応答 / ウイルス感染 / 胆管上皮細胞 / 自己免疫疾患 / 細胞性免疫 / ウェスタンブロティング / 電子顕微鏡 / ウェスタンブロッティング / 小児外科学
Outline of Final Research Achievements

This study investigated the significance and role of regulatory T cell (Treg) and autophagy in the development of the immunological environment of biliary atresia (BA). It revealed that neither frequency or function of Treg in the systemic and local environment did show significant difference compared to the normal controls. On the other hand, the autophagic activities in the systemic CD4 positive cells, in particular Treg, and the local bile duct cells were significantly increased. The effect of the accelerated activity of autophagy in both systemic and local environment on the immunological aspects in BA remains to be clarified.

Academic Significance and Societal Importance of the Research Achievements

本研究ではBAの病態について、①全身・局所環境においてTregのfrequencyは低下していなかった、②全身性Tregの機能は低下していなかった、③胆管上皮細胞と全身性T細胞でautophagy機能が亢進していた、④特にCD4/8陽性細胞とTregでautophagy機能が活性化していた、ことが示された。autophagyの機能異常が獲得免疫系を破綻させ、BAの病態を形成している可能性は依然示唆されており、今後の病因研究の方向性を明示している。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (57 results)

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article (32 results) (of which Peer Reviewed: 21 results,  Open Access: 6 results) Presentation (24 results) (of which Int'l Joint Research: 4 results) Book (1 results)

  • [Journal Article] Clinical outcome of ulcerative colitis with severe onset in children: a multicenter prospective cohort study.2023

    • Author(s)
      Nambu R, Arai K, Kudo T, Murakoshi T, Kunisaki R, Mizuochi T, Kato S, Kumagai H, Inoue M, Ishige T, Saito T, Noguchi A, Yodoshi T, Hagiwara SI, Iwata N, Nishimata S, Kakuta F, Tajiri H, Hiejima E, Toita N, Mochizuki T, Shimizu H, Iwama I, Hirano Y, Shimizu T; JPIBD-R.
    • Journal Title

      J Gastroenterol.

      Volume: - Issue: 5 Pages: 472-480

    • DOI

      10.1007/s00535-023-01972-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 術前薬物療法が奏功し完全切除し得た局所浸潤右副腎皮質癌の1乳児例.2022

    • Author(s)
      小関元太, 中田光政, 照井慶太, 小松秀吾, 山下喜晴, 力石浩志, 日野もえ子, 齋藤 武, 菱木知郎.
    • Journal Title

      日小外会誌.

      Volume: 58 Pages: 984-991

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腹壁閉鎖困難例に対するcomponent separation technique(CST)の応用 CSTおよび青山法による腹壁閉鎖の経験.2022

    • Author(s)
      照井慶太, 齋藤 武, 武之内史子, 小松秀吾, 笈田 諭, 岩井 潤, 菱木知郎.
    • Journal Title

      小児外科.

      Volume: 54 Pages: 1202-1206

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 先天性胆道拡張症 戸谷分類の課題 II型(憩室型)について.2022

    • Author(s)
      齋藤 武.
    • Journal Title

      小児外科.

      Volume: 54 Pages: 850-855

    • Related Report
      2022 Annual Research Report
  • [Journal Article] 高位・中間位鎖肛手術術式の成績と問題点 筋群切開を伴う術式について.2022

    • Author(s)
      岩井 潤, 中田光政, 佐永田友季子, 瀧口翔太, 齋藤 武.
    • Journal Title

      小児外科.

      Volume: 54 Pages: 656-660

    • Related Report
      2022 Annual Research Report
  • [Journal Article] A consensus statement on health‐care transition for childhood‐onset inflammatory bowel disease patients2022

    • Author(s)
      Kumagai H, Sugimoto K, et al.
    • Journal Title

      Pediatrics International

      Volume: 64 Issue: 1

    • DOI

      10.1111/ped.15241

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequency and function of circulating regulatory T-cells in biliary atresia.2022

    • Author(s)
      Oita S, Saito T, Sakamoto A, Fujimura L, Ohara Y, Fumita T, Terui K, Nakata M, Komatsu S, Matsuura G, Hatano M, Hishiki T.
    • Journal Title

      Pediatr Surg Int.

      Volume: 30(39) Issue: 1 Pages: 1-8

    • DOI

      10.1007/s00383-022-05307-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Double Common Bile Duct With Pancreaticobiliary Maljunction: A Case Report2021

    • Author(s)
      工藤 渉, 齋藤 武, 照井慶太, 中田光政, 小松秀吾, 原田和明, 秦 佳孝, 古金遼也.
    • Journal Title

      Journal of the Japanese Society of Pediatric Surgeons

      Volume: 57 Issue: 3 Pages: 618-624

    • DOI

      10.11164/jjsps.57.3_618

    • NAID

      130008027786

    • ISSN
      0288-609X, 2187-4247
    • Year and Date
      2021-04-20
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Optimization of surgical timing of congenital diaphragmatic hernia using the quantified flow patterns of patent ductus arteriosus2021

    • Author(s)
      Yoshitaka Shinno, Keita Terui, Mamiko Endo, Takeshi Saito, Mitsuyuki Nakata, Shugo Komatsu, Satoru Oita, Yoshio Katsumata, Yukiko Saeda, Genta Ozeki, Yoshiteru Ohsone, Tomoro Hishiki
    • Journal Title

      Pediatric Surgery International

      Volume: 37 Issue: 2 Pages: 197-203

    • DOI

      10.1007/s00383-020-04788-9

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice.2021

    • Author(s)
      Ohara Y, Fujimura L, Sakamoto A, Teratake Y, Hiraoka S, Koseki H, Saito T, Terui K, Mitsunaga T, Nakata M, Yoshida H, Hatano M.
    • Journal Title

      Sci Rep.

      Volume: 4;11(1) Issue: 1 Pages: 3191-3191

    • DOI

      10.1038/s41598-021-82785-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] How Parents of Adolescents and Young Adults with Biliary Atresia Surviving with Native Livers Transfer the Responsibility of Medical Treatment to Their Children in Japan.2021

    • Author(s)
      Hiratsuka K, Nakamura N, Sato N, Saito T.
    • Journal Title

      J Pediatr Nurs.

      Volume: 61 Pages: 115-121

    • DOI

      10.1016/j.pedn.2021.05.004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 横紋筋肉腫との鑑別を要した膀胱原発炎症性筋線維芽細胞腫瘍の1小児例.2021

    • Author(s)
      古金遼也,齋藤 武,照井慶太,中田光政,小松秀吾.
    • Journal Title

      日小外会誌.

      Volume: 57 Pages: 38-43

    • NAID

      130007988505

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 先天性食道閉鎖症2021

    • Author(s)
      齋藤 武.
    • Journal Title

      周産期医学.

      Volume: 51増 Pages: 795-797

    • Related Report
      2021 Research-status Report
  • [Journal Article] Sindbis viral structural protein cytotoxicity on human neuroblastoma cells.2020

    • Author(s)
      Saito EY, Saito K, Hishiki T, Takenouchi A, Saito T, Sato Y, Terui K, Matsunaga T, Shirasawa H, Yoshida H.
    • Journal Title

      Pediatr Surg Int.

      Volume: 36 Issue: 10 Pages: 1173-1180

    • DOI

      10.1007/s00383-020-04719-8

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phenotypic characteristics of pediatric inflammatory bowel disease in Japan: results from a multicenter registry.2020

    • Author(s)
      Arai K, Kunisaki R, Kakuta F, Hagiwara SI, Murakoshi T, Yanagi T, Shimizu T, Kato S, Ishige T, Aomatsu T, Inoue M, Saito T, Iwama I, Kawashima H, Kumagai H, Tajiri H, Iwata N, Mochizuki T, Noguchi A, Kashiwabara T, Shimizu H, Suzuki Y, Hirano Y, Fujiwara T.
    • Journal Title

      Intest Res.

      Volume: 18 Issue: 4 Pages: 412-420

    • DOI

      10.5217/ir.2019.00130

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Use of free thymic fat pad for recurrent tracheoesophageal fistula operation following esophageal atresia repair.2020

    • Author(s)
      Saito T, Suzuki H, Nakajima T, Sakairi Y, Terui K, Nakata M, Komatsu S, Yoshino I, Hishiki T.
    • Journal Title

      Journal of Pediatric Surgery Case Reports.

      Volume: 57 Pages: 101444-101444

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] トピックス 小児穿孔性虫垂炎における疾患特異的アンチバイオグラムの有用性2019

    • Author(s)
      柴田涼平, 齋藤 武, 照井慶太, 中田光政, 小松秀吾, 村田正太, 谷口俊史, 吉田英生
    • Journal Title

      小児科

      Volume: 60 Issue: 12 Pages: 1673-1681

    • DOI

      10.18888/sh.0000001109

    • ISSN
      0037-4121
    • Year and Date
      2019-11-01
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Standard protocol devised by the Japanese Pediatric Impedance Working Group for combined multichannel intraluminal impedance-pH measurements in children2019

    • Author(s)
      Fukahori S, Kawahara H, Oyama T, Saito T, Shimono R, Tanaka A, Noda T, Hatori R, Fujino J, Yagi M
    • Journal Title

      Surg Today

      Volume: 未定 Issue: 7 Pages: 664-671

    • DOI

      10.1007/s00595-019-01833-6

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Generation of conditional ALK F1174L mutant mouse models for the study of neuroblastoma pathogenesis.2019

    • Author(s)
      Ono S, Saito T, Terui K, Yoshida H, Enomoto H.
    • Journal Title

      Genesis.

      Volume: 57 Issue: 10 Pages: 1-8

    • DOI

      10.1002/dvg.23323

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acid and bolus exposure in pediatric reflux disease according to the presence and severity of esophageal mucosal lesions.2019

    • Author(s)
      Saito T, Uesato M, Terui K, Nakata M, Komatsu S, Yoshida H.
    • Journal Title

      Pediatr Surg Int.

      Volume: 35 Issue: 8 Pages: 887-893

    • DOI

      10.1007/s00383-019-04490-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation2019

    • Author(s)
      Harada, K., Ihara, F., Takami, M., Kamata, T., Mise, N., Yoshizawa, H., Hishiki, T., Saito, T., Terui, K., Nakata, M., Komatsu, S., Ikeuchi, T., Nakayama, T., Yoshida, H., Motohashi, S.
    • Journal Title

      Cancer Sci.

      Volume: 110 Issue: 3 Pages: 888-902

    • DOI

      10.1111/cas.13933

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 外科的疾患 SMA症候群2019

    • Author(s)
      中田光政, 照井慶太, 小松秀吾, 秦 佳孝, 笈田 諭, 勝俣善夫, 佐永田友季子, 小関元太, 齋藤 武
    • Journal Title

      小児内科

      Volume: 51 Pages: 1529-1531

    • Related Report
      2019 Research-status Report
  • [Journal Article] 臍帯ヘルニア 肝臓が還納できない2019

    • Author(s)
      照井慶太, 中田光政, 小松秀吾, 笈田 諭, 秦 佳孝, 勝俣善夫, 佐永田有季子, 小関元太, 齋藤 武
    • Journal Title

      小児外科

      Volume: 51 Pages: 983-986

    • Related Report
      2019 Research-status Report
  • [Journal Article] 特殊病態下の輸液管理 先天性横隔膜ヘルニア2019

    • Author(s)
      照井慶太, 遠藤真美子, 中田光政, 小松秀吾, 笈田 諭, 秦 佳孝, 勝俣善夫, 佐永田有季子, 小関元太, 大曽根義輝, 齋藤 武
    • Journal Title

      小児外科

      Volume: 51 Pages: 1130-1133

    • Related Report
      2019 Research-status Report
  • [Journal Article] 進行神経芽腫外科治療における術中・術後合併症2019

    • Author(s)
      小松秀吾, 齋藤 武, 照井慶太, 中田光政, 原田和明, 秦 佳孝, 古金遼也, 工藤 渉, 吉田英生
    • Journal Title

      小児外科

      Volume: 51 Pages: 295-298

    • Related Report
      2019 Research-status Report
  • [Journal Article] Significance and indications for reoperative portoenterostomy in biliary atresia in light of long-term outcome.2018

    • Author(s)
      Saito T, Terui K, Mitsunaga T, Nakata M, Komatsu S, Yoshida H.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Issue: 5 Pages: 275-280

    • DOI

      10.1002/jhbp.548

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frequency and proliferative response of circulating invariant natural killer T cells in pediatric patients with or without malignant solid tumors.2018

    • Author(s)
      Hishiki T, Mise N, Harada K, Ihara F, Takami M, Saito T, Terui K, Nakata M, Komatsu S, Yoshida H, and Motohashi S
    • Journal Title

      Pediatr. Surg. Int.

      Volume: 34 Issue: 2 Pages: 169-176

    • DOI

      10.1007/s00383-017-4185-1

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Invariant natural killer T infiltration in neuroblastoma with favorable outcome.2018

    • Author(s)
      Hishiki T, Mise N, Harada K, Ihara F, Takami M, Saito T, Terui K, Nakata M, Komatsu S, Yoshida H, and Motohashi S
    • Journal Title

      Pediatr. Surg. Int.

      Volume: 34 Issue: 2 Pages: 195-201

    • DOI

      10.1007/s00383-017-4189-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 胆道閉鎖症に対する再手術.2018

    • Author(s)
      齋藤 武,照井慶太,中田光政,小松秀吾,柴田涼平,原田和明,小林真史,勝俣善夫,西村雄宏,勝海大輔,吉田英生.
    • Journal Title

      小児外科

      Volume: 50 Pages: 55-60

    • Related Report
      2018 Research-status Report
  • [Journal Article] 胆道閉鎖症早期再手術:再手術.2018

    • Author(s)
      齋藤 武, 照井慶太, 中田光政, 小松秀吾, 柴田涼平,原田和明,勝俣善夫,西村雄宏,勝海大輔,吉田英生.
    • Journal Title

      小児外科

      Volume: 50 Pages: 257-260

    • Related Report
      2018 Research-status Report
  • [Journal Article] 術後腸閉塞症に対する手術.2018

    • Author(s)
      齋藤 武,照井慶太,中田光政,小松秀吾,吉田英生.
    • Journal Title

      小児外科

      Volume: 50 Pages: 815-818

    • Related Report
      2018 Research-status Report
  • [Journal Article] Prediction of respiratory collapse among pediatric patients with mediastinal tumors during induction of general anesthesia.2017

    • Author(s)
      Kawaguchi Y, Saito T, Mitsunaga T, Terui K, Nakata M, Matsuura G, Kouchi K, Yoshida H.
    • Journal Title

      J Pediatr Surg.

      Volume: - Issue: 7 Pages: 30612-7

    • DOI

      10.1016/j.jpedsurg.2017.09.013

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 先天性胆道拡張症におけるAlonso-Lej/戸谷Ⅱ型分類の意義.2022

    • Author(s)
      齋藤 武,安藤久實,石原 慎,糸井隆夫,漆原直人,大塚将之,越永従道,濵田吉則,諸冨嘉樹.
    • Organizer
      第59回日本小児外科学会.
    • Related Report
      2022 Annual Research Report
  • [Presentation] 一卵性双生児の網羅的ゲノム解析による胆道閉鎖症の遺伝的素因の解明.2022

    • Author(s)
      里村宜紀, 齋藤 武, 山野由貴, 井上泰輔, 福井美穂, 大沼真輔, 福岡智哉, 橘真紀子, 木村武司, 別所一彦.
    • Organizer
      第38回日本小児肝臓研究会.
    • Related Report
      2022 Annual Research Report
  • [Presentation] 食道閉鎖症術後の気管食道瘻再開通手術における留意点.2022

    • Author(s)
      齋藤 武,中田光政,岩井 潤,佐永田友希子,瀧口翔太.
    • Organizer
      第38回日本小児外科学会秋季シンポジウム.
    • Related Report
      2022 Annual Research Report
  • [Presentation] Alonso-Lej/戸谷Ⅱ型分類の意義.2021

    • Author(s)
      齋藤 武,安藤久實,石原 慎,糸井隆夫,漆原直人,大塚将之,越永従道,濵田吉則,諸冨嘉樹.
    • Organizer
      第44回日本膵・胆管合流異常研究会.
    • Related Report
      2021 Research-status Report
  • [Presentation] 当院における胆道閉鎖症の治療成績と長期自己肝生存例の検討.2021

    • Author(s)
      齋藤江里子,秦 佳孝,佐永田友季子,岩井 潤,齋藤 武.
    • Organizer
      第48回日本胆道閉鎖症研究会.
    • Related Report
      2021 Research-status Report
  • [Presentation] 小児クローン病に対するKono-S吻合の経験.2021

    • Author(s)
      齋藤 武,光永哲也,岩井 潤,齋藤江里子,秦 佳孝,勝海大輔,夏井款子,酒井 敦,高居宏武,陶山友徳.
    • Organizer
      第21回日本小児IBD研究会.
    • Related Report
      2020 Research-status Report
  • [Presentation] 日本小児炎症性腸疾患レジストリ研究グループ.日本小児炎症性腸疾患レジストリ研究2020:診断時情報.2021

    • Author(s)
      新井勝大,南部隆亮,村越孝次,国崎玲子,工藤孝広,水落建輝,角田文彦,齋藤 武,岩田直美,加藤沢子,井上幹大,熊谷秀規,野口篤子,石毛 崇,萩原真一朗,佐々木美香,田尻 仁,吉年俊文,西亦繁雄,青松友槻,望月貴博,戸坂成昭,清水泰岳,岩間 達,平野友梨,清水俊明.
    • Organizer
      第21回日本小児IBD研究会.
    • Related Report
      2020 Research-status Report
  • [Presentation] 口内炎と体重減少が症状だった小腸型Crohn病の1例.2021

    • Author(s)
      陶山友徳,酒井 敦,高居宏武,勝海大輔,秦 佳孝,齋藤江里子,岩井 潤,光永哲也,齋藤 武,夏井款子.
    • Organizer
      第21回日本小児IBD研究会.
    • Related Report
      2020 Research-status Report
  • [Presentation] 気管食道瘻再開通に対する手術の工夫.2020

    • Author(s)
      齋藤 武,鈴木秀海,中島崇裕,照井慶太,中田光政,小松秀吾,秦 佳孝,笈田 諭,勝俣善夫,佐永田友季子,吉野一郎,菱木知郎.
    • Organizer
      第57回日本小児外科学会学術術集会.
    • Related Report
      2020 Research-status Report
  • [Presentation] 胆道閉鎖症術後長期自己肝生存例の管理上の諸問題.2020

    • Author(s)
      齋藤 武,照井慶太,中田光政,小松秀吾,菱木知郎.
    • Organizer
      第57回日本小児外科学会学術術集会.
    • Related Report
      2020 Research-status Report
  • [Presentation] 粘膜ワクチンを用いた肥満や糖尿病に関連する腸内細菌Clostridium ramosumの制御2020

    • Author(s)
      川口 雄之亮, 藤本 康介, 齋藤 武, 菱木 知郎, 植松 智.
    • Organizer
      第57回日本小児外科学会学術術集会.
    • Related Report
      2020 Research-status Report
  • [Presentation] Ncx-/-マウスを用いた腸管神経異常疾患発症の分子機構解析2020

    • Author(s)
      笈田 諭, 坂本 明美, 藤村 理紗, 齋藤 武, 照井 慶太, 中田 光政, 小松 秀吾, 菱木 知郎, 幡野 雅彦.
    • Organizer
      第57回日本小児外科学会学術術集会.
    • Related Report
      2020 Research-status Report
  • [Presentation] 小児先天性胆道拡張症術後の肝内結石への対処2019

    • Author(s)
      齋藤 武, 照井慶太, 中田光政, 小松秀吾, 原田和明, 秦 佳孝, 工藤 渉, 吉田英生
    • Organizer
      第56回日本小児外科学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 小児胃食道逆流症の診断に対する更なる工夫:食道インピーダンスpH検査の有用性 小児食道MII-pH検査における手動解析の意義2019

    • Author(s)
      齋藤 武, 照井慶太, 中田光政, 小松秀吾, 原田和明, 秦 佳孝, 工藤 渉, 吉田英生
    • Organizer
      第56回日本小児外科学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 科における胆道閉鎖症の治療変遷と長期自己肝生存に関わる因子の検討2019

    • Author(s)
      工藤 渉, 齋藤 武, 照井慶太, 中田光政, 小松秀吾, 原田和明, 秦 佳孝, 古金遼也, 吉田英生
    • Organizer
      第56回日本小児外科学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] Strategy for Hepatolithiasis following Surgery for Pediatric Choledochal Cyst at a Single Institution.2019

    • Author(s)
      Saito T, Terui K, Nakata M, Komatsu S, Harada K, Shinno Y.
    • Organizer
      66th Annual Meeting of the British Association of Pediatric Surgeons.
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 口唇口蓋裂を共有する一絨毛膜二羊膜双胎の1児にのみ発症した胆道閉鎖症の1例2019

    • Author(s)
      笈田 諭, 照井慶太, 中田光政, 小松秀吾, 秦 佳孝, 勝俣善夫, 佐永田友季子, 小関元太, 齋藤 武
    • Organizer
      第46回日本胆道閉鎖症研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Management Strategy for Hepatolithiasis following Surgery for Pediatric Choledochal Cyst at a Single Institution.2019

    • Author(s)
      Saito T, Terui K, Nakata M, Komatsu S, Harada K, Shinno Y
    • Organizer
      66th Annual Meeting of the British Association of Pediatric Surgeons.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of the frequency and function of regulatory T-cell using human blood samples in biliary atresia.2019

    • Author(s)
      Oita S, Saito T, Sakamoto A, Terui K, Nakata M, Komatsu S, Harada K, Shinno Y, Fujimura L, Hatano M, Yoshida H.
    • Organizer
      52nd Annual Meeting of the Pacific Association of Pediatric Surgeons
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 先天性胆道拡張症術後の肝内結石症への対応.2018

    • Author(s)
      齋藤 武,照井慶太,中田光政,小松秀吾,原田和明,勝海大輔,古金遼也,吉田英生.
    • Organizer
      第80回日本臨床外科学会.
    • Related Report
      2018 Research-status Report
  • [Presentation] Assessment of the role of MII-pH in the evaluation of pediatric erosive reflux esophagitis.2018

    • Author(s)
      Saito T, Uesato M, Terui K, Nakata M, Komatsu S, Yoshida H.
    • Organizer
      51st Annual Meeting of the Pacific Association of Pediatric Surgeons.
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Alonso-Lej/戸谷分類Ⅱ型報告例の実際と同分類の課題.2018

    • Author(s)
      齋藤 武,照井慶太,中田光政,小松秀吾,原田和明,勝海大輔,古金遼也,吉田英生.
    • Organizer
      第41回日本膵・胆管合流異常研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 小児膵solid pseudo-papillary neoplasmに対する腹腔鏡下脾温存膵体尾部切除術における工夫.2018

    • Author(s)
      齋藤 武,吉富秀幸,照井慶太,中田光政,小松秀吾,原田和明,勝海大輔,古金遼也,大塚将之,吉田英生.
    • Organizer
      第31回日本内視鏡外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 胆道閉鎖症の病態形成における制御性T細胞の意義2018

    • Author(s)
      笈田 諭, 齋藤 武, 坂本明美, 照井慶太, 中田光政, 小松秀吾, 原田和 明, 秦 佳孝, 勝海大輔, 古金遼也, 藤村理紗, 幡野雅彦, 吉田英生.
    • Organizer
      第45回日本胆道閉鎖症研究会
    • Related Report
      2018 Research-status Report
  • [Book] Pancreaticobiliary Maljunction and Congenital Biliary Dilatation.2018

    • Author(s)
      Saito T and Yoshida H.
    • Publisher
      Springer nature Singapore Pte Ltd
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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