Research Project
Grant-in-Aid for Scientific Research (C)
This study investigated the significance and role of regulatory T cell (Treg) and autophagy in the development of the immunological environment of biliary atresia (BA). It revealed that neither frequency or function of Treg in the systemic and local environment did show significant difference compared to the normal controls. On the other hand, the autophagic activities in the systemic CD4 positive cells, in particular Treg, and the local bile duct cells were significantly increased. The effect of the accelerated activity of autophagy in both systemic and local environment on the immunological aspects in BA remains to be clarified.
本研究ではBAの病態について、①全身・局所環境においてTregのfrequencyは低下していなかった、②全身性Tregの機能は低下していなかった、③胆管上皮細胞と全身性T細胞でautophagy機能が亢進していた、④特にCD4/8陽性細胞とTregでautophagy機能が活性化していた、ことが示された。autophagyの機能異常が獲得免疫系を破綻させ、BAの病態を形成している可能性は依然示唆されており、今後の病因研究の方向性を明示している。
All 2023 2022 2021 2020 2019 2018 2017
All Journal Article (32 results) (of which Peer Reviewed: 21 results, Open Access: 6 results) Presentation (24 results) (of which Int'l Joint Research: 4 results) Book (1 results)
J Gastroenterol.
Volume: - Issue: 5 Pages: 472-480
10.1007/s00535-023-01972-1
日小外会誌.
Volume: 58 Pages: 984-991
小児外科.
Volume: 54 Pages: 1202-1206
Volume: 54 Pages: 850-855
Volume: 54 Pages: 656-660
Pediatrics International
Volume: 64 Issue: 1
10.1111/ped.15241
Pediatr Surg Int.
Volume: 30(39) Issue: 1 Pages: 1-8
10.1007/s00383-022-05307-8
Journal of the Japanese Society of Pediatric Surgeons
Volume: 57 Issue: 3 Pages: 618-624
10.11164/jjsps.57.3_618
130008027786
Pediatric Surgery International
Volume: 37 Issue: 2 Pages: 197-203
10.1007/s00383-020-04788-9
Sci Rep.
Volume: 4;11(1) Issue: 1 Pages: 3191-3191
10.1038/s41598-021-82785-1
J Pediatr Nurs.
Volume: 61 Pages: 115-121
10.1016/j.pedn.2021.05.004
日小外会誌.
Volume: 57 Pages: 38-43
130007988505
周産期医学.
Volume: 51増 Pages: 795-797
Volume: 36 Issue: 10 Pages: 1173-1180
10.1007/s00383-020-04719-8
Intest Res.
Volume: 18 Issue: 4 Pages: 412-420
10.5217/ir.2019.00130
Journal of Pediatric Surgery Case Reports.
Volume: 57 Pages: 101444-101444
小児科
Volume: 60 Issue: 12 Pages: 1673-1681
10.18888/sh.0000001109
Surg Today
Volume: 未定 Issue: 7 Pages: 664-671
10.1007/s00595-019-01833-6
Genesis.
Volume: 57 Issue: 10 Pages: 1-8
10.1002/dvg.23323
Volume: 35 Issue: 8 Pages: 887-893
10.1007/s00383-019-04490-5
Cancer Sci.
Volume: 110 Issue: 3 Pages: 888-902
10.1111/cas.13933
小児内科
Volume: 51 Pages: 1529-1531
小児外科
Volume: 51 Pages: 983-986
Volume: 51 Pages: 1130-1133
Volume: 51 Pages: 295-298
J Hepatobiliary Pancreat Sci.
Volume: 25 Issue: 5 Pages: 275-280
10.1002/jhbp.548
Pediatr. Surg. Int.
Volume: 34 Issue: 2 Pages: 169-176
10.1007/s00383-017-4185-1
Volume: 34 Issue: 2 Pages: 195-201
10.1007/s00383-017-4189-x
Volume: 50 Pages: 55-60
Volume: 50 Pages: 257-260
Volume: 50 Pages: 815-818
J Pediatr Surg.
Volume: - Issue: 7 Pages: 30612-7
10.1016/j.jpedsurg.2017.09.013