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In Utero deploying system for fetal myelomeningocele repari

Research Project

Project/Area Number 18K08536
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55010:General surgery and pediatric surgery-related
Research InstitutionOsaka University (2019-2020)
The University of Tokyo (2018)

Principal Investigator

Watanabe Miho  大阪大学, 医学系研究科, 助教 (40791728)

Co-Investigator(Kenkyū-buntansha) 小西 聡  立命館大学, 理工学部, 教授 (50288627)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords脊髄髄膜瘤 / 胎児治療 / 胎児再生治療 / 細胞 / 再生医療 / 細胞治療
Outline of Final Research Achievements

Myelomeningocele (MMC) is the most severe form of spina bifida. Although fetal surgical repair of an MMC at mid gestation has been shown to improve outcomes, open fetal surgery still has risks for both the mother and fetus. Thus, the development of a less invasive approach than the current open surgical approach is desirable to further improve neurological symptoms and reduce maternal and fetal risks. In this project, We created a thin-film drug delivery microdevice for a fetoscopic approach to inject cells over the MMC defect. This novel drug delivery microdevice functions for both suction-fixing and drug-retention on fetal skin in water. Also, the adhesion of the device was improved by adding a needle fixing structure and adhesive sheet.

Academic Significance and Societal Importance of the Research Achievements

本研究で行う、単ポートの子宮鏡を使用してデバイスを子宮内に挿入して再生誘導による組織被覆を行う胎児治療は、子宮壁・羊膜への侵襲が最小限に抑えられ母体合併症の軽減が大いに期待できるBreakthroughとなりえる技術開発であり、これまで近似した治療法は存在せず全くの新規治療となりえる。

Report

(2 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (1 results)

All 2019

All Presentation (1 results)

  • [Presentation] 吸着固定機能と薬剤供給・保持機能を備えたフィルム型ドラッグデリバリーデバイス2019

    • Author(s)
      平池三奈美、渡邊美穂、小西聡
    • Organizer
      The 36th Symposium
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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