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Mechanism of bacterial translocation after liver transplantation

Research Project

Project/Area Number 18K08567
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55010:General surgery and pediatric surgery-related
Research InstitutionKyoto University

Principal Investigator

Ogawa Eri  京都大学, 医学研究科, 助教 (30440506)

Co-Investigator(Kenkyū-buntansha) 八木 真太郎  京都大学, 医学研究科, 講師 (60447969)
長尾 美紀  京都大学, 医学研究科, 教授 (80523993)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肝移植 / bacterial translocation / 免疫 / 生体肝移植 / 腸内細菌 / 拒絶 / 門脈圧 / 腸管粘膜
Outline of Final Research Achievements

The present study suggests that the mechanism of bacterial translocation (BT) is not the transfer of bacteria but the transfer of toxins, such as LPS, as the main pathogen. Although humans are exposed to BT on a daily basis, it is unlikely to affect us if our immune system is normal. However, if the host immunity is impaired due to liver failure or uncompensated cirrhosis, BT may develop into severe infections. Under the condition of severe hepatic dysfunction associated with end-stage liver failure or post-transplant rejection, systemic/intestinal immunity and barrier function were impaired, which lead to dysbiosis of the gut microbiota, increase or decrease of particular strains of bacteria, and increased incidence of BT. This study successfully presented the importance of "gut-liver axis" in the clinical curse of liver transplantation in both humans and small animals.

Academic Significance and Societal Importance of the Research Achievements

小動物モデルとヒトの双方において,肝不全下での腸内細菌の変動にある一定の普遍性を確認できたことは本研究の重要な新規性の一つである.また,BTのメカニズムの重要な一端を明らかにできたことと肝機能が低下すると特定の菌の増減が観察されることを同定できたことは今後の肝移植周術期の治療戦略(抗生剤治療やシンバイオティクス治療の適応)の確立へとつながることが期待される.

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (23 results)

All 2021 2020 2019 2018

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 3 results) Presentation (4 results)

  • [Journal Article] Analyses Focused on Organisms Would Enhance the Value of Detecting Occult Bacteremia2021

    • Author(s)
      Siyuan Yao, Shintaro Yagi
    • Journal Title

      Journal of American College of Surgeon

      Volume: 印刷中 Issue: 1 Pages: 161-162

    • DOI

      10.1016/j.jamcollsurg.2021.03.031

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High‐flow nasal cannula oxygen therapy: Alternative respiratory therapy for severe post‐transplant hypoxemia in children with hepatopulmonary syndrome2020

    • Author(s)
      Hamada Satoshi、Okamoto Tatsuya、Ogawa Eri、Sonoda Mari、Okajima Hideaki、Hirai Toyohiro、Handa Tomohiro、Uemoto Shinji、Chin Kazuo
    • Journal Title

      Pediatric Transplantation

      Volume: 24 Issue: 8

    • DOI

      10.1111/petr.13813

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-Term Outcomes of Living-Donor Liver Transplantation for Progressive Familial Intrahepatic Cholestasis Type 12020

    • Author(s)
      Okamoto Tatsuya、Sonoda Mari、Ogawa Eri、Ito Shogo、Togawa Takao、Hayashi Hisamitsu、Okajima Hideaki、Uemoto Shiji
    • Journal Title

      Journal of Pediatric Gastroenterology & Nutrition

      Volume: Publish Ahead of Print Issue: 3 Pages: 425-429

    • DOI

      10.1097/mpg.0000000000002983

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical Pitfall in Right Posterior Sector Graft Procurement in Living Donor Liver Transplantation.2020

    • Author(s)
      Kusakabe J, Yagi S, Okamura Y, Iida T, Ogawa E, Ito T, Hata K, Taura K, Okajima H, Kaido T, Uemoto S.
    • Journal Title

      Liver Transpl.

      Volume: Feb;26(2) Issue: 2 Pages: 299-303

    • DOI

      10.1002/lt.25648

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Living donor liver transplantation in situs inversus totalis with a patient‐specific three‐dimensional printed liver model2020

    • Author(s)
      Ishii Takamichi、Fukumitsu Ken、Ogawa Eri、Okamoto Tatsuya、Uemoto Shinji
    • Journal Title

      Pediatric Transplantation

      Volume: 24 Issue: 3 Pages: 13675-13675

    • DOI

      10.1111/petr.13675

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of Graft Quality and Fluid Overload on Postoperative Massive Ascites After Living Donor Liver Transplantation2019

    • Author(s)
      Iwaki Kentaro、Yagi Shintaro、Morita Satoshi、Hamaguchi Yuhei、Masano Yuki、Yamamoto Gen、Ogawa Eri、Nagai Kazuyuki、Kamo Naoko、Hata Koichiro、Taura Kojiro、Okajima Hideaki、Kaido Toshimi、Uemoto Shinji
    • Journal Title

      Transplantation Proceedings

      Volume: 51 Issue: 6 Pages: 1779-1784

    • DOI

      10.1016/j.transproceed.2019.03.038

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Outcomes of liver transplantation for Alagille syndrome after Kasai portoenterostomy: Alagille Syndrome with agenesis of extrahepatic bile ducts at porta hepatis2019

    • Author(s)
      Gunadi、Kaneshiro Masakatshu、Okamoto Tatsuya、Sonoda Mari、Ogawa Eri、Okajima Hideaki、Uemoto Shiji
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 54 Issue: 11 Pages: 2387-2391

    • DOI

      10.1016/j.jpedsurg.2019.04.022

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Early post‐operative intravenous tacrolimus in pediatric liver transplant recipients is not superior to oral tacrolimus2019

    • Author(s)
      Sabra Tarek Abdelazeem、Okajima Hideaki、Yoshizawa Atsushi、Ogawa Eri、Okamoto Shinya、Osman Mohamed Abdelkader、Saad‐Eldin Yasser、Uemoto Shinji
    • Journal Title

      Pediatric Transplantation

      Volume: 23 Issue: 3

    • DOI

      10.1111/petr.13368

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of imbalanced graft‐to‐spleen volume ratio on outcomes following living donor liver transplantation in an era when simultaneous splenectomy is not typically indicated2019

    • Author(s)
      Yao Siyuan、Kaido Toshimi、Yagi Shintaro、Uozumi Ryuji、Iwamura Sena、Miyachi Yosuke、Shirai Hisaya、Kamo Naoko、Taura Kojiro、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      American Journal of Transplantation

      Volume: 印刷中 Issue: 10 Pages: 2783-2794

    • DOI

      10.1111/ajt.15337

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk-benefit point of the Model for End-stage Liver Disease score in patients waiting for deceased-donor liver transplantation: A single-center experience2019

    • Author(s)
      Iwamura Sena、Kaido Toshimi、Morita Satoshi、Miyachi Yosuke、Yao Siyuan、Shirai Hisaya、Kobayashi Atsushi、Hamaguchi Yuhei、Kamo Naoko、Yagi Shintaro、Uemoto Shinji
    • Journal Title

      Hepatology Research

      Volume: 印刷中 Issue: 6 Pages: 687-694

    • DOI

      10.1111/hepr.13320

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low Titers of Antidonor ABO Antibodies After ABO-Incompatible Living Donor Liver Transplantation2019

    • Author(s)
      Ueda Daisuke、Yoshizawa Atsushi、Kaneshiro Masakatsu、Hirata Yoshihiro、Yagi Shintaro、Hata Koichiro、Okajima Hideaki、Egawa Hiroto、Uemoto Shinji
    • Journal Title

      Transplantation Direct

      Volume: 5 Issue: 1 Pages: e420-e420

    • DOI

      10.1097/txd.0000000000000858

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of pretreatments on outcomes after living donor liver transplantation for hepatocellular carcinoma2019

    • Author(s)
      Ogawa Kohei、Kaido Toshimi、Okajima Hideaki、Fujimoto Yasuhiro、Yoshizawa Atsushi、Yagi Shintaro、Hori Tomohide、Iida Taku、Takada Yasutsugu、Uemoto Shinji
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 26 Issue: 2 Pages: 73-81

    • DOI

      10.1002/jhbp.602

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone Mineral Density as a Risk Factor for Patients Undergoing Surgery for Hepatocellular Carcinoma.2019

    • Author(s)
      Miyachi Y, Kaido T, Yao S, Shirai H, Kobayashi A, Hamaguchi Y, Kamo N, Yagi S, Uemoto S.
    • Journal Title

      World J Surg

      Volume: 43 Issue: 3 Pages: 920-928

    • DOI

      10.1007/s00268-018-4861-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bone mineral density correlates with survival after resection of extrahepatic biliary malignancies.2018

    • Author(s)
      Yao S, Kaido T, Okumura S, Iwamura S, Miyachi Y, Shirai H, Kobayashi A, Hamaguchi Y, Kamo N, Uozumi R, Yagi S, Uemoto S.
    • Journal Title

      Clin Nutr

      Volume: 37 Issue: 6 Pages: 32570-6

    • DOI

      10.1016/j.clnu.2018.12.004

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of sarcopenic obesity on outcomes in patients undergoing living donor liver transplantation.2018

    • Author(s)
      Kamo N, Kaido T, Hamaguchi Y, Okumura S, Kobayashi A, Shirai H, Yao S, Yagi S, Uemoto S.
    • Journal Title

      Clin Nutr

      Volume: 37 Issue: 5 Pages: 32457-9

    • DOI

      10.1016/j.clnu.2018.09.019

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Etiologies, risk factors, and outcomes of bacterial cholangitis after living donor liver transplantation.2018

    • Author(s)
      Yao S, Yagi S, Nagao M, Uozumi R, Iida T, Iwamura S, Miyachi Y, Shirai H, Kobayashi A, Okumura S, Hamaguchi Y, Masano Y, Kaido T, Okajima H, Uemoto S.
    • Journal Title

      Eur J Clin Microbiol Infect Dis.

      Volume: 10 Issue: 10 Pages: 1973-1982

    • DOI

      10.1007/s10096-018-3333-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Liver Transplantation for Intermediate-Stage Hepatocellular Carcinoma2018

    • Author(s)
      Kamo Naoko、Kaido Toshimi、Yagi Shintaro、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      Liver Cancer

      Volume: 7 Issue: 2 Pages: 179-189

    • DOI

      10.1159/000487058

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proposal for new selection criteria considering pre-transplant muscularity and visceral adiposity in living donor liver transplantation2018

    • Author(s)
      Hamaguchi Yuhei、Kaido Toshimi、Okumura Shinya、Kobayashi Atsushi、Shirai Hisaya、Yao Siyuan、Yagi Shintaro、Kamo Naoko、Okajima Hideaki、Uemoto Shinji
    • Journal Title

      Journal of Cachexia, Sarcopenia and Muscle

      Volume: 9 Issue: 2 Pages: 246-254

    • DOI

      10.1002/jcsm.12276

    • NAID

      120006463747

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic and therapeutic factors influencing the clinical outcome of hepatoblastoma after liver transplantation: A single-institute experience2018

    • Author(s)
      Umeda Katsutsugu、Okajima Hideaki、Kawaguchi Koji、Nodomi Seishiro、Saida Satoshi、Kato Itaru、Hiramatsu Hidefumi、Ogawa Eri、Yoshizawa Atsushi、Okamoto Shinya、Uemoto Shinji、Watanabe Kenichiro、Adachi Souichi
    • Journal Title

      Pediatric Transplantation

      Volume: 22 Issue: 2

    • DOI

      10.1111/petr.13113

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 肝不全における腸内細菌叢と腸内環境:ラット肝移植モデルと肝移植患者を用いた多角的検討2021

    • Author(s)
      姚思遠、八木真太郎、小川絵里、平田真章、宮地洋介、岩村宣亜、上本伸二
    • Organizer
      第121回日本外科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肝不全を伴う乳児小腸機能不全に対する治療戦略2021

    • Author(s)
      小川絵里、岡島英明、園田真理、岡本竜弥、伊藤孝司、秦浩一郎、増井俊彦、田浦康二朗
    • Organizer
      第33回日本腸管リハビリテーション・小腸移植研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 重度の肝肺症候群を伴う小児胆道閉鎖症に対して生体肝移植術後管理に一酸化窒素(NO)が有効であった2症例2019

    • Author(s)
      小川 絵里, 岡島 英明, 嵯峨 謙一, 園田 真理, 岡本 竜弥, 上本 伸二
    • Organizer
      日本移植学会
    • Related Report
      2019 Research-status Report
  • [Presentation] オーダーメイド3D肝臓模型を用いた肝切除ナビゲーションの試み2019

    • Author(s)
      小川 絵里, 岡島 英明, 鈴木 久美子, 金城 昌克, 園田 真理, 岡本 竜弥, 小木曾 聡, 福光 剣, 石井 隆道, 岡本 晋弥, 上本 伸二
    • Organizer
      日本小児外科学会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-12-28  

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