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Establishment of a new method using carbon monoxide aiming at long-term preservation of donor heart for heart transplantation

Research Project

Project/Area Number 18K08581
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55010:General surgery and pediatric surgery-related
Research InstitutionKeio University

Principal Investigator

Kimura Naritaka  慶應義塾大学, 医学部(信濃町), 講師 (90348657)

Co-Investigator(Kenkyū-buntansha) 大塚 崇  東京慈恵会医科大学, 医学部, 教授 (40306717)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords心移植 / 人工ガス運搬体 / 虚血再灌流傷害 / 心臓移植
Outline of Final Research Achievements

In this study, we examined the effect of carbon monoxide-bound artificial erythrocytes (CO-HbV), which is an artificial oxygen carrier, on ischemia-reperfusion injury during heart transplantation. Using a rat model of heart transplantation, the macroscopic morphology and histology of the donor heart were compared between the group to which only the cardioplegic solution was administered for cardiac arrest and the group to which the CO-HbV solution was also administered at the same time. In HE and Azan staining, contraction band necrosis specific to ischemia-reperfusion injury was confirmed in the control group, but no particular findings indicating cardiomyocyte injury were observed in the administration group. In this study, it was suggested that adding CO-HbV to cardioplegia for donor heart during heart transplantation may be effective in preventing myocardial ischemia-reperfusion injury.

Academic Significance and Societal Importance of the Research Achievements

心移植において移植心の虚血再灌流傷害は術後治療成績を悪化させる要因であるが、現時点で再灌流傷害を惹起しない決定的な治療法は確立されていない。一方、一酸化炭素(CO)は抗酸化・抗炎症作用などの生理活性作用を持ち、虚血再灌流傷害の抑制効果も動物実験で示されている。本研究では、一酸化炭素結合人工赤血球(CO-HbV)による心移植時の虚血再灌流傷害に対する効果をラットを用いて検証し、心移植の際の心筋保護にCO-HbVを付加することがは移植心の虚血再灌流傷害の予防に対し有効である可能性が示唆された。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (30 results)

All 2020 2019 2018

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 2 results) Presentation (14 results)

  • [Journal Article] No-touch saphenous vein graft harvesting technique for coronary artery bypass grafting.2020

    • Author(s)
      Yu Inaba, Masataka Yamazaki, Masatoshi Ohno, Kentaro Yamashita, Hiroaki Izumida, Kanako Hayashi, Tatsuo Takahashi, Naritaka Kimura, Tsutomu Ito, Hideyuki Shimizu.
    • Journal Title

      General Thoracic and Cardiovascular Surgery

      Volume: 68 Issue: 3 Pages: 248-253

    • DOI

      10.1007/s11748-019-01186-4

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Infiltration of tumor‐associated macrophages is involved in tumor programmed death‐ligand 1 expression in early lung adenocarcinoma2020

    • Author(s)
      Shima Toshiyuki、Shimoda Masayuki、Shigenobu Takao、Ohtsuka Takashi、Nishimura Tomoyasu、Emoto Katsura、Hayashi Yuichiro、Iwasaki Tatsuro、Abe Takayuki、Asamura Hisao、Kanai Yae
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 2 Pages: 727-738

    • DOI

      10.1111/cas.14272

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Simultaneous 2D and 3D simulation of thoracoscopic sleeve lobectomy: a quick understanding pitfalls2020

    • Author(s)
      Nakada Takeo、Noda Yuki、Kato Daiki、Mori Shohei、Asano Hisatoshi、Matsudaira Hideki、Ohtsuka Takashi
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: 印刷中 Issue: 5 Pages: e383-e385

    • DOI

      10.1016/j.athoracsur.2019.11.055

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Superior trans‐septal approach for minimally invasive mitral valve surgery via right small thoracotomy2019

    • Author(s)
      Yamazaki Masataka、Yoshitake Akihiro、Takahashi Tatsuo、Ito Tsutomu、Kimura Naritaka、Shimizu Hideyuki
    • Journal Title

      Journal of Cardiac Surgery

      Volume: 34 Issue: 8 Pages: 728-731

    • DOI

      10.1111/jocs.14101

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] In Vivo Remodeling of an Extracellular Matrix Cardiac Patch in an Ovine Model2019

    • Author(s)
      Baker R. Scott、Zafar Farhan、Kimura Naritaka、Knilans Timothy、Osinska Hanna、Robbins Jeffrey、Taylor Michael、Morales David L.S.
    • Journal Title

      ASAIO Journal

      Volume: 65 Issue: 7 Pages: 744-752

    • DOI

      10.1097/mat.0000000000000864

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis2019

    • Author(s)
      Saito N、Araya J、Ito S、Tsubouchi K、Minagawa S、Hara H、Ito A、Nakano T、Hosaka Y、Ichikawa A、Kadota T、Yoshida M、Fujita Y、Utsumi H、Kurita Y、Kobayashi K、Hashimoto M、Wakui H、Numata T、Kaneko Y、Asano H、Odaka M、Ohtsuka T、Morikawa T、Nakayama K、Kuwano K.
    • Journal Title

      The Journal of Immunology

      Volume: 202 Issue: 5 Pages: 1428-1440

    • DOI

      10.4049/jimmunol.1801293

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factors for recurrence of primary spontaneous pneumothorax after thoracoscopic surgery2019

    • Author(s)
      Asano Hisatoshi、Ohtsuka Takashi、Noda Yuki、Kato Daiki、Mori Shohei、Nakada Takeo、Matsudaira Hideki
    • Journal Title

      Journal of Thoracic Disease

      Volume: 11 Issue: 5 Pages: 1940-1944

    • DOI

      10.21037/jtd.2019.04.105

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors and cancer recurrence associated with postoperative complications after thoracoscopic lobectomy for clinical stage I non‐small cell lung cancer2019

    • Author(s)
      Nakada Takeo、Noda Yuki、Kato Daiki、Shibasaki Takamasa、Mori Shohei、Asano Hisatoshi、Matsudaira Hideki、Hirano Jun、Odaka Makoto、Ohtsuka Takashi
    • Journal Title

      Thoracic Cancer

      Volume: 10 Issue: 10 Pages: 1945-1952

    • DOI

      10.1111/1759-7714.13173

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recovery of pulmonary function after lung wedge resection2019

    • Author(s)
      Mori Shohei、Shibazaki Takamasa、Noda Yuki、Kato Daiki、Nakada Takeo、Asano Hisatoshi、Matsudaira Hideki、Ohtsuka Takashi
    • Journal Title

      Journal of Thoracic Disease

      Volume: 11 Issue: 9 Pages: 3738-3745

    • DOI

      10.21037/jtd.2019.09.32

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis2019

    • Author(s)
      Tsubouchi K、Araya J、Yoshida M、Sakamoto T、Koumura T、Minagawa S、Hara H、Hosaka Y、Ichikawa A、Saito N、Kadota T、Kurita Y、Kobayashi K、Ito S、Fujita Y、Utsumi H、Hashimoto M、Wakui H、Numata T、Kaneko Y、Mori S、Asano Hi、Matsudaira H、Ohtsuka T、Nakayama K、Nakanishi Y、Imai H、Kuwano K
    • Journal Title

      The Journal of Immunology

      Volume: 203 Issue: 8 Pages: 2076-2087

    • DOI

      10.4049/jimmunol.1801232

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Demographics, Safety and Quality, and Prognostic Information in Both the Seventh and Eighth Editions of the TNM Classification in 18,973 Surgical Cases of the Japanese Joint Committee of Lung Cancer Registry Database in 20102019

    • Author(s)
      Okami Jiro、Shintani Yasushi、Okumura Meinoshin、Ito Hiroyuki、Ohtsuka Takashi、Toyooka Shinichi、Mori Takeshi、Watanabe Shun-ichi、Date Hiroshi、Yokoi Kohei、Asamura Hisao、Nagayasu Takeshi、Miyaoka Etsuo、Yoshino Ichiro
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 14 Issue: 2 Pages: 212-222

    • DOI

      10.1016/j.jtho.2018.10.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The prevention of tracheal graft occlusion using pioglitazone: A mouse tracheal transplant model study.2019

    • Author(s)
      Shigenobu T, Ohtsuka T ,Shimoda M
    • Journal Title

      Transplant Immunology

      Volume: 53 Pages: 21-27

    • DOI

      10.1016/j.trim.2018.12.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thoracic Endovascular Aortic Repair for Pseudoaneurysm after Interrupted Aortic Arch Repair2018

    • Author(s)
      Hayashi Kanako、Kimura Naritaka、Ohno Masatoshi、Yamashita Kentaro、Izumida Hiroaki、Inaba Yu、Takahashi Tatsuo、Yamazaki Masataka、Ito Tsutomu、Shimizu Hideyuki
    • Journal Title

      Annals of Vascular Diseases

      Volume: 11 Issue: 4 Pages: 549-552

    • DOI

      10.3400/avd.cr.18-00079

    • NAID

      130007550492

    • ISSN
      1881-641X, 1881-6428
    • Year and Date
      2018-12-25
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regenerative Therapy for Patients with Congenital Heart Disease2018

    • Author(s)
      Kimura Naritaka
    • Journal Title

      The Keio Journal of Medicine

      Volume: 68 Issue: 2 Pages: 29-38

    • DOI

      10.2302/kjm.2018-0002-IR

    • NAID

      130007666613

    • ISSN
      0022-9717, 1880-1293
    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Thoraco-abdominal aortic aneurysm rupture in a patient with Shprintzen?Goldberg syndrome2018

    • Author(s)
      Kimura Naritaka、Inaba Yu、Kameyama Kaori、Shimizu Hideyuki
    • Journal Title

      Interactive CardioVascular and Thoracic Surgery

      Volume: 26 Issue: 6 Pages: 1039-1040

    • DOI

      10.1093/icvts/ivy003

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stonehenge technique is associated with faster aortic clamp time in group of minimally invasive aortic valve replacement via right infra-axillary thoracotomy2018

    • Author(s)
      Yamazaki Masataka、Yoshitake Akihiro、Takahashi Tatsuo、Ito Tsutomu、Kimura Naritaka、Hirano Akinori、Iida Yasunori、Takanashi Shuichiro、Shimizu Hideyuki
    • Journal Title

      General Thoracic and Cardiovascular Surgery

      Volume: 66 Issue: 12 Pages: 700-706

    • DOI

      10.1007/s11748-018-0987-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 症候性左鎖骨下動脈閉塞を認め一期的手術を施行した成人先天性心疾患の2例2020

    • Author(s)
      木村成卓、秋山章、伊藤努、山崎真敬、高橋辰郎、川合雄二郎、赤松雄太、浅原祐太、飯尾みなみ、金山拓亮、橋本崇、船石耕士、松尾健太郎、志水秀行
    • Organizer
      第22回日本成人先天性心疾患学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 低酸素血症を契機にIVC左房間交通が判明したASD術後の一成人例2020

    • Author(s)
      船石耕士、木村成卓、松尾健太郎、橋本崇、金山拓亮、浅原祐太、飯尾みなみ、赤松雄太、川合雄二郎、秋山章、高橋辰郎、山崎真敬、伊藤努、志水秀行
    • Organizer
      第182回日本胸部外科学会関東甲信越地方会
    • Related Report
      2019 Research-status Report
  • [Presentation] 心房中隔欠損症に肺動脈瘤を合併した一例2019

    • Author(s)
      赤松雄太、木村成卓、伊藤努、山崎真敬、高橋辰郎、秋山章、川合雄二郎、岡英俊、中川知彦、中嶋信太郎、村田哲、志水秀行
    • Organizer
      第180回日本胸部外科学会関東甲信越地方会
    • Related Report
      2019 Research-status Report
  • [Presentation] 肺高血圧に対する段階的心房中隔欠損孔閉鎖術の経過中に急激に進行した大動脈弁輪拡張症に対し大動脈基部置換術を同時に施行した若年女性の一例2019

    • Author(s)
      秋山章、木村成卓、山本一希、荒木耕生、古道一樹、前田潤、福島裕之、山岸敬幸
    • Organizer
      第55回日本小児循環器学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 低出生体重児の症候性動脈管開存への外科的介入の意義2019

    • Author(s)
      木村成卓、秋山章、前田潤、山岸敬幸
    • Organizer
      第55回日本小児循環器学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 若年者の先天性心疾患による左心系弁病変に対する生体弁置換の治療成績2019

    • Author(s)
      木村成卓、秋山章、伊藤努、山崎真敬、高橋辰郎、川合雄二郎、赤松雄太、浅原祐太、飯尾みなみ、金山拓亮、橋本崇、船石耕士、松尾健太郎、志水秀行
    • Organizer
      第72回日本胸部外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] ファロー四徴症術後の肺動脈弁逆流に対する当院における外科的介入2019

    • Author(s)
      秋山章、木村成卓、伊藤努、山崎真敬、高橋辰郎、川合雄二郎、赤松雄太、飯尾みなみ、浅原祐太、金山拓亮、橋本崇、船石耕士、松尾健太郎、志水秀行
    • Organizer
      第72回日本胸部外科学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Fontan術後に可逆性後部白質脳症を発症した一例2019

    • Author(s)
      飯尾みなみ、木村成卓、船石耕士、松尾健太郎、橋本崇、金山拓亮、浅原祐太、秋山章、高橋辰郎、山崎真敬、伊藤努、志水秀行
    • Organizer
      第181回日本胸部外科学会関東甲信越地方会
    • Related Report
      2019 Research-status Report
  • [Presentation] 右腋窩小切開アプローチによるASD修復術の有用性2019

    • Author(s)
      岡英俊、木村成卓、伊藤努、山崎真敬、高橋辰郎、稲葉佑、川合雄二郎、赤松雄太、中川知彦、中嶋信太郎、村田哲、志水秀行
    • Organizer
      第49回日本心臓血管外科学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 周術期管理に苦慮したファロー四徴症術後PRの一成人例2019

    • Author(s)
      中嶋信太郎、木村成卓、伊藤努、山崎真敬、高橋辰郎、稲葉佑、川合雄二郎、赤松雄太、岡英俊、中川知彦、村田哲、志水秀行
    • Organizer
      第179回日本胸部外科学会関東甲信越地方会
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      2018 Research-status Report
  • [Presentation] 次世代の心臓外科医がMICSを安全に習得してもらうための取り組み2018

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      木村成卓、伊藤努、山崎真敬、高橋辰郎、稲葉佑、川合雄二郎、赤松雄太、岡英俊、中嶋信太郎、中川知彦、村田哲、志水秀行
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      第71回日本胸部外科学会
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      2018 Research-status Report
  • [Presentation] 成人先天性心疾患患者の大動脈病変に対する治療戦略2018

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      木村成卓、伊藤努、山崎真敬、高橋辰郎、稲葉佑、川合雄二郎、赤松雄太、岡英俊、中川知彦、中嶋信太郎、村田哲、志水秀行
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      第49回日本心臓血管外科学会
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      2018 Research-status Report
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      林可奈子、木村成卓、大野昌利、山下健太郎、泉田博彬、稲葉佑、川合雄二郎、川口新治、高橋辰郎、山﨑真敬、伊藤努、志水秀行
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      第46回日本血管外科学会
    • Related Report
      2018 Research-status Report
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      岡英俊、木村成卓、伊藤努、山崎真敬、高橋辰郎、稲葉佑、川合雄二郎、赤松雄太、中川知彦、中嶋信太郎、村田哲、志水秀行
    • Organizer
      第71回日本胸部外科学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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