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Development of the new hemostatic which is available by emergency surgery and the platelet agent

Research Project

Project/Area Number 18K08587
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55010:General surgery and pediatric surgery-related
Research InstitutionKumamoto Health Science University

Principal Investigator

Kozuma Yukinori  熊本保健科学大学, 保健科学部, 准教授 (90550145)

Co-Investigator(Kenkyū-buntansha) 二宮 治彦  筑波大学, 医学医療系, 教授 (10198533)
山本 隆敏  熊本保健科学大学, 保健科学部, 講師 (10746233)
登尾 一平  熊本保健科学大学, 保健科学部, 助教 (00832007)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords血小板 / 人工髄液 / 抗血小板薬 / 止血薬 / 血小板機能 / 外科手術 / 止血 / 巨核球
Outline of Final Research Achievements

Previously, sodium bicarbonate in artificial cerebrospinal fluid (aCSF) was found to facilitate physiological hemostasis by amplifying platelet aggregation. This study aimed to verify the amplification effect of aCSF on platelet-dependent hemostasis in the presence of antiplatelet agents. Compared with normal saline (NS), aCSF amplified aspirin or clopidogrel-inhibited platelet aggregation by recovering inhibited Platelet activation (phosphatidylserine (PS) exposure, CD62P expression, GPIIb activation, and MP release in platelets). The prolonged tail bleeding time in aspirin-injected mice was significantly shorter in the presence of aCSF than in NS. aCSF and sodium bicarbonate restore inhibited physiological hemostasis, even in the presence of aspirin or clopidogrel by restoring suppressed platelet aggregation.

Academic Significance and Societal Importance of the Research Achievements

強力な止血薬として臨床応用の可能性が高い人工髄液に含まれる重炭酸塩をターゲットとした。本研究により、重炭酸塩による血小板活性化能の増強効果が抗血小板薬使用時においても実証されれば、患者 QOL 向上はもちろん、安全かつ安価な新規止血薬の発見となり、学術的価値は高く、社会的意義も大きい。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (20 results)

All 2021 2020 2019 2018

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results) Presentation (12 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] 医療系大学の双方向型授業におけるインフルエンザ感染拡大のリスクと対策2021

    • Author(s)
      山本隆敏、田邊香野、登尾一平、水本豪、川口辰哉、池田勝義、楢原真二、上妻行則
    • Journal Title

      厚生の指標

      Volume: 68 Pages: 33-39

    • NAID

      40022496682

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The effect of roller head pump on platelet deterioration during the simulated extracorporeal circulation.2020

    • Author(s)
      Furugaki T, Shigeta O, Kozuma Y, Tsukada T, Nakajima T, Sakamoto H,Mathis BJ, Hiramatsu Y, Suzuki Y.
    • Journal Title

      Journal of

      Volume: -

    • NAID

      120007169660

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 巨核球造血におけるアポトーシス関連タンパクの役割2020

    • Author(s)
      上妻行則、登尾一平
    • Journal Title

      熊本保健科学大学研究誌

      Volume: 17 Pages: 1-9

    • NAID

      40022193889

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 学内における交差混合試験理解のための Rivaroxaban の応用2020

    • Author(s)
      登尾一平、山本隆敏、平野京介、佛淵悠大、渡邊一史、田邊香野、川口辰哉、上妻行則
    • Journal Title

      熊本保健科学大学研究誌

      Volume: 17 Pages: 59-70

    • NAID

      120006841028

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 交差混合試験の新規実習教材の開発:直接経口抗凝固薬を用いたインヒビター疑似検体の可能性2019

    • Author(s)
      登尾一平、山本隆敏、坂本亜理紗、田邊香野、川口辰哉、楢原真二、杉内博幸、上妻行則
    • Journal Title

      臨床検査学教育

      Volume: 11 Pages: 175-181

    • NAID

      40022025394

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] calpain はがん転移における腫瘍細胞の遊走および浸潤に関与するが、腫瘍細胞によって誘導される血小板凝集には関与しない2019

    • Author(s)
      上妻行則、田代ゆう子、登尾一平、二宮治彦
    • Journal Title

      熊本保健科学大学研究誌

      Volume: 16 Pages: 17-28

    • NAID

      120006631841

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rivaroxaban は学内実習における交差混合試験の凝固因子インヒビターとして有用である2019

    • Author(s)
      登尾一平、山本隆敏、上妻行則
    • Journal Title

      熊本保健科学大学研究誌

      Volume: 16 Pages: 131-140

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stratifin inhibits SCFFBW7 formation and blocks ubiqutination of oncoproteins during the course of lung adenocartinogenesis.2019

    • Author(s)
      1.Shiba-Ishi A, Hong J, Hirokawa T, Kim Y, Nakagawa T, Sakashita S, Sakamoto N, Kozuma Y, Sato Y, Noguchi M.
    • Journal Title

      Clin Cancer Res

      Volume: 25 Issue: 9 Pages: 2809-2820

    • DOI

      10.1158/1078-0432.ccr-18-3631

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Significance of measuring microparticles derived from stored platelets.2021

    • Author(s)
      Noboruo I, Nambu M, Kawaguchi T, Kozuma Y.
    • Organizer
      The 6th Allied Health Sciences International Symposium 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Daratumumab の輸血検査干渉の回避を目指した基礎研究2020

    • Author(s)
      登尾一平、山本隆敏、田邊香野、池田勝義、川口辰哉、上妻行則.
    • Organizer
      第68回日本輸血・細胞治療学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 保管血小板における MP の経時的変化とその役割2020

    • Author(s)
      登尾一平、山本隆敏、田邊香野、川口辰哉、上妻行則.
    • Organizer
      第42回日本血栓止血学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Microparticles released from stored platelet increase coagulation ability.2020

    • Author(s)
      Noboruo I, Yamamoto T, Tanabe K, Kawaguchi T, Ikeda K, Kozuma Y.
    • Organizer
      The XXVIII Congress of the International Society on Thrombosis and Haemostasis.
    • Related Report
      2020 Research-status Report
  • [Presentation] 保存血小板における老化マーカーの変化2019

    • Author(s)
      登尾一平、山本隆敏、田邊香野、川口辰哉、上妻行則
    • Organizer
      日本輸血細胞治療学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 医療系大学における遺伝子技術教育教材の開発と飲酒に関する生活指導への応用の可能性2019

    • Author(s)
      田邊香野、楢原真二、上妻行則、山本隆敏、川口辰哉
    • Organizer
      日本臨床検査学教育学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 保存血小板における老化マーカーの変化2019

    • Author(s)
      登尾一平、山本隆敏、田邊香野、川口辰哉、上妻行則
    • Organizer
      日本臨床検査学教育学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 交差混合試験の新規実習教材の開発-直接経口抗凝固薬、ribaroxaban を用いたインヒビター疑似検体の有用性の検討ー2019

    • Author(s)
      渡邊一史、平野京介、佛淵悠大、登尾一平、山本隆敏、上妻行則
    • Organizer
      日本臨床検査学教育学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 保存血小板における老化マーカーの有用性の検討2019

    • Author(s)
      登尾一平、山本隆敏、田邊香野、川口辰哉、上妻行則
    • Organizer
      日本血栓止血学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] MMP is involved in platelet senescence on platelet concentrates.2019

    • Author(s)
      I, Noboruo, T. Yamamoto, K. Tanabe, T. Kawaguchi, Y. Kozuma
    • Organizer
      Congress of International Society on Thrombosis and Haemostasis
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Artificial cerebrospinal fluid can recover platelet function inhibited by aspirin.2019

    • Author(s)
      Y. Kozuma, I. Noboruo, T. Kawaguchi, H. Ninomiya, T. Yamamoto
    • Organizer
      Congress of International Society on Thrombosis and Haemostasis
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経内視鏡手術で用いられる人工髄液による aspirin 添加血小板の活性化増強効果2018

    • Author(s)
      上妻行則、井上智佐子、山本哲哉、二宮治彦
    • Organizer
      第40回日本血栓止血学会学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-12-25  

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