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Diagnosis of the acute rejection using miRNAs in the bile juice

Research Project

Project/Area Number 18K08622
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionKumamoto University

Principal Investigator

Sugawara Yasuhiko  熊本大学, 大学院生命科学研究部(医), 准教授 (90313155)

Co-Investigator(Kenkyū-buntansha) 吉井 大貴  熊本大学, 大学院生命科学研究部(医), 学術研究員 (00792582)
日比 泰造  熊本大学, 大学院生命科学研究部(医), 教授 (10338072)
大矢 雄希  熊本大学, 大学院生命科学研究部(医), 助教 (90613422)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Keywords拒絶反応 / エキソソームmRNA / エクソソーム / マイクロRNA / 胆汁 / 急性拒絶反応 / RT-PCR / miRNA
Outline of Final Research Achievements

The 1 ml bile juice was sampled from the tube inserted to the bile duct of the transplanted liver on the 7, 10, 14, 17, 21, 24, 28, 35 and 42 days after the operation. The subject was the 11 patients who underwent living donor liver transplantation from June 2019 to October 2020 and was obtained the informed consent. Of the patients, two were complicated with the acute cellular rejection on the 11 and 10 postoperative days, respectively. The miR221 levels decreased significantly on the 7 and 14 postoperative days, respectively. There were no significant changes in the miR221 levels in the other 9 patients during the observation period.

Academic Significance and Societal Importance of the Research Achievements

周術期にはグラフトは再生しているためmiR221が発現亢進している。拒絶反応があり、再生のプロセスが阻害されると、miR221の発現も抑えられる可能性がある。胆汁中のmiR221レベルの測定で、肝移植後の拒絶反応の診断ができる可能性が示唆された。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (14 results)

All 2021 2020 2019

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 5 results) Presentation (7 results)

  • [Journal Article] In vivo dynamics and adaptation of HTLV-1-infected clones under different clinical conditions2021

    • Author(s)
      Izaki Mikiko、Yasunaga Jun-ichirou、Nosaka Kisato、Sugata Kenji、Utsunomiya Hayato、Suehiro Youko、Shichijo Takafumi、Yamada Asami、Sugawara Yasuhiko、Hibi Taizo、Inomata Yukihiro、Akari Hirofumi、Melamed Anat、Bangham Charles、Matsuoka Masao
    • Journal Title

      PLOS Pathogens

      Volume: 17 Issue: 2 Pages: e1009271-e1009271

    • DOI

      10.1371/journal.ppat.1009271

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Surgical treatment of hepatocellular carcinoma.2021

    • Author(s)
      Sugawara Y, Hibi T.
    • Journal Title

      Biosci Trends

      Volume: Publish Ahead of Print

    • NAID

      130008062730

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Portal Vein Complications After Adult Living Donor Liver Transplantation: Time of Onset and Deformity Patterns Affect Long‐Term Outcomes2021

    • Author(s)
      Sambommatsu Yuzuru、Shimata Keita、Ibuki Sho、Narita Yasuko、Isono Kaori、Honda Masaki、Irie Tomoaki、Kadohisa Masashi、Kawabata Seiichi、Yamamoto Hidekazu、Sugawara Yasuhiko、Ikeda Osamu、Inomata Yukihiro、Hibi Taizo
    • Journal Title

      Liver Transplantation

      Volume: Online ahead of print Issue: 6 Pages: 854-865

    • DOI

      10.1002/lt.25977

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term outcomes of living donor liver transplantation in patients with a prior history of nonhepatic malignancy2020

    • Author(s)
      Yamamoto H, Sambommatsu Y, Ibuki S, Shimata K, Sugawara Y, Hibi T.
    • Journal Title

      BioScience Trends

      Volume: 14 Issue: 1 Pages: 42-47

    • DOI

      10.5582/bst.2019.01313

    • NAID

      130007809049

    • ISSN
      1881-7815, 1881-7823
    • Year and Date
      2020-02-29
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ki67 expression at Kasai portoenterostomy as a prognostic factor in patients with biliary atresia2020

    • Author(s)
      Yoshii D、Inomata Y、Komohara Y、Shimata K、Honda M、Hayashida S、Oya Y、Yamamoto H、Yamamoto H、Sugawara Y、Hibi T
    • Journal Title

      BJS Open

      Volume: 4 Issue: 5 Pages: 873-883

    • DOI

      10.1002/bjs5.50308

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Donor Age on the Outcome of Living-donor Liver Transplantation2020

    • Author(s)
      Kadohisa Masashi、Inomata Yukihiro、Uto Keiichi、Hayashida Shintaro、Ohya Yuki、Yamamoto Hidekazu、Sugawara Yasuhiko、Hibi Taizo
    • Journal Title

      Transplantation

      Volume: Publish Ahead of Print Issue: 2 Pages: 328-337

    • DOI

      10.1097/tp.0000000000003246

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Donor Age on the Outcome of Living-donor Liver Transplantation: Special Consideration to the Feasibility of Using Elderly Donors2020

    • Author(s)
      Kadohisa M, Inomata Y, Uto K, Hayashida S, Ohya Y, Yamamoto H, Sugawara Y, Hibi T.
    • Journal Title

      Transplantation

      Volume: 52 Pages: 23-25

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 移植関連研究における生体イメージング法の応用2020

    • Author(s)
      本田 正樹, 門久 政司, 冨田 真裕, 内田 皓士, 嶋田 圭太, 石井 政嗣, 磯野 香織, 山本 栄和, 菅原 寧彦, 日比 泰造
    • Organizer
      第56回日本移植学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 当院での肝細胞癌に対する術後病理Japan criteria内とcriteria外による生体肝移植の長期成績の比較検討2020

    • Author(s)
      石井 政嗣, 富田 真裕, 内田 皓士, 嶋田 圭太, 磯野 香織, 本田 正樹, 山本 栄和, 菅原 寧彦, 日比 泰造
    • Organizer
      第56回日本移植学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 急性肝不全に対する当院の診療体制の現状と今後の課題2020

    • Author(s)
      嶋田 圭太, 吉丸 洋子, 田中 基彦, 冨田 真裕, 石井 政嗣, 山本 栄和, 菅原 寧彦, 田中 靖人, 日比 泰造
    • Organizer
      第56回日本移植学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 当院におけるアルコール性肝硬変に対する生体肝移植症例の検討2020

    • Author(s)
      山本 栄和, 安藤 惠子, 冨田 真裕, 内田 皓士, 嶋田 圭太, 石井 政嗣, 磯野 香織, 本田 正樹, 菅原 寧彦, 日比 泰造
    • Organizer
      第56回日本移植学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肝移植後の血栓性微小血管症の診断および治療戦略2020

    • Author(s)
      冨田 真裕, 嶋田 圭太, 石井 政嗣, 内田 皓士, 磯野 香織, 本田 正樹, 山本 栄和, 菅原 寧彦, 日比 泰造
    • Organizer
      第56回日本移植学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 当院における生体肝移植高齢ドナーの現状2020

    • Author(s)
      門久 政司, 猪股 裕紀洋, 嶋田 圭太, 石井 政嗣, 冨田 真裕, 内田 皓士, 磯野 香織, 本田 正樹, 山本 栄和, 菅原 寧彦, 日比 泰造
    • Organizer
      第56回日本移植学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 門亢症と肝移植 生体肝移植後の門脈圧亢進症 門脈ステント留置を行った症例の検討2019

    • Author(s)
      三本松 譲, 成田 泰子, 本田 正樹, 嶋田 圭太, 伊吹 省, 磯野 香織, 林田 信太朗, 大矢 雄希, 山本 栄和, 菅原 寧彦, 猪股 裕紀洋, 日比 泰造
    • Organizer
      日本門脈圧亢進症学会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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