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Analysis of the interaction between pancreatic stromal cells and adenocarcinoma via complement component 5a receptor

Research Project

Project/Area Number 18K08623
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionKumamoto University

Principal Investigator

TAKAMORI Hiroshi  熊本大学, 病院, 非常勤診療医師 (90363514)

Co-Investigator(Kenkyū-buntansha) 今井 克憲  熊本大学, 大学院生命科学研究部(医), 助教 (60555746)
岡部 弘尚  熊本大学, 病院, 非常勤診療医師 (40573621)
橋本 大輔  熊本大学, 病院, 非常勤診療医師 (80508507)
新田 英利  熊本大学, 病院, 非常勤診療医師 (90555749)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords補体C5a / C5a受容体 / 癌間質細胞 / 膵星細胞 / 癌浸潤 / 癌転移 / 浸潤 / 転移 / 膵癌 / C5a
Outline of Final Research Achievements

The aim of this study is to analyze pancreatic cancer - tumor stromal cells interaction via C5a- C5a receptor axis and establish a targeted therapy using this mechanism. In fact, tumor stromal cells of the pancreas expressed both C5a receptor and alpha-SMA in human pancreatic cancer tissues. The overall survival rate of the patients who highly expressed both C5aR and alpha-SMA were significantly worse than that of the patients who less expressed. In vitro, C5a enhanced alpha-SMA expression in pancreatic stromal cells, which was suggested that pancreatic stromal cells could be activated via C5a-C5a receptor axis.

Academic Significance and Societal Importance of the Research Achievements

今回の研究結果により、PSCsはC5aR(補体の受容体の1つ)を発現しておりかつC5a(補体の1つ)に反応することでαSMAを発現させることから、PSCsは補体系カスケードにより活性化させることが分かった。補体により活性化したPCSsが膵癌細胞の浸潤転移を促進させる結果およびメカニズムまでは今回の研究においては見いだせなかった。しかし今回補体系をブロックすることでPSCの活性化を抑制し、膵癌の進展を抑える可能性があることが見いだせたため、今後、膵癌に対する新たな分子標的治療法の開発につながる可能性が示唆される結果となった。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2021 2020 2019 2018

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 4 results) Presentation (9 results)

  • [Journal Article] Efficacy of delayed primary closure with intrawound continuous negative pressure and irrigation treatment after surgery for colorectal perforation2021

    • Author(s)
      Ogawa Katsuhiro、Nitta Hidetoshi、Masuda Toshiro、Matsumoto Katsutaka、Okino Tetsuya、Miyamoto Yuji、Baba Hideo、Takamori Hiroshi
    • Journal Title

      Acute Medicine & Surgery

      Volume: 8 Issue: 1

    • DOI

      10.1002/ams2.633

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rupture of a huge infectious abdominal chronic expanding hematoma2021

    • Author(s)
      Masuda Toshiro、Harada Kazuto、Shimizu Kenji、Karashima Ryuichi、Nitta Hidetoshi、Matsumoto Katsutaka、Okino Tetsuya、Kamio Takihiro、Baba Hideo、Takamori Hiroshi
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: - Issue: 3 Pages: 782-786

    • DOI

      10.1007/s12328-021-01366-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Varied application of intercostal trans-diaphragmatic ports for laparoscopic hepatectomy2020

    • Author(s)
      Hayashi Hiromitsu、Yamashita Yo-ichi、Okabe Hirohisa、Imai Katsunori、Higashi Takaaki、Yamamura Kensuke、Chikamoto Akira、Beppu Toru、Takamori Hiroshi、Baba Hideo
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 6 Pages: e0234919-e0234919

    • DOI

      10.1371/journal.pone.0234919

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frailty Predicts Severe Postoperative Complication after Elective Hepatic Resection2019

    • Author(s)
      Okabe Hirohisa、Hayashi Hiromitsu、Higashi Takaaki、Nitta Hidetoshi、Ikuta Yoshiaki、Yusa Toshihiko、Takeyama Hideaki、Ogawa Katsuhiro、Ozaki Nobuyuki、Akahoshi Shinichi、Ogata Kenichi、Osaki Takayuki、Baba Hideo、Takamori Hiroshi
    • Journal Title

      Gastrointestinal Tumors

      Volume: 6 Issue: 1-2 Pages: 28-35

    • DOI

      10.1159/000500086

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conversion surgery for initially unresectable pancreatic ductal adenocarcinoma with synchronous liver metastasis after treatment with FOLFIRINOX2019

    • Author(s)
      Ozaki Kentaro、Hayashi Hiromitsu、Ikuta Yoshiaki、Masuda Toshiro、Akaboshi Shinichi、Ogata Kenichi、Matumoto Katsutaka、Ogawa Katsuhiro、Kamio Takihiro、Baba Hideo、Takamori Hiroshi
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: 12 Issue: 6 Pages: 603-608

    • DOI

      10.1007/s12328-019-00965-z

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of FBXW7, a cell-cycle regulator, as a predictive marker of recurrence of gastrointestinal stromal tumors2019

    • Author(s)
      Koga Yuki、Iwatsuki Masaaki、Yamashita Kohei、Kiyozumi Yuki、Kurashige Junji、Masuda Toshiro、Eto Kojiro、Iwagami Shiro、Harada Kazuto、Ishimoto Takatsugu、Baba Yoshifumi、Yoshida Naoya、Miyanari Nobutomo、Takamori Hiroshi、Ajani Jaffer A.、Baba Hideo
    • Journal Title

      Gastric Cancer

      Volume: 22(6) Issue: 6 Pages: 1100-1108

    • DOI

      10.1007/s10120-019-00950-y

    • NAID

      40022051031

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frailty predicts severe postoperative complications after elective colorectal surgery2019

    • Author(s)
      Okabe Hirohisa、Ohsaki Takayuki、Ogawa Katsuhiro、Ozaki Nobuyuki、Hayashi Hiromitsu、Akahoshi Shinichi、Ikuta Yoshiaki、Ogata Kenichi、Baba Hideo、Takamori Hiroshi
    • Journal Title

      The American Journal of Surgery

      Volume: 217 Issue: 4 Pages: 677-681

    • DOI

      10.1016/j.amjsurg.2018.07.009

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessing the economic advantage of laparoscopic vs. open approaches for colorectal cancer by a propensity score matching analysis2018

    • Author(s)
      Hayashi Hiromitsu、Ozaki Nobuyuki、Ogawa Katsuhiro、Ikuta Yoshiaki、Tanaka Hideyuki、Ogata Kenichi、Doi Koichi、Takamori Hiroshi
    • Journal Title

      Surgery Today

      Volume: 48 Issue: 4 Pages: 439-448

    • DOI

      10.1007/s00595-017-1606-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] Necessity of postoperative adjuvant chemotherapy in ampullary cancer from prognostic and recurrence factors.2019

    • Author(s)
      Shinjiro Tomiyasu, Akira Tsuji, Kunitaka Kuramoto, Hiroki Sugita, Hiroshi Takamori, Masahiko Hirota, Yukihiro Inomata, Hideo Baba
    • Organizer
      The 31th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery
    • Related Report
      2019 Research-status Report
  • [Presentation] Predictive model for pleural effusion required drainage after hepatic resectionPredictive model for pleural effusion required drainage after hepatic resection.2019

    • Author(s)
      Hidetoshi Nitta, Kazuki Matsumura, Takaaki Higashi, Toshiro Masuda, Shinichi Akahoshi, Yoshiaki Ikuta, Hiroshi Takamori
    • Organizer
      The 31th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery
    • Related Report
      2019 Research-status Report
  • [Presentation] Clinical impact of pancreaticoduodenectomy with previous history of upper abdominal surgery2019

    • Author(s)
      Yoshiaki Ikuta, Takaaki Higashi, Nitta Hidetoshi, Shinichi Akahoshi, Toshiro Masuda, Hiroshi Takamori
    • Organizer
      The 31th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery
    • Related Report
      2019 Research-status Report
  • [Presentation] Endoscopic Retrograde and Percutaneous Transhepatic Gall Bladder Drainage Followed by Cholecystectomy for Acute Cholecystitis2019

    • Author(s)
      Toshiro Masuda, Kazuki Matsumura, Takaaki Higashi, Kenji Shimizu, Katsuhiro Ogawa, Hidetoshi Nitta, Shinichi Akahoshi, Katsutaka Matsumoto, Yoshiaki Ikuta, Tetsuya Okino, Hiroshi Takamori
    • Organizer
      The 31th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery
    • Related Report
      2019 Research-status Report
  • [Presentation] Clinical significance of caveolin-1 expression in cancerassociated fibroblasts in patients with intrahepatic cholangiocarcinoma following hepatectomy.2019

    • Author(s)
      Takanobu Yamao, Yo-ichi Yamashita, Kiyoshi Kaziyama, Tomoharu Yoshizumi, Kengo Fukuzawa, Keishi Sugimachi, Yasuharu Ikeda, Hiroshi Takamori, Masahiko Hirota, Nobutomo Miyanari, Shinichi Aishima, Hideo Baba
    • Organizer
      The 31th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery
    • Related Report
      2019 Research-status Report
  • [Presentation] Endoscopic Retrograde Gall Bladder Drainage followed by cholecystectomy for acute cholecystitis with more than 72 hours after its onset2018

    • Author(s)
      Toshiro Masuda, Kenichi Ogata, Taishi Yamane, Hideaki Takeyama, Katsuhiro Ogawa, Hiromitsu Hayashi, Shinichi Akahoshi, Katsutaka Matsumoto, Yoshiaki Ikuta, Hiroshi Takamori.
    • Organizer
      The 30th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery.
    • Related Report
      2018 Research-status Report
  • [Presentation] Conversion surgery after 21 courses of FOLFIRINOX in a patient with metastatic pancreatic cancer (UR-M): report of a case.2018

    • Author(s)
      Kentaro Ozaki, Hiromitu Hayashi, Yoshiaki Ikuta, Sinichi Akahosi, Kenichi Ogata, Katutaka Matumoto, Toshiro Masuda, Katsuhiro Ogawa, Hideaki Takeyama Taishi Yamane, Hiroshi Takamori.
    • Organizer
      The 30th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery.
    • Related Report
      2018 Research-status Report
  • [Presentation] A benefi t of laparoscopic approach in hepatic posterior sectionectomy.2018

    • Author(s)
      Hiromitsu Hayashi, Yoshiaki Ikuta, Toshiro Masuda, Kenichi Ogata, Katsutaka Matsumoto, Shinichi Akaboshi, Katsuhiro Ogawa, Hideaki Takeyama, Taishi Yamane, Hiroshi Takamori.
    • Organizer
      The 30th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery.
    • Related Report
      2018 Research-status Report
  • [Presentation] Assessment and validation of functional liver resection rate considering venous occlusive area after extended hepatectomy.2018

    • Author(s)
      Hidetoshi Nitta, Toshihiko Yusa, Yosuke Nakao, Rumi Itoyama, Yuki Kitano, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Yo-ichi Yamashita, Akira Chikamoto, Hideo Baba.
    • Organizer
      The 30th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery.
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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