Analysis of the interaction between pancreatic stromal cells and adenocarcinoma via complement component 5a receptor
| Project/Area Number |
18K08623
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
今井 克憲 熊本大学, 大学院生命科学研究部(医), 助教 (60555746)
岡部 弘尚 熊本大学, 病院, 非常勤診療医師 (40573621)
橋本 大輔 熊本大学, 病院, 非常勤診療医師 (80508507)
新田 英利 熊本大学, 病院, 非常勤診療医師 (90555749)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 補体C5a / C5a受容体 / 癌間質細胞 / 膵星細胞 / 癌浸潤 / 癌転移 / 浸潤 / 転移 / 膵癌 / C5a |
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| Outline of Final Research Achievements |
The aim of this study is to analyze pancreatic cancer - tumor stromal cells interaction via C5a- C5a receptor axis and establish a targeted therapy using this mechanism. In fact, tumor stromal cells of the pancreas expressed both C5a receptor and alpha-SMA in human pancreatic cancer tissues. The overall survival rate of the patients who highly expressed both C5aR and alpha-SMA were significantly worse than that of the patients who less expressed. In vitro, C5a enhanced alpha-SMA expression in pancreatic stromal cells, which was suggested that pancreatic stromal cells could be activated via C5a-C5a receptor axis.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究結果により、PSCsはC5aR（補体の受容体の１つ）を発現しておりかつC5a（補体の１つ）に反応することでαSMAを発現させることから、PSCsは補体系カスケードにより活性化させることが分かった。補体により活性化したPCSsが膵癌細胞の浸潤転移を促進させる結果およびメカニズムまでは今回の研究においては見いだせなかった。しかし今回補体系をブロックすることでPSCの活性化を抑制し、膵癌の進展を抑える可能性があることが見いだせたため、今後、膵癌に対する新たな分子標的治療法の開発につながる可能性が示唆される結果となった。
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Report
(4 results)
Research Products
(17 results)
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[Presentation] Endoscopic Retrograde and Percutaneous Transhepatic Gall Bladder Drainage Followed by Cholecystectomy for Acute Cholecystitis2019
Author(s)
Toshiro Masuda, Kazuki Matsumura, Takaaki Higashi, Kenji Shimizu, Katsuhiro Ogawa, Hidetoshi Nitta, Shinichi Akahoshi, Katsutaka Matsumoto, Yoshiaki Ikuta, Tetsuya Okino, Hiroshi Takamori
Organizer
The 31th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery
Related Report
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[Presentation] Clinical significance of caveolin-1 expression in cancerassociated fibroblasts in patients with intrahepatic cholangiocarcinoma following hepatectomy.2019
Author(s)
Takanobu Yamao, Yo-ichi Yamashita, Kiyoshi Kaziyama, Tomoharu Yoshizumi, Kengo Fukuzawa, Keishi Sugimachi, Yasuharu Ikeda, Hiroshi Takamori, Masahiko Hirota, Nobutomo Miyanari, Shinichi Aishima, Hideo Baba
Organizer
The 31th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery
Related Report
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[Presentation] Assessment and validation of functional liver resection rate considering venous occlusive area after extended hepatectomy.2018
Author(s)
Hidetoshi Nitta, Toshihiko Yusa, Yosuke Nakao, Rumi Itoyama, Yuki Kitano, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Yo-ichi Yamashita, Akira Chikamoto, Hideo Baba.
Organizer
The 30th Meeting of Japanese Society of Hepato-Biliary Pancreatic Surgery.
Related Report
