Expression and role of LRRC8A in esophageal squamous cell carcinoma.

• Project/Area Number: 18K08628
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Harada Kyoichi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (80804822)
• Co-Investigator(Kenkyū-buntansha): 大辻 英吾 京都府立医科大学, 医学(系)研究科(研究院), 教授 (20244600) ; 塩崎 敦 京都府立医科大学, 医学(系)研究科(研究院), 助教 (40568086)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 食道癌 / 食道外科学 / イオンチャネル / 低浸透圧

Outline of Final Research Achievements

The depletion of LRRC8A using siRNA decreased cell proliferation and cellular movement, and promoted the induction of apoptosis in human esophageal squamous cell carcinoma (ESCC) cells. The microarray analysis revealed that G1/S checkpoint regulation, PI3K/AKT signaling, MMP, and integrin signaling-related genes, such as p21, p27, E2F7, AKT, Bcl2, MMP1 and ITGAvα, were up- or down-regulated in LRRC8A-depleted cells. An immunohistochemical analysis revealed a relationship between strong LRRC8A expression and a poor prognosis in ESCC patients. Further, hypotonic solution at low temperature increased initial water influx via activation of AQP5 and decreased Cl- efflux via inhibition of LRRC8A. These results provide an insight into the role of LRRC8A as a mediator and/or a biomarker for ESCC. Further, Low temperature enhances hypotonicity-induced cytocidal effects, which may contribute to development of a novel lavage method to reduce peritoneal recurrence.

Academic Significance and Societal Importance of the Research Achievements

LRRC8Aが食道扁平上皮癌組織において高発現し、そのRNA干渉が癌細胞に抑制効果を示すことを新たに見出した。LRRC8Aのp21、p27、E2F7やMMP、Integrinを介する新たな腫瘍進展制御機構や、予後因子としての意義を明らかにし、バイオマーカーや治療標的としての可能性を示した。また、温度変化がLRRC8Aの発現変化を介してRVDを制御する機構を解明し、LRRC8Aや温度制御を利用した、低浸透細胞破壊療法への応用が期待される。

Research Products

• [Journal Article] Amlodipine and Verapamil, Voltage-Gated Ca2+ Channel Inhibitors, Suppressed the Growth of Gastric Cancer Stem Cells (2021)
  • Author(s): Shiozaki Atsushi、Katsurahara Keita、Kudou Michihiro、Shimizu Hiroki、Kosuga Toshiyuki、Ito Hiroshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Otsuji Eigo
  • Journal Title: Annals of Surgical Oncology Volume: - Issue: 9 Pages: 5400-5411
  • DOI: 10.1245/s10434-021-09645-0
  • Peer Reviewed
• [Journal Article] Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers (2021)
  • Author(s): Shiozaki Atsushi、Marunaka Yoshinori、Otsuji Eigo
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 9 Pages: 616933-616933
  • DOI: 10.3389/fcell.2021.616933
  • Peer Reviewed / Open Access
• [Journal Article] Expression and Role of CFTR in Human Esophageal Squamous Cell Carcinoma (2021)
  • Author(s): Matsumoto Yoshihisa、Shiozaki Atsushi、Kosuga Toshiyuki、Kudou Michihiro、Shimizu Hiroki、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
  • Journal Title: Annals of Surgical Oncology Volume: - Issue: 11 Pages: 6424-6436
  • DOI: 10.1245/s10434-021-09752-y
  • Peer Reviewed
• [Journal Article] Functional Analysis and Clinical Significance of Chloride Channel 2 Expression in Esophageal Squamous Cell Carcinoma (2021)
  • Author(s): Mitsuda Masato、Shiozaki Atsushi、Kudou Michihiro、Shimizu Hiroki、Arita Tomohiro、Kosuga Toshiyuki、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
  • Journal Title: Annals of Surgical Oncology Volume: - Issue: 9 Pages: 5384-5397
  • DOI: 10.1245/s10434-021-09659-8
  • Peer Reviewed
• [Journal Article] ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer. (2021)
  • Author(s): Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.
  • Journal Title: Cancer Science Volume: 112 Issue: 3 Pages: 1026-1037
  • DOI: 10.1111/cas.14796
  • Peer Reviewed / Open Access
• [Journal Article] LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway (2021)
  • Author(s): Kurashima Kento、Shiozaki Atsushi、Kudou Michihiro、Shimizu Hiroki、Arita Tomohiro、Kosuga Toshiyuki、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
  • Journal Title: Gastric Cancer Volume: - Issue: 5 Pages: 1063-1075
  • DOI: 10.1007/s10120-021-01187-4
  • NAID: 40022653221
  • Peer Reviewed
• [Journal Article] Clinical safety and efficacy of neoadjuvant combination chemotherapy of tranilast in advanced esophageal squamous cell carcinoma: Phase I/II study (TNAC). (2020)
  • Author(s): Shiozaki A, Kudou M, Fujiwara H, Konishi H, Shimizu H, Arita T, Kosuga T, Yamamoto Y, Morimura R, Ikoma H, Kuriu Y, Kubota T, Okamoto K, Otsuji E.
  • Journal Title: Medicine Volume: 99 Issue: 50 Pages: e23633-e23633
  • DOI: 10.1097/md.0000000000023633
  • Peer Reviewed / Open Access
• [Journal Article] ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell Carcinoma. (2020)
  • Author(s): Katsurahara K, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
  • Journal Title: Ann Surg Oncol. Volume: ー Issue: 9 Pages: 3218-3230
  • DOI: 10.1245/s10434-020-08368-y
  • Peer Reviewed
• [Journal Article] Clinical significance of the distance between the cricoid cartilage and upper edge of the tumor using PET?CT in cervical esophageal cancer (2020)
  • Author(s): Katsurahara Keita、Shiozaki Atsushi、Fujiwara Hitoshi、Konishi Hirotaka、Kudou Michihiro、Shoda Katsutoshi、Arita Tomohiro、Kosuga Toshiyuki、Morimura Ryo、Murayama Yasutoshi、Kuriu Yoshiaki、Ikoma Hisashi、Kubota Takeshi、Nakanishi Masayoshi、Okamoto Kazuma、Otsuji Eigo
  • Journal Title: Oncology Letters Volume: -
  • DOI: 10.3892/ol.2020.11901
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer (2020)
  • Author(s): Tanaka Yoshihiro、Murayama Yasutoshi、Matsumoto Tatsuya、Kubo Hidemasa、Harada Kyoichi、Matsuo Hisataka、Kubota Takeshi、Okamoto Kazuma、Otsuji Eigo
  • Journal Title: Oncology Letters Volume: 20 Issue: 4 Pages: 1-1
  • DOI: 10.3892/ol.2020.11943
  • Peer Reviewed / Open Access
• [Journal Article] 5-ALA-assistant automated detection of lymph node metastasis in gastric cancer patients. (2020)
  • Author(s): Matsumoto T, Murayama Y, Matsuo H, Okochi K, Koshiishi N, Harada Y, Tanaka H, Takamatsu T, Otsuji E.
  • Journal Title: Gastric Cancer. Volume: ー Issue: 4 Pages: 725-733
  • DOI: 10.1007/s10120-020-01044-w
  • Peer Reviewed
• [Journal Article] Case of a 5mm Rectal Neuroendocrine Tumor(G1)with Lymph Node Metastasis. (2020)
  • Author(s): Takemoto K, Harada K, Toma A, Imura T, Ochiai T, Otsuji E.
  • Journal Title: Gan To Kagaku Ryoho. Volume: 47 Pages: 652-654
  • Peer Reviewed
• [Journal Article] The expression and role of TRPV2 in esophageal squamous cell carcinoma. (2019)
  • Author(s): Kudou M, Shiozaki A, Yamazato Y, Katsurahara K, Kosuga T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 16055-16055
  • DOI: 10.1038/s41598-019-52227-0
  • Peer Reviewed / Open Access
• [Journal Article] Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells. (2019)
  • Author(s): Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.
  • Journal Title: Int J Oncol. Volume: 55 Pages: 905-914
  • DOI: 10.3892/ijo.2019.4853
  • Peer Reviewed
• [Journal Article] LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma. (2019)
  • Author(s): Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
  • Journal Title: Am J Pathol. Volume: 189 Issue: 10 Pages: 1973-1985
  • DOI: 10.1016/j.ajpath.2019.06.006
  • Peer Reviewed
• [Journal Article] Deep-UV excitation fluorescence microscopy for detection of lymph node metastasis using deep neural network. (2019)
  • Author(s): Matsumoto T, Niioka H, Kumamoto Y, Sato J, Inamori O, Nakao R, Harada Y, Konishi E, Otsuji E, Tanaka H, Miyake J, Takamatsu T.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 16912-16912
  • DOI: 10.1038/s41598-019-53405-w
  • Peer Reviewed / Open Access
• [Journal Article] Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer (2018)
  • Author(s): Shiozaki Atsushi、Ariyoshi Yosuke、Iitaka Daisuke、Kosuga Toshiyuki、Shimizu Hiroki、Kudou Michihiro、Konishi Tomoki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Ichikawa Daisuke、Otsuji Eigo
  • Journal Title: Gastric Cancer Volume: 22 Issue: 3 Pages: 473-485
  • DOI: 10.1007/s10120-018-0874-2
  • NAID: 40021884050
  • Peer Reviewed
• [Journal Article] Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma (2018)
  • Author(s): Shiozaki A, Hikami S, Ichikawa D, Kosuga T, Shimizu H, Kudou M, Yamazato Y, Kobayashi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E
  • Journal Title: Oncotarget Volume: 9 Issue: 40 Pages: 25993-26006
  • DOI: 10.18632/oncotarget.25417
  • Peer Reviewed / Open Access
• [Journal Article] Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma (2018)
  • Author(s): Yamazato Yuzo、Shiozaki Atsushi、Ichikawa Daisuke、Kosuga Toshiyuki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Otsuji Eigo
  • Journal Title: Oncotarget Volume: 9 Issue: 52 Pages: 29957-29974
  • DOI: 10.18632/oncotarget.25722
  • Peer Reviewed / Open Access
• [Journal Article] Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma (2018)
  • Author(s): Kobayashi Toshiyuki、Shiozaki Atsushi、Nako Yoshito、Ichikawa Daisuke、Kosuga Toshiyuki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Otsuji Eigo
  • Journal Title: Oncotarget Volume: 9 Issue: 33 Pages: 23237-23252
  • DOI: 10.18632/oncotarget.25296
  • Peer Reviewed / Open Access
• [Journal Article] Photodynamic diagnosis of peritoneal metastasis in human pancreatic cancer using 5?aminolevulinic acid during staging laparoscopy (2018)
  • Author(s): Harada Kyoichi、Murayama Yasutoshi、Kubo Hidemasa、Matsuo Hisataka、Morimura Ryo、Ikoma Hisashi、Fujiwara Hitoshi、Okamoto Kazuma、Tanaka Tohru、Otsuji Eigo
  • Journal Title: Oncology Letters Volume: 16 Pages: 821-828
  • DOI: 10.3892/ol.2018.8732
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Feeding Jejunostomy via Gastric Tube Versus Jejunum After Esophageal Cancer Surgery (2018)
  • Author(s): KONISHI TOMOKI、SHIOZAKI ATSUSHI、FUJIWARA HITOSHI、KONISHI HIROTAKA、TAKEMOTO KENICHI、KUDOU MICHIHIRO、SHODA KATSUTOSHI、ARITA TOMOHIRO、KOSUGA TOSHIYUKI、MORIMURA RYO、MURAYAMA YASUTOSHI、KURIU YOSHIAKI、IKOMA HISASHI、KUBOTA TAKESHI、NAKANISHI MASAYOSHI、OKAMOTO KAZUMA、OTSUJI EIGO
  • Journal Title: Anticancer Research Volume: 38 Issue: 8 Pages: 4941-4945
  • DOI: 10.21873/anticanres.12811
  • Peer Reviewed
• [Journal Article] Relationship Between Postoperative CRP and Prognosis in Thoracic Esophageal Squamous Cell Carcinoma (2018)
  • Author(s): KATSURAHARA KEITA、SHIOZAKI ATSUSHI、FUJIWARA HITOSHI、KONISHI HIROTAKA、KUDOU MICHIHIRO、SHODA KATSUTOSHI、ARITA TOMOHIRO、KOSUGA TOSHIYUKI、MORIMURA RYO、MURAYAMA YASUTOSHI、KURIU YOSHIAKI、IKOMA HISASHI、KUBOTA TAKESHI、NAKANISHI MASAYOSHI、OKAMOTO KAZUMA、OTSUJI EIGO
  • Journal Title: Anticancer Research Volume: 38 Issue: 11 Pages: 6513-6518
  • DOI: 10.21873/anticanres.13016
  • Peer Reviewed
• [Journal Article] Glutathione S‐transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma (2018)
  • Author(s): Ogino Shinpei、Konishi Hirotaka、Ichikawa Daisuke、Matsubara Daiki、Shoda Katsutoshi、Arita Tomohiro、Kosuga Toshiyuki、Komatsu Shuhei、Shiozaki Atsushi、Okamoto Kazuma、Kishimoto Mitsuo、Otsuji Eigo
  • Journal Title: Cancer Science Volume: 110 Issue: 2 Pages: 795-804
  • DOI: 10.1111/cas.13896
  • Peer Reviewed
• [Journal Article] Value of Preoperative PET-CT in the Prediction of Pathological Stage of Gastric Cancer (2018)
  • Author(s): Kudou Michihiro、Kosuga Toshiyuki、Kubota Takeshi、Okamoto Kazuma、Komatsu Shuhei、Shoda Katsutoshi、Konishi Hirotaka、Shiozaki Atsushi、Fujiwara Hitoshi、Arita Tomohiro、Morimura Ryo、Murayama Yasutoshi、Kuriu Yoshiaki、Ikoma Hisashi、Nakanishi Masayoshi、Otsuji Eigo
  • Journal Title: Annals of Surgical Oncology Volume: 25 Issue: 6 Pages: 1633-1639
  • DOI: 10.1245/s10434-018-6455-0
  • Peer Reviewed
• [Journal Article] Detection of fusion gene in cell-free DNA of a gastric synovial sarcoma. (2018)
  • Author(s): Ogino S, Konishi H, Ichikawa D, Hamada J, Shoda K, Arita T, Komatsu S, Shiozaki A, Okamoto K, Yamazaki S, Yasukawa S, Konishi E, Otsuji E.
  • Journal Title: World J Gastroenterol. Volume: 24 Issue: 8 Pages: 949-956
  • DOI: 10.3748/wjg.v24.i8.949
  • Peer Reviewed / Open Access
• [Presentation] 4-aminopyridineは膵癌幹細胞増殖抑制に関与する (2020)
  • Author(s): 小西智規、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、 藤原斉、岡本和真、大辻英吾.
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるCFTR（cystic fibrosis transmembrane conductance regulator）の発現の意義 (2020)
  • Author(s): 松本順久、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西智規、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾.
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 食道癌におけるTRPV2発現の意義 (2020)
  • Author(s): 加藤俊治、工藤道弘、塩﨑敦、小菅敏幸、山里有三、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、 中西正芳、藤原斉、岡本和真、大辻英吾.
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるTumor stroma ratioと，そのheterogeneityの臨床的意義 (2020)
  • Author(s): 倉島研人、工藤道弘、塩﨑敦、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、 藤原斉、岡本和真、大辻英吾
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 食道癌幹細胞におけるイオン輸送体の発現と意義 (2020)
  • Author(s): 深見知之、工藤道弘、松本順久、塩﨑敦、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、 中西正芳、藤原斉、岡本和真、大辻英吾.
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるCLCN2の発現と意義 (2020)
  • Author(s): 満田雅人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、 藤原斉、岡本和真、岸本光夫、大辻英吾.
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 食道癌におけるANO9の発現と機能解析 (2020)
  • Author(s): 井上博之、塩﨑敦、小菅敏幸、工藤道弘、葛原啓太、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、 藤原斉、岡本和真、大辻英吾
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるNa+/K+-ATPase発現の意義と機能解析について (2020)
  • Author(s): 中村慶、塩﨑敦、工藤道弘、小菅敏幸、小林利行、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中 西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 胃癌におけるLeucine-Rich Repeat-Containing protein 8A (LRRC8A)の発現とその意義 (2020)
  • Author(s): 倉島研人、塩﨑敦、小菅敏幸、清水浩紀、工藤道弘、有田智洋、山本有祐、小西博貴、森村玲、栗生宜明、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 胃癌におけるLeucine-Rich Repeat-Containing protein 8A (LRRC8A)の機能と臨床的意義について (2020)
  • Author(s): 倉島研人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、小西博貴、窪田健、藤原斉、岡本和真、大辻英吾
  • Organizer: 第75回日本消化器外科学会総会
• [Presentation] 食道扁平上皮癌におけるTRPV2発現の臨床病理学的意義についての検討 (2019)
  • Author(s): 加藤俊治、塩﨑敦、山里有三、小菅敏幸、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、森村玲、生駒久視、村山康利、栗生宜明、中西正芳、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 膵癌幹細胞における4-aminopyridineの抗腫瘍効果について (2019)
  • Author(s): 小西智規、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道癌におけるLeucine-Rich Repeat-Containing protein 8A（LRRC8A）発現と機能解析 (2019)
  • Author(s): 倉島研人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるAno9発現の意義 (2019)
  • Author(s): 葛原啓太、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] ヒト食道扁平上皮癌におけるNa+/K+-ATPase発現と役割 (2019)
  • Author(s): 小林利行、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西博貴、小松周平、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、小西英一、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるCLC-2（Chloride Channel protein 2）発現の意義 (2019)
  • Author(s): 満田雅人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌におけるCFTR（cystic fibrosis transmembrane conductance regulator）の発現の意義 (2019)
  • Author(s): 松本順久、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾．
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 胃癌細胞の低浸透圧処理後容積変化における低温刺激の影響 (2019)
  • Author(s): 中村慶、塩﨑敦、小菅敏幸、山里有三、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 低浸透圧による細胞容積制御を介した胃癌細胞へのパクリタキセル取り込み増強効果 (2019)
  • Author(s): 小菅敏幸、塩﨑敦、工藤道弘、飯高大介、小林利行、竹本健一、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、岡本和真、藤原斉、小松周平、市川大輔、大辻英吾.
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] High CD44 gastric cancer stem cells are suppressed by voltage gated Ca2+ channel blocker. (2019)
  • Author(s): Keita Katsurahara, Atsushi Shiozaki, Michihiro Kudou, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Yasutoshi Murayama, Takeshi Kubota, Masayoshi Nakanishi, Hitoshi Fujiwara, Eigo Otsuji.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] The development of novel targeted therapies to over-expressed ion transporters in esophageal cancer stem cells. (2019)
  • Author(s): Yoshihisa Matsumoto, Michihiro Kudou, Atsushi Shiozaki, Toshiyuki Kosuga, Ryo Morimura , Yasutoshi Murayama, Yoshiaki Kuriu , Hisashi Ikoma, Takeshi Kubota, Masayoshi Nakanishi, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji.
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] 胃癌におけるヨウ化ナトリウム共輸送体のIFNシグナルを介する腫瘍制御機構の解明 (2019)
  • Author(s): 塩﨑敦、有吉要輔、小菅敏幸、工藤道弘、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第57回日本癌治療学会学術集会
• [Presentation] 食道癌幹細胞特異的に発現するion channelの同定と新規標的治療への応用 (2018)
  • Author(s): 塩﨑敦, 工藤道弘, 藤原斉, 小西博貴, 庄田勝俊, 有田智洋, 小菅敏幸, 森村玲, 村山康利, 栗生宜明, 生駒久視, 窪田健, 中西正芳, 岡本和真, 大辻英吾
  • Organizer: JDDW2018（第16回日本消化器外科学会大会）
• [Presentation] 食道扁平上皮癌におけるAnion exchanger 2の細胞遊走能制御機構の解明 (2018)
  • Author(s): 塩﨑敦、樋上翔一郎、小菅敏幸、工藤道弘、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] 食道癌幹細胞に高発現する TRPV2 を標的とした新たな治療方法の開発 (2018)
  • Author(s): 葛原啓太、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌における Na+/K+-ATPase の発現意義 (2018)
  • Author(s): 松本順久、塩﨑敦、小林利行、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌における Aquaporin 1 の発現機能 (2018)
  • Author(s): 山里有三、塩﨑敦、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道扁平上皮癌における CLIC1 の発現意義と機能解析 (2018)
  • Author(s): 小林利行、塩﨑敦、名幸義人、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 食道癌における Leucine-Rich Repeat-Containing protein 8A（LRRC8A）発現の臨床的意義について (2018)
  • Author(s): 小西智規、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 胃癌細胞における低温刺激がもたらすRegulatory Volume Decrease (RVD) への影響． (2018)
  • Author(s): 満田雅人、塩﨑敦、山里有三、小菅敏幸、庄田勝俊、小西博貴、窪田健、藤原斉、岡本和真、大辻英吾．
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] Functional analysis and prognostic value of sodium iodide symporter (NIS) in gastric cancer (2018)
  • Author(s): Atsushi Shiozaki, Yosuke Ariyoshi, Toshiyuki Kosuga, Michihiro Kudou, Katsutoshi Shoda, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Yoshinori Marunaka, Eigo Otsuji
  • Organizer: 第77回日本癌学会学術総会