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Expression and role of LRRC8A in esophageal squamous cell carcinoma.

Research Project

Project/Area Number 18K08628
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Harada Kyoichi  京都府立医科大学, 医学(系)研究科(研究院), 助教 (80804822)

Co-Investigator(Kenkyū-buntansha) 大辻 英吾  京都府立医科大学, 医学(系)研究科(研究院), 教授 (20244600)
塩崎 敦  京都府立医科大学, 医学(系)研究科(研究院), 助教 (40568086)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords食道癌 / 食道外科学 / イオンチャネル / 低浸透圧
Outline of Final Research Achievements

The depletion of LRRC8A using siRNA decreased cell proliferation and cellular movement, and promoted the induction of apoptosis in human esophageal squamous cell carcinoma (ESCC) cells. The microarray analysis revealed that G1/S checkpoint regulation, PI3K/AKT signaling, MMP, and integrin signaling-related genes, such as p21, p27, E2F7, AKT, Bcl2, MMP1 and ITGAvα, were up- or down-regulated in LRRC8A-depleted cells. An immunohistochemical analysis revealed a relationship between strong LRRC8A expression and a poor prognosis in ESCC patients. Further, hypotonic solution at low temperature increased initial water influx via activation of AQP5 and decreased Cl- efflux via inhibition of LRRC8A. These results provide an insight into the role of LRRC8A as a mediator and/or a biomarker for ESCC. Further, Low temperature enhances hypotonicity-induced cytocidal effects, which may contribute to development of a novel lavage method to reduce peritoneal recurrence.

Academic Significance and Societal Importance of the Research Achievements

LRRC8Aが食道扁平上皮癌組織において高発現し、そのRNA干渉が癌細胞に抑制効果を示すことを新たに見出した。LRRC8Aのp21、p27、E2F7やMMP、Integrinを介する新たな腫瘍進展制御機構や、予後因子としての意義を明らかにし、バイオマーカーや治療標的としての可能性を示した。また、温度変化がLRRC8Aの発現変化を介してRVDを制御する機構を解明し、LRRC8Aや温度制御を利用した、低浸透細胞破壊療法への応用が期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (57 results)

All 2021 2020 2019 2018

All Journal Article (26 results) (of which Peer Reviewed: 26 results,  Open Access: 12 results) Presentation (31 results)

  • [Journal Article] Amlodipine and Verapamil, Voltage-Gated Ca2+ Channel Inhibitors, Suppressed the Growth of Gastric Cancer Stem Cells2021

    • Author(s)
      Shiozaki Atsushi、Katsurahara Keita、Kudou Michihiro、Shimizu Hiroki、Kosuga Toshiyuki、Ito Hiroshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Otsuji Eigo
    • Journal Title

      Annals of Surgical Oncology

      Volume: - Issue: 9 Pages: 5400-5411

    • DOI

      10.1245/s10434-021-09645-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers2021

    • Author(s)
      Shiozaki Atsushi、Marunaka Yoshinori、Otsuji Eigo
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 9 Pages: 616933-616933

    • DOI

      10.3389/fcell.2021.616933

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression and Role of CFTR in Human Esophageal Squamous Cell Carcinoma2021

    • Author(s)
      Matsumoto Yoshihisa、Shiozaki Atsushi、Kosuga Toshiyuki、Kudou Michihiro、Shimizu Hiroki、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Annals of Surgical Oncology

      Volume: - Issue: 11 Pages: 6424-6436

    • DOI

      10.1245/s10434-021-09752-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Analysis and Clinical Significance of Chloride Channel 2 Expression in Esophageal Squamous Cell Carcinoma2021

    • Author(s)
      Mitsuda Masato、Shiozaki Atsushi、Kudou Michihiro、Shimizu Hiroki、Arita Tomohiro、Kosuga Toshiyuki、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Annals of Surgical Oncology

      Volume: - Issue: 9 Pages: 5384-5397

    • DOI

      10.1245/s10434-021-09659-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer.2021

    • Author(s)
      Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 3 Pages: 1026-1037

    • DOI

      10.1111/cas.14796

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway2021

    • Author(s)
      Kurashima Kento、Shiozaki Atsushi、Kudou Michihiro、Shimizu Hiroki、Arita Tomohiro、Kosuga Toshiyuki、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Gastric Cancer

      Volume: - Issue: 5 Pages: 1063-1075

    • DOI

      10.1007/s10120-021-01187-4

    • NAID

      40022653221

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical safety and efficacy of neoadjuvant combination chemotherapy of tranilast in advanced esophageal squamous cell carcinoma: Phase I/II study (TNAC).2020

    • Author(s)
      Shiozaki A, Kudou M, Fujiwara H, Konishi H, Shimizu H, Arita T, Kosuga T, Yamamoto Y, Morimura R, Ikoma H, Kuriu Y, Kubota T, Okamoto K, Otsuji E.
    • Journal Title

      Medicine

      Volume: 99 Issue: 50 Pages: e23633-e23633

    • DOI

      10.1097/md.0000000000023633

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell Carcinoma.2020

    • Author(s)
      Katsurahara K, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
    • Journal Title

      Ann Surg Oncol.

      Volume: ー Issue: 9 Pages: 3218-3230

    • DOI

      10.1245/s10434-020-08368-y

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of the distance between the cricoid cartilage and upper edge of the tumor using PET?CT in cervical esophageal cancer2020

    • Author(s)
      Katsurahara Keita、Shiozaki Atsushi、Fujiwara Hitoshi、Konishi Hirotaka、Kudou Michihiro、Shoda Katsutoshi、Arita Tomohiro、Kosuga Toshiyuki、Morimura Ryo、Murayama Yasutoshi、Kuriu Yoshiaki、Ikoma Hisashi、Kubota Takeshi、Nakanishi Masayoshi、Okamoto Kazuma、Otsuji Eigo
    • Journal Title

      Oncology Letters

      Volume: -

    • DOI

      10.3892/ol.2020.11901

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of 5-aminolevulinic acid-mediated photodynamic therapy in a mouse model of esophageal cancer2020

    • Author(s)
      Tanaka Yoshihiro、Murayama Yasutoshi、Matsumoto Tatsuya、Kubo Hidemasa、Harada Kyoichi、Matsuo Hisataka、Kubota Takeshi、Okamoto Kazuma、Otsuji Eigo
    • Journal Title

      Oncology Letters

      Volume: 20 Issue: 4 Pages: 1-1

    • DOI

      10.3892/ol.2020.11943

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 5-ALA-assistant automated detection of lymph node metastasis in gastric cancer patients.2020

    • Author(s)
      Matsumoto T, Murayama Y, Matsuo H, Okochi K, Koshiishi N, Harada Y, Tanaka H, Takamatsu T, Otsuji E.
    • Journal Title

      Gastric Cancer.

      Volume: ー Issue: 4 Pages: 725-733

    • DOI

      10.1007/s10120-020-01044-w

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of a 5mm Rectal Neuroendocrine Tumor(G1)with Lymph Node Metastasis.2020

    • Author(s)
      Takemoto K, Harada K, Toma A, Imura T, Ochiai T, Otsuji E.
    • Journal Title

      Gan To Kagaku Ryoho.

      Volume: 47 Pages: 652-654

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The expression and role of TRPV2 in esophageal squamous cell carcinoma.2019

    • Author(s)
      Kudou M, Shiozaki A, Yamazato Y, Katsurahara K, Kosuga T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 16055-16055

    • DOI

      10.1038/s41598-019-52227-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells.2019

    • Author(s)
      Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.
    • Journal Title

      Int J Oncol.

      Volume: 55 Pages: 905-914

    • DOI

      10.3892/ijo.2019.4853

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma.2019

    • Author(s)
      Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
    • Journal Title

      Am J Pathol.

      Volume: 189 Issue: 10 Pages: 1973-1985

    • DOI

      10.1016/j.ajpath.2019.06.006

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Deep-UV excitation fluorescence microscopy for detection of lymph node metastasis using deep neural network.2019

    • Author(s)
      Matsumoto T, Niioka H, Kumamoto Y, Sato J, Inamori O, Nakao R, Harada Y, Konishi E, Otsuji E, Tanaka H, Miyake J, Takamatsu T.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 16912-16912

    • DOI

      10.1038/s41598-019-53405-w

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer2018

    • Author(s)
      Shiozaki Atsushi、Ariyoshi Yosuke、Iitaka Daisuke、Kosuga Toshiyuki、Shimizu Hiroki、Kudou Michihiro、Konishi Tomoki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Ichikawa Daisuke、Otsuji Eigo
    • Journal Title

      Gastric Cancer

      Volume: 22 Issue: 3 Pages: 473-485

    • DOI

      10.1007/s10120-018-0874-2

    • NAID

      40021884050

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma2018

    • Author(s)
      Shiozaki A, Hikami S, Ichikawa D, Kosuga T, Shimizu H, Kudou M, Yamazato Y, Kobayashi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 40 Pages: 25993-26006

    • DOI

      10.18632/oncotarget.25417

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma2018

    • Author(s)
      Yamazato Yuzo、Shiozaki Atsushi、Ichikawa Daisuke、Kosuga Toshiyuki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Otsuji Eigo
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 52 Pages: 29957-29974

    • DOI

      10.18632/oncotarget.25722

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chloride intracellular channel 1 as a switch among tumor behaviors in human esophageal squamous cell carcinoma2018

    • Author(s)
      Kobayashi Toshiyuki、Shiozaki Atsushi、Nako Yoshito、Ichikawa Daisuke、Kosuga Toshiyuki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Marunaka Yoshinori、Otsuji Eigo
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 33 Pages: 23237-23252

    • DOI

      10.18632/oncotarget.25296

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photodynamic diagnosis of peritoneal metastasis in human pancreatic cancer using 5?aminolevulinic acid during staging laparoscopy2018

    • Author(s)
      Harada Kyoichi、Murayama Yasutoshi、Kubo Hidemasa、Matsuo Hisataka、Morimura Ryo、Ikoma Hisashi、Fujiwara Hitoshi、Okamoto Kazuma、Tanaka Tohru、Otsuji Eigo
    • Journal Title

      Oncology Letters

      Volume: 16 Pages: 821-828

    • DOI

      10.3892/ol.2018.8732

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Feeding Jejunostomy via Gastric Tube Versus Jejunum After Esophageal Cancer Surgery2018

    • Author(s)
      KONISHI TOMOKI、SHIOZAKI ATSUSHI、FUJIWARA HITOSHI、KONISHI HIROTAKA、TAKEMOTO KENICHI、KUDOU MICHIHIRO、SHODA KATSUTOSHI、ARITA TOMOHIRO、KOSUGA TOSHIYUKI、MORIMURA RYO、MURAYAMA YASUTOSHI、KURIU YOSHIAKI、IKOMA HISASHI、KUBOTA TAKESHI、NAKANISHI MASAYOSHI、OKAMOTO KAZUMA、OTSUJI EIGO
    • Journal Title

      Anticancer Research

      Volume: 38 Issue: 8 Pages: 4941-4945

    • DOI

      10.21873/anticanres.12811

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship Between Postoperative CRP and Prognosis in Thoracic Esophageal Squamous Cell Carcinoma2018

    • Author(s)
      KATSURAHARA KEITA、SHIOZAKI ATSUSHI、FUJIWARA HITOSHI、KONISHI HIROTAKA、KUDOU MICHIHIRO、SHODA KATSUTOSHI、ARITA TOMOHIRO、KOSUGA TOSHIYUKI、MORIMURA RYO、MURAYAMA YASUTOSHI、KURIU YOSHIAKI、IKOMA HISASHI、KUBOTA TAKESHI、NAKANISHI MASAYOSHI、OKAMOTO KAZUMA、OTSUJI EIGO
    • Journal Title

      Anticancer Research

      Volume: 38 Issue: 11 Pages: 6513-6518

    • DOI

      10.21873/anticanres.13016

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Glutathione S‐transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma2018

    • Author(s)
      Ogino Shinpei、Konishi Hirotaka、Ichikawa Daisuke、Matsubara Daiki、Shoda Katsutoshi、Arita Tomohiro、Kosuga Toshiyuki、Komatsu Shuhei、Shiozaki Atsushi、Okamoto Kazuma、Kishimoto Mitsuo、Otsuji Eigo
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 2 Pages: 795-804

    • DOI

      10.1111/cas.13896

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Value of Preoperative PET-CT in the Prediction of Pathological Stage of Gastric Cancer2018

    • Author(s)
      Kudou Michihiro、Kosuga Toshiyuki、Kubota Takeshi、Okamoto Kazuma、Komatsu Shuhei、Shoda Katsutoshi、Konishi Hirotaka、Shiozaki Atsushi、Fujiwara Hitoshi、Arita Tomohiro、Morimura Ryo、Murayama Yasutoshi、Kuriu Yoshiaki、Ikoma Hisashi、Nakanishi Masayoshi、Otsuji Eigo
    • Journal Title

      Annals of Surgical Oncology

      Volume: 25 Issue: 6 Pages: 1633-1639

    • DOI

      10.1245/s10434-018-6455-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of fusion gene in cell-free DNA of a gastric synovial sarcoma.2018

    • Author(s)
      Ogino S, Konishi H, Ichikawa D, Hamada J, Shoda K, Arita T, Komatsu S, Shiozaki A, Okamoto K, Yamazaki S, Yasukawa S, Konishi E, Otsuji E.
    • Journal Title

      World J Gastroenterol.

      Volume: 24 Issue: 8 Pages: 949-956

    • DOI

      10.3748/wjg.v24.i8.949

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 4-aminopyridineは膵癌幹細胞増殖抑制に関与する2020

    • Author(s)
      小西智規、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、 藤原斉、岡本和真、大辻英吾.
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるCFTR(cystic fibrosis transmembrane conductance regulator)の発現の意義2020

    • Author(s)
      松本順久、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西智規、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾.
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食道癌におけるTRPV2発現の意義2020

    • Author(s)
      加藤俊治、工藤道弘、塩﨑敦、小菅敏幸、山里有三、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、 中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるTumor stroma ratioと,そのheterogeneityの臨床的意義2020

    • Author(s)
      倉島研人、工藤道弘、塩﨑敦、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、 藤原斉、岡本和真、大辻英吾
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食道癌幹細胞におけるイオン輸送体の発現と意義2020

    • Author(s)
      深見知之、工藤道弘、松本順久、塩﨑敦、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、 中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるCLCN2の発現と意義2020

    • Author(s)
      満田雅人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、 藤原斉、岡本和真、岸本光夫、大辻英吾.
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食道癌におけるANO9の発現と機能解析2020

    • Author(s)
      井上博之、塩﨑敦、小菅敏幸、工藤道弘、葛原啓太、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、 藤原斉、岡本和真、大辻英吾
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるNa+/K+-ATPase発現の意義と機能解析について2020

    • Author(s)
      中村慶、塩﨑敦、工藤道弘、小菅敏幸、小林利行、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中 西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胃癌におけるLeucine-Rich Repeat-Containing protein 8A (LRRC8A)の発現とその意義2020

    • Author(s)
      倉島研人、塩﨑敦、小菅敏幸、清水浩紀、工藤道弘、有田智洋、山本有祐、小西博貴、森村玲、栗生宜明、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 胃癌におけるLeucine-Rich Repeat-Containing protein 8A (LRRC8A)の機能と臨床的意義について2020

    • Author(s)
      倉島研人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、小西博貴、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第75回日本消化器外科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるTRPV2発現の臨床病理学的意義についての検討2019

    • Author(s)
      加藤俊治、塩﨑敦、山里有三、小菅敏幸、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、森村玲、生駒久視、村山康利、栗生宜明、中西正芳、大辻英吾.
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 膵癌幹細胞における4-aminopyridineの抗腫瘍効果について2019

    • Author(s)
      小西智規、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 食道癌におけるLeucine-Rich Repeat-Containing protein 8A(LRRC8A)発現と機能解析2019

    • Author(s)
      倉島研人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 食道扁平上皮癌におけるAno9発現の意義2019

    • Author(s)
      葛原啓太、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] ヒト食道扁平上皮癌におけるNa+/K+-ATPase発現と役割2019

    • Author(s)
      小林利行、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西博貴、小松周平、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、小西英一、大辻英吾.
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 食道扁平上皮癌におけるCLC-2(Chloride Channel protein 2)発現の意義2019

    • Author(s)
      満田雅人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾.
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 食道扁平上皮癌におけるCFTR(cystic fibrosis transmembrane conductance regulator)の発現の意義2019

    • Author(s)
      松本順久、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾.
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 胃癌細胞の低浸透圧処理後容積変化における低温刺激の影響2019

    • Author(s)
      中村慶、塩﨑敦、小菅敏幸、山里有三、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 低浸透圧による細胞容積制御を介した胃癌細胞へのパクリタキセル取り込み増強効果2019

    • Author(s)
      小菅敏幸、塩﨑敦、工藤道弘、飯高大介、小林利行、竹本健一、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、岡本和真、藤原斉、小松周平、市川大輔、大辻英吾.
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] High CD44 gastric cancer stem cells are suppressed by voltage gated Ca2+ channel blocker.2019

    • Author(s)
      Keita Katsurahara, Atsushi Shiozaki, Michihiro Kudou, Katsutoshi Shoda, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Yasutoshi Murayama, Takeshi Kubota, Masayoshi Nakanishi, Hitoshi Fujiwara, Eigo Otsuji.
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] The development of novel targeted therapies to over-expressed ion transporters in esophageal cancer stem cells.2019

    • Author(s)
      Yoshihisa Matsumoto, Michihiro Kudou, Atsushi Shiozaki, Toshiyuki Kosuga, Ryo Morimura , Yasutoshi Murayama, Yoshiaki Kuriu , Hisashi Ikoma, Takeshi Kubota, Masayoshi Nakanishi, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji.
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 胃癌におけるヨウ化ナトリウム共輸送体のIFNシグナルを介する腫瘍制御機構の解明2019

    • Author(s)
      塩﨑敦、有吉要輔、小菅敏幸、工藤道弘、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第57回日本癌治療学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 食道癌幹細胞特異的に発現するion channelの同定と新規標的治療への応用2018

    • Author(s)
      塩﨑敦, 工藤道弘, 藤原斉, 小西博貴, 庄田勝俊, 有田智洋, 小菅敏幸, 森村玲, 村山康利, 栗生宜明, 生駒久視, 窪田健, 中西正芳, 岡本和真, 大辻英吾
    • Organizer
      JDDW2018(第16回日本消化器外科学会大会)
    • Related Report
      2018 Research-status Report
  • [Presentation] 食道扁平上皮癌におけるAnion exchanger 2の細胞遊走能制御機構の解明2018

    • Author(s)
      塩﨑敦、樋上翔一郎、小菅敏幸、工藤道弘、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 食道癌幹細胞に高発現する TRPV2 を標的とした新たな治療方法の開発2018

    • Author(s)
      葛原啓太、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 食道扁平上皮癌における Na+/K+-ATPase の発現意義2018

    • Author(s)
      松本順久、塩﨑敦、小林利行、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 食道扁平上皮癌における Aquaporin 1 の発現機能2018

    • Author(s)
      山里有三、塩﨑敦、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 食道扁平上皮癌における CLIC1 の発現意義と機能解析2018

    • Author(s)
      小林利行、塩﨑敦、名幸義人、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 食道癌における Leucine-Rich Repeat-Containing protein 8A(LRRC8A)発現の臨床的意義について2018

    • Author(s)
      小西智規、塩﨑敦、工藤道弘、庄田勝俊、有田智洋、小菅敏幸、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 胃癌細胞における低温刺激がもたらすRegulatory Volume Decrease (RVD) への影響.2018

    • Author(s)
      満田雅人、塩﨑敦、山里有三、小菅敏幸、庄田勝俊、小西博貴、窪田健、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第73回日本消化器外科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Functional analysis and prognostic value of sodium iodide symporter (NIS) in gastric cancer2018

    • Author(s)
      Atsushi Shiozaki, Yosuke Ariyoshi, Toshiyuki Kosuga, Michihiro Kudou, Katsutoshi Shoda, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Yoshinori Marunaka, Eigo Otsuji
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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