Development of a highly sensitive diagnostic system for gallbladder cancer using Glycan molecular markers
| Project/Area Number |
18K08632
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
Higuchi Ryota 東京女子医科大学, 医学部, 講師 (20318059)
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| Co-Investigator(Kenkyū-buntansha) |
有泉 俊一 東京女子医科大学, 医学部, 准教授 (40277158)
山本 雅一 東京女子医科大学, 医学部, 教授 (60220498)
長嶋 洋治 東京女子医科大学, 医学部, 教授 (10217995)
正田 純一 筑波大学, 医学医療系, 教授 (90241827)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 胆嚢癌 / 診断 / マーカー / WFA / 糖鎖 / 術前 / 予後 / 成績 / 腫瘍マーカー / 分子 / 胆道癌 / CA19.9 / MUC1 / 胆管癌 / WFA-sialyl MUC1 / バイオマーカー / 糖鎖医学 / レクチン |
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| Outline of Final Research Achievements |
Diagnosis with a new glycoprotein molecular marker (WFA-sialylated MUC1; WFA) was superior in patients with gallbladder cancer compared to the patients with benign biliary tract disease. WFA does not depend on the cancer stage or tissue type in the diagnosis of benign biliary tract disease and gallbladder cancer, and stage I / II and papillary or well differentiated cancers it also showed more accurate diagnostic ability than conventional tumor markers. WFA in the bile was also significantly higher in patients with gallbladder cancer than in those with benign biliary tract disease. Its diagnostic ability was superior to conventional tumor markers, and the diagnosis was accurate. WFA is a useful biomarker for the diagnosis of gallbladder cancer and is suggested that it should be used in the clinical setting in the near future.
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| Academic Significance and Societal Importance of the Research Achievements |
胆嚢癌は予後不良で早期診断の難しい癌であることが知られているが,本研究にて胆汁/血清 WFA-sialylated MUC1 が胆嚢癌で有用なバイオマーカーである可能性が示唆された.簡便で容易な測定システムは,肝臓の線維化マーカー(Mac-2 Binding Protein 糖鎖修飾異性体)を測定する免疫学的測定装置としてすでに認可され,全国多くの医療施設に導入されている. MUC1 糖鎖修飾異性体の測定システムもこの免疫学的測定装置に搭載可能であり,有用性が証明できれば安価で容易に全国にてこのマーカーの測定が可能となる.全国への検査方法の普及と治療成績の向上につなげることが期待される.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Resectional surgery in gallbladder cancer with jaundice-how to improve the outcome?2021
Author(s)
Chaudhary RK, Higuchi R, Yazawa T, Uemura S, Izumo W, Matsunaga Y, Nagano E, Sato Y, Ota T, Furukawa T, Yamamoto M.
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Journal Title
Langenbecks Arch Surg.
Volume: Online ahead of print.
Issue: 3
Pages: 791-800
DOI
Related Report
Peer Reviewed
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[Journal Article] Molecular targeting of HER2-overexpressing biliary tract cancer cells with trastuzumab emtansine, an antibody-cytotoxic drug conjugate.2019
Author(s)
Yamashita-Kashima Y, Yoshimura Y, Fujimura T, Shu S, Yanagisawa M, Yorozu K, Furugaki K, Higuchi R, Shoda J, Harada N.
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Journal Title
Cancer Chemother Pharmacol
Volume: 83
Issue: 4
Pages: 659-671
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Survey of preoperative management protocol for perihilar cholangiocarcinoma at 10 Japanese high-volume centers with a combined experience of 2,778 cases.2019
Author(s)
Chaudhary RJ, Higuchi R, Nagino M, Unno M, Ohtsuka M, Endo I, Hirano S, Uesaka K, Hasegawa K, Wakai T, Uemoto S, Yamamoto M.
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Journal Title
J Hepatobiliary Pancreat Sci.
Volume: 11
Issue: 11
Pages: 490-502
DOI
Related Report
Peer Reviewed
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[Journal Article] Multinational validation of the American Joint Committee on Cancer 8th edition pancreatic cancer staging system in a pancreas head cancer cohort.2018
Author(s)
Kwon W, He J, Higuchi R, Son D, Lee SY, Kim J, Kim H, Kim SW, Wolfgang CL, Cameron JL, Yamamoto M, Jang JY.
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Journal Title
J Hepatobiliary Pancreat Sci
Volume: 25
Issue: 9
Pages: 418-427
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 肝門部胆管癌の切除成績 特に術後門脈血栓について2019
Author(s)
樋口 亮太, 谷澤 武久, 植村 修一郎, 出雲 渉, 長野 恵梨香, 有泉 俊一, 小寺 由人, 太田 岳洋, 古川 徹, 江川 裕人, 山本 雅一
Organizer
日本外科学会定期学術集会
Related Report
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[Presentation] 広範囲胆管癌に対する当科の治療方針の変遷2019
Author(s)
谷澤 武久, 樋口 亮太, 植村 修一郎, 出雲 渉, 向山 美々, 松永 雄太郎, 椎原 正尋, 長野 栄理香, 小寺 由人, 有泉 俊一, 古川 徹, 江川 裕人, 山本 雅一
Organizer
日本外科学会定期学術集会
Related Report
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