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Development of a novel method of prevention for pancreatic fistula using hydrogel sheets

Research Project

Project/Area Number 18K08641
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

Tamura Takafumi  筑波大学, 医学医療系, 研究員 (20633192)

Co-Investigator(Kenkyū-buntansha) 大河内 信弘  筑波大学, 医学医療系, 客員教授 (40213673)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords膵液瘻 / ハイドロゲル / 膵液瘻ラットモデル
Outline of Final Research Achievements

Post operative pancreatic fistula is a serious life-threatening complication, but there is no definitive preventive measure. The effect of the newly developed hydrogel sheet on preventing pancreatic fistula was verified. By dissecting the rat pancreas to create a pancreatic fistula model and attaching a hydrogel sheet to the dissection site, pancreatic fistula could be prevented with a higher effect than existing medical materials. There is no problem with the safety of long-term use in animal experiments, and it will be a new approach for the prevention of pancreatic fistula in the future.

Academic Significance and Societal Importance of the Research Achievements

手術手技が画期的な進歩を遂げた現在の医療においても、膵切除術後の膵液瘻の発生率は依然として高値である。膵液瘻は入院期間の増加や致死的な結果を招くこともあり様々な対策が考えられてきたが根絶に至っていない。生体への安全性を担保した上で高い柔軟性・引張強度を持ち、低い膨潤性と弾力性を併せ持つ新規ハイドロゲル製剤は動物実験において高い精度で膵液瘻を予防しており、今後の外科医療において革新的な方法となり得る。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2021 2019 2018

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] A novel hydrogel sheet prevents postoperative pancreatic fistula in a rat model2021

    • Author(s)
      Akira Kemmochi, Takafumi Tamura, Yoshio Shimizu, Yohei Owada, Yusuke Ozawa, Katsuji Hisakura, Tatsuya Oda, Yayoi Kawano, Takehisa Hanawa, Nobuhiro Ohkohchi
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: Volume28, Issue2 Issue: 2 Pages: 192-201

    • DOI

      10.1002/jhbp.867

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 新規ハイドロゲル製剤の膵液瘻予防効果の検討2019

    • Author(s)
      釼持明
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 新規ハイドロゲル製剤の膵液瘻予防効果の検討2019

    • Author(s)
      釼持明、田村孝史、久倉勝治
    • Organizer
      第119回日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新規ハイドロゲル製剤を用いた膵液瘻治療法の開発2018

    • Author(s)
      釼持明、田村孝史、久倉勝治
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新規ハイドロゲル製剤を用いた膵切除術後の膵液瘻治療2018

    • Author(s)
      釼持明、田村孝史、久倉勝治
    • Organizer
      第73回日本消化器外科学会総会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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