• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Preoperative serum IL-6 concentration associated with CDX2 expression in gastric cancer

Research Project

Project/Area Number 18K08652
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionFukushima Medical University

Principal Investigator

saito motonobu  福島県立医科大学, 医学部, 講師 (90611749)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords胃癌 / CDX2 / IL-6/STAT3シグナル / IL-6/STAT3
Outline of Final Research Achievements

Caudal-type homeobox 2 (CDX2) is a homeobox protein involved in intestinal differentiation, both in normal and aberrant locations. Through this function, CDX2 is associated with inflammation and has a pivotal role in inflammation-related gastric carcinogenesis. In the present study, based on our previous findings, we further explored the inflammation-related carcinogenesis in patients with gastric cancer. Subsequently, to confirm CDX2 suppression due to the IL-6/STAT3 pathway, we investigated the interaction between preoperative serum IL-6 concentration and CDX2 expression in gastric cancer specimens. Consistent with aforementioned in vitro experiment, cases with negative CDX2 expression showed significantly higher IL-6 concentration than those with positive CDX2 expression. This result suggests that CDX2 expression may be suppressed by IL-6 thus contributing to gastric carcinogenesis.

Academic Significance and Societal Importance of the Research Achievements

日本人の癌死の内訳として未だ胃癌の割合は高く、その発生機序を調べることは予防や治療に繋がることから重要な研究の位置を占める。ヘリコバクター・ピロリ菌が胃癌発生に関与することは多くの報告によって明らかとなっており、そのピロリ菌によって発現が調整されるCDX2の胃癌発生に関わる機序を本研究では調べた。その結果、ピロリ菌とCDX2と炎症のメディエーターであるIL-6/STAT3シグナルとの相互関係が明らかとなり、胃癌発生の複雑なメカニズムが多少なりとも紐解かれた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (17 results)

All 2021 2020 2019 2018

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 16 results) Presentation (1 results)

  • [Journal Article] PD-L1 overexpression in EBV-positive gastric cancer is caused by unique genomic or epigenomic mechanisms2021

    • Author(s)
      Nakano Hiroshi、Saito Motonobu、Nakajima Shotaro、Saito Katsuharu、Nakayama Yuko、Kase Koji、Yamada Leo、Kanke Yasuyuki、Hanayama Hiroyuki、Onozawa Hisashi、Okayama Hirokazu、Fujita Shotaro、Sakamoto Wataru、Saze Zenichiro、Momma Tomoyuki、Mimura Kosaku、Ohki Shinji、Goto Akiteru、Kono Koji
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1982-1982

    • DOI

      10.1038/s41598-021-81667-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Collision of Epstein?Barr virus-positive and -negative gastric cancer, diagnosed by molecular analysis: a case report2021

    • Author(s)
      Miyabe Ken、Saito Motonobu、Koyama Kei、Umakoshi Michinobu、Ito Yukinobu、Yoshida Makoto、Kudo-Asabe Yukitsugu、Saito Katsuharu、Nanjo Hiroshi、Maeda Daichi、Matsusaka Keisuke、Goto Akiteru、Kono Koji
    • Journal Title

      BMC Gastroenterology

      Volume: 21 Issue: 1 Pages: 97-97

    • DOI

      10.1186/s12876-021-01683-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Selective sensitivity of EZH2 inhibitors based on synthetic lethality in ARID1A-deficient gastric cancer2020

    • Author(s)
      Yamada Leo、Saito Motonobu、Thar Min Aung Kyi、Saito Katsuharu、Ashizawa Mai、Kase Koji、Nakajima Shotaro、Onozawa Hisashi、Okayama Hirokazu、Endo Hisahito、Fujita Shotaro、Sakamoto Wataru、Saze Zenichiro、Momma Tomoyuki、Mimura Kosaku、Ohki Shinji、Kono Koji
    • Journal Title

      Gastric Cancer

      Volume: 24 Issue: 1 Pages: 60-71

    • DOI

      10.1007/s10120-020-01094-0

    • NAID

      40022454373

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ARID1A deficiency in EBV-positive gastric cancer is partially regulated by EBV-encoded miRNAs, but not by DNA promotor hypermethylation2020

    • Author(s)
      Kase Koji、Saito Motonobu、Nakajima Shotaro、Takayanagi Daisuke、Saito Katsuharu、Yamada Leo、Ashizawa Mai、Nakano Hiroshi、Hanayama Hiroyuki、Onozawa Hisashi、Kono Koji, et al.
    • Journal Title

      Carcinogenesis

      Volume: 42 Issue: 1 Pages: 21-30

    • DOI

      10.1093/carcin/bgaa123

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogeneity of ARID1A expression in gastric cancer may affect patient survival and therapeutic efficacy2020

    • Author(s)
      Saito Motonobu、Kohno Takashi、Kono Koji
    • Journal Title

      Human Pathology

      Volume: 101 Pages: 80-81

    • DOI

      10.1016/j.humpath.2020.04.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microanatomy of inferior mesenteric artery sheath in colorectal cancer surgery2019

    • Author(s)
      Sakamoto Wataru、Yamada Leo、Suzuki Osamu、Kikuchi Tomohiro、Okayama Hirokazu、Endo Hisahito、Fujita Shotaro、Saito Motonobu、Momma Tomoyuki、Saze Zenichiro、Ohki Shinji、Kono Koji
    • Journal Title

      Journal of the Anus, Rectum and Colon

      Volume: 3 Issue: 4 Pages: 167-174

    • DOI

      10.23922/jarc.2019-016

    • NAID

      130007738778

    • ISSN
      2432-3853
    • Year and Date
      2019-10-30
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression profile of CADM1 and CADM4 in triple negative breast cancer with primary systemic therapy2019

    • Author(s)
      Kanke Yasuyuki、Saito Motonobu、Abe Noriko、Saito Katsuharu、Goto Akiteru、Ohtake Tohru、Murakami Yoshinori、Kono Koji
    • Journal Title

      Oncology Letters

      Volume: 17 Pages: 921-926

    • DOI

      10.3892/ol.2018.9727

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] microRNA-148a-3p regulates immunosuppression in DNA mismatch repair-deficient colorectal cancer by targeting PD-L12019

    • Author(s)
      Ashizawa Mai、Okayama Hirokazu、Ishigame Teruhide、Thar Min Aung Kyi、Saito Katsuharu、Ujiie Daisuke、Murakami Yuko、Kikuchi Tomohiro、Nakayama Yuko、Noda Masaru、Tada Takeshi、Endo Hisahito、Fujita Shotaro、Sakamoto Wataru、Saito Motonobu、Saze Zenichiro、Momma Tomoyuki、Ohki Shinji、Mimura Kosaku、Kono Koji
    • Journal Title

      Molecular Cancer Research

      Volume: Epub ahead of print Issue: 6 Pages: 1403-1413

    • DOI

      10.1158/1541-7786.mcr-18-0831

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intestinal Beh?et disease associated with myelodysplastic syndrome accompanying trisomy 8 successfully treated with abdominal surgery followed by hematopoietic stem cell transplantation2019

    • Author(s)
      Asano Tomoyuki、Sato Shuzo、Furuya Makiko Yashiro、Takahashi Hiroshi、Shichishima-Nakamura Akiko、Ohkawara Hiroshi、Fujiwara Tatsuo、Gunji Naohiko、Hashimoto Choichiro、Momma Tomoyuki、Saito Motonobu、Nakano Hiroshi、Watanabe Guy、 et al.
    • Journal Title

      Medicine

      Volume: 98 Issue: 46 Pages: e17979-e17979

    • DOI

      10.1097/md.0000000000017979

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] KRT17 as a prognostic biomarker for stage II colorectal cancer2019

    • Author(s)
      Ujiie Daisuke、Okayama Hirokazu、Saito Katsuharu、Ashizawa Mai、Thar Min Aung Kyi、Endo Eisei、Kase Koji、Yamada Leo、Kikuchi Tomohiro、Hanayama Hiroyuki、Fujita Shotaro、Sakamoto Wataru、Endo Hisahito、Saito Motonobu、Mimura Kosaku、Saze Zenichiro、Momma Tomoyuki、Ohki Shinji、Kono Koji
    • Journal Title

      Carcinogenesis

      Volume: 0 Issue: 5 Pages: 0-0

    • DOI

      10.1093/carcin/bgz192

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A subset of patients with MSS/MSI?low?colorectal cancer showed increased CD8(+) TILs together with up?regulated IFN?γ2019

    • Author(s)
      Kikuchi Tomohiro、Mimura Kosaku、Okayama Hirokazu、Nakayama Yuko、Saito Katsuharu、Yamada Leo、Endo Eisei、Sakamoto Wataru、Fujita Shotaro、Endo Hisahito、Saito Motonobu、Momma Tomoyuki、Saze Zenichiro、Ohki Shinji、Kono Koji
    • Journal Title

      Oncology Letters

      Volume: 66 Pages: 10-66

    • DOI

      10.3892/ol.2019.10953

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Nucleolar Stress?Specific p53?miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network2018

    • Author(s)
      Fujiwara Yuko、Saito Motonobu、Robles Ana I.、Nishida Momoyo、Takeshita Fumitaka、Watanabe Masatoshi、Ochiya Takahiro、Yokota Jun、Kohno Takashi、Harris Curtis C.、Tsuchiya Naoto
    • Journal Title

      EBioMedicine

      Volume: 33 Pages: 33-48

    • DOI

      10.1016/j.ebiom.2018.06.031

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells2018

    • Author(s)
      Shimura Tatsuo、Shibata Masahiko、Gonda Kenji、Hayase Suguru、Sakamoto Wataru、Okayama Hirokazu、Fujita Shotaro、Saito Motonobu、Momma Tomoyuki、Ohki Shinji、Kono Koji
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 64 Issue: 2 Pages: 64-72

    • DOI

      10.5387/fms.2018-10

    • NAID

      130007469562

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer2018

    • Author(s)
      Noda Masaru、Okayama Hirokazu、Kofunato Yasuhide、Chida Shun、Saito Katsuharu、Tada Takeshi、Ashizawa Mai、Nakajima Takahiro、Aoto Keita、Kikuchi Tomohiro、Sakamoto Wataru、Endo Hisahito、Fujita Shotaro、Saito Motonobu、Momma Tomoyuki、Ohki Shinji、Kono Koji
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: 315-315

    • DOI

      10.1371/journal.pone.0200315

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma2018

    • Author(s)
      Thar Min Aung Kyi、Okayama Hirokazu、Saito Motonobu、Ashizawa Mai、Aoto Keita、Nakajima Takahiro、Saito Katsuharu、Hayase Suguru、Sakamoto Wataru、Tada Takeshi、Hanayama Hiroyuki、Saze Zenichirou、Momma Tomoyuki、Ohki Shinji、Sato Yusuke、Motoyama Satoru、Mimura Kosaku、Kono Koji
    • Journal Title

      Cancer Medicine

      Volume: 7 Issue: 7 Pages: 3321-3330

    • DOI

      10.1002/cam4.1564

    • NAID

      120007126995

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Augmentation of antibody-dependent cellular cytotoxicity with defucosylated monoclonal antibodies in patients with GI-tract cancer2018

    • Author(s)
      Nakajima Takahiro、Okayama Hirokazu、Ashizawa Mai、Noda Masaru、Aoto Keita、Saito Motonobu、Monma Tomoyuki、Ohki Shinji、Shibata Masahiko、Takenoshita Seiichi、Kono Koji
    • Journal Title

      Oncology Letters

      Volume: 15 Pages: 2604-2610

    • DOI

      10.3892/ol.2017.7556

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 胃癌発生に関与するCDX2とIL-6/STAT3シグナルの検討2020

    • Author(s)
      山田玲央、齋藤元伸、遠藤英成、加瀬晃志、菅家康之、渡辺洋平、花山寛之、小野澤寿志、岡山洋和、坂本渉、藤田正太郎、佐瀬善一郎、門馬智之、三村耕作、河野浩二
    • Organizer
      第31回消化器癌発生学会総会
    • Related Report
      2020 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi