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Search for novel compounds that can ameliorate NAFLD and search for pathology-specific biomarkers

Research Project

Project/Area Number 18K08654
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionOsaka City University

Principal Investigator

TAKEMURA Shigekazu  大阪市立大学, 大学院医学研究科, 講師 (00322363)

Co-Investigator(Kenkyū-buntansha) 南山 幸子  京都府立大学, 生命環境科学研究科, 教授 (00362989)
久保 正二  大阪市立大学, 大学院医学研究科, 准教授 (80221224)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords非アルコール性脂肪性肝炎 / 線維化 / アリルシステイン / セラミド / 脂肪性肝炎 / 肝線維化 / 非アルコール性脂肪性肝疾患 / バイオマーカー / マクロファージ
Outline of Final Research Achievements

In this study, we investigated the effect of S-allyl glutathione (SAG) on the progression of NAFLD/NASH via suppression of macrophage polarization. First, we were able to induce NAFLD by high-fat diet using a rat NAFLD model that is more in line with clinical conditions. As a result of quantitative analysis of ceramide in the liver, there was no difference in the total amount of ceramide between the various groups. On the other hand, the percentage of specific ceramide molecular species was found to be highly variable in NAFLD. Histologically, the fat droplets in the hepatocytes were reduced in size after SAG treatment. At the same time, we confirmed that SAG treatment reduced pro-inflammatory and anti-inflammatory cytokines and caused a significant decrease in fibrosis markers.

Academic Significance and Societal Importance of the Research Achievements

低分子化合物であるSAGは、マクロファージの分極制御を介してNAFLDにおける炎症応答を軽減し、筋線維芽細胞の活性化を制御、線維化を改善することによってNAFLD病態を改善する作用を有することが判明した。一方、脂質組成に影響されるセラミドの分子種をNAFLDの病態のバイオマーカーとする可能性が確認されたがその詳細はさらなる検討が必要である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (53 results)

All 2021 2020 2019 2018 2017

All Journal Article (33 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 33 results,  Open Access: 22 results) Presentation (15 results) (of which Int'l Joint Research: 7 results) Book (5 results)

  • [Journal Article] Intrahepatic cholangiocarcinoma with a tumor thrombus extending from the inferior vena cava to the right atrium: a case report2021

    • Author(s)
      Hamano Genya、Takemura Shigekazu、Tanaka Shogo、Shinkawa Hiroji、Aota Takanori、Fujii Hiromichi、Murakami Takashi、Kuwae Yuko、Kubo Shoji
    • Journal Title

      Surgical Case Reports

      Volume: 7 Issue: 1 Pages: 3-3

    • DOI

      10.1186/s40792-020-01085-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between the confluent form of pancreatic and bile duct and histopathological findings in pancreaticobiliary maljunction: A case series study2021

    • Author(s)
      Horiike Masaki、Morotomi Yoshiki、Takemura Shigekazu、Tanaka Shogo、Shinkawa Hiroji、Hashimoto Shigeo、Wakasa Kenichi、Kubo Shoji
    • Journal Title

      Annals of Medicine and Surgery

      Volume: 63 Pages: 102180-102180

    • DOI

      10.1016/j.amsu.2021.102180

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nomograms predicting extra- and early intrahepatic recurrence after hepatic resection of hepatocellular carcinoma2021

    • Author(s)
      Shinkawa Hiroji、Tanaka Shogo、Takemura Shigekazu、Amano Ryosuke、Kimura Kenjiro、Kinoshita Masahiko、Takahashi Kanae、Matsuzaki Shuichiro、Kubo Shoji
    • Journal Title

      Surgery

      Volume: 169 Issue: 4 Pages: 922-928

    • DOI

      10.1016/j.surg.2020.10.012

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020496

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Durable response after discontinuation of pembrolizumab therapy for intrahepatic cholangiocarcinoma: a case report2021

    • Author(s)
      Eguchi Shimpei、Shinkawa Hiroji、Sato Yasunori、Nakai Kozo、Takemura Shigekazu、Tanaka Shogo、Amano Ryosuke、Kimura Kenjiro、Ohira Go、Nishio Kohei、Kinoshita Masahiko、Tauchi Jun、Miyazaki Toru、Ishihara Atsushi、Shirai Daisuke、Kubo Shoji
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: - Issue: 3 Pages: 858-865

    • DOI

      10.1007/s12328-021-01396-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Food additive-induced oxidative stress in rat male reproductive organs and hippocampus2021

    • Author(s)
      Minamiyama Yukiko、Takemura Shigekazu、Ichikawa Hiroshi
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 701 Pages: 108810-108810

    • DOI

      10.1016/j.abb.2021.108810

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Bisphenol A on Oxidative Stress in the Rat Brain2020

    • Author(s)
      Kobayashi Keiko、Liu Yanchen、Ichikawa Hiroshi、Takemura Shigekazu、Minamiyama Yukiko
    • Journal Title

      Antioxidants

      Volume: 9 Issue: 3 Pages: 240-240

    • DOI

      10.3390/antiox9030240

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive Value of the Age-Adjusted Charlson Comorbidity Index for Outcomes After Hepatic Resection of Hepatocellular Carcinoma2020

    • Author(s)
      Shinkawa H, Tanaka S, Takemura S, Amano R, Kimura K, Nishioka T, Miyazaki T, Kubo S
    • Journal Title

      World Journal of Surgery

      Volume: 44 Issue: 11 Pages: 3901-3914

    • DOI

      10.1007/s00268-020-05686-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical outcomes for hepatocellular carcinoma detected after hepatitis C virus eradiation by direct-acting antivirals2020

    • Author(s)
      Tanaka S, Shinkawa H, Tamori A, Takemura S, Takahashi S, Amano R, Kimura K, Ohira G, Kawada N, Kubo S
    • Journal Title

      Journal of Surgical Oncology

      Volume: 122 Issue: 8 Pages: 1543-1552

    • DOI

      10.1002/jso.26184

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunosuppressive tumor microenvironment in occupational cholangiocarcinoma: Supportive evidence for the efficacy of immune checkpoint inhibitor therapy2020

    • Author(s)
      Sato Yasunori, Tanaka Shogo, Kinoshita Masahiko, Takemura Shigekazu, Shinkawa Hiroji, Kokudo Takashi, Hasegawa Kiyoshi, Tanaka Hiromu, Yoshimoto Hidero, Mori Akira, Yamamura Minako, Sasaki Motoko, Harada Kenichi, Kubo Shoji
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 27 Issue: 11 Pages: 860-869

    • DOI

      10.1002/jhbp.788

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic value of expanded liver transplantation criteria-the 5-5-500 rule-in patients with hepatic resection for intermediate-stage hepatocellular carcinoma2020

    • Author(s)
      Shinkawa H, Tanaka S, Takemura S, Amano R, Kimura K, Kinoshita M, Miyazaki T, Kubo S
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 27 Issue: 10 Pages: 682-689

    • DOI

      10.1002/jhbp.792

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mortality analysis of Aeromonas hydrophila infection in hepato-biliary pancreatic surgery: Multicenter retrospective observational study2020

    • Author(s)
      Ueno M, Iida H, Kaibori M, Komeda K, Takemura S, Noda T, Ikoma H, Nomi T, Hayami S, Hirokawa F, Tanaka S, Matsui K, Ishizaki M, Morimura R, Hokuto D, Eguchi H, Tani M, Yamaue H, Kubo S
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 27 Issue: 10 Pages: 747-755

    • DOI

      10.1002/jhbp.805

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New Hepatic Resection Criteria for Intermediate-Stage Hepatocellular Carcinoma Can Improve Long-Term Survival: A Retrospective, Multicenter Collaborative Study2020

    • Author(s)
      Iida H, Kaibori M, Hirokawa F, Inoue Y, Ueno M, Matsui K, Ishizaki M, Tanaka S, Takemura S, Nomi T, Hokutou D, Noda T, Eguchi H, Nakai T, Maehira H, Mori H, Tani M, Kubo S.
    • Journal Title

      Asian Pac J Cancer Prev

      Volume: 21 Issue: 10 Pages: 2903-2911

    • DOI

      10.31557/apjcp.2020.21.10.2903

    • NAID

      120006901560

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of the Preoperative C-reactive Protein to Albumin Ratio on the Long-Term Outcomes of Hepatic Resection for Intrahepatic Cholangiocarcinoma2020

    • Author(s)
      Ito Tokuji、Shinkawa Hiroji、Takemura Shigekazu、Tanaka Shogo、Nishioka Takayoshi、Miyazaki Toru、Ishihara Atsushi、Kubo Shoji
    • Journal Title

      Asian Pacific Journal of Cancer Prevention

      Volume: 21 Issue: 8 Pages: 2373-2379

    • DOI

      10.31557/apjcp.2020.21.8.2373

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Precancerous Lesions and Liver Atrophy as Risk Factors for Hepatolithiasis-Related Death after Liver Resection for Hepatolithiasis2020

    • Author(s)
      Miyazaki Toru、Shinkawa Hiroji、Takemura Shigekazu、Tanaka Shogo、Amano Ryosuke、Kimura Kenjiro、Ohira Go、Nishio Kohei、Kinoshita Masahiko、Tsuchi Jun、Ishihara Atsushi、Eguchi Shimpei、Shirai Daisuke、Yamamoto Takatsugu、Wakasa Kenichi、Kawada Norifumi、Kubo Shoji
    • Journal Title

      Asian Pacific Journal of Cancer Prevention

      Volume: 21 Issue: 12 Pages: 3647-3654

    • DOI

      10.31557/apjcp.2020.21.12.3647

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Idenitification of factors predicting the onset of gallbladder cancer complicated with pancreatobiliary maljuntion2020

    • Author(s)
      Horiike M, Morotomi Y, Takemura S, Tanaka S, Shinkawa H, Shibata T, Kubo S
    • Journal Title

      Osaka City Medical Journal

      Volume: 66 Pages: 49-57

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Actions of various sweeteners on rat sperm.2020

    • Author(s)
      Minamiyama Y, Kobayashi K, Noguchi Y, Takemura S, Ichikawa H.
    • Journal Title

      Glycative Stress Research

      Volume: 7 Pages: 132-141

    • NAID

      130007882255

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-term administration of prophylactic antibiotics in patients undergoing open and laparoscopic hepatic resection2020

    • Author(s)
      Shinkawa H, Tanaka S, Takemura S, Amano R, Kimura K, Nishioka T, Ito T, Miyazaki T, Ishihara A, Kubo S
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor size drives the prognosis after hepatic resection of solitary hepatocellular carcinoma without vascular invasion2020

    • Author(s)
      Shinkawa H, Tanaka S, Takemura S, Ishihara T, Yamamoto K, Kubo S
    • Journal Title

      Journal of Gastrointestinal Surgery

      Volume: 24 Issue: 5 Pages: 1040-1048

    • DOI

      10.1007/s11605-019-04273-2

    • NAID

      120006872634

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019979

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Outcomes of non-B non-C hepatocellular carcinoma with reference to patients with Interferon-Induced hepatitis C virus eradication2019

    • Author(s)
      Shinkawa H, Tanaka S, Takemura S, Ito T, Aota T, Miyazaki T, Kubo S
    • Journal Title

      Journal of Gastrointestinal Surgery

      Volume: - Issue: 8 Pages: 1809-1817

    • DOI

      10.1007/s11605-019-04339-1

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multifocal origin of occupational cholangiocarcinoma revealed by comparison of multilesion mutational profiles2019

    • Author(s)
      Mimaki Sachiyo、Watanabe Masahiko、Kinoshita Masahiko、Yamashita Riu、Haeno Hiroshi、Takemura Shigekazu、Tanaka Shogo、Marubashi Shigeru、Totsuka Yukari、Shibata Tatsuhiro、Nakagama Hitoshi、Ochiai Atsushi、Nakamori Shoji、Kubo Shoji、Tsuchihara Katsuya
    • Journal Title

      Carcinogenesis

      Volume: - Issue: 3 Pages: 368-376

    • DOI

      10.1093/carcin/bgz120

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difficulty classifications of laparoscopic repeated liver resection in patients with recurrent hepatocellular carcinoma2019

    • Author(s)
      Kinoshita Masahiko、Kanazawa Akishige、Kodai Shintaro、Shimizu Sadatoshi、Murata Akihiro、Nishio Kohei、Hamano Genya、Shinkawa Hiroji、Tanaka Shogo、Takemura Shigekazu、Tsukamoto Tadashi、Kubo Shoji
    • Journal Title

      Asian Journal of Endoscopic Surgery

      Volume: - Issue: 3 Pages: 366-374

    • DOI

      10.1111/ases.12746

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A phase I study for adjuvant chemotherapy of gemcitabine plus S-1 in patients with biliary tract cancer undergoing curative resection without major hepatectomy (KHBO1202)2018

    • Author(s)
      Yanagimoto Hiroaki、Toyokawa Hideyoshi、Sakai Daisuke、Wada Hiroshi、Satoi Sohei、Yamamoto Tomohisa、Nagano Hiroaki、Toyoda Masanori、Ajiki Tetsuo、Satake Hironaga、Tsuji Akihito、Miyamoto Atsushi、Tsujie Masanori、Takemura Shigekazu、Yanagihara Kazuhiro、Ioka Tatsuya
    • Journal Title

      Cancer Chemotherapy and Pharmacology

      Volume: 81 Issue: 3 Pages: 461-468

    • DOI

      10.1007/s00280-017-3513-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Stagnation of histopathological improvement is a predictor of hepatocellular carcinoma development after hepatitis C virus eradication2018

    • Author(s)
      Motoyama H, Tamori A, Kubo S, Uchida-Kobayashi S, Takemura S, Tanaka S, Ohfuji S, Teranishi Y, Kozuka R, Kawamura E, Hagihara A, Morikawa H, Enomoto M, Murakami Y, Kawada N.
    • Journal Title

      PLoS One.

      Volume: 13 Issue: 3 Pages: e0194163

    • DOI

      10.1371/journal.pone.0194163

    • NAID

      120006411697

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2020442

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Obesity and recurrence-free survival in patients with hepatocellular carcinoma after achieving sustained virological response to interferon therapy for chronic hepatitis C2018

    • Author(s)
      Shinkawa Hiroji、Tanaka Shogo、Takemura Shigekazu、Ito Tokuji、Aota Takanori、Koda Masaki、Miyazaki Toru、Yamamoto Takatsugu、Kubo Shoji
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: 2 Issue: 4 Pages: 319-326

    • DOI

      10.1002/ags3.12183

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pirfenidone suppresses polarization to M2 phenotype macrophages and the fibrogenic activity of rat lung fibroblasts2018

    • Author(s)
      Toda Michihito、Mizuguchi Shinjiro、Minamiyama Yukiko、Yamamoto-Oka Hiroko、Aota Takanori、Kubo Shoji、Nishiyama Noritoshi、Shibata Toshihiko、Takemura Shigekazu
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 63 Issue: 1 Pages: 58-65

    • DOI

      10.3164/jcbn.17-111

    • NAID

      130007387138

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-Term Prognostic Factors after Hepatic Resection for Hepatitis C Virus-Related Hepatocellular Carcinoma, with a Special Reference to Viral Status2018

    • Author(s)
      Koda Masaki、Tanaka Shogo、Takemura Shigekazu、Shinkawa Hiroji、Kinoshita Masahiko、Hamano Genya、Ito Tokuji、Kawada Norifumi、Shibata Toshihiko、Kubo Shoji
    • Journal Title

      Liver Cancer

      Volume: 7 Issue: 3 Pages: 261-276

    • DOI

      10.1159/000486902

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Operative outcomes after laparoscopic splenectomy with special reference to prophylactic antibiotics2018

    • Author(s)
      Matsuda Tsunemi、Kubo Shoji、Ueno Masaki、Takifuji Katsunari、Yamaue Hiroki、Takemura Shigekazu、Tanaka Shogo、Shinkawa Hiroji、Yamada Koichi、Kakeya Hiroshi
    • Journal Title

      Asian Journal of Endoscopic Surgery

      Volume: 12 Issue: 4 Pages: 380-387

    • DOI

      10.1111/ases.12661

    • NAID

      120006900914

    • URL

      https://ocu-omu.repo.nii.ac.jp/records/2019651

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pirfenidone suppresses polarization to M2 phenotype macrophages and the fibrogenic activity of rat lung fibroblasts.2018

    • Author(s)
      Toda M, Mizuguchi S, Minamiyama Y, Yamamoto-Oka H, Aota T, Kubo S, Nishiyama N, Shibata T, Takemura S.
    • Journal Title

      J Clin Biochem Nutr.

      Volume: 63 Pages: 58-65

    • DOI

      10.1016/j.ejphar.2019.02.006

    • NAID

      130007387138

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-term outcomes after biliary diversion operation for pancreaticobiliary maljunction in adult patients2018

    • Author(s)
      Aota T, Kubo S, Takemura S, Tanaka S, Amano R, Kimura K, Yamazoe S, Shinkawa H, Ohira G, Shibata T, Horiike M
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: 3 Issue: 2 Pages: 217-223

    • DOI

      10.1002/ags3.12239

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Indications for laparoscopic liver resection of mass-forming intrahepatic cholangiocarcinoma2018

    • Author(s)
      Kinoshita M, Kanazawa A, Takemura S, Tanaka S, Kodai S, Shinkawa H, Shimizu S, Murata A, Nishio K, Hamano G, Ito T, Tsukamoto T, Kubo S
    • Journal Title

      Asian Journal of Endoscopic Surgery

      Volume: - Issue: 1 Pages: 46-58

    • DOI

      10.1111/ases.12703

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perioperative allogenic blood transfusion is a poor prognostic factor after hepatocellular carcinoma surgery: a multi-center analysis2017

    • Author(s)
      Wada Hiroshi、Eguchi Hidetoshi、Nagano Hiroaki、Kubo Shoji、Nakai Takuya、Kaibori Masaki、Hayashi Michihiro、Takemura Shigekazu、Tanaka Shogo、Nakata Yasuyuki、Matsui Kosuke、Ishizaki Morihiko、Hirokawa Fumitoshi、Komeda Koji、Uchiyama Kazuhisa、Kon Masanori、Doki Yuichiro、Mori Masaki
    • Journal Title

      Surgery Today

      Volume: 48 Issue: 1 Pages: 73-79

    • DOI

      10.1007/s00595-017-1553-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Carbon monoxide-releasing molecule, CORM-3, modulates alveolar macrophage M1/M2 phenotype in vitro2017

    • Author(s)
      Yamamoto-Oka Hiroko、Mizuguchi Shinjiro、Toda Michihito、Minamiyama Yukiko、Takemura Shigekazu、Shibata Toshihiko、Cepinskas Gediminas、Nishiyama Noritoshi
    • Journal Title

      Inflammopharmacology

      Volume: 26 Issue: 2 Pages: 435-445

    • DOI

      10.1007/s10787-017-0371-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] S-allyl-glutathione improves experimental liver fibrosis by regulating Kupffer cell activation in rats.2017

    • Author(s)
      Takemura S, Azuma H, Osada-Oka M, Kubo S, Shibata T, Minamiyama Y.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 314(2) Issue: 2 Pages: G150-G163

    • DOI

      10.1152/ajpgi.00023.2017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Impact of laparoscopic liver resection for hepatocellular carcinoma on the development of postoperative complication2020

    • Author(s)
      Shirai D, Shinkawa H, Takemura S, Tanaka S, Amano R, Kimura K, Yamazoe S, Ohira G, Nishioka T, Tauchi J, Miyazaki T, Ishihara A, Eguchi S, Kubo S
    • Organizer
      Asian Pacific Association for the Study of the Liver 2020 Annual Meeting (APASL2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Tumor size and survival outcomes after liver resection in patients with a solitary hepatocellular carcinoma without macroscopic vascular invasion2020

    • Author(s)
      Shinkawa H, Tanaka S, Takemura S, Amano R, Kimura K, Yamazoe S, Ohira G, Nishioka T, Tauchi J, Miyazaki T, Ishihara A, Eguchi S, Shirai D, Kubo S
    • Organizer
      Asian Pacific Association for the Study of the Liver 2020 Annual Meeting (APASL2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Efficacy of re-TACE after Lenvatinib treatment for TACE-refractory hepatocellular carcinima2020

    • Author(s)
      Uchida-Kobayashi S, Kageyama K, Yamamoto A, Odagiri N, Yoshida K, Kotani K, Motoyama H, Kawamura E, Hahihara A, Fujii H, Enomoto M, Tamori A, Takemura S, Kubo S, Miki Y, Kawada N
    • Organizer
      Asian Pacific Association for the Study of the Liver 2020 Annual Meeting (APASL2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Genetic profiling using resected samples of juvenile-onset human cholangiocarcinoma: SKI gene regulates expressions of ERK1/2 and p21 resulating in cell cylce inhaibition2020

    • Author(s)
      Kawamura E, Matsubara T, Higuchi M, Daikoku A, Takada S, Deguchi A, Odagiri N, Ito T, Kinoshita M, Yuasa H, Urushima H, Sato-Matsubara M, Tanaka S, Takemura S, Iwaisako K, Enomoto M, Murakami Y, Taguchi Y, Tamori A, Kubo S, Ikeda K, Kawada N
    • Organizer
      Asian Pacific Association for the Study of the Liver 2020 Annual Meeting (APASL2020)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Age-adjusted Charlson-Comorbidity Index predicts short-term and long-term outcomes after hepatic resection of hepatocellular carcinoma2020

    • Author(s)
      Shinkawa H,Tanaka S, Takemura S, Amano R, Kimura K, Yamazoe S, Ohira G, Nishioka T, Kubo S
    • Organizer
      IHPBA 2021 Virtual Congress
    • Related Report
      2020 Annual Research Report
  • [Presentation] Exposome-induced oxidative stress and protective effects of antioxidants in rats2019

    • Author(s)
      Minamiyama Y, Kobayashi K, Kawatani R, Ichikawa H, Takemura S, Fuhua Y, Inufusa H, Yoshikawa T
    • Organizer
      2019 Sustainable Industrial Processing Summit and Exhibition
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] S-allyl-glutathione regulates macrophage polarization in rats2019

    • Author(s)
      Minamiyama Y, Takemura S, Mizushima K, Ara T, Ichikawa H, Kubo S
    • Organizer
      The Society for Redox Biology and Medicine's 26th Annual Conference(SfRBM 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of a new rat model to assess the acute exacerbation of pulmonary fibrosis.2019

    • Author(s)
      Miyamoto H, Takemura S, Tsukioka T, Toda M, Minamiyama Y
    • Organizer
      The Society for Redox Biology and Medicine's 26th Annual Conference(SfRBM 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Exposome-induced oxidative stress on both epididymis and hippocampus in rats2019

    • Author(s)
      Minamiyama Y, Kobayashi K, Kawatani R, Osada-Oka M, Takemura S, Ichikawa H
    • Organizer
      The 7th International Conference on Food Factors/The 12th International Conference and Exhibition on Nutraceuticals and Functional Foods(ICoFF2019/ISNFF2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinicopathological features and outcomes in patients with non-B, non-C hepatocellular carcinoma and hepatitis C-related hepatocellular carcinoma2018

    • Author(s)
      Shinkawa H, Tanaka S, Takemura S, Ito T, Aota T, Koda M, Miyazaki T, Kubo S
    • Organizer
      The 30th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery
    • Related Report
      2018 Research-status Report
  • [Presentation] Survival outcomes of non-B, non-C hepatocellular carcinoma with reference to hepatitis C-related hepatocellular carcinoma2018

    • Author(s)
      Shinkawa H, Tanaka S, Takemura S, Ito T, Aota T, Koda M, Miyazaki T, Kubo S
    • Organizer
      13th IHPBA World Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Clinical features and surgical treatment outcome in HCC patients with tumor thrombus expanding to inferior vena cava or right atrium2018

    • Author(s)
      Takemura S
    • Organizer
      The 8th Japan-Chaina Hepato-Pancreato-Biliary Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] New criteria of hepatectomy for multiple hepatocellular carcinoma to be expected for long-term survival ―Multicenter collaborative research―2018

    • Author(s)
      Iida H, Kaibori M, Hirokawa F, Inoue Y, Ueno M, Matsui K, Ishizaki M, Tanaka S, Takemura S, Nomi T, Hokutou D, Noda T, Eguchi H, Nakai T, Maehira H, Mori H, Tani M, Kubo S
    • Organizer
      Advances in Liver Surgery-Wakayama Medical University International Symposium in 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 進行肝細胞癌に対する外科切除術後の予後の変遷と集学的治療の影響2018

    • Author(s)
      竹村茂一,田中肖吾,新川寛二,伊藤得路,江田将樹,青田尚哲,宮崎 徹,久保正二
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] マクロファージ分極制御による臓器線維化治療薬の開発 -ラット肝線維化モデルにおけるS-アリルグルタチオンの効果-2018

    • Author(s)
      竹村茂一,南山幸子,青田尚哲,戸田道仁,岡 真優子,小林慧子,宮本 光,久保正二
    • Organizer
      第71回日本酸化ストレス学会学術集会
    • Related Report
      2018 Research-status Report
  • [Book] 別冊日本臨床 肝・胆道系症候群(第3版) 肝臓編(上)2021

    • Author(s)
      田中肖吾,竹村茂一,新川寛二,天野良亮,久保正二
    • Publisher
      日本臨牀社
    • Related Report
      2020 Annual Research Report
  • [Book] 別冊日本臨床 肝・胆道系症候群(第4版) 肝臓編(上)2021

    • Author(s)
      竹村茂一,久保正二
    • Publisher
      日本臨牀社
    • Related Report
      2020 Annual Research Report
  • [Book] 手術2021

    • Author(s)
      木下正彦、金沢景繁、竹村茂一、田中肖吾、新川寛二、久保正二
    • Publisher
      金原出版
    • Related Report
      2020 Annual Research Report
  • [Book] 手術2019

    • Author(s)
      竹村茂一、久保正二
    • Total Pages
      11
    • Publisher
      金原出版株式会社
    • Related Report
      2018 Research-status Report
  • [Book] 臨床消化器内科2018

    • Author(s)
      久保正二、竹村茂一、田中肖吾、新川寛二
    • Total Pages
      6
    • Publisher
      (株)日本メディカルセンター
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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