Search for novel compounds that can ameliorate NAFLD and search for pathology-specific biomarkers
Project/Area Number |
18K08654
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 55020:Digestive surgery-related
|
Research Institution | Osaka City University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
南山 幸子 京都府立大学, 生命環境科学研究科, 教授 (00362989)
久保 正二 大阪市立大学, 大学院医学研究科, 准教授 (80221224)
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 非アルコール性脂肪性肝炎 / 線維化 / アリルシステイン / セラミド / 脂肪性肝炎 / 肝線維化 / 非アルコール性脂肪性肝疾患 / バイオマーカー / マクロファージ |
Outline of Final Research Achievements |
In this study, we investigated the effect of S-allyl glutathione (SAG) on the progression of NAFLD/NASH via suppression of macrophage polarization. First, we were able to induce NAFLD by high-fat diet using a rat NAFLD model that is more in line with clinical conditions. As a result of quantitative analysis of ceramide in the liver, there was no difference in the total amount of ceramide between the various groups. On the other hand, the percentage of specific ceramide molecular species was found to be highly variable in NAFLD. Histologically, the fat droplets in the hepatocytes were reduced in size after SAG treatment. At the same time, we confirmed that SAG treatment reduced pro-inflammatory and anti-inflammatory cytokines and caused a significant decrease in fibrosis markers.
|
Academic Significance and Societal Importance of the Research Achievements |
低分子化合物であるSAGは、マクロファージの分極制御を介してNAFLDにおける炎症応答を軽減し、筋線維芽細胞の活性化を制御、線維化を改善することによってNAFLD病態を改善する作用を有することが判明した。一方、脂質組成に影響されるセラミドの分子種をNAFLDの病態のバイオマーカーとする可能性が確認されたがその詳細はさらなる検討が必要である。
|
Report
(4 results)
Research Products
(53 results)
-
-
-
-
-
-
-
-
-
[Journal Article] Immunosuppressive tumor microenvironment in occupational cholangiocarcinoma: Supportive evidence for the efficacy of immune checkpoint inhibitor therapy2020
Author(s)
Sato Yasunori, Tanaka Shogo, Kinoshita Masahiko, Takemura Shigekazu, Shinkawa Hiroji, Kokudo Takashi, Hasegawa Kiyoshi, Tanaka Hiromu, Yoshimoto Hidero, Mori Akira, Yamamura Minako, Sasaki Motoko, Harada Kenichi, Kubo Shoji
-
Journal Title
Journal of Hepato-Biliary-Pancreatic Sciences
Volume: 27
Issue: 11
Pages: 860-869
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Mortality analysis of Aeromonas hydrophila infection in hepato-biliary pancreatic surgery: Multicenter retrospective observational study2020
Author(s)
Ueno M, Iida H, Kaibori M, Komeda K, Takemura S, Noda T, Ikoma H, Nomi T, Hayami S, Hirokawa F, Tanaka S, Matsui K, Ishizaki M, Morimura R, Hokuto D, Eguchi H, Tani M, Yamaue H, Kubo S
-
Journal Title
J Hepatobiliary Pancreat Sci
Volume: 27
Issue: 10
Pages: 747-755
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] New Hepatic Resection Criteria for Intermediate-Stage Hepatocellular Carcinoma Can Improve Long-Term Survival: A Retrospective, Multicenter Collaborative Study2020
Author(s)
Iida H, Kaibori M, Hirokawa F, Inoue Y, Ueno M, Matsui K, Ishizaki M, Tanaka S, Takemura S, Nomi T, Hokutou D, Noda T, Eguchi H, Nakai T, Maehira H, Mori H, Tani M, Kubo S.
-
Journal Title
Asian Pac J Cancer Prev
Volume: 21
Issue: 10
Pages: 2903-2911
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Stagnation of histopathological improvement is a predictor of hepatocellular carcinoma development after hepatitis C virus eradication.2018
Author(s)
Motoyama H, Tamori A, Kubo S, Uchida-Kobayashi S, Takemura S, Tanaka S, Ohfuji S, Teranishi Y, Kozuka R, Kawamura E, Hagihara A, Morikawa H, Enomoto M, Murakami Y, Kawada N.
-
Journal Title
PLoS One.
Volume: 13
Issue: 3
Pages: 0194163-0194163
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
[Journal Article] Long-term outcomes after biliary diversion operation for pancreaticobiliary maljunction in adult patients2018
Author(s)
Aota T, Kubo S, Takemura S, Tanaka S, Amano R, Kimura K, Yamazoe S, Shinkawa H, Ohira G, Shibata T, Horiike M
-
Journal Title
Annals of Gastroenterological Surgery
Volume: 3
Issue: 2
Pages: 217-223
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Indications for laparoscopic liver resection of mass-forming intrahepatic cholangiocarcinoma2018
Author(s)
Kinoshita M, Kanazawa A, Takemura S, Tanaka S, Kodai S, Shinkawa H, Shimizu S, Murata A, Nishio K, Hamano G, Ito T, Tsukamoto T, Kubo S
-
Journal Title
Asian Journal of Endoscopic Surgery
Volume: -
Issue: 1
Pages: 46-58
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Presentation] Impact of laparoscopic liver resection for hepatocellular carcinoma on the development of postoperative complication2020
Author(s)
Shirai D, Shinkawa H, Takemura S, Tanaka S, Amano R, Kimura K, Yamazoe S, Ohira G, Nishioka T, Tauchi J, Miyazaki T, Ishihara A, Eguchi S, Kubo S
Organizer
Asian Pacific Association for the Study of the Liver 2020 Annual Meeting (APASL2020)
Related Report
-
[Presentation] Tumor size and survival outcomes after liver resection in patients with a solitary hepatocellular carcinoma without macroscopic vascular invasion2020
Author(s)
Shinkawa H, Tanaka S, Takemura S, Amano R, Kimura K, Yamazoe S, Ohira G, Nishioka T, Tauchi J, Miyazaki T, Ishihara A, Eguchi S, Shirai D, Kubo S
Organizer
Asian Pacific Association for the Study of the Liver 2020 Annual Meeting (APASL2020)
Related Report
-
[Presentation] Efficacy of re-TACE after Lenvatinib treatment for TACE-refractory hepatocellular carcinima2020
Author(s)
Uchida-Kobayashi S, Kageyama K, Yamamoto A, Odagiri N, Yoshida K, Kotani K, Motoyama H, Kawamura E, Hahihara A, Fujii H, Enomoto M, Tamori A, Takemura S, Kubo S, Miki Y, Kawada N
Organizer
Asian Pacific Association for the Study of the Liver 2020 Annual Meeting (APASL2020)
Related Report
-
[Presentation] Genetic profiling using resected samples of juvenile-onset human cholangiocarcinoma: SKI gene regulates expressions of ERK1/2 and p21 resulating in cell cylce inhaibition2020
Author(s)
Kawamura E, Matsubara T, Higuchi M, Daikoku A, Takada S, Deguchi A, Odagiri N, Ito T, Kinoshita M, Yuasa H, Urushima H, Sato-Matsubara M, Tanaka S, Takemura S, Iwaisako K, Enomoto M, Murakami Y, Taguchi Y, Tamori A, Kubo S, Ikeda K, Kawada N
Organizer
Asian Pacific Association for the Study of the Liver 2020 Annual Meeting (APASL2020)
Related Report
-
-
-
-
-
-
-
-
-
[Presentation] New criteria of hepatectomy for multiple hepatocellular carcinoma to be expected for long-term survival ―Multicenter collaborative research―2018
Author(s)
Iida H, Kaibori M, Hirokawa F, Inoue Y, Ueno M, Matsui K, Ishizaki M, Tanaka S, Takemura S, Nomi T, Hokutou D, Noda T, Eguchi H, Nakai T, Maehira H, Mori H, Tani M, Kubo S
Organizer
Advances in Liver Surgery-Wakayama Medical University International Symposium in 2019
Related Report
Int'l Joint Research
-
-
-
-
-
-
[Book] 手術2019
Author(s)
竹村茂一、久保正二
Total Pages
11
Publisher
金原出版株式会社
Related Report
-
[Book] 臨床消化器内科2018
Author(s)
久保正二、竹村茂一、田中肖吾、新川寛二
Total Pages
6
Publisher
(株)日本メディカルセンター
Related Report