| Project/Area Number |
18K08661
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
石崎 守彦 関西医科大学, 医学部, 講師 (10509467)
松井 康輔 関西医科大学, 医学部, 講師 (40460828)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 胆嚢癌 / ICGラクトソーム / Photodynamic Therapy / ICG-ラクトソーム / インドシアニングリーン・ラクトソーム / 胆嚢癌治療 / 光線力学療法 |
|---|
| Outline of Final Research Achievements |
ICG-lactosomes accumulated in xenograft tumors and PDT had an antitumor effect on these malignant tumors. NIF imaging with ICG-lactosomes and PDT may be useful diagnostic and/or therapeutic agents for gallbladder cancer. this study suggests that ICGlactosomes are useful as novel diagnostic and therapeutic agents for gallbladder cancer. In the future, this research group will optimize the dose and irradiation conditions of the drug and consider the treatment effects on other carcinomas to develop this treatment for clinical applications. PDT with ICG-lactosomes used in the present study can be repeated and be used for endoscopic and laparoscopic treatments for gallbladder cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
ICGラクトソームは腫瘍選択性と局所滞留機能を有し、術中腫瘍の範囲や腫瘍残存を確認可能である。腫瘍追加切除やPDTを行なう事が可能となり、局所根治性の向上が期待できる。
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