Immunogenomic profile associated with response to neoadjuvant chemoradiotherapy in patients with rectal cancer
| Project/Area Number |
18K08664
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
AKIYOSHI Takashi 公益財団法人がん研究会, 有明病院 大腸外科, 副部長 (50625598)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 直腸癌 / 術前放射線化学療法 / 免疫ゲノム解析 / 化学放射線療法 / 微小免疫環境 / TCRレパトア / 放射線化学療法 / 免疫環境 |
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| Outline of Final Research Achievements |
The significance of T-cell complexity in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (CRT) remains unknown. High-throughput T-cell receptor (TCR) β sequencing was applied to quantify the TCR repertoire of pre-treatment biopsies from 67 patients with advanced rectal cancer receiving preoperative CRT. Diversity index was used to represent the complexity of the TCR repertoire in a tumor. Changes in TCR repertoire before and after CRT were also analyzed in 23 patients. Diversity indices were significantly higher for good responders than for non-responders. Larger changes in TCR repertoires before and after CRT were correlated with better recurrence-free survival. The complexity and dynamic change in the TCR repertoire might serve as a useful indicator of response to CRT in patients with rectal cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
腫瘍浸潤CD8陽性T細胞の密度が直腸癌に対する術前化学放射線療法(CRT)の治療効果と相関することはこれまで報告されていたが、本研究でははじめて腫瘍浸潤CD8陽性T細胞の密度だけでなくT細胞レパトアの多様性がCRTの治療効果の予測に有用であることを示した。
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Prognostic impact of residual lateral lymph node metastasis after neoadjuvant (chemo)radiotherapy in patients with advanced low rectal cancer2019
Author(s)
Akiyoshi T, Toda S, Tominaga T, Oba K, Tomizawa K, Hanaoka Y, Nagasaki T, Konishi T, Matoba S, Fukunaga Y, Ueno M, Kuroyanagi H
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Journal Title
BJS Open
Volume: 3
Issue: 6
Pages: 822-829
DOI
Related Report
Peer Reviewed / Open Access
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