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Development of precision medicine for pancreatic cancer combining near infrared imaging and biological information

Research Project

Project/Area Number 18K08671
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionDokkyo Medical University (2020)
Chiba University (2018-2019)

Principal Investigator

Yoshitomi Hideyuki  獨協医科大学, 医学部, 教授 (60375631)

Co-Investigator(Kenkyū-buntansha) 高野 重紹  千葉大学, 大学院医学研究院, 助教 (20436380)
安西 尚彦  千葉大学, 大学院医学研究院, 教授 (70276054)
大塚 将之  千葉大学, 大学院医学研究院, 教授 (90334185)
賀川 真吾  千葉大学, 医学部附属病院, 助教 (90507302)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膵癌 / 近赤外線 / 浸潤 / 血管内凝固 / 癌間質 / 腫瘍進展 / 血小板 / 膵臓癌 / 近赤外線イメージ / 遺伝子変異 / Precision medicine
Outline of Final Research Achievements

The purpose of this study was to identify the extent of tumor progression of pancreatic cancer and analyze oncological features using near-infrared technology. Pancreatic cancer specimens were imaged with a near-infrared camera and compared with pathological findings. The tumor tissue was represented as a low absorption region, with the highest contrast around 1400 nm. Considering that the tumor tissue has a large amount of water, the tumor cell expression of Myl-9, which is related to intravascular coagulation, was examined. As a result, the prognosis was poor and the frequency of hematogenous metastasis was high in cases with strong expression. Attenuation of Myl-9 expression with siRNA in cell lines reduced cell migration and infiltration. These data suggested that the tumor tissue could be accurately identified by the near-infrared image. It is also suggested that Myl-9 regulates the migration and invasion ability of pancreatic cancer cells and may be involved in cancer metastasis.

Academic Significance and Societal Importance of the Research Achievements

本研究により、近赤外線イメージは腫瘍の組織内進展を可視化できる可能性が示された。また、十分なコントラスト、解像度が得られていないものの、現在、その装置の改良を行っている。最終的には手術切除標本にて正確に腫瘍進展範囲を同定する事で、過不足のない郭清範囲の同定、治癒切除率の向上に結びつき、膵癌患者の予後改善に寄与すると考えられる。また、血管内凝固に関連するMyl-9が膵癌細胞の遊走、浸潤能を制御していることが示され、Myl-9の働きを阻害する薬物、もしくは抗体が膵癌における主に転移の抑制をもたらす可能性があり、将来的な新たな治療法確立の基礎的データを示すことができた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (18 results)

All 2021 2020 2019 2018

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 4 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] Usefulness of the MALDI-TOF MS technology with membrane filter protocol for the rapid identification of microorganisms in perioperative drainage fluids of hepatobiliary pancreatic surgery2021

    • Author(s)
      Sogawa Kazuyuki、Takano Shigetsugu、Ishige Takayuki、Yoshitomi Hideyuki、Kagawa Shingo、Furukawa Katsunori、Takayashiki Tsukasa、Kuboki Satoshi、Nomura Fumio、Ohtsuka Masayuki
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 2 Pages: e0246002-e0246002

    • DOI

      10.1371/journal.pone.0246002

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparing prognostic factors of Glut-1 expression and maximum standardized uptake value by FDG-PET in patients with resectable pancreatic cancer2020

    • Author(s)
      Takahashi Makoto、Nojima Hiroyuki、Kuboki Satoshi、Horikoshi Takuro、Yokota Tetsuo、Yoshitomi Hideyuki、Furukawa Katsunori、Takayashiki Tsukasa、Takano Shigetsugu、Ohtsuka Masayuki
    • Journal Title

      Pancreatology

      Volume: 20 Issue: 6 Pages: 1205-1212

    • DOI

      10.1016/j.pan.2020.07.407

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcomes and significance of preoperative lymphocyte-to-monocyte ratio as a prognostic indicator in patients with invasive pancreatic neoplasms after repeat pancreatectomy2020

    • Author(s)
      Takano Shigetsugu、Yoshitomi Hideyuki、Kagawa Shingo、Furukawa Katsunori、Takayashiki Tsukasa、Kuboki Satoshi、Suzuki Daisuke、Sakai Nozomu、Mishima Takashi、Nakadai Eri、Miyazaki Masaru、Ohtsuka Masayuki
    • Journal Title

      BMC Cancer

      Volume: 20 Issue: 1 Pages: 111-111

    • DOI

      10.1186/s12885-020-6602-4

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological features and prognosis of surgical resected cases of biliary cancer with pancreaticobiliary maljunction2020

    • Author(s)
      Takayashiki Tsukasa、Yoshitomi Hideyuki、Furukawa Katsunori、Kuboki Satoshi、Miyazaki Masaru、Ohtsuka Masayuki
    • Journal Title

      Hepatobiliary & Pancreatic Diseases International

      Volume: 19 Issue: 1 Pages: 97-100

    • DOI

      10.1016/j.hbpd.2019.10.002

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Expression of Yes-Associated Protein (YAP) Maintains Putative Cancer Stemness and Is Associated with Poor Prognosis in Intrahepatic Cholangiocarcinoma2019

    • Author(s)
      Sugiura Kensuke、Mishima Takashi、Takano Shigetsugu、Yoshitomi Hideyuki、Furukawa Katsunori、Takayashiki Tsukasa、Kuboki Satoshi、Takada Mamoru、Miyazaki Masaru、Ohtsuka Masayuki
    • Journal Title

      The American Journal of Pathology

      Volume: 189 Issue: 9 Pages: 1863-1877

    • DOI

      10.1016/j.ajpath.2019.05.014

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Conversion surgery for initially unresectable pancreatic cancer: current status and unresolved issues2019

    • Author(s)
      Yoshitomi Hideyuki、Takano Shigetsugu、Furukawa Katsunori、Takayashiki Tsukasa、Kuboki Satoshi、Ohtsuka Masayuki
    • Journal Title

      Surgery Today

      Volume: 印刷中 Issue: 11 Pages: 894-906

    • DOI

      10.1007/s00595-019-01804-x

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feasibility and safety of distal pancreatectomy with en bloc celiac axis resection (DP-CAR) combined with neoadjuvant therapy for borderline resectable and unresectable pancreatic body/tail cancer.2019

    • Author(s)
      Yoshitomi H, Sakai N, Kagawa S, Takano S, Ueda A, Kato A, Furukawa K, Takayashiki T, Kuboki S, Miyzaki M, Ohtsuka M
    • Journal Title

      Langenbecks Arch Surg.

      Volume: In press Issue: 4 Pages: 1-8

    • DOI

      10.1007/s00423-019-01775-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of annexin II and stromal tenascin C promotes epithelial to mesenchymal transition and correlates with distant metastasis in pancreatic cancer.2018

    • Author(s)
      Yoneura N, Takano S, Yoshitomi H, Nakata Y, Shimazaki R, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Miyazaki M, Ohtsuka M.
    • Journal Title

      Int J Mol Med.

      Volume: 42 Pages: 821-830

    • DOI

      10.3892/ijmm.2018.3652

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 膵癌微小環境での補体因子が及ぼす転移機構の解明2020

    • Author(s)
      高野重紹、島崎怜理、佐藤守、高田護、吉富秀幸、賀川真吾、古川勝規、高屋敷吏、久保木知、鈴木大亮、酒井望、三島敬、大塚将之
    • Organizer
      第29回 日本がん転移学会 学術集会・総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 局所進行膵癌に対する手術手技の工夫と成績2020

    • Author(s)
      吉富秀幸、高野重紹、賀川真吾、古川勝規、高屋敷吏、久保木知、鈴木大亮、酒井望、三島敬、中台英里、大塚将之
    • Organizer
      第120回 日本外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] UR膵癌に対する,Conversion Surgeryの治療成績2020

    • Author(s)
      賀川真吾 吉富秀幸 古川勝規 高屋敷 吏 久保木 知 高野重紹 鈴木大亮 酒井 望 三島 敬 大塚将之
    • Organizer
      第75回 日本消化器外科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Feasibility and safety of distal pancreatectomy with en bloc celiac axis resection (DP-CAR) combined with neoadjuvant therapy for borderline resectable and unresectable pancreatic body/tail cancer2019

    • Author(s)
      Yoshitomi H, Takano S, Kagawa S, Furukawa K, Takayashiki T, Kuboki S, Miyazaki M, Ohtsuka M
    • Organizer
      The 7th Biennial Congress of the Asian-Pasific Hepato-Pancreato-Biliary Association
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Conversion Surgery for Unresectable Pancreatic Cancer. Does It Work or Not?2019

    • Author(s)
      Yoshitomi H, Takano S, Kagawa S, Furukawa K, Kuboki S, Miyazaki M, Otsuka M
    • Organizer
      The 31th Anniversary World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 動脈進展を伴う膵体部癌に対するDistal pancreatectomy with en-bloc celiac axis resection (DP-CAR): Pros and Cons2019

    • Author(s)
      吉富秀幸、高野重紹、賀川真吾、酒井望、加藤厚、古川勝規、高屋敷吏、久保木知、鈴木大亮、野島広之、三島敬、中台英里、宮崎勝、大塚将之
    • Organizer
      第119回 日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Prospective phase II trial of neoadjuvant chemotherapy with gemcitabine and S-1 (GS) for Borderline resectable (BR)/ Unresectable (UR) pancreatic cancer (CAP-003 study)2018

    • Author(s)
      Hideyuki Yoshitomi, Shigetsugu Takano, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Masaru Miyazaki, Masayuki Ohtsuka
    • Organizer
      2018 ASCO annual meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Combination of Neoadjuvant Chemo(radio)therapy and Distal Pancreatectomy with en-bloc Celiac Axis Resection (DP-CAR) for Locally Advanced Pancreatic Body Cancer2018

    • Author(s)
      Hideyuki Yoshitomi, Masaru Miyazaki, Masayuki Otsuka
    • Organizer
      The 30th anniversary World Congess of the International Association of Surgeons, Gastroenterologists and Oncologists
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Borderline(BR)膵体尾部癌に対する腹腔動脈幹合併尾側膵切除術(DP-CAR) -術前補助療法による治療成績の改善-2018

    • Author(s)
      吉富秀幸、酒井望、賀川真吾、高野重紹、加藤厚、古川勝規、高屋敷吏、久保木知、鈴木大亮、野島広之、三島敬、宮崎勝、大塚将之
    • Organizer
      第118回 日本外科学会定期学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] UR-LAおよびUR-M膵癌に対するConversion Surgery2018

    • Author(s)
      吉富秀幸、高野重紹、賀川真吾、古川勝規、高屋敷吏、久保木知、鈴木大亮、酒井望、野島広之、大塚将之
    • Organizer
      第73回 日本消化器外科学会総会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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