The mechanistic exploration of epigenetic change as for organ specific metastasis in gastric cancer
Project/Area Number |
18K08700
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 55020:Digestive surgery-related
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Research Institution | Mie University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
奥川 喜永 三重大学, 医学部附属病院, 講師 (30555545)
安田 裕美 三重大学, 医学部附属病院, 助教 (60586767)
吉山 繁幸 三重大学, 医学系研究科, リサーチアソシエイト (60444436)
大井 正貴 三重大学, 医学部附属病院, 准教授 (40418752)
楠 正人 三重大学, 医学系研究科, 寄附講座大学教員 (50192026)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 胃癌 / 腹膜播種 / circular RNA / エピゲノム / 予後予測 / ノンコーディングRNA |
Outline of Final Research Achievements |
In this study, we decided to quantify the expression level of Circ0000892 using GC tissues and adjacent normal mucosa (n=138, respectively) by qRT-PCR method. As a result, the expression level of Circ0000892 was significantly low in GC tissues compared with adjacent normal mucosa (p<0.001). Furthermore, the low expression group of Circ0000892 showed significantly poorer overall survival and disease free survival (p<0.05) compared with high expression group.
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Academic Significance and Societal Importance of the Research Achievements |
胃癌腹膜播種進展に関与するcircular RNAはバイオマーカーとしての有用性には大きな期待が寄せられると考えられる。本研究ではCirc0000892が胃癌進展ならびに予後マーカーとして有用となりうる可能性を証明した。今後はcircular RNAの網羅的プロファイリングをおこない特に腹膜播種進展に関してのバイオマーカー的意義を検証していく予定だが、本研究成果はその試金石として重要な役割を果たしていると考える。
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Crohn's-Like Lymphoid Reaction is Associated with Oncological Prognosis and Nutritional Status in Patients with Pathological Stage II/III Gastric Cancer.2020
Author(s)
Omura Y, Toiyama Y, Okugawa Y, Yamamoto A, Yin C, Kusunoki K, Kusunoki Y, Shigemori T, Ide S, Kitajima T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Ohi M, Kusunoki M.
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Journal Title
Ann Surg Oncol
Volume: 27
Issue: 1
Pages: 259-267
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Soluble PD-L1 Expression in Circulation as a Predictive Marker for Recurrence and Prognosis in Gastric Cancer: Direct Comparison of the Clinical Burden Between Tissue and Serum PD-L1 Expression.2019
Author(s)
Shigemori T, Toiyama Y, Okugawa Y, Yamamoto A, Yin C, Narumi A, Ichikawa T, Ide S, Shimura T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Ohi M, Araki T, Kusunoki M.
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Journal Title
Ann Surg Oncol.
Volume: 26
Issue: 3
Pages: 876-883
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Colony-stimulating factor-1 and colony-stimulating factor-1 receptor co-expression is associated with disease progression in gastric cancer.2018
Author(s)
Okugawa Y, Toiyama Y, Ichikawa T, Kawamura M, Yasuda H, Fujikawa H, Saigusa S, Ohi M, Araki T, Tanaka K, Inoue Y, Tanaka M, Miki C, Kusunoki M.
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Journal Title
Int J Oncol.
Volume: 53
Pages: 737-749
DOI
Related Report
Peer Reviewed
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