• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The expression and functional roles of solute carrier family 37 member 1 in colorectal cancer

Research Project

Project/Area Number 18K08712
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionFukushima Medical University

Principal Investigator

Momma Tomoyuki  福島県立医科大学, 医学部, 准教授 (20622335)

Co-Investigator(Kenkyū-buntansha) 齋藤 元伸  福島県立医科大学, 医学部, 講師 (90611749)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords大腸癌 / SLCトランスポーター / 抗癌剤耐性 / SLC37A1 / 薬剤耐性 / トランスポーター
Outline of Final Research Achievements

SLC family 37 member 1 (SLC37A1) expression was significantly increased in colon cancer tumorous tissues compared with that in non-tumorous tissues. The cases with upregulated expression of SLC37A1 by immunohistochemical staining were significantly associated with positive venous invasion and liver metastasis. Furthermore, upregulated SLC37A1 expression was associated with poor overall survival time in the present cohort. These results indicated that SLC37A1 is involved in the hematogenous metastasis of CRC. To investigate whether SLC37A1 is associated with hematogenous metastasis and glycolipid metabolism, SLC37A1 was knocked down in colon cancer cells. Sialyl Lewis A and sialyl Lewis X were upregulated in SLC37A-knockdown cell. The present study is the first to propose a key role of SLC37A1 in CRC, and additional studies are warranted to reveal the functional role of SLC37A1 in CRC development.

Academic Significance and Societal Importance of the Research Achievements

再発・進行大腸癌に対しては治療ガイドラインに沿って抗癌剤治療をおこなうが、抗癌剤の治療はいずれ効果を示さなくなる。抗癌剤に対する耐性の機序として薬剤トランスポーターが関与することがわかっているものの、SLCトランスポーターについてはほとんどわかっていなかった。本研究では、SLC37A1が大腸癌で高発現していること、予後予測バイオマーカーとなりうること、さらに糖脂質代謝に関連することで抗癌剤耐性や大腸癌の進展に関与しうる可能性が示唆された。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (14 results)

All 2020 2019 2018

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 14 results)

  • [Journal Article] Higher modified Glasgow Prognostic Score and multiple stapler firings for rectal transection are risk factors for anastomotic leakage after low anterior resection in rectal cancer2020

    • Author(s)
      Sakamoto Wataru、Ohki Shinji、Kikuchi Tomohiro、Okayama Hirokazu、Fujita Shotaro、Endo Hisahito、Saito Motonobu、Saze Zenichiro、Momma Tomoyuki、Kono Koji
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 66 Issue: 1 Pages: 10-16

    • DOI

      10.5387/fms.2019-17

    • NAID

      130007834284

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer2020

    • Author(s)
      Matsumoto Takuro、Okayama Hirokazu、Nakajima Shotaro、Saito Katsuharu、Nakano Hiroshi、Endo Eisei、Kase Koji、Ito Misato、Yamauchi Naoto、Yamada Leo、Kanke Yasuyuki、Onozawa Hisashi、Fujita Shotaro、Sakamoto Wataru、Saito Motonobu、Saze Zenichiro、Momma Tomoyuki、Mimura Kosaku、Kono Koji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 23 Pages: 9081-9081

    • DOI

      10.3390/ijms21239081

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A TGFβ-Dependent Stromal Subset Underlies Immune Checkpoint Inhibitor Efficacy in DNA Mismatch Repair?Deficient/Microsatellite Instability-High Colorectal Cancer2020

    • Author(s)
      Endo Eisei、Okayama Hirokazu、Saito Katsuharu、Nakajima Shotaro、Yamada Leo、Ujiie Daisuke、Kase Koji、Fujita Shotaro、Endo Hisahito、Sakamoto Wataru、Saito Motonobu、Saze Zenichiro、Momma Tomoyuki、Ohki Shinji、Mimura Kosaku、Kono Koji
    • Journal Title

      Molecular Cancer Research

      Volume: 18 Issue: 9 Pages: 1402-1413

    • DOI

      10.1158/1541-7786.mcr-20-0308

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microanatomy of inferior mesenteric artery sheath in colorectal cancer surgery2019

    • Author(s)
      Sakamoto Wataru、Yamada Leo、Suzuki Osamu、Kikuchi Tomohiro、Okayama Hirokazu、Endo Hisahito、Fujita Shotaro、Saito Motonobu、Momma Tomoyuki、Saze Zenichiro、Ohki Shinji、Kono Koji
    • Journal Title

      Journal of the Anus, Rectum and Colon

      Volume: 3 Issue: 4 Pages: 167-174

    • DOI

      10.23922/jarc.2019-016

    • NAID

      130007738778

    • ISSN
      2432-3853
    • Year and Date
      2019-10-30
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] microRNA-148a-3p regulates immunosuppression in DNA mismatch repair-deficient colorectal cancer by targeting PD-L12019

    • Author(s)
      Ashizawa Mai、Okayama Hirokazu、Ishigame Teruhide、Thar Min Aung Kyi、Saito Katsuharu、Ujiie Daisuke、Murakami Yuko、Kikuchi Tomohiro、Nakayama Yuko、Noda Masaru、Tada Takeshi、Endo Hisahito、Fujita Shotaro、Sakamoto Wataru、Saito Motonobu、Saze Zenichiro、Momma Tomoyuki、Ohki Shinji、Mimura Kosaku、Kono Koji
    • Journal Title

      Molecular Cancer Research

      Volume: Epub ahead of print Issue: 6 Pages: 1403-1413

    • DOI

      10.1158/1541-7786.mcr-18-0831

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic role of ARID1A negative expression in gastric cancer2019

    • Author(s)
      Ashizawa Mai、Saito Motonobu、Min Aung Kyi Thar、Ujiie Daisuke、Saito Katsuharu、Sato Takahiro、Kikuchi Tomohiro、Okayama Hirokazu、Fujita Shotaro、Endo Hisahito、Sakamoto Wataru、Momma Tomoyuki、Ohki Shinji、Goto Akiteru、Kono Koji
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 6769-6769

    • DOI

      10.1038/s41598-019-43293-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MLH1 germline mutation associated with Lynch syndrome in a family followed for more than 45?years2019

    • Author(s)
      Momma Tomoyuki、Gonda Kenji、Akama Yoshinori、Endo Eisei、Ujiie Daisuke、Fujita Shotaro、Maejima Yuko、Horita Shoichiro、Shimomura Kenju、Saji Shigehira、Kono Koji、Yashima Rei、Watanabe Fumiaki、Sugano Kokichi、Nomizu Tadashi
    • Journal Title

      BMC Medical Genetics

      Volume: 20 Issue: 1 Pages: 67-67

    • DOI

      10.1186/s12881-019-0792-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intestinal Beh?et disease associated with myelodysplastic syndrome accompanying trisomy 8 successfully treated with abdominal surgery followed by hematopoietic stem cell transplantation2019

    • Author(s)
      Asano Tomoyuki、Sato Shuzo、Furuya Makiko Yashiro、Takahashi Hiroshi、Shichishima-Nakamura Akiko、Ohkawara Hiroshi、Fujiwara Tatsuo、Gunji Naohiko、Hashimoto Choichiro、Momma Tomoyuki、Saito Motonobu、Nakano Hiroshi、Watanabe Guy、 et al.
    • Journal Title

      Medicine

      Volume: 98 Issue: 46 Pages: e17979-e17979

    • DOI

      10.1097/md.0000000000017979

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] KRT17 as a prognostic biomarker for stage II colorectal cancer2019

    • Author(s)
      Ujiie Daisuke、Okayama Hirokazu、Saito Katsuharu、Ashizawa Mai、Thar Min Aung Kyi、Endo Eisei、Kase Koji、Yamada Leo、Kikuchi Tomohiro、Hanayama Hiroyuki、Fujita Shotaro、Sakamoto Wataru、Endo Hisahito、Saito Motonobu、Mimura Kosaku、Saze Zenichiro、Momma Tomoyuki、Ohki Shinji、Kono Koji
    • Journal Title

      Carcinogenesis

      Volume: 0 Issue: 5 Pages: 0-0

    • DOI

      10.1093/carcin/bgz192

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A subset of patients with MSS/MSI?low?colorectal cancer showed increased CD8(+) TILs together with up?regulated IFN?γ2019

    • Author(s)
      Kikuchi Tomohiro、Mimura Kosaku、Okayama Hirokazu、Nakayama Yuko、Saito Katsuharu、Yamada Leo、Endo Eisei、Sakamoto Wataru、Fujita Shotaro、Endo Hisahito、Saito Motonobu、Momma Tomoyuki、Saze Zenichiro、Ohki Shinji、Kono Koji
    • Journal Title

      Oncology Letters

      Volume: 66 Pages: 10-66

    • DOI

      10.3892/ol.2019.10953

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic role of FUT8 expression in relation to p53 status in stage II and III colorectal cancer2018

    • Author(s)
      Noda Masaru、Okayama Hirokazu、Kofunato Yasuhide、Chida Shun、Saito Katsuharu、Tada Takeshi、Ashizawa Mai、Nakajima Takahiro、Aoto Keita、Kikuchi Tomohiro、Sakamoto Wataru、Endo Hisahito、Fujita Shotaro、Saito Motonobu、Momma Tomoyuki、Ohki Shinji、Kono Koji
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: 315-315

    • DOI

      10.1371/journal.pone.0200315

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma2018

    • Author(s)
      Thar Min Aung Kyi、Okayama Hirokazu、Saito Motonobu、Ashizawa Mai、Aoto Keita、Nakajima Takahiro、Saito Katsuharu、Hayase Suguru、Sakamoto Wataru、Tada Takeshi、Hanayama Hiroyuki、Saze Zenichirou、Momma Tomoyuki、Ohki Shinji、Sato Yusuke、Motoyama Satoru、Mimura Kosaku、Kono Koji
    • Journal Title

      Cancer Medicine

      Volume: 7 Issue: 7 Pages: 3321-3330

    • DOI

      10.1002/cam4.1564

    • NAID

      120007126995

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan Synthesis2018

    • Author(s)
      Noda Masaru、Okayama Hirokazu、Tachibana Kazunoshin、Sakamoto Wataru、Saito Katsuharu、Thar Min Aung Kyi、Ashizawa Mai、Nakajima Takahiro、Aoto Keita、Momma Tomoyuki、Katakura Kyoko、Ohki Shinji、Kono Koji
    • Journal Title

      Clinical Cancer Research

      Volume: 24 Issue: 18 Pages: 4468-4481

    • DOI

      10.1158/1078-0432.ccr-17-3533

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeted therapy according to next generation sequencing-based panel sequencing2018

    • Author(s)
      Saito Motonobu、Momma Tomoyuki、Kono Koji
    • Journal Title

      FUKUSHIMA JOURNAL OF MEDICAL SCIENCE

      Volume: 64 Issue: 1 Pages: 9-14

    • DOI

      10.5387/fms.2018-02

    • NAID

      130006708201

    • ISSN
      0016-2590, 2185-4610
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi