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Multicenter prospective observational study of the patients who undergo total pancreatectomy

Research Project

Project/Area Number 18K08718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionKindai University

Principal Investigator

Matsumoto Ippei  近畿大学, 医学部, 准教授 (30379408)

Co-Investigator(Kenkyū-buntansha) 亀井 敬子  近畿大学, 医学部, 講師 (30411606)
竹山 宜典  近畿大学, 医学部, 教授 (70263374)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywords膵全摘術 / 術後QOL / 膵性糖尿病 / 膵外分泌機能不全 / 術後脂肪肝 / 術後栄養障害 / QOL / 脂肪肝 / 膵内外分泌機能不全
Outline of Final Research Achievements

A multicenter prospective observational study was conducted to assess quality of life (QOL), nutritional and blood control status, and nonalcoholic fatty liver disease after total pancreatectomy (TP). The study included 286 patients from 71 institutions in Japan.
QOL deteriorated in most components but improved mental health after TP. The occurrence rate of nonalcoholic fatty liver disease was 19.6%. Female and high BMI were identified as risk factors for nonalcoholic fatty liver disease after TP. Blood sugar levels were stable at 3 months after TP and HbA1c levels averaged at 7.0%-8.0% thereafter. Nutritional makers decreased at one month after TP and improved at 3 months after TP and thereafter. Body weight loss after TP more than or equal 0.3 kg and total cholesterol level <136 mg/dL at 6 months after TP and HbA1c less than or equal 8.9% and rapid-acting insulin use at 12 months after TP were independent risk factors for hypoglycemic events after TP.

Academic Significance and Societal Importance of the Research Achievements

膵全摘術は、血糖コントロールの困難さによる重症糖尿病や膵外分泌機能不全による栄養障害がQOLの低下を招く術式と認識されている。しかし、膵全摘適応患者数はhigh volume centerでも年間数例であるため、多数例、前向き研究の報告はない。本研究は世界で初めての膵全摘術における多数例の前向き研究である。術前後のQOL、栄養指標、膵性糖尿病、術後脂肪肝について検討され、膵全摘術周術期の実態が高いエビデンスをもって示された極めて意義ある研究である。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (35 results)

All 2022 2021 2020 2019 2018 Other

All Journal Article (15 results) (of which Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (19 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Remarks (1 results)

  • [Journal Article] Incidence and risk factors of nonalcoholic fatty liver disease after total pancreatectomy: A first multicenter prospective study in Japan2022

    • Author(s)
      Kato Hiroyuki、Kamei Keiko、Suto Hironobu、Misawa Takeyuki、Unno Michiaki、Nitta Hiroyuki、Satoi Sohei、Kawabata Yasunari、Ohtsuka Masayuki、Rikiyama Toshiki、Sudo Takeshi、Matsumoto Ippei、Okano Keiichi、Suzuki Yasuyuki、Sata Naohiro、Isaji Shuji、Sugiyama Masanori、Takeyama Yoshifumi
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 29 Issue: 4 Pages: 428-438

    • DOI

      10.1002/jhbp.1093

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-Year Observation of Glucose Metabolism After Pancreaticoduodenectomy: A Single-Center Prospective Study in Japan2022

    • Author(s)
      Niwano Fumimaru、Babaya Naru、Hiromine Yoshihisa、Matsumoto Ippei、Kamei Keiko、Taketomo Yasunori、Yoshida Sawa、Takeyama Yoshifumi、Noso Shinsuke、Ikegami Hiroshi
    • Journal Title

      The Journal of Clinical Endocrinology and Metabolism

      Volume: 107 Issue: 12 Pages: 3362-3369

    • DOI

      10.1210/clinem/dgac529

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factors associated with hypoglycemic events after total pancreatectomy: A nationwide multicenter prospective study in Japan2022

    • Author(s)
      Suto H, Kamei K, Kato H, Nisawa T, Unno M, Nitta H, Satoi S, Kawabata Y, Ohtsuka M, Rikiyama T, Sudo T, Matsumoto I, Hirano T, Okano K, Suzuki Y, Sata N, Isaji S, Sugiyama M, Takeyama Y
    • Journal Title

      Surgery

      Volume: 172 Issue: 3 Pages: 962

    • DOI

      10.1016/j.surg.2022.04.031

    • URL

      https://pure.teikyo.jp/en/publications/271919c0-d55b-4ff6-942f-dda6f2afecef

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膵臓外科における栄養療法2022

    • Author(s)
      松本逸平、亀井敬子、登 千穂子、吉田雄太、川口晃平、李 東河、松本正孝、村瀬貴昭、里井俊平、武部敦志、中居卓也、竹山宜典
    • Journal Title

      臨床外科

      Volume: 77 Pages: 70-76

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Glucose Metabolism After Pancreatectomy: Opposite Extremes Between Pancreaticoduodenectomy and Distal Pancreatectomy2021

    • Author(s)
      Niwano Fumimaru、Babaya Naru、Hiromine Yoshihisa、Matsumoto Ippei、Kamei Keiko、Noso Shinsuke、Taketomo Yasunori、Takeyama Yoshifumi、Kawabata Yumiko、Ikegami Hiroshi
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism

      Volume: - Issue: 5 Pages: e2203-e2214

    • DOI

      10.1210/clinem/dgab036

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diabetic control and nutritional status up to 1 year after total pancreatectomy: a nationwide multicentre prospective study2021

    • Author(s)
      Suto H, Kamei K, Kato H, Misawa T, Unno M, Nitta H, Satoi S, Kawabata Y, Takano S, Rikiyama T, Sudo T, Matsumoto I, Hirao T, Okano K, Suzuki Y, Sata N, Isaji S, Sugiyama M, Takeyama Y,
    • Journal Title

      Br J Surg

      Volume: 108 Issue: 7 Pages: 753-762

    • DOI

      10.1093/bjs/znab097

    • URL

      https://pure.teikyo.jp/en/publications/7cd3e6c2-780c-46bd-b437-e4c2f45ac7e6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diabetic control and nutritional status up to one year after total pancreatectomy: a nationwide multicenter prospective study2021

    • Author(s)
      Suto H, Kamei K, Kato H, Misawa T, Unno M, Nitta H, Satoi S, Kawabata Y, Takano S, Rikiyama T, Sudo T, Matsumoto I, Hirao T, Okano K, Suzuki Y, Sata N, Isaji S, Sugiyama M, Takeyama Y
    • Journal Title

      Br J Surg

      Volume: -

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 膵癌診療ガイドライン2019改訂のポイント 外科的治療法2020

    • Author(s)
      仲田興平、尾上俊介、川井 学、大塚隆生、松本逸平、元井冬彦、里井壮平、藤井 努、花田敬士、遠藤 格、中村雅史
    • Journal Title

      膵臓

      Volume: 35 Pages: 52-57

    • Related Report
      2020 Research-status Report
  • [Journal Article] IPMN・MCN国際診療ガイドライン総まとめ 主膵管型IPMNの手術適応と術式2020

    • Author(s)
      竹山宜典
    • Journal Title

      胆と膵

      Volume: 41 Pages: 37-40

    • Related Report
      2020 Research-status Report
  • [Journal Article] 胆膵疾患における栄養サポート 膵全摘後の代謝栄養サポート2020

    • Author(s)
      竹山宜典
    • Journal Title

      胆と膵

      Volume: 41 Pages: 657-661

    • Related Report
      2020 Research-status Report
  • [Journal Article] 胃全摘の既往がある患者に対して膵全摘をおこなうか2020

    • Author(s)
      竹山宜典
    • Journal Title

      臨床外科

      Volume: 75 Pages: 684-688

    • Related Report
      2020 Research-status Report
  • [Journal Article] 膵疾患の栄養管理 膵全摘術後の栄養管理2020

    • Author(s)
      亀井敬子
    • Journal Title

      臨床栄養

      Volume: 135 Pages: 620-623

    • Related Report
      2020 Research-status Report
  • [Journal Article] すぐに使える周術期管理マニュアル 術式別の術前・術中・術後管理マニュアル 膵 膵全摘術2019

    • Author(s)
      亀井敬子、松本逸平、竹山宜典
    • Journal Title

      臨床外科

      Volume: 74 Pages: 193-196

    • Related Report
      2019 Research-status Report
  • [Journal Article] 膵全摘術後栄養障害とQOL2018

    • Author(s)
      松本逸平、亀井敬子、竹山宜典、他
    • Journal Title

      胆と膵

      Volume: 39 Pages: 475-479

    • Related Report
      2018 Research-status Report
  • [Journal Article] Insulin deficiency with and without glucagon: A comparative study between total pancreatectomy and type 1 diabetes.2018

    • Author(s)
      Niwano F, Hiromine Y, Noso S, Babaya N, Ito H, Yasutake S, Matsumoto I, Takeyama Y, Kawabata Y, Ikegami H.
    • Journal Title

      J Diabetes Investig.

      Volume: 9 Issue: 5 Pages: 1084-1090

    • DOI

      10.1111/jdi.12799

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Outcomes of total pancreatectomy in patients with pancreatic ductal adenocarcinoma2022

    • Author(s)
      Lee D, Matsumoto I, Nobori C, Yoshida Y, Kawaguchi K, Matsumoto M, Murase T, Kamei K, Satoi S, Takebe A, Nakai T, Takeyama Y
    • Organizer
      第34回日本肝胆膵外科学会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Outcomes of total pancreatectomy with pancreatic ductal adenocarcinoma2022

    • Author(s)
      Lee D, Matsumoto I, Nobori C, Yoshida Y, Kawaguchi K, Matsumoto M, Kamei K, Satoi S, Takebe A, Nakai T, Takeyama Y
    • Organizer
      Joint Congress of the 26th Meeting of International Association of Pancreatology (IAP) and the 53rd Annual Meeting of Japan Pancreas Society (JPS)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Outcomes of total pancreatectomy in patients with pancreatic ductal adenocarcinoma at our hospital2022

    • Author(s)
      Lee D, Matsumoto I, Nobori C, Yoshida Y, Kawaguchi K, Matsumoto M, Satoi S, Kamei K, Takebe A, Takeyama Y
    • Organizer
      第77回日本消化器外科学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 膵癌に対する膵全摘術の治療成績と膵断端陽性例の病理学的検討2022

    • Author(s)
      膵癌に対する膵全摘術の治療成績と膵断端陽性例の病理学的検討
    • Organizer
      第26回日本外科病理学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 膵切除前後における内分泌・代謝動向の前向き観察研究(KIP-MED study) 膵頭十二指腸切除術と膵体尾部切除の相違2021

    • Author(s)
      庭野史丸、馬場谷 成、廣峰義久、松本逸平、亀井敬子、武友保憲、川畑由美子、竹山宜典、能宗伸輔、池上博司
    • Organizer
      第64回日本糖尿学会年次学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 残膵全摘の短期・長期成績に関する検討2020

    • Author(s)
      亀井敬子、松本逸平、川口晃平、吉田雄太、村瀬貴昭、里井俊平、武部敦志、中居卓也、竹山宜典
    • Organizer
      第37回日本胆膵病態・生理研究会
    • Related Report
      2020 Research-status Report
  • [Presentation] 膵全摘患者のQOL調査~多施設共同前向き研究結果~2020

    • Author(s)
      亀井敬子、松本逸平、加藤宏之、須藤広誠、三澤健之、海野倫明、新田浩幸、里井壯平、川畑康成、大塚将之、力山敏樹、首藤 毅、岡野圭一、鈴木康之、佐田尚宏、伊佐地秀司、杉山政則、竹山宜典
    • Organizer
      第51回日本膵臓学会大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 膵全摘後の脂肪肝発生頻度とそのリスク解析-膵全摘患者に対する前向き実態調査の結果から-2020

    • Author(s)
      加藤宏之、亀井敬子、須藤広誠、三澤健之、海野倫明、新田浩幸、里井壯平、川畑康成、大塚将之、力山敏樹、首藤 毅、松本逸平、岡野圭一、鈴木康之、佐田尚宏、伊佐地秀司、杉山政則、竹山宜典
    • Organizer
      第51回日本膵臓学会大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 膵全摘術後の糖尿病コントロールと栄養指標の変化について2020

    • Author(s)
      須藤広誠、亀井敬子、加藤宏之、三澤健之、海野倫明、新田浩幸、里井壯平、川畑康成、大塚将之、力山敏樹、首藤 毅、松本逸平、岡野圭一、鈴木康之、佐田尚宏、伊佐地秀司、杉山政則、竹山宜典
    • Organizer
      第51回日本膵臓学会大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 残膵全摘の短期・長期成績に関する検討2020

    • Author(s)
      亀井敬子、松本逸平、川口晃平、吉田雄太、村瀬貴昭、里井俊平、武部敦志、中居卓也、竹山宜典
    • Organizer
      JDDW 2020 第18回日本消化器外科学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 膵全摘術後の栄養障害とその対策2020

    • Author(s)
      松本逸平、吉田雄太、川口晃平、松本正孝、村瀬貴昭、亀井敬子、里井俊平、武部敦志、庭野史丸、廣峰義久、馬場谷 成、中居卓也、池上博司、竹山宜典
    • Organizer
      日本外科代謝栄養学会第57回学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 浸潤性膵管癌に対する膵全摘術の短期・長期成績2019

    • Author(s)
      松本逸平、吉田雄太、川口晃平、松本正孝、村瀬貴昭、岩崎寿光、亀井敬子、武部敦志、中居卓也、竹山宜典
    • Organizer
      第119回日本外科学会定期学術集
    • Related Report
      2019 Research-status Report
  • [Presentation] Evaluation of nutritional status and postoperative management after total pancreatectomy2019

    • Author(s)
      Kamei K, Matsumoto I, Yoshida Y, Kawaguchi K, Matsumoto M, Murase T, Takebe A, Nakai T, Takeyama Y
    • Organizer
      The 31st Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery
    • Related Report
      2019 Research-status Report
  • [Presentation] 浸潤性膵管癌に対する膵全摘術の短期・長期成績2019

    • Author(s)
      亀井敬子、松本逸平、吉田雄太、川口晃平、松本正孝、村瀬貴昭、里井俊平、武部敦志、竹山宜典
    • Organizer
      第46回日本膵切研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 膵全摘術の短期・長期成績と周術期管理2019

    • Author(s)
      松本逸平、亀井敬子、吉田雄太、川口晃平、松本正孝、村瀬貴昭、里井俊平、武部敦志、竹山宜典
    • Organizer
      第81回日本臨床外科学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 亀井敬子2019

    • Author(s)
      膵全摘臨床研究報告 膵全摘患者のQOL調査
    • Organizer
      第7回膵全摘を考える会
    • Related Report
      2019 Research-status Report
  • [Presentation] 浸潤性膵管癌に対する膵全摘術の治療成績2018

    • Author(s)
      松本逸平
    • Organizer
      第49回日本膵臓学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 膵全摘後の栄養障害とその対策2018

    • Author(s)
      松本逸平
    • Organizer
      第13回膵癌術前治療研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 膵全摘術の治療成績2018

    • Author(s)
      松本逸平
    • Organizer
      JDDW 2018 KOBE
    • Related Report
      2018 Research-status Report
  • [Remarks] 近畿大学医学部外科学教室

    • URL

      http://www.kindai-geka.jp

    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

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