| Project/Area Number |
18K08728
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55030:Cardiovascular surgery-related
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| Research Institution | Nagoya University |
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Principal Investigator |
BANNO Hiroshi 名古屋大学, 医学部附属病院, 講師 (80584721)
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| Co-Investigator(Kenkyū-buntansha) |
杉本 昌之 名古屋大学, 医学部附属病院, 病院講師 (00447814)
高橋 範子 名古屋大学, 医学部附属病院, その他 (10439177)
古森 公浩 名古屋大学, 医学系研究科, 教授 (40225587)
柴田 玲 名古屋大学, 医学系研究科, 特任教授 (70343689)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Xa阻害剤 / 動脈瘤 / 血管病 / 内膜肥厚 / 血管新生 |
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| Outline of Final Research Achievements |
Aneurysm model: Xa inhibitor was administered to mouse ascites-derived macrophages and gene expression analysis was performed. Apixaban administration suppressed MCP-1 expression, and edoxaban administration significantly increased TNF-α, IL-1b, IL-6, cathepsin K, and S gene expression. Therefore, apixaban and edoxaban were administered to the mouse aneurysm model, but the aneurysm-suppressing effect was not confirmed. On the contrary, anal bleeding was observed at all concentrations as a possible side effect.
Intimal hyperplasia model: A bypass model using the external jugular vein as a graft was created using rabbits. The intimal hyperplasia was evaluated by classifying into the edoxaban-administered group and the non-administered group, but no significant difference was observed between the two groups.
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| Academic Significance and Societal Importance of the Research Achievements |
Xa阻害剤には抗凝固作用以外の多面的作用を有し，血管保護作用を発揮することが示唆される．本研究ではアピキサバン，エドキサバンによる動脈瘤形成および血管内膜肥厚の抑制，予防効果を期待して，検討を行ったが，残念ながらその効果は明らかではなかった．
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