The role of salt-inducible kinase(SIK) in aortic dissection
Project/Area Number |
18K08747
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 55030:Cardiovascular surgery-related
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Research Institution | Kurume University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
青木 浩樹 久留米大学, 付置研究所, 教授 (60322244)
田中 啓之 久留米大学, 医学部, 教授 (70197466)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 大動脈解離 / 塩分負荷 / 細胞外マトリックス / SIK / 血管平滑筋 / IL-17 / 塩分過多 |
Outline of Final Research Achievements |
In this project, we investigated the role of Salt-inducible kinase(SIK) in the pathology of aortic dissection. In vitro, excessive NaCl promoted the expression of SIK1, SIK3, and induced the phosphorylation of HDAC4, the down streram molecule of SIK pathway in vascular smooth muscle cells. These data suggested that excess salt activates the SIK pathway. In addition, SIK inhibitors suppressed the TGF pathway and enhanced both contractile vascular smooth muscle and secretory vascular smooth muscle markers. These results suggested that SIK may play an important role in ECM metabolism and vascular smooth muscle differentiation in vascular smooth muscle cells.
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Academic Significance and Societal Importance of the Research Achievements |
大動脈解離は最近増加傾向にある致死的疾患である。本邦において社会的責任が大きくなる50歳以上の男性に多く発症することから、社会的な影響も大きい。現在外科的加療もしくは降圧加療のみしか治療がなく、大動脈解離病態の解明は、新たな治療ターゲットにつながることが期待される。本研究でSIKが大動脈解離病態に大きく関与している可能性を示すことができた。更なる役割解明が新たな治療法確立への一歩となることが期待される。
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] High Salt Intake Worsens Aortic Dissection in Mice2020
Author(s)
Nishida Norifumi、Aoki Hiroki、Ohno-Urabe Satoko、Nishihara Michihide、Furusho Aya、Hirakata Saki、Hayashi Makiko、Ito Sohei、Yamada Hiroshi、Hirata Yuichiro、Yasukawa Hideo、Imaizumi Tsutomu、Tanaka Hiroyuki、Fukumoto Yoshihiro
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 40
Issue: 1
Pages: 189-205
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] The role of B cells and IgG in aortic dissection.2020
Author(s)
Nishida N, Furusho A, Aoki H, Hirakata S, Ito S, Hayashi M, Hashimoto Y, Majima R, Fukumoto Y
Organizer
ESC Congress 2020, The Digital Experience, vertual event
Related Report
Int'l Joint Research
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[Presentation] Syk activation is a defense mechanism of aortic wall against aortic dissection.2020
Author(s)
Hashimoto Y, Aoki H, Majima R, Hayashi M, Nishida N, Ito S, Furusho A, Hirakata S, Ohno-Urabe S, Fukumoto Y
Organizer
ESC Congress 2020, The Digital Experience, vertual event
Related Report
Int'l Joint Research
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[Presentation] Overactivation of macrophage promotes aortic dissection through the induction of Ink4a/Arf and impairment of smooth muscle proliferation in mouse aorta.2018
Author(s)
Ohno-Urabe S, Aoki H, Nishihara M, Furusho A, Hirakata S, Nishida N, Ito S, Hayashi Y, Ito S, Hashimoto Y, Majima R, Fukumoto Y
Organizer
ESC Congress 2018
Related Report
Int'l Joint Research
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[Presentation] MRTF-A mediates aortic smooth muscle cell apoptosis and inflammatory response to develop aortic dissection.2018
Author(s)
Ito S, Aoki H, Nishihara M, Ohno-Urabe S, Furusho A, Hirakata S, Nishida N, Hayashi Y, Ito S, Hashimoto Y, Majima R, Kuwahara K, Fukumoto Y
Organizer
ESC Congress 2018
Related Report
Int'l Joint Research
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