| Project/Area Number |
18K08756
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55030:Cardiovascular surgery-related
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| Research Institution | Osaka University |
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Principal Investigator |
MORI Daisuke 大阪大学, 医学系研究科, 特任助教(常勤) (90735185)
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| Co-Investigator(Kenkyū-buntansha) |
谷岡 秀樹 大阪大学, 医学部附属病院, 医員 (10815509)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 重傷心不全予防 / 脂肪由来間葉系幹細胞 / 内視鏡的細胞移植 / 内視鏡的細胞移植術 / 低侵襲内視鏡的細胞移植術 / ロボット支援下冠動脈バイパス術併用 / 剣状突起下アプローチ / 至適細胞移植時期 / 内視鏡的値侵襲移植術 / 他家細胞移植 / 心筋再生療法 |
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| Outline of Final Research Achievements |
We have developed a technique for endoscopically transplanting adipose-derived mesenchymal stem cells into a porcine myocardial infarction model using the cell spray method. After cell transplantation using this method,cardiac function improved and its effectiveness could be confirmed.We have developed balloon stabilizers and quattro sprays, which are auxiliary devices for endoscopic cell spraying, and are considering applying for a patent.
In the future,we will make presentations at academic conferences on research results and continue research toward practical use.
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| Academic Significance and Societal Importance of the Research Achievements |
この方法が確立すれば低侵襲に心臓表面に細胞を移植することができ、患者さんの負担が軽減される。また間葉系幹細胞は虚血性心筋症の増悪を予防することが期待できるため、将来的に心不全予防治療になると考えられる。
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