• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of methods to reduce spinal cord ischemia-reperfusion disorder by exosomes

Research Project

Project/Area Number 18K08760
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55030:Cardiovascular surgery-related
Research InstitutionYamaguchi University

Principal Investigator

MORIKAGE Noriyasu  山口大学, 医学部附属病院, 講師 (50335741)

Co-Investigator(Kenkyū-buntansha) 上野 耕司  山口大学, 医学部附属病院, 助教 (30736070)
佐村 誠  山口大学, 医学部附属病院, 助教 (30773402)
濱野 公一  山口大学, 大学院医学系研究科, 教授 (60263787)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsエクソソーム / エクソソーム治療 / 脊髄虚血再灌流障害 / 幹細胞エクソソーム
Outline of Final Research Achievements

Exosomes are 20-100 nm membrane vesicles secreted from cells. It is thought that exosomes have the characteristics of the parent cell. there is a possibility of new treatment instead of cell therapy.
This study showed that exosomes administered in the tail vein may reach the lumbar spine for mice model of spinal cord ischemia-reperfusion disorder.
This result suggested that administration of exosomes might be one of methods to reduce spinal cord ischemia-reperfusion disorder occurred by stent graft for thoracic aortic aneurysm.

Academic Significance and Societal Importance of the Research Achievements

エクソソーム、細胞から分泌される直径20~100 nmの膜小胞であり、エクソソームを分泌する細胞の形質を持つと言われている。そのため、幹細胞由来のエクソソームは、新しい治療法になる可能性がある。
本研究結果では、静脈投与したエクソソームが、腰椎に到達することを示した。この結果は、エクソソーム投与が、脊髄虚血再灌流障害を軽減させる方法の一つになる可能性を示す足掛かりとなるものである。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (28 results)

All 2020 2019 2018

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 13 results) Presentation (13 results)

  • [Journal Article] Interface Pressures Derived from a Tubular Elastic Bandage2020

    • Author(s)
      Suehiro Kotaro、Morikage Noriyasu、Harada Takasuke、Samura Makoto、Nagase Takashi、Takeuchi Yuriko、Mizoguchi Takahiro、Suzuki Ryo、Kurazumi Hiroshi、Hamano Kimikazu
    • Journal Title

      Annals of Vascular Diseases

      Volume: 13 Issue: 4 Pages: 410-413

    • DOI

      10.3400/avd.oa.20-00136

    • NAID

      130007961270

    • ISSN
      1881-641X, 1881-6428
    • Year and Date
      2020-12-25
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Allogeneic fibroblast sheets accelerate cutaneous aound healing equivalent to autologous fibroblast sgeets in mice2020

    • Author(s)
      Takashi Nagase, Koji Ueno, Takahiro Mizoguchi, Makoto Samura, Takasuke Harada, Kotaro Suehiro, Bungo Shirasawa, Noriyasu Morikage, Kimikazu Hamano
    • Journal Title

      American journal of Translational Research

      Volume: 12 Pages: 2652-2663

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endovascular Aneurysm Repair With Inferior Mesenteric Artery Embolization for Preventing Type II Endoleak2020

    • Author(s)
      Samura Makoto、Morikage Noriyasu、Otsuka Ryo、Mizoguchi Takahiro、Takeuchi Yuriko、Nagase Takashi、Harada Takasuke、Yamashita Osamu、Suehiro Kotaro、Hamano Kimikazu
    • Journal Title

      Annals of Surgery

      Volume: 271 Issue: 2 Pages: 238-244

    • DOI

      10.1097/sla.0000000000003299

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regular Compression Therapy May Not Be Necessary for Lymphedema in Arms without a Subcutaneous Echo-Free Space2020

    • Author(s)
      Suehiro Kotaro、Morikage Noriyasu、Harada Takasuke、Samura Makoto、Nagase Takashi、Mizoguchi Takahiro、Hamano Kimikazu
    • Journal Title

      Annals of Vascular Surgery

      Volume: 62 Pages: 258-262

    • DOI

      10.1016/j.avsg.2019.04.020

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perioperative variations in indices derived from noninvasive assessments to detect postmastectomy lymphedema2019

    • Author(s)
      Suehiro Kotaro、Yamamoto Shigeru、Honda Saiko、Morikage Noriyasu、Harada Eijiro、Takemoto Yoshihiro、Nagano Hiroaki、Hamano Kimikazu
    • Journal Title

      Journal of Vascular Surgery: Venous and Lymphatic Disorders

      Volume: 7 Issue: 4 Pages: 562-569

    • DOI

      10.1016/j.jvsv.2019.02.012

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reverse slider technique using the Endurant stent graft for accurate proximal sealing in hostile neck endovascular aneurysm repair2019

    • Author(s)
      Morikage Noriyasu、Nishimura Junichi、Mizoguchi Takahiro、Takeuchi Yuriko、Nagase Takashi、Samura Makoto、Harada Takasuke、Aga Kenichiro、Masuda Munetaka、Hamano Kimikazu
    • Journal Title

      Journal of Vascular Surgery Cases and Innovative Techniques

      Volume: 5 Issue: 3 Pages: 332-337

    • DOI

      10.1016/j.jvscit.2019.03.012

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recurrent Delayed Periaortitis after Endovascular Aneurysm Repair2019

    • Author(s)
      Samura Makoto、Morikage Noriyasu、Mizoguchi Takahiro、Takeuchi Yuriko、Nagase Takashi、Harada Takasuke、Suehiro Kotaro、Hamano Kimikazu
    • Journal Title

      Journal of Vascular and Interventional Radiology

      Volume: 30 Issue: 10 Pages: 1695-1698

    • DOI

      10.1016/j.jvir.2018.09.010

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of Embolization of Inferior Mesenteric Artery to Prevent Type II Endoleak Following Endovascular Aneurysm Repair: A Review of the Literature2018

    • Author(s)
      Samura M, Morikage N, Mizoguchi T, Takeuchi Y, Nagase T, Harada T, Suehiro K, Hamano K
    • Journal Title

      Annals of Vascular Diseases

      Volume: 11 Issue: 3 Pages: 259-264

    • DOI

      10.3400/avd.ra.18-00064

    • NAID

      130007490138

    • ISSN
      1881-641X, 1881-6428
    • Year and Date
      2018-09-25
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autologous fibroblasts, peripheral blood mononuclear cells, and fibrin glue accelerate healing of refractory cutaneous ulcers in diabetic mice2018

    • Author(s)
      Mizoguchi T, Ueno K, Yanagihara M, Samura M, Kurazumi H, Suzuki R, Morikage N, Hamano K
    • Journal Title

      Am J Transl Res

      Volume: 10(9) Pages: 2920-2928

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aggressive Decongestion in Limbs with Lymphedema without Subcutaneous Echo-Free Space2018

    • Author(s)
      Suehiro K, Morikage N, Ueda K, Samura M, Takeuchi Y, Nagase T, Mizoguchi T, Hamano K
    • Journal Title

      Ann Vasc Surg

      Volume: 53 Pages: 205-211

    • DOI

      10.1016/j.avsg.2018.04.033

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Midterm Outcomes of Endovascular Aortic Aneurysm Repair with Carbon Dioxide-Guided Angiography2018

    • Author(s)
      Takeuchi Y, Morikage N, Matsuno Y, Nakamura T, Samura M, Ueda K, Harada T, Ikeda Y, Suehiro K, Ito H, Sakata K, Hamano K
    • Journal Title

      Ann Vasc Surg

      Volume: 51 Pages: 170-176

    • DOI

      10.1016/j.avsg.2018.02.036

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment of Cutaneous Ulcers with Multilayered Mixed Sheets of Autologous Fibroblasts and Peripheral Blood Mononuclear Cells2018

    • Author(s)
      Mizoguchi T, Ueno K, Takeuchi Y, Samura M, Suzuki R, Murata T, Hosoyama T, Morikage N, Hamano K
    • Journal Title

      Cell Physiol Biochem

      Volume: 47(1) Issue: 1 Pages: 201-211

    • DOI

      10.1159/000489767

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation Between Changes in Extremity Volume and Bioelectrical Impedance in Arm and Leg Lymphedema2018

    • Author(s)
      Suehiro K, Morikage N, Ueda K, Samura M, Takeuchi Y, Nagase T, Mizoguchi T, Nakamura K, Hamano K
    • Journal Title

      Lymphat Res Biol

      Volume: 16(4) Issue: 4 Pages: 385-389

    • DOI

      10.1089/lrb.2017.0063

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Venous hemodynamics assessed with air plethysmography in legs with lymphedema2018

    • Author(s)
      Suehiro K, Morikage N, Ueda K, Samura M, Takeuchi Y, Nagase T, Mizoguchi T, Nakamura K, Hamano K
    • Journal Title

      Vasc Med

      Volume: 23(2) Issue: 2 Pages: 139-142

    • DOI

      10.1177/1358863x17745372

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm2018

    • Author(s)
      Yoshimura K, Morikage N, Nishino-Fujimoto S, Furutani A, Shirasawa B, HamanoK
    • Journal Title

      Curr Drug Targets

      Volume: 印刷中 Issue: 11 Pages: 1265-1275

    • DOI

      10.2174/1389450119666171227223331

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 異なる創傷治癒モデルにおける自家および他家細胞シートの創傷治癒効果の比較検討2020

    • Author(s)
      永瀬隆、上野耕司、吉峯宗大、岩本圭亮、溝口高弘、佐村誠、柳原正志、森景則保、濱野公一
    • Organizer
      第19回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] EVAR症例の長期予後改善のためのTypeⅡエンドリークへの取り組み2020

    • Author(s)
      森景則保
    • Organizer
      第26回日本血管内治療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 傍腎動脈腹部大動脈瘤に対するchimney EVARの早期・中期成績2020

    • Author(s)
      森景則保、藤田顕弘、溝口高弘、永瀬隆、佐村誠、原田剛佑、末廣晃太郎、濱野公一
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Multiple re-entryを有する慢性B型大動脈解離に対する完全re-entry閉鎖の有用性2020

    • Author(s)
      森景則保
    • Organizer
      第50回日本心臓血管外科学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] EVARの長期成績改善への取り組み2020

    • Author(s)
      森景則保
    • Organizer
      第15回Japan Endovascular Symposium
    • Related Report
      2020 Annual Research Report
  • [Presentation] 破裂性傍腎動脈型腹部大動脈瘤に対するchimney EVARの適応拡大-早期・中期成績をopen surgical repairと比較して-2020

    • Author(s)
      森景則保、溝口高弘、永瀬隆、竹内由利子、佐村誠、原田剛佑、末廣晃太郎、濱野公一
    • Organizer
      第61回日本脈管学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Reasons and treatment options for late type Ⅱ endoleaks2020

    • Author(s)
      森景則保
    • Organizer
      NEXT2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] Early and mid-term outcomes of the chimney endovascular aneurysm repair for juxtarenal abdominal aortic aneurysms2020

    • Author(s)
      森景則保
    • Organizer
      第48回日本血管外科学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 傍腎動脈腹部大動脈瘤に対するchimney EVARの早期・中期成績-人工血管置換術に代わる治療法となり得るか?-2019

    • Author(s)
      森景則保、大塚 遼、溝口高弘、永瀨 隆、佐村 誠、原田剛佑、末廣晃太郎、濱野公一
    • Organizer
      第47回日本血管外科学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] EndurantによるchimneyEVAR時に発生した最も注意すべき術中合併症2019

    • Author(s)
      森景則保
    • Organizer
      第25回日本血管内治療学会学術総会・第14回Japan Endovascular Symposium
    • Related Report
      2019 Research-status Report
  • [Presentation] Juxtarenal AAAに対するchimney EVARの良好な成績を得るためのTips2019

    • Author(s)
      森景則保
    • Organizer
      第25回日本血管内治療学会学術総会・第14回Japan Endovascular Symposium
    • Related Report
      2019 Research-status Report
  • [Presentation] EVAR長期成績安定のためのtypeⅡエンドリーク制御への取り組み2019

    • Author(s)
      森景則保
    • Organizer
      第25回日本血管内治療学会学術総会・第14回Japan Endovascular Symposium
    • Related Report
      2019 Research-status Report
  • [Presentation] 破裂性腹部大動脈瘤(RAAA)に対する当科のEVAR治療戦略の有益性-治療戦略確立後の連続EVARの治療成績2019

    • Author(s)
      森景則保、溝口高弘、永瀬隆、佐村誠、原田剛佑、末廣晃太郎、濱野公一
    • Organizer
      第60回日本脈管学会総会
    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-12-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi