Integrated understanding of postoperative cognitive dysfunction based on aging-related sarcopenia.

• Project/Area Number: 18K08808
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Akita University
• Principal Investigator: Goyagi Toru 秋田大学, 医学部附属病院, 講師 (30302277)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 術後認知機能障害 / サルコペニア / 筋肉量 / BDNF / 神経新生 / 運動療法 / POCD / トレッドミル / 骨格筋萎縮 / PND / 骨格筋量減少 / 尾懸垂モデル / 高脂肪高炭水化物食 / SHRラット / 長趾伸筋 / ヒラメ筋 / マイオカイン

Outline of Final Research Achievements

The study examined whether preoperative loss of muscle mass (sarcopenia) was associated with a complication of cognitive decline after surgery. We established that tail suspension of rats creates a sarcopenia model. Using this model, we found that a decrease in muscle mass due to preoperative tail suspension promoted a decline in postoperative cognitive function. This was thought to be due in part to decreased neurotrophic factor BDNF in the hippocampus and decreased neurogenesis in the dentate gyrus. Exercise restored the preoperative decline in muscle mass and attenuated the postoperative cognitive decline. Exercise increased BDNF and neurogenesis.
This study suggests that preoperative sarcopenia worsens postoperative cognitive function and that preoperative exercise may reduce this deterioration.

Academic Significance and Societal Importance of the Research Achievements

術前の身体機能により、術後の認知機能に影響を与えることが判明した。筋肉量が落ちると、術後の認知機能が低下しやすくなり、術前に運動すると術後認知機能の低下を防止することができる。術後合併症を軽減するため術前の筋肉量が重要であることを示している。

Research Products

• [Journal Article] Low Skeletal Muscle Mass Is Associated With Perioperative Neurocognitive Disorder Due To Decreased Neurogenesis in Rats (2021)
  • Author(s): Nemoto Akira、Goyagi Toru、Nemoto Wataru、Nakagawasai Osamu、Tan-No Koichi、Niiyama Yukitoshi
  • Journal Title: Anesthesia & Analgesia Volume: 134 Issue: 1 Pages: 194-203
  • DOI: 10.1213/ane.0000000000005681
  • Peer Reviewed / Open Access
• [Journal Article] Tail suspension is useful as a sarcopenia model in rats (2021)
  • Author(s): Nemoto Akira、Goyagi Toru
  • Journal Title: Laboratory Animal Research Volume: 37 Issue: 1 Pages: 1-7
  • DOI: 10.1186/s42826-020-00083-9
  • Peer Reviewed / Open Access
• [Presentation] The effect of preoperative exercise for postoperative cognitive dysfunction in muscular atrophic rats. (2021)
  • Author(s): Nemoto A, Sunaga S, Goyagi T, Niiyama Y
  • Organizer: Euroanaesthesia 2021 Meeting
  • Int'l Joint Research
• [Presentation] 運動は認知機能を改善するか (2021)
  • Author(s): 合谷木徹
  • Organizer: 日本麻酔科学会第68回学術集会
• [Presentation] 術前骨格筋量の減少は海馬内神経新生抑制を伴い術後認知機能障害を引き起こす (2021)
  • Author(s): 根本晃, 合谷木徹 , 新山幸俊
  • Organizer: 日本麻酔科学会第68回学術集会
• [Presentation] 骨格筋衰退ラットで術後認知機能障害に対する術前運動療法の効果. (2021)
  • Author(s): 根本晃, 合谷木徹 , 新山幸俊
  • Organizer: 日本神経麻酔集中治学会第25回学術集会
• [Presentation] 骨格筋量の減少は神経新生を抑え術後認知機能障害を引き起こす (2020)
  • Author(s): 根本晃、合谷木徹
  • Organizer: 第24回日本神経麻酔集中治療学会
• [Presentation] 骨格筋量の減少は術後認知機能障害を誘発させる (2020)
  • Author(s): 根本晃、合谷木徹
  • Organizer: 日本麻酔科学会第67回学術集会
• [Presentation] Low skeletal muscle mass induces postoperative cognitive dysfunction in middle-aged rats (2020)
  • Author(s): Nemoto A., Goyagi T.
  • Organizer: Eeuroanesthesia2020
• [Presentation] 筋肉は術後認知機能低下改善にも重要 (2020)
  • Author(s): 合谷木 徹
  • Organizer: 日本麻酔科学会第68回学術集会
  • Invited
• [Presentation] ラット下肢筋力低下に及ぼす要因 (2019)
  • Author(s): 根本晃、合谷木徹
  • Organizer: 第23回日本神経麻酔集中治療学会