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Development of a definitive diagnosis of perioperative anaphylaxis: measurement of antigen-specific IgE and urinary markers

Research Project

Project/Area Number 18K08809
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55050:Anesthesiology-related
Research InstitutionGunma University

Principal Investigator

Takazawa Tomonori  群馬大学, 医学部附属病院, 准教授 (30400766)

Co-Investigator(Kenkyū-buntansha) 村田 幸久  東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40422365)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsアナフィラキシー
Outline of Final Research Achievements

In this study, urine samples were collected from patients who developed anaphylaxis during the perioperative period, and the Tetranor-PGDM concentration was measured. So far, urine samples for 11 cases have been collected, and measurement of Tetranor-PGDM concentration by mass spectrometer has been completed in all cases. As a result, changes in Tetranor-PGDM concentration in perioperative anaphylaxis cases are becoming clear. Applicants are also working on the development of a blood-specific IgE measurement method for sugammadex.

Academic Significance and Societal Importance of the Research Achievements

申請者らが研究対象としてきた周術期アナフィラキシーにおいて、技術と経験の蓄積によって、皮膚テストとBATの診断精度は高まった。しかし、患者によっては侵襲のある皮膚テストを敬遠し、検査が行えないことがある。しかし、今回の開発対象となる特異的IgE測定や尿中マーカーが実用化されれば、低侵襲で実施可能な検査の選択肢が増えることになり、研究開発の意義は大きいと考える

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (52 results)

All 2021 2020 2019 2018

All Journal Article (28 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 20 results,  Open Access: 7 results) Presentation (23 results) (of which Int'l Joint Research: 4 results,  Invited: 8 results) Book (1 results)

  • [Journal Article] Drug-induced anaphylaxis during general anesthesia in 14 tertiary hospitals in Japan: a retrospective, multicenter, observational study2021

    • Author(s)
      Horiuchi Tatsuo、Takazawa Tomonori、Orihara Masaki、Sakamoto Shinya、Nagumo Kazuhiro、Saito Shigeru
    • Journal Title

      Journal of Anesthesia

      Volume: 35 Issue: 1 Pages: 154-160

    • DOI

      10.1007/s00540-020-02886-5

    • NAID

      40022476222

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] スガマデクスに由来するアナフィラキシーについて知っておくべきこと2021

    • Author(s)
      高澤知規
    • Journal Title

      日本臨床麻酔学会誌

      Volume: 41 Pages: 188-193

    • NAID

      130008028631

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 周術期の薬の使い方 パーフェクトガイド 第3章 1アレルギー/アナフィラキシー2021

    • Author(s)
      折原雅紀、高澤知規
    • Journal Title

      月刊薬事

      Volume: 63 Pages: 100-105

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Anaphylaxis caused by butylscopolamine bromide: a case report.2020

    • Author(s)
      Shiraishi T, Nakamura M, Horiuchi T, Takazawa T.
    • Journal Title

      JA Clinical Reports

      Volume: 6 Issue: 1 Pages: 26-26

    • DOI

      10.1186/s40981-020-00331-w

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does sugammadex have multiple mechanisms for causing anaphylaxis?2020

    • Author(s)
      Orihara Masaki、Nagumo Kazuhiro、Takazawa Tomonori
    • Journal Title

      The Journal of Allergy and Clinical Immunology: In Practice

      Volume: 8 Issue: 7 Pages: 2457-2458

    • DOI

      10.1016/j.jaip.2020.04.049

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 手術室におけるアナフィラキシーショックへの対応2020

    • Author(s)
      高澤知規
    • Journal Title

      麻酔

      Volume: 69

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 周術期管理:アレルギー既往 局所麻酔薬と抗菌薬を中心に2020

    • Author(s)
      高澤知規
    • Journal Title

      LiSA

      Volume: 26 Pages: 247-252

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 皮膚テストと好塩基球活性化試験により確定診断したセファゾリンによるアナフィラキシーショックの小児症例2020

    • Author(s)
      齊藤保雅、堀内辰男、高澤知規、高橋淳子、大川牧生、富岡昭裕、齋藤繁
    • Journal Title

      麻酔

      Volume: 69 Pages: 1130-1134

    • NAID

      40022372021

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬剤アレルギー 臨床現場における対応】全身麻酔におけるアレルギー2020

    • Author(s)
      折原雅紀、高澤知規
    • Journal Title

      アレルギーの臨床

      Volume: 40 Pages: 886-889

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Comparison of incidence of anaphylaxis between sugammadex and neostigmine: a retrospective multicentre observational study.2020

    • Author(s)
      Orihara M, Takazawa T, Horiuchi T, Sakamoto S, Nagumo K, Tomita Y, Tomioka A, Yoshida N, Yokohama A, Saito S.
    • Journal Title

      British Journal of Anaesthesia

      Volume: 124 Issue: 2 Pages: 154-163

    • DOI

      10.1016/j.bja.2019.10.016

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions: current status.2019

    • Author(s)
      Garvey LH, Ebo DG, Kroigaard M, Savic S, Clarke R, Cooke P, Dewachter P, Garcez T, Guttormsen AB, Hopkins PM, Hepner DL, Khan DA, Kolawole H, Kopac P, Marshall S, Mertes PM, Platt P, Rose M, Sabato V, Sadleir P, Savic L, Scherer K, Takazawa T, Volcheck GW, Voltolini S, Laguna JJ.
    • Journal Title

      British Journal of Anaesthesia

      Volume: 123 Issue: 1 Pages: e126-e134

    • DOI

      10.1016/j.bja.2019.03.018

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions.2019

    • Author(s)
      Hopkins PM, Cooke PJ, Clarke RC, Guttormsen AB, Platt PR, Dewachter P, Ebo DG, Garcez T, Garvey LH, Hepner DL, Khan DA, Kolawole H, Kopac P, Kroigaard M, Laguna JJ, Marshal SD, Mertes PM, Rose MA, Savato V, Savic LC, Savic S, Takazawa T, Volcheck GW, Voltolini S, Sadlier PHM
    • Journal Title

      British Journal of Anaesthesia

      Volume: 123 Issue: 1 Pages: e29-e37

    • DOI

      10.1016/j.bja.2019.02.029

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations.2019

    • Author(s)
      Savic LC, Khan DA, Kopac P, Clarke RC, Cooke PJ, Dewachter P, Ebo DG, Garcez T, Garvey LH, Guttormsen AB, Hopkins PM, Hepner DL, Kolawole H, Kroigaard M, Laguna JJ, Marshal SD, Mertes PM,Platt PR, Rose MA, Savato V, Sadlier PHM, Savic S, Takazawa T, Voltolini S, Volcheck GW.
    • Journal Title

      British Journal of Anaesthesia

      Volume: 123 Issue: 1 Pages: e82-e94

    • DOI

      10.1016/j.bja.2019.01.026

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Management of suspected immediate perioperative allergic reactions -an international overview and consensus recommendations.2019

    • Author(s)
      Garvey LH, Dewachter P, Hepner DL, Kolawole H, Mertes P, Voltolini S, Clarke RC, Cooke PJ, Tomaz G, Guttormsen AB, Ebo DG, Hopkins PM, Khan DA, Kopac P, Kroigaard, Laguna JJ, Marshal SD, Platt PR, Rose MA, Savato V, Sadleir P, Savic L, Savic S, Scherer K, Takazawa T, Volcheck GW.
    • Journal Title

      British Journal of Anaesthesia

      Volume: 123 Issue: 1 Pages: e50-e64

    • DOI

      10.1016/j.bja.2019.04.044

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mepivacaine-induced anaphylactic shock in a pregnant woman undergoing combined spinal and epidural anesthesia for cesarean delivery: a case report.2019

    • Author(s)
      Takahashi M, Hotta K, Inoue S, Takazawa T, Horiuchi T, Igarashi T, Takeuchi M.
    • Journal Title

      JA Clinical Reports

      Volume: 5 Issue: 1 Pages: 84-84

    • DOI

      10.1186/s40981-019-0302-6

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 手術室発症のアナフィラキシーショック2019

    • Author(s)
      高澤知規
    • Journal Title

      日本臨床麻酔学会誌

      Volume: 39 Pages: 408-414

    • NAID

      130007686848

    • Related Report
      2019 Research-status Report
  • [Journal Article] 病態から見る血圧:アナフィラキシーショック2019

    • Author(s)
      高澤知規
    • Journal Title

      LiSA 別冊秋号

      Volume: 26 Pages: 157-162

    • Related Report
      2019 Research-status Report
  • [Journal Article] In vitro diagnostic tests for perioperative hypersensitivity, a narrative review: potential, limitations, and perspectives2019

    • Author(s)
      Takazawa Tomonori、Sabato Vito、Ebo Didier G.
    • Journal Title

      British Journal of Anaesthesia

      Volume: 印刷中 Issue: 1 Pages: e117-e125

    • DOI

      10.1016/j.bja.2019.01.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparative epidemiology of suspected perioperative hypersensitivity reactions2019

    • Author(s)
      Mertes Paul Michel、Ebo Didier G.、Garcez Tomaz、Rose Michael、Sabato Vito、Takazawa Tomonori et al.
    • Journal Title

      British Journal of Anaesthesia

      Volume: 印刷中 Issue: 1 Pages: e16-e28

    • DOI

      10.1016/j.bja.2019.01.027

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Usefulness of Basophil Activation Tests for Diagnosis of Sugammadex-Induced Anaphylaxis2018

    • Author(s)
      Horiuchi Tatsuo、Yokohama Akihiko、Orihara Masaki、Tomita Yukinari、Tomioka Akihiro、Yoshida Nagahide、Takahashi Kenichiro、Saito Shigeru、Takazawa Tomonori
    • Journal Title

      Anesthesia & Analgesia

      Volume: 126 Issue: 5 Pages: 1509-1516

    • DOI

      10.1213/ane.0000000000002879

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Required cefazolin concentration to maximize diagnostic accuracy of the basophil activation test for cefazolin-induced anaphylaxis2018

    • Author(s)
      Horiuchi Tatsuo、Takazawa Tomonori、Orihara Masaki、Sakamoto Shinya、Yokohama Akihiko、Takahashi Junko、Tomioka Akihiro、Yoshida Nagahide、Hagiwara Kazuaki、Saito Shigeru
    • Journal Title

      Journal of Anesthesia

      Volume: 32 Issue: 6 Pages: 797-805

    • DOI

      10.1007/s00540-018-2555-z

    • NAID

      40021753149

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is sugammadex alone sufficient to cause anaphylaxis?2018

    • Author(s)
      Orihara Masaki、Takazawa Tomonori、Saito Shigeru
    • Journal Title

      Journal of Anesthesia

      Volume: 32 Issue: 2 Pages: 307-307

    • DOI

      10.1007/s00540-018-2453-4

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【筋弛緩管理up-to-date】 ロクロニウム、スガマデクスとアナフィラキシー2018

    • Author(s)
      高澤 知規
    • Journal Title

      麻酔

      Volume: 68 Pages: 41-51

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 周術期アナフィラキシー研究の現状と今後の展望 好塩基球活性化試験の有用性2018

    • Author(s)
      高澤知規, 杉山由紀
    • Journal Title

      臨床麻酔

      Volume: 42 Pages: 1361-1367

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] スガマデクスが原因と思われるアナフィラキシーショック(Kounis症候群)の1症例2018

    • Author(s)
      高橋淳子、堀内辰男、熊倉みなみ、大川牧生、富岡昭裕、高澤知規
    • Journal Title

      麻酔

      Volume: 67 Pages: 637-641

    • NAID

      40021590646

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] スガマデクスによりアナフィラキシーショックを発症した妊婦症例2018

    • Author(s)
      戸田光、石渡美和子、不聞一貴、佐藤克彦、小坂康晴、堀内辰男、高澤知規、岡本浩嗣
    • Journal Title

      麻酔

      Volume: 67 Pages: 647-650

    • NAID

      40021644329

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2回目のスガマデクス投与によりアナフィラキシーを呈した1症例2018

    • Author(s)
      折原雅紀、高澤知規、堀内辰男、岩光麗美、渡邉巌、齋藤繁
    • Journal Title

      臨床麻酔

      Volume: 42 Pages: 619-621

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【薬物アレルギーをめぐって】 全身麻酔中のアナフィラキシー2018

    • Author(s)
      堀内辰男, 高澤知規
    • Journal Title

      アレルギー・免疫

      Volume: 25 Pages: 50-57

    • Related Report
      2018 Research-status Report
  • [Presentation] 手術室におけるアナフィラキシーショックへの対応2020

    • Author(s)
      高澤知規
    • Organizer
      日本麻酔科学会第67回学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ロクロニウムによるアナフィラキシー:好塩基球活性化試験による診断のためのカットオフ値の検討と発生頻度の調査2020

    • Author(s)
      南雲一洋、高澤知規、折原雅紀、堀内辰男、坂本晋也、齋藤繁
    • Organizer
      日本麻酔科学会第67回学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 術直後に血圧低下をきたし、薬剤性アナフィラキシーと鑑別を要した敗血症性ショックの1症例2020

    • Author(s)
      中曽根千草、折原雅紀、高澤知規、南雲一洋、廣木忠直、齋藤繁
    • Organizer
      日本臨床麻酔学会第40回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 好塩基球活性化試験により発症メカニズムが推定できた、スガマデクスによるアナフィラキシーの1症例2020

    • Author(s)
      堀内辰男、折原雅紀、坂本晋也、南雲一洋、高澤知規、内山睦、齋藤繁
    • Organizer
      日本臨床麻酔学会第40回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] IgEの関与が示唆されたクロルヘキシジンによるアナフィラキシーの1症例2020

    • Author(s)
      折原雅紀、高澤知規、南雲一洋、丸山登、碓氷桃子、齋藤繁
    • Organizer
      日本臨床麻酔学会第40回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Comparison of sugammadex and neostigmine in terms of the incidence of anaphylaxis: A retrospective observational study2019

    • Author(s)
      Orihara M, Takazawa T, Horiuchi T, Sakamoto S, Nagumo K, Tomita Y, Yoshida N, Yokohama A, Saito S
    • Organizer
      American Society for Anesthesiologists Annual Meeting 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Intraoperative anaphylaxis related to aprotinin after local application of fibrin sealant probably caused by and IgE-dependent mechamism: A case report2019

    • Author(s)
      Horiuchi T, Takazawa T, Orihara M, Sakamoto S, Uchiyama M, Yota Y, Yano H, Mogi K, Taguchi M, Saito S
    • Organizer
      EAACI Annual Meeting 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 周術期アナフィラキシーショック2019

    • Author(s)
      高澤知規
    • Organizer
      日本臨床麻酔学会第39回大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 抗菌薬使用時の注意事項:アレルギー反応を含めて2019

    • Author(s)
      高澤知規
    • Organizer
      日本臨床麻酔学会第39回大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 周術期に必要なアナフィラキシーの知識2019

    • Author(s)
      高澤知規
    • Organizer
      2019年度 第12回周術期管理チームセミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] スガマデクスに由来するアナフィラキシーについて知っておくべきこと2019

    • Author(s)
      高澤知規
    • Organizer
      日本臨床麻酔学会第39回大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 術中アナフィラキシー発症後血中トリプターゼ値の経時的変化を認めた1症例2019

    • Author(s)
      坂本 晋也、福良 治彦、家島 仁史、高橋 利文、折原 雅紀、堀内 辰男、高澤 知規、齋藤 繁
    • Organizer
      日本臨床麻酔学会第39回大会
    • Related Report
      2019 Research-status Report
  • [Presentation] スガマデクスによるアナフィラキシーが疑われた一例2019

    • Author(s)
      南雲 一洋、堀内 辰男、折原 雅紀、高澤 知規、齋藤 繁
    • Organizer
      日本麻酔科学会関東甲信越東京支部第59回合同学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] A case of sugammadex-induced anaphylactic shock2018

    • Author(s)
      Ishibashi C, Matsumoto S, Horiuchi T, Orihara M, Takazawa T, Yamaguchi K
    • Organizer
      American Society of Anesthesiologists Annual Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Basophil activation tests can distinguish between IgE dependent and independent drug-induced anaphylaxis2018

    • Author(s)
      Horiuchi T, Takazawa T, Saito S
    • Organizer
      EAACI Drug Hypersensitivity Meeting
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 手術室発症のアナフィラキシーショック2018

    • Author(s)
      高澤 知規
    • Organizer
      日本臨床麻酔学会第38回大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 麻酔中のアナフィラキシー2018

    • Author(s)
      高澤 知規
    • Organizer
      第46回日本歯科麻酔学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 抗菌薬の適正使用とアナフィラキシーショック対応2018

    • Author(s)
      高澤 知規
    • Organizer
      第22回 日本神経麻酔集中治療学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ロクロニウムによるアナフィラキシーと診断した患者に対し筋弛緩薬を使用せずに再手術を行った1症例2018

    • Author(s)
      飯塚 紗希、堀内 辰男、関 智子、須藤 亮、高澤 知規、齋藤 繁
    • Organizer
      日本臨床麻酔学会第38回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 複数の抗菌薬へのアレルギーの既往を有する患者の麻酔2018

    • Author(s)
      坂本 尚子、加藤 崇央、杉本 真由、堀内 辰男、高澤 知規、小山 薫
    • Organizer
      日本麻酔科学会関東甲信越。東京支部第58回合同学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 日本国内における周術期アナフィラキシーの文献的考察2018

    • Author(s)
      坂本 晋也、高澤 知規、堀内 辰男、折原 雅紀、南雲 一洋、齋藤 繁
    • Organizer
      日本麻酔科学会関東甲信越。東京支部第58回合同学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ブチルスコポラミンに対するアナフィラキシーショックの1症例2018

    • Author(s)
      白石 としえ、仲村 光世、平林 清子、益本 憲太郎、堀内 辰男、高澤 知規
    • Organizer
      日本麻酔科学会関東甲信越。東京支部第58回合同学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ロクロニウムによるアナフィラキシー患者の再手術に対して被疑薬を使用せずに麻酔管理を行った1症例2018

    • Author(s)
      折原 雅紀、高澤 知規、坂本 晋也、堀内 辰男、齋藤 繁
    • Organizer
      日本麻酔科学会関東甲信越。東京支部第58回合同学術集会
    • Related Report
      2018 Research-status Report
  • [Book] 救急・集中治療 最新ガイドライン 2020-'212020

    • Author(s)
      岡元 和文
    • Total Pages
      484
    • Publisher
      総合医学社
    • ISBN
      9784883786848
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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