Development of a definitive diagnosis of perioperative anaphylaxis: measurement of antigen-specific IgE and urinary markers
| Project/Area Number |
18K08809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
村田 幸久 東京大学, 大学院農学生命科学研究科(農学部), 准教授 (40422365)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アナフィラキシー |
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| Outline of Final Research Achievements |
In this study, urine samples were collected from patients who developed anaphylaxis during the perioperative period, and the Tetranor-PGDM concentration was measured. So far, urine samples for 11 cases have been collected, and measurement of Tetranor-PGDM concentration by mass spectrometer has been completed in all cases. As a result, changes in Tetranor-PGDM concentration in perioperative anaphylaxis cases are becoming clear. Applicants are also working on the development of a blood-specific IgE measurement method for sugammadex.
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| Academic Significance and Societal Importance of the Research Achievements |
申請者らが研究対象としてきた周術期アナフィラキシーにおいて、技術と経験の蓄積によって、皮膚テストとBATの診断精度は高まった。しかし、患者によっては侵襲のある皮膚テストを敬遠し、検査が行えないことがある。しかし、今回の開発対象となる特異的IgE測定や尿中マーカーが実用化されれば、低侵襲で実施可能な検査の選択肢が増えることになり、研究開発の意義は大きいと考える
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] The use of drug provocation testing in the investigation of suspected immediate perioperative allergic reactions: current status.2019
Author(s)
Garvey LH, Ebo DG, Kroigaard M, Savic S, Clarke R, Cooke P, Dewachter P, Garcez T, Guttormsen AB, Hopkins PM, Hepner DL, Khan DA, Kolawole H, Kopac P, Marshall S, Mertes PM, Platt P, Rose M, Sabato V, Sadleir P, Savic L, Scherer K, Takazawa T, Volcheck GW, Voltolini S, Laguna JJ.
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Journal Title
British Journal of Anaesthesia
Volume: 123
Issue: 1
Pages: e126-e134
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions.2019
Author(s)
Hopkins PM, Cooke PJ, Clarke RC, Guttormsen AB, Platt PR, Dewachter P, Ebo DG, Garcez T, Garvey LH, Hepner DL, Khan DA, Kolawole H, Kopac P, Kroigaard M, Laguna JJ, Marshal SD, Mertes PM, Rose MA, Savato V, Savic LC, Savic S, Takazawa T, Volcheck GW, Voltolini S, Sadlier PHM
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Journal Title
British Journal of Anaesthesia
Volume: 123
Issue: 1
Pages: e29-e37
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations.2019
Author(s)
Savic LC, Khan DA, Kopac P, Clarke RC, Cooke PJ, Dewachter P, Ebo DG, Garcez T, Garvey LH, Guttormsen AB, Hopkins PM, Hepner DL, Kolawole H, Kroigaard M, Laguna JJ, Marshal SD, Mertes PM,Platt PR, Rose MA, Savato V, Sadlier PHM, Savic S, Takazawa T, Voltolini S, Volcheck GW.
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Journal Title
British Journal of Anaesthesia
Volume: 123
Issue: 1
Pages: e82-e94
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Management of suspected immediate perioperative allergic reactions -an international overview and consensus recommendations.2019
Author(s)
Garvey LH, Dewachter P, Hepner DL, Kolawole H, Mertes P, Voltolini S, Clarke RC, Cooke PJ, Tomaz G, Guttormsen AB, Ebo DG, Hopkins PM, Khan DA, Kopac P, Kroigaard, Laguna JJ, Marshal SD, Platt PR, Rose MA, Savato V, Sadleir P, Savic L, Savic S, Scherer K, Takazawa T, Volcheck GW.
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Journal Title
British Journal of Anaesthesia
Volume: 123
Issue: 1
Pages: e50-e64
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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