| Project/Area Number |
18K08822
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Nagoya City University |
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Principal Investigator |
SOBUE Kazuya 名古屋市立大学, 医薬学総合研究院(医学), 教授 (90264738)
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| Co-Investigator(Kenkyū-buntansha) |
太田 晴子 名古屋市立大学, 医薬学総合研究院(医学), 講師 (90534751)
草間 宣好 名古屋市立大学, 医薬学総合研究院(医学), 講師 (60336691)
大澤 匡弘 名古屋市立大学, 医薬学総合研究院(薬学), 准教授 (80369173)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 慢性疼痛 / 海馬 / 神経細胞の新生低下 / 神経細胞新生 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the mechanism (neural circuits involved) and physiological significance of the decrease in hippocampal neurogenesis in chronic pain, and to examine the possibility that this is one of the causes of prolonged pain. We found that neuropathic pain-induced decrease in hippocampal neurogenesis involves a decrease in the number of neural progenitor cells in the subgranular zone (SGZ) of the hippocampal dentate gyrus and activation of the neural circuitry projecting from the spinal dorsal horn (SDH) to the lateral parabrachial nucleus (LPB). Since SDH-LPB nerves are negative affective circuits, the decrease in hippocampal neurogenesis due to stimulation involves activation of neural circuits that transmit the negative emotions of pain. In addition, we found that somatosensory neural circuits of pain are not involved in the decrease of hippocampal neurogenesis.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、神経障害性疼痛による海馬の神経新生低下に、海馬歯状回の顆粒細胞下帯（SGZ）の神経前駆細胞数の低下や脊髄後角（SDH）から外側腕傍核（LPB）に投射する神経回路の活性化が関わることが明らかになった。これが痛みの遷延化の原因のひとつである可能性があり、今後の研究で慢性疼痛の治療法開発につながる可能性がある。
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