The development of screening test for the chronic postoperative pain
| Project/Area Number |
18K08826
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55050:Anesthesiology-related
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| Research Institution | Meikai University |
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Principal Investigator |
Yuka Oono 明海大学, 歯学部, 准教授 (70451961)
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| Co-Investigator(Kenkyū-buntansha) |
小長谷 光 明海大学, 歯学部, 教授 (20251548)
大上 沙央理 明海大学, 歯学部, 講師 (80451962)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 遷延性術後痛 / スクリーニング / CPM |
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| Outline of Final Research Achievements |
Aim: To investigate the relationship between pre-operative conditioned pain modulation (CPM) and pain catastrophizing scale (PCS) and acute post-operative pain (POP) severity after orthognathic surgery by assessing pre-operative CPM and PCS. Methods: The pressure pain threshold and tonic painful cold-heat pulse stimulation were used as the test and conditioning stimuli, respectively. The pain area under the post-operative VAS area under the curve (VASAUC) was estimated. The associations between CPM, PCS, and VASAUC were also analyzed. Results: For patients with negative CPM effects, multiple regression analysis revealed a prediction formula of log(VASAUC) = (－0.02 × CPM effect) + (0.13 × PCS-Magnification) + 5.10 (adjusted R2 = 0.4578, p=0.00002, CPM effect; p=0.002, PCS-Magnification; p=0.0004), indicating that a weaker CPM and higher PCS scores were associated with more acute POP after surgery. Conclusion: CPM and PCS can predict acute POP following orthognathic surgery.
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| Academic Significance and Societal Importance of the Research Achievements |
術前に評価した、内因性疼痛調節機構を反映すると考えられるConditioned Pain Modulation（CPM）と痛みの破局的思考Pain Catastrophizing Scale（PCS）が、術後痛を予測することが示唆された。術後急性痛は遷延性術後痛発症のリスクファクターであることが報告されており、本研究成果から術後急性痛発症のリスクが高い患者を同定することは、遷延性術後痛発症のスクリーニングにつながり、遷延性術後痛発症予防、ひいては治療に難渋する慢性疼痛発症予防に繋がると考えられる。結果として、国民のQOL上昇、医療費抑制等、大きな医療的、社会的及び経済的波及効果が見込まれる。
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Report
(5 results)
Research Products
(33 results)
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[Journal Article] 【ペインリハビリテーションの新潮流・新戦略】 ペインリハビリテーションの実践 慢性疼痛の原因となる各種疾患について ペインリハビリテーション各論 顎関節症の原因・治療・リハビリテーション2018
Author(s)
松香 芳三,小見山 道,石垣 尚一,鳥巣 哲朗,佐藤 仁,大倉 一夫,大野 由夏,島田 明子,山崎 陽子,峯 篤史,長縄 拓哉,佐久間 泰司,佐々木 啓一,今村 佳樹
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Journal Title
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Peer Reviewed
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[Presentation] Conditioned pain modulation (CPM) predicts acute post-operative pain in orthognathic surgery2018
Author(s)
Oono Y, Takashima K, Imamura T, Uchida S, Takagi S, Makino K, Nagasaka H, Gazerani P, Wang K, Arendt-Nielsen L, Kohase H.
Organizer
the 17th World Congress on Pain, Boston, USA, September 12 to 16, 2018.
Related Report
Int'l Joint Research
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[Presentation] Can the increase of emotional sweating rate predict the disturbance of anterograde amnesic effect during intravenous sedation？2018
Author(s)
Hayakawa K, Takagi S, Takashima K, Imamura T, Uchida S, Makino K, Kohase H.
Organizer
the 17th World Congress on Pain, Boston, USA, September 12 to 16, 2018.
Related Report
Int'l Joint Research
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[Presentation] Pain catastrophizing scale (PCS)-magnification correlates the period of acute post-operative pain in orthognathic surgery2018
Author(s)
Takashima K, Oono Y, Matsumoto K, Hayakawa K, Matsumura M, Uesugi N, Uchida S, Takagi S,Kobayashi K, Makino K, Hasegawa A, Nagasaka H, Wang K, Arendt-Nielsen L, Kohase H.
Organizer
The International Federation of Dental Anesthesiology Societies, Nara, Japan, 5-7 October 2018
Related Report
Int'l Joint Research
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[Presentation] 顎変形症手術において術前のconditioned pain modulation(CPM)測定は術後痛発症を予測する2018
Author(s)
高島 恵子, 大野 由夏, 松本 勝洋, 松村 真由美, 上杉 典子, 早川 華穂, 内田 茂則, 高木 沙央理, 長谷川 彰彦, 長坂 浩, 小長谷 光
Organizer
第45回日本歯科麻酔学会総会・学術集会 2018年10月4日～10月7日 松本、長野
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