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Myeloid-derived suppressor cells infiltrate the brain and suppress neuroinflammation in a mouse model of focal traumatic brain injury

Research Project

Project/Area Number 18K08886
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionOsaka University

Principal Investigator

Hosomi Sanae  大阪大学, 医学部附属病院, 医員 (90644005)

Co-Investigator(Kenkyū-buntansha) 梅村 穣  大阪大学, 医学系研究科, 招へい教員 (20743561)
吉矢 和久  大阪大学, 医学系研究科, 招へい教員 (40379201)
嶋津 岳士  大阪大学, 医学系研究科, 教授 (50196474)
小倉 裕司  大阪大学, 医学系研究科, 准教授 (70301265)
大西 光雄  大阪大学, 医学系研究科, 招へい教員 (70597830)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords神経炎症 / ミクログリア / MDSC / 骨髄由来抑制細胞 / 頭部外傷 / 慢性神経炎症 / 高次脳機能障害
Outline of Final Research Achievements

Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive characteristics allowing them to limit inflammation and facilitate wound healing and recovery. Although MDSCs are a newly-determined cell type that has drawn recent attention in the immunology field, their neuroimmunological characteristics remain unstudied. In this study, we explored the suppressive role of MDSCs in cerebral inflammatory reactions after focal traumatic brain injury (TBI) using in vivo imaging. We determined that CD11b+/Gr-1+ cells infiltrating the contusion area are MDSCs by morphological, functional, and phenotypic analysis. MDSCs are among the first responders to tissue injury, responding even prior to microglial activation. Positron emission tomography imaging of translocator protein results suggest that infiltrating MDSCs suppress neuronal inflammation and interact with resident immune cells, like microglia, following focal TBI.

Academic Significance and Societal Importance of the Research Achievements

従来、免疫特権と考えられていた中枢神経でのMDSCsに関する論文は少ない。熱傷および敗血症のような急性炎症モデルにおいては、MDSCは自然免疫応答を増加させ有益な役割を 果たすことが報告されているが、頭部外傷後の神経炎 症におけるMDSCの役割やメカニズムはほとんど解明されていない。我々はMDSCが頭部外 傷後の神経炎症を抑制する役割を担うことを世界に先駆けて発見した。本研究では、神経炎症におけるMDSCのまだ解明されていない免疫応答を解明することができた。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2022 2021 2020 2019 2018

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 10 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Association of Pre-Hospital Helicopter Transport with Reduced Mortality in Traumatic Brain Injury in Japan: A Nationwide Retrospective Cohort Study.2022

    • Author(s)
      Hosomi S, Kitamura T, Sobue T, Nakagawa Y, Ogura H, Shimazu T.
    • Journal Title

      Journal of neurotrauma.

      Volume: 39(1-2) Issue: 1-2 Pages: 76-85

    • DOI

      10.1089/neu.2021.0181

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide Improvements in Geriatric Mortality due to Traumatic Brain Injury in Japan.2022

    • Author(s)
      Hosomi S, Kitamura T, Sobue T, Nakagawa Y, Ogura H, Shimazu T.
    • Journal Title

      BMC Emerg Med.

      Volume: 22(1) Issue: 1 Pages: 24-24

    • DOI

      10.1186/s12873-022-00577-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Survival Trends in Adults with Out-of-Hospital Cardiac Arrests after Traffic Collisions in Japan: A Population-Based Study2022

    • Author(s)
      Hosomi S, Kitamura T, Sobue T, Zha L, Kiyohara K, Oda J.
    • Journal Title

      J Clin Med.

      Volume: 11(3) Issue: 3 Pages: 745-745

    • DOI

      10.3390/jcm11030745

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiology and Outcome of Pediatric Out-of-Hospital Cardiac Arrest after Traffic Collision in Japan: A Population-Based Study2022

    • Author(s)
      Hosomi S, Kitamura T, Sobue T, Zha L, Kiyohara K, Oda J.
    • Journal Title

      J Clin Med.

      Volume: 11(3) Issue: 3 Pages: 831-831

    • DOI

      10.3390/jcm11030831

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex and age differences in isolated traumatic brain injury: a retrospective observational study.2021

    • Author(s)
      Hosomi S, Kitamura T, Sobue T, Ogura H, Shimazu T.
    • Journal Title

      BMC Neurol.

      Volume: 21(1) Issue: 1 Pages: 261-261

    • DOI

      10.1186/s12883-021-02305-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Survival outcomes after traumatic brain injury during national academic meeting days in Japan.2021

    • Author(s)
      Hosomi S, Kitamura T, Sobue T, Ogura H, Shimazu T.
    • Journal Title

      Sci Rep.

      Volume: 11(1) Issue: 1 Pages: 15206-15206

    • DOI

      10.1038/s41598-021-94759-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between vasopressor use and mortality in patients with severe traumatic brain injury: a nationwide retrospective cohort study in Japan.2021

    • Author(s)
      Hosomi S, Sobue T, Kitamura T, Hirayama A, Ogura H, Shimazu T.
    • Journal Title

      Acute Med Surg.

      Volume: 8(1) Issue: 1

    • DOI

      10.1002/ams2.695

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Original experimental rat model of blast-induced mild traumatic brain injury: a pilot study.2021

    • Author(s)
      Matsuura H, Ohnishi M, Yoshioka Y, Togami Y, Hosomi S, Umemura Y, Ebihara T, Shimizu K, Ogura H, Shimazu T.
    • Journal Title

      Brain Injury

      Volume: 16 Issue: 3 Pages: 1-14

    • DOI

      10.1080/02699052.2020.1861653

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Traumatic brain injury-related inflammatory projection: Beyond local inflammatory responses2020

    • Author(s)
      Sanae Hosomi, Mitsuo Ohnishi, Hiroshi Ogura, Takeshi Shimazu
    • Journal Title

      Acute Medicine & Surgery

      Volume: -

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myeloid-Derived Suppressor Cells Infiltrate the Brain and Suppress Neuroinflammation in a Mouse Model of Focal Traumatic Brain Injury2019

    • Author(s)
      Hosomi S, Koyama Y, Watabe T, Ohnishi M, Ogura H, Yamashita T, Shimazu T.
    • Journal Title

      Neuroscience

      Volume: 406 Pages: 457-466

    • DOI

      10.1016/j.neuroscience.2019.03.015

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inflammatory projections after focal brain injury trigger neuronal network disruption: An 18F-DPA714 PET study in mice2018

    • Author(s)
      Hosomi S, Watabe T, Mori Y, Koyama Y, Adachi S, Hoshi N, Ohnishi M, Ogura H, Yoshioka Y, Hatazawa J, Yamashita T, Shimazu T.
    • Journal Title

      NeuroImage: clinical

      Volume: 20 Pages: 946-954

    • DOI

      10.1016/j.nicl.2018.09.031

    • NAID

      120006543327

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Myeloid-derived suppressor cells infiltrate the brain and suppress neuroinflammation in a mouse model of traumatic brain injury2018

    • Author(s)
      S. Hosomi, Y. Koyama, T. Watabe, M. Ohnishi, H. Ogura, T. Shimazu
    • Organizer
      31st Annual Congress of the European Society of Intensive Care Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Interpretation of TSPO uptake after focal brain injury : an 18F-DPA714 PET study in mice2018

    • Author(s)
      Sanae Hosomi, Tadashi Watabe, Mitsuo Ohnishi, Hiroshi Ogura, Jun Hatazawa, Takeshi Shimazu
    • Organizer
      第58回 日本核医学会学術総会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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