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Development of a novel method to discriminate the pathophysiology of inflammation based on pattern recognition

Research Project

Project/Area Number 18K08892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionNagasaki University

Principal Investigator

Tajima Goro  長崎大学, 病院(医学系), 准教授 (00437427)

Co-Investigator(Kenkyū-buntansha) 松本 直也  長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (50359808)
山野 修平  長崎大学, 病院(医学系), 助教 (60570538)
梅原 敬弘  産業医科大学, 医学部, 准教授 (60617421)
池松 和哉  長崎大学, 医歯薬学総合研究科(医学系), 教授 (80332857)
田崎 修  長崎大学, 病院(医学系), 教授 (90346221)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords全身性炎症反応 / 敗血症 / 熱傷 / パターン認識 / 全身性炎症 / 遺伝子 / パターン / パターン分析 / 炎症 / 感染 / 自然免疫 / パターン解析 / 判別分析
Outline of Final Research Achievements

Using mouse model of different pathological systemic inflammation, infectious inflammation (sepsis) and non-infectious inflammation (burns), RNA sequencing of leukocytes was performed by next-generation sequencing. Gene expression in each systemic inflammation comprehensively underwent transcriptome analysis, and a group of genes characteristic of each pathophysiology was extracted by GO analysis. Gene expression was patterned by scaling PCR measurements of gene groups. Gene expression had a characteristic pattern of each pathophysiology, and by performing canonical discriminant analysis on the measured and patterned values, each pathophysiology could be discriminated 100% independently of the severity. The results suggest that the gene expression patterns extracted by transcriptome analysis may be a novel method for discriminating inflammatory pathophysiology.

Academic Significance and Societal Importance of the Research Achievements

集中治療患者における原因不明の発熱や炎症病態では、炎症・抗炎症に関わるさまざまなバイオマーカーの上昇が報告されるが、単独のマーカーによる診断は困難で、常に‘炎症と抗炎症のバランス’が重要であることが強調されてきた。本研究により複数マーカーの活性化のバランス(=パターン)を評価することで、‘炎症と抗炎症のバランス’を評価する新たな方法の可能性が示唆された。、複数マーカーのパターンを新たな指標として‘どのような’炎症か(炎症の量ではなく質)を評価することで、これまで診断不能であった不明熱や炎症病態の判別が可能となり、適切な病態理解、治療決定につなげられる可能性がある。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2022 2021 2020 2019 2018

All Presentation (8 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] 全身性炎症におけるトランスクリプトーム解析を用いた病態判別法2022

    • Author(s)
      田島吾郎、上村恵理、村橋志門、三浦深雪、池松和哉、田崎修
    • Organizer
      第50回日本救急医学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 病態と重症度からみた自然免疫システム の遺伝子発現分析2021

    • Author(s)
      田島吾郎、上村恵理、村橋志門、三浦深雪、梅原敬弘、池松和哉、田崎修
    • Organizer
      第48回日本救急医学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] PATTERN-BASED ANALYSIS OF GENE EXPRESSION PROFILES BY CANONICAL DISCRIMINANT ANALYSIS COULD IDENTIFY PATHOPHYSIOLOGY REGARDLESS OF DISEASE SEVERITY2020

    • Author(s)
      Goro Tajima, Eri Uemura, Ayako Tokunaga, Miyuki Miura, Takahiro Umehara, Kazuya Ikematsu, Osamu Tasaki
    • Organizer
      79th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 自然免疫システム遺伝子発現のパターン分析による病態判別2020

    • Author(s)
      田島吾郎、上村恵理、徳永彩子、三浦深雪、梅原敬弘、池松和哉、田崎修
    • Organizer
      第48回日本救急医学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] PATTERN-BASED ANALYSIS OF GENE EXPRESSION PROFILE BY CANONICAL DISCRIMINANT ANALYSIS COULD IDENTIFY THE PATHOPHYSIOLOGY REGARDLESS OF THE SEVERITY2020

    • Author(s)
      Goro Tajima, Eri Uemura, Ayako Tokunaga, Miyuki Miura, Takahiro Umehara, Kazuya Ikematsu, Osamu Tasaki
    • Organizer
      79th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 全身性炎症における自然免疫システムの遺伝子発現パターンによる病態判別2019

    • Author(s)
      田島吾郎、徳永彩子、梅原敬弘、池松和哉、田崎修
    • Organizer
      第47回日本救急医学会
    • Related Report
      2019 Research-status Report
  • [Presentation] NOVEL METHOD TO DISCRIMINATE THE PATHOPHYSIOLOGY OF INFLAMMATION BY PATTERN OF INNATE IMMUNE SYSTEM2019

    • Author(s)
      田島 吾郎
    • Organizer
      Society of Critical Care Medicine 48th Critical Care Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 全身性炎症における自然免疫受容体発現パターンの経時変化2018

    • Author(s)
      田島 吾郎
    • Organizer
      第46回日本救急医学会総会・学術総会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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