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Novel therapy for sepsis with probiotic-derived intestinal barriers enhancing molecules

Research Project

Project/Area Number 18K08906
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55060:Emergency medicine-related
Research InstitutionAsahikawa Medical College

Principal Investigator

Takauji Shuhei  旭川医科大学, 医学部, 助教 (20793897)

Co-Investigator(Kenkyū-buntansha) 上野 伸展  旭川医科大学, 医学部, 特任講師 (30436000)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsプロバイオティクス / 腸内細菌 / 敗血症 / 急性膵炎 / 腸内細菌叢 / 重症急性膵炎 / 多臓器不全 / 腸管バリア / Dysbiosis
Outline of Final Research Achievements

Polyphosphate (Poly P) derived from L.brevis altered the intestinal microbiome, decreasing the virulent bacteria Desulfovibrio and increasing the beneficial bacteria Alistipes. In addition, polyphosphate also enhances the intestinal barrier function. Intestinal microbiome is associated with the aggravation of acute pancreatitis, and Poly P attenuates acute pancreatitis through both modification of the intestinal microbiome and enhancement of the intestinal barrier integrity.

Academic Significance and Societal Importance of the Research Achievements

これまで我々が行ってきた長鎖ポリリン酸による研究はいずれも腸管病変を対象にその治療効果を検討してきた。これに対して本研究は長鎖ポリリン酸が腸内細菌叢の変化を引き起こし、膵臓などの腸管外の遠隔臓器にまで作用を及ぼしている可能性を示した点において、その学術的意義は大きい。本研究の社会的意義は、将来、腸内細菌叢をターゲットとした他臓器疾患の治療薬開発につながる可能性を示したことである。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2021 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Polyphosphate, derived from the probiotic Lactobacillus brevis, modulates the intestinal microbiome and attenuates acute pancreatitis.2021

    • Author(s)
      Takauji S, Konishi H, Fujiya M, Ueno N, Tanaka H, Sato H, Isozaki S, Kashima S, Moriichi K, Mizukami Y, Okumura T.
    • Journal Title

      Dig Dis Sci

      Volume: - Issue: 11 Pages: 1-1

    • DOI

      10.1007/s10620-020-06747-9

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Nationwide Comparison Between Sepsis-2 and Sepsis-3 Definition in Japan.2019

    • Author(s)
      Shuhei Takauji, Mineji Hayakawa, Satoshi Fujita
    • Journal Title

      Journal of Intensive Care Medicine

      Volume: - Issue: 12 Pages: 1389-1395

    • DOI

      10.1177/0885066618823151

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 偶発性低体温症に対する V-A ECMO導入と予後について2018

    • Author(s)
      高氏修平
    • Organizer
      第46回 日本救急医学会総会・学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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